{"id":"https://openalex.org/W4385235463","doi":"https://doi.org/10.1162/artl_a_00411","title":"Explorative Synthetic Biology in AI: Criteria of Relevance and a Taxonomy for Synthetic Models of Living and Cognitive Processes","display_name":"Explorative Synthetic Biology in AI: Criteria of Relevance and a Taxonomy for Synthetic Models of Living and Cognitive Processes","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4385235463","doi":"https://doi.org/10.1162/artl_a_00411","pmid":"https://pubmed.ncbi.nlm.nih.gov/37490711"},"language":"en","primary_location":{"id":"doi:10.1162/artl_a_00411","is_oa":true,"landing_page_url":"https://doi.org/10.1162/artl_a_00411","pdf_url":"https://direct.mit.edu/artl/article-pdf/doi/10.1162/artl_a_00411/2150522/artl_a_00411.pdf","source":{"id":"https://openalex.org/S2181302","display_name":"Artificial Life","issn_l":"1064-5462","issn":["1064-5462","1530-9185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315718","host_organization_name":"The MIT Press","host_organization_lineage":["https://openalex.org/P4310315718"],"host_organization_lineage_names":["The MIT Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Artificial Life","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://direct.mit.edu/artl/article-pdf/doi/10.1162/artl_a_00411/2150522/artl_a_00411.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058164094","display_name":"Luisa Damiano","orcid":"https://orcid.org/0000-0003-4786-524X"},"institutions":[{"id":"https://openalex.org/I200420086","display_name":"IULM University","ror":"https://ror.org/04pp4xq32","country_code":"IT","type":"education","lineage":["https://openalex.org/I200420086"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Luisa Damiano","raw_affiliation_strings":["IULM University, Research Group on the Epistemology of the Sciences of the Artificial, Department of Communication, Arts, and Media. luisa.damiano@iulm.it"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IULM University, Research Group on the Epistemology of the Sciences of the Artificial, Department of Communication, Arts, and Media. luisa.damiano@iulm.it","institution_ids":["https://openalex.org/I200420086"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005149620","display_name":"Pasquale Stano","orcid":"https://orcid.org/0000-0002-2228-2825"},"institutions":[{"id":"https://openalex.org/I142910587","display_name":"University of Salento","ror":"https://ror.org/03fc1k060","country_code":"IT","type":"education","lineage":["https://openalex.org/I142910587"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pasquale Stano","raw_affiliation_strings":["University of Salento, Department of Biological and Environmental Sciences and Technologies"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Salento, Department of Biological and Environmental Sciences and Technologies","institution_ids":["https://openalex.org/I142910587"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5058164094"],"corresponding_institution_ids":["https://openalex.org/I200420086"],"apc_list":null,"apc_paid":null,"fwci":1.5747,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.83082754,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"29","issue":"3","first_page":"367","last_page":"387"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9812999963760376,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9812999963760376,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.9577999711036682,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12002","display_name":"Computability, Logic, AI Algorithms","score":0.9143999814987183,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/relevance","display_name":"Relevance (law)","score":0.776393711566925},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6351486444473267},{"id":"https://openalex.org/keywords/cognition","display_name":"Cognition","score":0.6116477251052856},{"id":"https://openalex.org/keywords/cognitive-science","display_name":"Cognitive science","score":0.5960017442703247},{"id":"https://openalex.org/keywords/embodied-cognition","display_name":"Embodied cognition","score":0.5529614686965942},{"id":"https://openalex.org/keywords/cognitive-robotics","display_name":"Cognitive robotics","score":0.49791836738586426},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"Synthetic biology","score":0.4615516662597656},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4582892656326294},{"id":"https://openalex.org/keywords/artificial-life","display_name":"Artificial life","score":0.45478522777557373},{"id":"https://openalex.org/keywords/software","display_name":"Software","score":0.4384566843509674},{"id":"https://openalex.org/keywords/field","display_name":"Field (mathematics)","score":0.42021292448043823},{"id":"https://openalex.org/keywords/management-science","display_name":"Management science","score":0.34226253628730774},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.15971747040748596},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.12909480929374695},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.0903407633304596}],"concepts":[{"id":"https://openalex.org/C158154518","wikidata":"https://www.wikidata.org/wiki/Q7310970","display_name":"Relevance (law)","level":2,"score":0.776393711566925},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6351486444473267},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.6116477251052856},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.5960017442703247},{"id":"https://openalex.org/C100609095","wikidata":"https://www.wikidata.org/wiki/Q1335050","display_name":"Embodied cognition","level":2,"score":0.5529614686965942},{"id":"https://openalex.org/C192327766","wikidata":"https://www.wikidata.org/wiki/Q1038799","display_name":"Cognitive robotics","level":3,"score":0.49791836738586426},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.4615516662597656},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4582892656326294},{"id":"https://openalex.org/C19273510","wikidata":"https://www.wikidata.org/wiki/Q263847","display_name":"Artificial life","level":2,"score":0.45478522777557373},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.4384566843509674},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.42021292448043823},{"id":"https://openalex.org/C539667460","wikidata":"https://www.wikidata.org/wiki/Q2414942","display_name":"Management science","level":1,"score":0.34226253628730774},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.15971747040748596},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12909480929374695},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0903407633304596},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D058615","descriptor_name":"Synthetic Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1162/artl_a_00411","is_oa":true,"landing_page_url":"https://doi.org/10.1162/artl_a_00411","pdf_url":"https://direct.mit.edu/artl/article-pdf/doi/10.1162/artl_a_00411/2150522/artl_a_00411.pdf","source":{"id":"https://openalex.org/S2181302","display_name":"Artificial Life","issn_l":"1064-5462","issn":["1064-5462","1530-9185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315718","host_organization_name":"The MIT Press","host_organization_lineage":["https://openalex.org/P4310315718"],"host_organization_lineage_names":["The MIT Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Artificial Life","raw_type":"journal-article"},{"id":"pmid:37490711","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37490711","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Artificial life","raw_type":null}],"best_oa_location":{"id":"doi:10.1162/artl_a_00411","is_oa":true,"landing_page_url":"https://doi.org/10.1162/artl_a_00411","pdf_url":"https://direct.mit.edu/artl/article-pdf/doi/10.1162/artl_a_00411/2150522/artl_a_00411.pdf","source":{"id":"https://openalex.org/S2181302","display_name":"Artificial Life","issn_l":"1064-5462","issn":["1064-5462","1530-9185"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315718","host_organization_name":"The MIT Press","host_organization_lineage":["https://openalex.org/P4310315718"],"host_organization_lineage_names":["The MIT Press"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Artificial Life","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4385235463.pdf"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W30879150","https://openalex.org/W1504184224","https://openalex.org/W1851468646","https://openalex.org/W1902366942","https://openalex.org/W1969139884","https://openalex.org/W1973513361","https://openalex.org/W1976174548","https://openalex.org/W1995341919","https://openalex.org/W2001771035","https://openalex.org/W2004628972","https://openalex.org/W2005252032","https://openalex.org/W2011598430","https://openalex.org/W2014625274","https://openalex.org/W2022305914","https://openalex.org/W2027268537","https://openalex.org/W2027635233","https://openalex.org/W2031343926","https://openalex.org/W2033169157","https://openalex.org/W2033873715","https://openalex.org/W2039234396","https://openalex.org/W2044663075","https://openalex.org/W2047882868","https://openalex.org/W2049004176","https://openalex.org/W2052750603","https://openalex.org/W2054935170","https://openalex.org/W2068486494","https://openalex.org/W2081250164","https://openalex.org/W2084010976","https://openalex.org/W2093232756","