{"id":"https://openalex.org/W2109236791","doi":"https://doi.org/10.1162/neco.2010.02-09-969","title":"Alteration of Ambient GABA by Phasic and Tonic Neuronal Activation","display_name":"Alteration of Ambient GABA by Phasic and Tonic Neuronal Activation","publication_year":2010,"publication_date":"2010-01-25","ids":{"openalex":"https://openalex.org/W2109236791","doi":"https://doi.org/10.1162/neco.2010.02-09-969","mag":"2109236791","pmid":"https://pubmed.ncbi.nlm.nih.gov/20100072"},"language":"en","primary_location":{"id":"doi:10.1162/neco.2010.02-09-969","is_oa":false,"landing_page_url":"https://doi.org/10.1162/neco.2010.02-09-969","pdf_url":null,"source":{"id":"https://openalex.org/S207023548","display_name":"Neural Computation","issn_l":"0899-7667","issn":["0899-7667","1530-888X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315718","host_organization_name":"The MIT Press","host_organization_lineage":["https://openalex.org/P4310315718"],"host_organization_lineage_names":["The MIT Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Computation","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073667862","display_name":"Osamu Hoshino","orcid":null},"institutions":[{"id":"https://openalex.org/I6178835","display_name":"Ibaraki University","ror":"https://ror.org/00sjd5653","country_code":"JP","type":"education","lineage":["https://openalex.org/I6178835"]},{"id":"https://openalex.org/I65143321","display_name":"Hitachi (Japan)","ror":"https://ror.org/02exqgm79","country_code":"JP","type":"company","lineage":["https://openalex.org/I65143321"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Osamu Hoshino","raw_affiliation_strings":["Department of Intelligent Systems Engineering, Ibaraki University, Hitachi, Ibaraki, 316-8511 Japan","Department of Intelligent Systems Engineering, Ibaraki University, Hitachi, Ibaraki, 316-8511 Japan,"],"affiliations":[{"raw_affiliation_string":"Department of Intelligent Systems Engineering, Ibaraki University, Hitachi, Ibaraki, 316-8511 Japan","institution_ids":["https://openalex.org/I6178835","https://openalex.org/I65143321"]},{"raw_affiliation_string":"Department of Intelligent Systems Engineering, Ibaraki University, Hitachi, Ibaraki, 316-8511 Japan,","institution_ids":["https://openalex.org/I6178835","https://openalex.org/I65143321"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5073667862"],"corresponding_institution_ids":["https://openalex.org/I6178835","https://openalex.org/I65143321"],"apc_list":null,"apc_paid":null,"fwci":0.6313,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.70451643,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"22","issue":"5","first_page":"1358","last_page":"1382"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9915000200271606,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tonic","display_name":"Tonic (physiology)","score":0.92555832862854},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.7504639625549316},{"id":"https://openalex.org/keywords/stimulus","display_name":"Stimulus (psychology)","score":0.5681769251823425},{"id":"https://openalex.org/keywords/inhibitory-postsynaptic-potential","display_name":"Inhibitory postsynaptic potential","score":0.5299704074859619},{"id":"https://openalex.org/keywords/gabaergic","display_name":"GABAergic","score":0.5239236950874329},{"id":"https://openalex.org/keywords/auditory-cortex","display_name":"Auditory cortex","score":0.4754894971847534},{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.46380284428596497},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4001224637031555},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.29951342940330505}],"concepts":[{"id":"https://openalex.org/C127573956","wikidata":"https://www.wikidata.org/wiki/Q7821376","display_name":"Tonic (physiology)","level":2,"score":0.92555832862854},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7504639625549316},{"id":"https://openalex.org/C2779918689","wikidata":"https://www.wikidata.org/wiki/Q3771842","display_name":"Stimulus (psychology)","level":2,"score":0.5681769251823425},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.5299704074859619},{"id":"https://openalex.org/C2779177108","wikidata":"https://www.wikidata.org/wiki/Q18356742","display_name":"GABAergic","level":3,"score":0.5239236950874329},{"id":"https://openalex.org/C2780297895","wikidata":"https://www.wikidata.org/wiki/Q18676","display_name":"Auditory cortex","level":2,"score":0.4754894971847534},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.46380284428596497},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4001224637031555},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.29951342940330505},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000161","descriptor_name":"Acoustic Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000161","descriptor_name":"Acoustic Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000161","descriptor_name":"Acoustic Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001303","descriptor_name":"Auditory Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001303","descriptor_name":"Auditory Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001303","descriptor_name":"Auditory Cortex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001306","descriptor_name":"Auditory Pathways","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001306","descriptor_name":"Auditory Pathways","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001306","descriptor_name":"Auditory Pathways","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001307","descriptor_name":"Auditory Perception","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001307","descriptor_name":"Auditory Perception","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001307","descriptor_name":"Auditory