{"id":"https://openalex.org/W2280222389","doi":"https://doi.org/10.1162/jocn_a_00939","title":"A Genetic Polymorphism of the Human Dopamine Transporter Determines the Impact of Sleep Deprivation on Brain Responses to Rewards and Punishments","display_name":"A Genetic Polymorphism of the Human Dopamine Transporter Determines the Impact of Sleep Deprivation on Brain Responses to Rewards and Punishments","publication_year":2016,"publication_date":"2016-02-26","ids":{"openalex":"https://openalex.org/W2280222389","doi":"https://doi.org/10.1162/jocn_a_00939","mag":"2280222389","pmid":"https://pubmed.ncbi.nlm.nih.gov/26918589"},"language":"en","primary_location":{"id":"doi:10.1162/jocn_a_00939","is_oa":false,"landing_page_url":"https://doi.org/10.1162/jocn_a_00939","pdf_url":null,"source":{"id":"https://openalex.org/S123144817","display_name":"Journal of Cognitive Neuroscience","issn_l":"0898-929X","issn":["0898-929X","1530-8898"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315718","host_organization_name":"The MIT Press","host_organization_lineage":["https://openalex.org/P4310315718"],"host_organization_lineage_names":["The MIT Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cognitive Neuroscience","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102988632","display_name":"Stephanie M. Greer","orcid":"https://orcid.org/0000-0002-6987-4617"},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephanie M. Greer","raw_affiliation_strings":["University of California, Berkeley"],"affiliations":[{"raw_affiliation_string":"University of California, Berkeley","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063915859","display_name":"Andrea N. Goldstein","orcid":null},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea N. Goldstein","raw_affiliation_strings":["University of California, Berkeley"],"affiliations":[{"raw_affiliation_string":"University of California, Berkeley","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052014576","display_name":"Brian Knutson","orcid":"https://orcid.org/0000-0002-7669-426X"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Knutson","raw_affiliation_strings":["Stanford University"],"affiliations":[{"raw_affiliation_string":"Stanford University","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074973044","display_name":"Matthew P. Walker","orcid":"https://orcid.org/0000-0002-7839-6389"},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew P. Walker","raw_affiliation_strings":["University of California, Berkeley"],"affiliations":[{"raw_affiliation_string":"University of California, Berkeley","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5102988632"],"corresponding_institution_ids":["https://openalex.org/I95457486"],"apc_list":null,"apc_paid":null,"fwci":2.1127,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.86003316,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"28","issue":"6","first_page":"803","last_page":"810"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dopamine-transporter","display_name":"Dopamine transporter","score":0.7780066132545471},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.7503307461738586},{"id":"https://openalex.org/keywords/dopamine","display_name":"Dopamine","score":0.7209227085113525},{"id":"https://openalex.org/keywords/sleep-deprivation","display_name":"Sleep deprivation","score":0.6452526450157166},{"id":"https://openalex.org/keywords/dopaminergic","display_name":"Dopaminergic","score":0.6061305999755859},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.5937537550926208},{"id":"https://openalex.org/keywords/cognition","display_name":"Cognition","score":0.20743241906166077}],"concepts":[{"id":"https://openalex.org/C2776755682","wikidata":"https://www.wikidata.org/wiki/Q2271947","display_name":"Dopamine transporter","level":4,"score":0.7780066132545471},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.7503307461738586},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.7209227085113525},{"id":"https://openalex.org/C2778329153","wikidata":"https://www.wikidata.org/wiki/Q1364801","display_name":"Sleep deprivation","level":3,"score":0.6452526450157166},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.6061305999755859},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5937537550926208},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.20743241906166077}],"mesh":[{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011678","descriptor_name":"Punishment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011678","descriptor_name":"Punishment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011678","descriptor_name":"Punishment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012201","descriptor_name":"Reward","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012201","descriptor_name":"Reward","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012201","descriptor_name":"Reward","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012892","descriptor_name":"Sleep Deprivation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012892","descriptor_name":"Sleep Deprivation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012892","descriptor_name":"Sleep Deprivation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012892","descriptor_name":"Sleep Deprivation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012892","descriptor_name":"Sleep Deprivation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012892","descriptor_name":"Sleep Deprivation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D017286","descriptor_name":"Polysomnography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017286","descriptor_name":"Polysomnography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017286","descriptor_name":"Polysomnography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050483","descriptor_name":"Dopamine Plasma Membrane Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050483","descriptor_name":"Dopamine Plasma Membrane Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050483","descriptor_name":"Dopamine