https://openalex.org/W2103053013","https://openalex.org/W2111870329","https://openalex.org/W2113235751","https://openalex.org/W2114485587","https://openalex.org/W2121893739","https://openalex.org/W2122739151","https://openalex.org/W2124425296","https://openalex.org/W2125421487","https://openalex.org/W2126901778","https://openalex.org/W2145955413","https://openalex.org/W2154649797","https://openalex.org/W2171934634","https://openalex.org/W2251410821","https://openalex.org/W2488224828","https://openalex.org/W2572851392","https://openalex.org/W2581689784","https://openalex.org/W2623995088","https://openalex.org/W2782490738","https://openalex.org/W2794644823","https://openalex.org/W2899311976","https://openalex.org/W3042527119","https://openalex.org/W3081421405","https://openalex.org/W3127532932","https://openalex.org/W3153161395","https://openalex.org/W3184437466","https://openalex.org/W3201776997","https://openalex.org/W3217538042","https://openalex.org/W4211255591","https://openalex.org/W4229952927","https://openalex.org/W4231327205","https://openalex.org/W4231406112","https://openalex.org/W4231563569","https://openalex.org/W4238058591","https://openalex.org/W4248607104","https://openalex.org/W4249580161","https://openalex.org/W4250587850","https://openalex.org/W4254796216","https://openalex.org/W4281960506","https://openalex.org/W4299830491","https://openalex.org/W4360619249","https://openalex.org/W4390819718","https://openalex.org/W6602559188","https://openalex.org/W6639435266","https://openalex.org/W6660932796","https://openalex.org/W6680090583","https://openalex.org/W6780298308"],"related_works":["https://openalex.org/W1570928019","https://openalex.org/W2354934853","https://openalex.org/W2964506265","https://openalex.org/W2513760693","https://openalex.org/W2378966853","https://openalex.org/W2499464837","https://openalex.org/W2170009172","https://openalex.org/W2150044110","https://openalex.org/W370653845","https://openalex.org/W4388576587"],"abstract_inverted_index":{"This":[0],"article":[1,72,137],"tackles":[2],"the":[3,6,27,30,39,48,55,76,79,93,102,114,128,153,181,195,199,207,230,241],"topic":[4],"of":[5,20,29,32,42,58,81,87,105,113,116,131,150,156,161,165,171,173,185,194,201,209,214,232,244],"special":[7],"issue":[8],"\"Biology":[9],"in":[10,14,22,70,121],"AI:":[11],"New":[12],"Frontiers":[13],"Hardware,":[15],"Software":[16],"and":[17,35,45,84,89,107,133,143,158,168,191,216,224],"Wetware":[18],"Modeling":[19],"Cognition\"":[21],"two":[23],"ways.":[24],"It":[25],"addresses":[26],"problem":[28],"relevance":[31,80,210],"hardware,":[33,82],"software,":[34,83],"wetware":[36,85,212],"models":[37,86,98,125,213],"for":[38,152,175,229],"scientific":[40,103],"understanding":[41,104],"biological":[43,88,132],"cognition,":[44,59,159],"it":[46],"clarifies":[47],"contributions":[49],"that":[50,78,96,219],"synthetic":[51,56,124,154,176,220,237],"biology,":[52],"construed":[53],"as":[54],"exploration":[57,130],"can":[60,99,126,222],"offer":[61],"to":[62,101,119,146,179,240],"artificial":[63],"intelligence":[64],"(AI).":[65],"The":[66],"research":[67],"work":[68],"proposed":[69],"this":[71],"is":[73],"based":[74],"on":[75,139],"idea":[77],"cognitive":[90,134,217],"processes-that":[91],"is,":[92],"concrete":[94],"contribution":[95],"these":[97,202],"make":[100],"life":[106,157],"cognition-is":[108],"still":[109],"unclear,":[110],"mainly":[111],"because":[112],"lack":[115],"explicit":[117],"criteria":[118,167],"assess":[120],"what":[122],"ways":[123],"support":[127],"experimental":[129],"phenomena.":[135],"Our":[136],"draws":[138],"elements":[140],"from":[141],"cybernetic":[142],"autopoietic":[144],"epistemology":[145],"define":[147],"a":[148,163,169,226],"framework":[149],"reference,":[151],"study":[155],"capable":[160],"generating":[162],"set":[164],"assessment":[166],"classification":[170],"forms":[172,208],"relevance,":[174],"models,":[177],"able":[178],"overcome":[180],"sterile,":[182],"traditional":[183],"polarization":[184],"their":[186],"evaluation":[187],"between":[188],"mere":[189],"imitation":[190],"full":[192],"reproduction":[193],"target":[196],"processes.":[197],"On":[198],"basis":[200],"tools,":[203],"we":[204],"tentatively":[205],"map":[206],"characterizing":[211],"living":[215],"processes":[218],"biology":[221,238],"produce":[223],"outline":[225],"programmatic":[227],"direction":[228],"development":[231],"\"organizationally":[233],"relevant":[234],"approaches\"":[235],"applying":[236],"techniques":[239],"investigative":[242],"field":[243],"(embodied)":[245],"AI.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5}],"updated_date":"2026-08-02T14:50:37.381335","created_date":"2025-10-10T00:00:00"}