{"id":"https://openalex.org/W2146519678","doi":"https://doi.org/10.1162/089976698300017520","title":"GABAergic Inhibitory Control of the Transient and Sustained Components of Orientation Selectivity in a Model Microcolumn in Layer 4 of Cat Visual Cortex","display_name":"GABAergic Inhibitory Control of the Transient and Sustained Components of Orientation Selectivity in a Model Microcolumn in Layer 4 of Cat Visual Cortex","publication_year":1998,"publication_date":"1998-05-01","ids":{"openalex":"https://openalex.org/W2146519678","doi":"https://doi.org/10.1162/089976698300017520","mag":"2146519678","pmid":"https://pubmed.ncbi.nlm.nih.gov/9573409"},"language":"en","primary_location":{"id":"doi:10.1162/089976698300017520","is_oa":false,"landing_page_url":"https://doi.org/10.1162/089976698300017520","pdf_url":null,"source":{"id":"https://openalex.org/S207023548","display_name":"Neural Computation","issn_l":"0899-7667","issn":["0899-7667","1530-888X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315718","host_organization_name":"The MIT Press","host_organization_lineage":["https://openalex.org/P4310315718"],"host_organization_lineage_names":["The MIT Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Computation","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018733687","display_name":"Paul C. Bush","orcid":null},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I76766440","display_name":"University of San Francisco","ror":"https://ror.org/029m7xn54","country_code":"US","type":"education","lineage":["https://openalex.org/I76766440"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paul Bush","raw_affiliation_strings":["Department of Physiology, University of California, San Francisco, San Francisco, CA 94143-0444, U.S.A"],"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of California, San Francisco, San Francisco, CA 94143-0444, U.S.A","institution_ids":["https://openalex.org/I76766440","https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004043467","display_name":"Nicholas J. Priebe","orcid":"https://orcid.org/0000-0002-0171-0691"},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I76766440","display_name":"University of San Francisco","ror":"https://ror.org/029m7xn54","country_code":"US","type":"education","lineage":["https://openalex.org/I76766440"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas Priebe","raw_affiliation_strings":["Department of Physiology, University of California, San Francisco, San Francisco, CA 94143-0444, U.S.A"],"affiliations":[{"raw_affiliation_string":"Department of Physiology, University of California, San Francisco, San Francisco, CA 94143-0444, U.S.A","institution_ids":["https://openalex.org/I76766440","https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5018733687"],"corresponding_institution_ids":["https://openalex.org/I180670191","https://openalex.org/I76766440"],"apc_list":null,"apc_paid":null,"fwci":0.5404,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.65320397,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":"4","first_page":"855","last_page":"867"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10427","display_name":"Visual perception and processing mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inhibitory-postsynaptic-potential","display_name":"Inhibitory postsynaptic potential","score":0.7940559387207031},{"id":"https://openalex.org/keywords/gabaergic","display_name":"GABAergic","score":0.7490038275718689},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.6727765202522278},{"id":"https://openalex.org/keywords/excitatory-postsynaptic-potential","display_name":"Excitatory postsynaptic potential","score":0.6714335083961487},{"id":"https://openalex.org/keywords/visual-cortex","display_name":"Visual cortex","score":0.6475797295570374},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.4786345064640045},{"id":"https://openalex.org/keywords/orientation","display_name":"Orientation (vector space)","score":0.4488351047039032},{"id":"https://openalex.org/keywords/cortex","display_name":"Cortex (anatomy)","score":0.4115299880504608},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.38488030433654785},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.34168824553489685},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3334869146347046},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.24388840794563293},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.20390325784683228},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.166225403547287},{"id":"https://openalex.org/keywords/geometry","display_name":"Geometry","score":0.14424651861190796}],"concepts":[{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.7940559387207031},{"id":"https://openalex.org/C2779177108","wikidata":"https://www.wikidata.org/wiki/Q18356742","display_name":"GABAergic","level":3,"score":0.7490038275718689},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6727765202522278},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.6714335083961487},{"id":"https://openalex.org/C2779345533","wikidata":"https://www.wikidata.org/wiki/Q75785","display_name":"Visual cortex","level":2,"score":0.6475797295570374},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.4786345064640045},{"id":"https://openalex.org/C16345878","wikidata":"https://www.wikidata.org/wiki/Q107472979","display_name":"Orientation (vector