Perception","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007395","descriptor_name":"Interneurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009433","descriptor_name":"Neural Inhibition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009433","descriptor_name":"Neural Inhibition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009433","descriptor_name":"Neural Inhibition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010507","descriptor_name":"Periodicity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010507","descriptor_name":"Periodicity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010507","descriptor_name":"Periodicity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1162/neco.2010.02-09-969","is_oa":false,"landing_page_url":"https://doi.org/10.1162/neco.2010.02-09-969","pdf_url":null,"source":{"id":"https://openalex.org/S207023548","display_name":"Neural Computation","issn_l":"0899-7667","issn":["0899-7667","1530-888X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315718","host_organization_name":"The MIT Press","host_organization_lineage":["https://openalex.org/P4310315718"],"host_organization_lineage_names":["The MIT Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Computation","raw_type":"journal-article"},{"id":"pmid:20100072","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20100072","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural computation","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W88389025","https://openalex.org/W1578289944","https://openalex.org/W1834606595","https://openalex.org/W1963576035","https://openalex.org/W1966692769","https://openalex.org/W1977265431","https://openalex.org/W1982662582","https://openalex.org/W1984212133","https://openalex.org/W1989998569","https://openalex.org/W2013045879","https://openalex.org/W2018118045","https://openalex.org/W2023781008","https://openalex.org/W2025114609","https://openalex.org/W2025603247","https://openalex.org/W2029215893","https://openalex.org/W2037416589","https://openalex.org/W2054349135","https://openalex.org/W2054930781","https://openalex.org/W2060535140","https://openalex.org/W2061769920","https://openalex.org/W2072472879","https://openalex.org/W2080218996","https://openalex.org/W2087356150","https://openalex.org/W2094850964","https://openalex.org/W2104291446","https://openalex.org/W2128806021","https://openalex.org/W2135382901","https://openalex.org/W2144841925","https://openalex.org/W2147540108","https://openalex.org/W2160482844","https://openalex.org/W2168467995","https://openalex.org/W4206600001","https://openalex.org/W4293254491"],"related_works":["https://openalex.org/W2041310765","https://openalex.org/W2047983188","https://openalex.org/W2233272215","https://openalex.org/W1963483448","https://openalex.org/W609478862","https://openalex.org/W1996480186","https://openalex.org/W3131262190","https://openalex.org/W2031277397","https://openalex.org/W2951553096","https://openalex.org/W2084829611"],"abstract_inverted_index":{"Neurons":[0],"of":[1,50,55,80,122,142,157,172,192,208,236,248],"primary":[2],"auditory":[3,57,104,269],"cortex":[4],"(AI)":[5],"emit":[6],"spikes":[7,41,70],"(action":[8],"potentials)":[9],"in":[10,17,102,257],"two":[11],"distinct":[12],"manners,":[13],"responding":[14],"to":[15,97,148,151,161,201,222,225],"sounds":[16],"an":[18,56],"onset":[19,54,88,241],"or":[20],"a":[21,43,60,76,99,110,152,162,166,198,255],"sustained":[22,92,216],"manner.":[23],"The":[24,37,139,155],"former":[25],"AI":[26,249,259],"neurons":[27,260],"are":[28,95],"called":[29],"phasic":[30,38,111,158,184,202],"cells":[31,39,67,147],"and":[32,64,85,117,133,218],"the":[33,53,65,72,87,91,120,170,180,206,209,215,220,226,233,245,267],"latter":[34],"tonic":[35,66,146,153,163,173,187,210],"cells.":[36,174],"generate":[40,69],"for":[42,179,266],"brief":[44],"time":[45],"period":[46],"(less":[47],"than":[48],"hundreds":[49],"milliseconds)":[51],"at":[52,205],"stimulus":[58],"(e.g.,":[59],"tone":[61],"frequency":[62],"sound),":[63],"continuously":[68],"throughout":[71],"stimulation":[73],"period.":[74],"Simulating":[75],"neural":[77],"network":[78,221],"model":[79],"AI,":[81],"we":[82],"investigated":[83],"whether":[84],"how":[86],"discharges":[89,93,195,217,252],"influence":[90],"that":[94,232,262],"believed":[96],"play":[98],"central":[100],"role":[101,256],"encoding":[103],"information.":[105],"Onset":[106],"discharges,":[107,242],"triggered":[108,239],"by":[109,129,189,197,240],"input,":[112],"briefly":[113],"excited":[114],"GABAergic":[115],"interneurons":[116],"transiently":[118],"increased":[119],"level":[121],"ambient":[123,143,237],"GABA,":[124,238],"which":[125],"was":[126],"immediately":[127],"recognized":[128],"extrasynaptic":[130],"GABA(a)":[131],"receptors":[132],"provided":[134],"inhibitory":[135],"currents":[136],"into":[137],"neurons.":[138,250],"transient":[140],"alteration":[141,235],"GABA":[144],"allowed":[145,219],"respond":[149],"selectively":[150],"input.":[154,270],"timing":[156,178],"input":[159,185,188,200,211],"relative":[160],"one":[164],"had":[165],"great":[167],"impact":[168],"on":[169],"responsiveness":[171],"We":[175,230],"found":[176],"optimal":[177],"best":[181],"selective":[182],"responsiveness:":[183],"preceding":[186],"several":[190],"tens":[191],"milliseconds.":[193],"Offset":[194,251],"induced":[196],"secondary":[199],"cells,":[203],"applied":[204],"end":[207],"period,":[212],"suddenly":[213],"terminated":[214],"return":[223],"rapidly":[224],"ongoing-spontaneous":[227],"neuronal":[228],"state.":[229],"suggest":[231],"transporter-mediated":[234],"may":[243,253],"improve":[244],"response":[246],"property":[247],"have":[254],"resetting":[258],"so":[261],"they":[263],"can":[264],"prepare":[265],"next":[268]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