Plasma Membrane Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059031","descriptor_name":"Anticipation, Psychological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059031","descriptor_name":"Anticipation, Psychological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059031","descriptor_name":"Anticipation, Psychological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060005","descriptor_name":"Genotyping Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060005","descriptor_name":"Genotyping Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060005","descriptor_name":"Genotyping Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1162/jocn_a_00939","is_oa":false,"landing_page_url":"https://doi.org/10.1162/jocn_a_00939","pdf_url":null,"source":{"id":"https://openalex.org/S123144817","display_name":"Journal of Cognitive Neuroscience","issn_l":"0898-929X","issn":["0898-929X","1530-8898"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315718","host_organization_name":"The MIT Press","host_organization_lineage":["https://openalex.org/P4310315718"],"host_organization_lineage_names":["The MIT Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cognitive Neuroscience","raw_type":"journal-article"},{"id":"pmid:26918589","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26918589","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cognitive neuroscience","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1206391664","https://openalex.org/W1538619854","https://openalex.org/W1911622955","https://openalex.org/W1964544901","https://openalex.org/W1967306986","https://openalex.org/W1973729800","https://openalex.org/W1973891477","https://openalex.org/W1991476660","https://openalex.org/W1995141428","https://openalex.org/W1997639097","https://openalex.org/W2000875378","https://openalex.org/W2008060633","https://openalex.org/W2010390532","https://openalex.org/W2015859900","https://openalex.org/W2020672544","https://openalex.org/W2024145182","https://openalex.org/W2025015792","https://openalex.org/W2030782909","https://openalex.org/W2031254430","https://openalex.org/W2047601130","https://openalex.org/W2058721253","https://openalex.org/W2070924027","https://openalex.org/W2092868760","https://openalex.org/W2097323670","https://openalex.org/W2107133943","https://openalex.org/W2107219405","https://openalex.org/W2107867628","https://openalex.org/W2108092648","https://openalex.org/W2117703496","https://openalex.org/W2128472904","https://openalex.org/W2137746168","https://openalex.org/W2139283948","https://openalex.org/W2140009084","https://openalex.org/W2145344765","https://openalex.org/W2148902913","https://openalex.org/W2151935022","https://openalex.org/W2159401467","https://openalex.org/W2164179901","https://openalex.org/W2167978793","https://openalex.org/W2168807446","https://openalex.org/W2808011097","https://openalex.org/W3022302886","https://openalex.org/W3122286671","https://openalex.org/W3123832781","https://openalex.org/W3125583209"],"related_works":["https://openalex.org/W2018161271","https://openalex.org/W1891167896","https://openalex.org/W2995805787","https://openalex.org/W2052871164","https://openalex.org/W2147600591","https://openalex.org/W2030104137","https://openalex.org/W2919532134","https://openalex.org/W2075610673","https://openalex.org/W2800704592","https://openalex.org/W24746368"],"abstract_inverted_index":{"Despite":[0],"an":[1,49,150],"emerging":[2],"link":[3],"between":[4,180],"alterations":[5],"in":[6,38,42,64,152,176,195],"motivated":[7],"behavior":[8],"and":[9,25,53,88,183,188,216],"a":[10,113,167,203],"lack":[11],"of":[12,16,23,34,78,115,130,172,186],"sleep,":[13],"the":[14,32,43,59,65,76,106,116,140,178,198],"impact":[15,77],"sleep":[17,79,102,134,161,181,209],"deprivation":[18,80,182],"on":[19,81,105,170],"human":[20,66,171],"brain":[21],"mechanisms":[22],"reward":[24,97],"punishment":[26],"remain":[27],"largely":[28],"unknown,":[29],"as":[30],"does":[31],"role":[33],"trait":[35,62,173],"dopamine":[36,67,74,123,147],"activity":[37],"modulating":[39],"such":[40],"effects":[41],"mesolimbic":[44],"system.":[45],"Combining":[46],"fMRI":[47],"with":[48,71,91,207],"established":[50],"incentive":[51],"paradigm":[52],"individual":[54],"genotyping,":[55],"here,":[56],"we":[57],"test":[58],"hypothesis":[60],"that":[61],"differences":[63],"transporter":[68],"(DAT)":[69],"gene-associated":[70],"altered":[72],"synaptic":[73],"signalling-govern":[75],"neural":[82,184],"sensitivity":[83,153],"to":[84,120,144,154],"impending":[85],"monetary":[86,131,155],"gains":[87],"losses.":[89],"Consistent":[90],"this":[92],"framework,":[93],"markedly":[94],"different":[95],"striatal":[96,126],"responses":[98],"were":[99],"observed":[100],"following":[101,133,160],"loss":[103,156],"depending":[104],"DAT":[107,118,142,199],"functional":[108],"polymorphisms.":[109],"Only":[110],"participants":[111,137],"carrying":[112],"copy":[114],"nine-repeat":[117],"allele-linked":[119,143],"higher":[121],"phasic":[122,146],"activity-expressed":[124],"amplified":[125],"response":[127],"during":[128],"anticipation":[129],"gain":[132],"deprivation.":[135],"Moreover,":[136],"homozygous":[138],"for":[139],"ten-repeat":[141],"lower":[145],"activity-selectively":[148],"demonstrated":[149],"increase":[151],"within":[157],"anterior":[158],"insula":[159],"loss.":[162],"Together,":[163],"these":[164],"data":[165],"reveal":[166],"mechanistic":[168],"dependency":[169],"dopaminergic":[174],"function":[175],"determining":[177],"interaction":[179],"processing":[185],"rewards":[187],"punishments.":[189],"Such":[190],"findings":[191],"have":[192],"clinical":[193],"implications":[194],"disorders":[196],"where":[197],"genetic":[200],"polymorphism":[201],"presents":[202],"known":[204],"risk":[205],"factor":[206],"comorbid":[208],"disruption,":[210],"including":[211],"attention":[212],"hyperactive":[213],"deficit":[214],"disorder":[215],"substance":[217],"abuse.":[218]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}