{"id":"https://openalex.org/W3164942501","doi":"https://doi.org/10.1162/isal_a_00435","title":"Towards open-ended evolutionary simulator for developing novel tumour drug delivery systems","display_name":"Towards open-ended evolutionary simulator for developing novel tumour drug delivery systems","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3164942501","doi":"https://doi.org/10.1162/isal_a_00435","mag":"3164942501"},"language":"en","primary_location":{"id":"doi:10.1162/isal_a_00435","is_oa":false,"landing_page_url":"https://doi.org/10.1162/isal_a_00435","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The 2021 Conference on Artificial Life","raw_type":"proceedings-article"},"type":"preprint","indexed_in":["arxiv","crossref","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/2105.11760","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067703795","display_name":"Igor Bala\u017e","orcid":"https://orcid.org/0000-0002-6831-9232"},"institutions":[{"id":"https://openalex.org/I170726198","display_name":"University of Novi Sad","ror":"https://ror.org/00xa57a59","country_code":"RS","type":"education","lineage":["https://openalex.org/I170726198"]}],"countries":["RS"],"is_corresponding":true,"raw_author_name":"Igor Balaz","raw_affiliation_strings":["University of Novi Sad,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Novi Sad,","institution_ids":["https://openalex.org/I170726198"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081846428","display_name":"Tara Petri\u0107","orcid":"https://orcid.org/0000-0003-4791-7185"},"institutions":[{"id":"https://openalex.org/I170726198","display_name":"University of Novi Sad","ror":"https://ror.org/00xa57a59","country_code":"RS","type":"education","lineage":["https://openalex.org/I170726198"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Tara Petri\u0107","raw_affiliation_strings":["Laboratory of Meteorology, Biophysics and Physics, University of Novi Sad, Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Meteorology, Biophysics and Physics, University of Novi Sad, Serbia","institution_ids":["https://openalex.org/I170726198"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056085212","display_name":"Namid Stillman","orcid":"https://orcid.org/0000-0001-6991-7923"},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Namid Stillman","raw_affiliation_strings":["University of Bristol, UK \u2028"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bristol, UK \u2028","institution_ids":["https://openalex.org/I36234482"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5067703795"],"corresponding_institution_ids":["https://openalex.org/I170726198"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0485257,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6365978121757507},{"id":"https://openalex.org/keywords/simulation","display_name":"Simulation","score":0.6048320531845093},{"id":"https://openalex.org/keywords/scale","display_name":"Scale (ratio)","score":0.4612411856651306},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3245247006416321},{"id":"https://openalex.org/keywords/human\u2013computer-interaction","display_name":"Human\u2013computer interaction","score":0.3220086097717285}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6365978121757507},{"id":"https://openalex.org/C44154836","wikidata":"https://www.wikidata.org/wiki/Q45045","display_name":"Simulation","level":1,"score":0.6048320531845093},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.4612411856651306},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3245247006416321},{"id":"https://openalex.org/C107457646","wikidata":"https://www.wikidata.org/wiki/Q207434","display_name":"Human\u2013computer interaction","level":1,"score":0.3220086097717285},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1162/isal_a_00435","is_oa":false,"landing_page_url":"https://doi.org/10.1162/isal_a_00435","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The 2021 Conference on Artificial Life","raw_type":"proceedings-article"},{"id":"pmh:oai:arXiv.org:2105.11760","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2105.11760","pdf_url":"https://arxiv.org/pdf/2105.11760","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"mag:3164942501","is_oa":true,"landing_page_url":"https://arxiv.org/pdf/2105.11760.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"arXiv (Cornell University)","raw_type":null},{"id":"doi:10.48550/arxiv.2105.11760","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.2105.11760","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:2105.11760","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2105.11760","pdf_url":"https://arxiv.org/pdf/2105.11760","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.75}],"awards":[{"id":"https://openalex.org/G8589293388","display_name":null,"funder_award_id":"800983","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3164942501.pdf","grobid_xml":"https://content.openalex.org/works/W3164942501.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W2001812417","https://openalex.org/W2023473613","https://openalex.org/W2053852245","https://openalex.org/W2067982358","https://openalex.org/W2513408092","https://openalex.org/W2591741825","https://openalex.org/W3009385911","https://openalex.org/W3040766129","https://openalex.org/W3042581126","https://openalex.org/W3104166392","https://openalex.org/W3104751314","https://openalex.org/W3107416466"],"related_works":["https://openalex.org/W3184718886","https://openalex.org/W2125106561","https://openalex.org/W1967738030","https://openalex.org/W2355022822","https://openalex.org/W1965890101","https://openalex.org/W2919452396","https://openalex.org/W2111366919","https://openalex.org/W2071450637","https://openalex.org/W2085220982","https://openalex.org/W2554745122","https://openalex.org/W2112871768","https://openalex.org/W1492630165","https://openalex.org/W2017342469","https://openalex.org/W2011266044"],"abstract_inverted_index":{"Tumours":[0],"behave":[1],"as":[2],"moving":[3],"targets":[4],"that":[5,94],"can":[6,48],"evade":[7],"chemotherapeutic":[8],"treatments":[9],"by":[10,79,110],"rapidly":[11],"acquiring":[12],"resistance":[13],"via":[14],"various":[15],"mechanisms.":[16],"In":[17],"Balaz":[18],"et":[19],"al.":[20],"(2021,":[21],"Biosystems;":[22],"199:104290)":[23],"we":[24,62],"initiated":[25],"the":[26,29,53,64,71,84,88,95,98,111],"development":[27],"of":[28,34,52,66,97],"agent-based":[30,43],"open-ended":[31],"evolutionary":[32],"simulator":[33,44,104],"novel":[35],"drug":[36],"delivery":[37],"systems":[38],"(DDS).":[39],"It":[40],"is":[41,105],"an":[42],"where":[45],"evolvable":[46,67],"agents":[47],"change":[49],"their":[50,77,81],"perception":[51],"environment":[54],"and":[55,75],"thus":[56],"adapt":[57],"to":[58,70,107],"tumour":[59],"mutations.":[60],"Here":[61],"mapped":[63],"parameters":[65],"agent":[68],"properties":[69],"realistic":[72],"biochemical":[73],"boundaries":[74],"test":[76],"efficacy":[78],"simulating":[80],"behaviour":[82],"at":[83],"cell":[85],"scale":[86],"using":[87],"stochastic":[89],"simulator,":[90],"STEPS.":[91],"We":[92],"show":[93],"shape":[96],"parameter":[99],"space":[100],"evolved":[101],"in":[102],"our":[103],"comparable":[106],"those":[108],"obtained":[109],"rational":[112],"design.":[113]},"counts_by_year":[],"updated_date":"2026-05-23T08:51:43.019350","created_date":"2025-10-10T00:00:00"}