space)","level":2,"score":0.4488351047039032},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.4115299880504608},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38488030433654785},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.34168824553489685},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3334869146347046},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.24388840794563293},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.20390325784683228},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.166225403547287},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.14424651861190796}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009949","descriptor_name":"Orientation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009949","descriptor_name":"Orientation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009949","descriptor_name":"Orientation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014793","descriptor_name":"Visual Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014793","descriptor_name":"Visual Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014793","descriptor_name":"Visual Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018756","descriptor_name":"GABA Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018756","descriptor_name":"GABA Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018756","descriptor_name":"GABA Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D058787","descriptor_name":"GABA-A Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058787","descriptor_name":"GABA-A Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058787","descriptor_name":"GABA-A Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058788","descriptor_name":"GABA-B Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058788","descriptor_name":"GABA-B Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058788","descriptor_name":"GABA-B Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1162/089976698300017520","is_oa":false,"landing_page_url":"https://doi.org/10.1162/089976698300017520","pdf_url":null,"source":{"id":"https://openalex.org/S207023548","display_name":"Neural Computation","issn_l":"0899-7667","issn":["0899-7667","1530-888X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315718","host_organization_name":"The MIT Press","host_organization_lineage":["https://openalex.org/P4310315718"],"host_organization_lineage_names":["The MIT Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Computation","raw_type":"journal-article"},{"id":"pmid:9573409","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9573409","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural computation","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W38110003","https://openalex.org/W1488345817","https://openalex.org/W1852401591","https://openalex.org/W1867287134","https://openalex.org/W1914401667","https://openalex.org/W1944592753","https://openalex.org/W1963945272","https://openalex.org/W1972479192","https://openalex.org/W1977055641","https://openalex.org/W1991233288","https://openalex.org/W1996737327","https://openalex.org/W2009861136","https://openalex.org/W2013070880","https://openalex.org/W2014167862","https://openalex.org/W2015155811","https://openalex.org/W2018566861","https://openalex.org/W2028112831","https://openalex.org/W2035847543","https://openalex.org/W2043853686","https://openalex.org/W2055833339","https://openalex.org/W2056469536","https://openalex.org/W2056934252","https://openalex.org/W2059058130","https://openalex.org/W2065799397","https://openalex.org/W2081929610","https://openalex.org/W2082354908","https://openalex.org/W2082722155","https://openalex.org/W2097625534","https://openalex.org/W2097694278","https://openalex.org/W2102966617","https://openalex.org/W2116279703","https://openalex.org/W2116491807","https://openalex.org/W2121324852","https://openalex.org/W2129090497","https://openalex.org/W2137413309","https://openalex.org/W2145026357","https://openalex.org/W2145889472","https://openalex.org/W2160170375","https://openalex.org/W2161578473","https://openalex.org/W2161804170","https://openalex.org/W2268182211"],"related_works":["https://openalex.org/W2950596497","https://openalex.org/W2436760910","https://openalex.org/W4303432678","https://openalex.org/W2043066229","https://openalex.org/W2974163011","https://openalex.org/W2142526561","https://openalex.org/W2023878078","https://openalex.org/W2003973922","https://openalex.org/W2106951973","https://openalex.org/W2137821247"],"abstract_inverted_index":{"Recently":[0],"proposed":[1],"models":[2],"of":[3,9,37,77,125,148,196,211],"orientation":[4],"tuning":[5],"in":[6,108,152],"layer":[7,109,114],"4":[8,115],"cat":[10],"primary":[11],"visual":[12],"cortex":[13],"(Somers,":[14],"Nelson,":[15],"&":[16,23,58,68,136,140],"Sur,":[17],"1995;":[18],"Douglas,":[19],"Koch,":[20],"Mahowald,":[21],"Martin,":[22,134],"Suarez,":[24],"1995)":[25],"rely":[26],"on":[27,181],"widespread":[28],"inhibitory":[29,111],"intracortical":[30,46],"connections":[31,47],"to":[32,98,170],"suppress":[33],"the":[34,49,73,85,123,157,161,168,197],"nonoptimal":[35,96],"component":[36,76,94],"a":[38,105,146,149,193],"broadly":[39],"tuned":[40,82],"thalamic":[41,78],"input,":[42],"while":[43,164],"local":[44],"excitatory":[45,113],"amplify":[48],"optimal":[50],"component.":[51],"However,":[52],"new":[53],"experimental":[54,178],"data":[55,179],"(Ferster,":[56,64],"Chung,":[57],"Wheat,":[59],"1996)":[60,70],"and":[61,83,112,159,172,200,204],"theoretical":[62],"analyses":[63],"1987;":[65],"Krukowski,":[66],"Priebe,":[67],"Miller,":[69],"show":[71],"that":[72,84],"temporally":[74],"modulated":[75],"input":[79],"is":[80],"well":[81,188],"cortical":[86],"circuitry":[87],"must":[88],"simply":[89],"subtract":[90],"an":[91,208],"unmodulated":[92],"DC":[93,158],"at":[95,201],"orientations":[97,203],"obtain":[99],"sharp":[100],"tuning.":[101],"In":[102],"addition,":[103],"within":[104,128],"single":[106,150],"hypercolumn":[107],"4,":[110],"neurons":[116],"have":[117,144],"approximately":[118],"equal-sized":[119],"axonal":[120],"fields,":[121],"making":[122],"most":[124],"their":[126,129],"synapses":[127],"own":[130],"dendritic":[131],"field":[132],"(Kisvarday,":[133],"Whitteridge,":[135,141],"Somogyi,":[137],"1985;":[138],"Martin":[139],"1984).":[142],"We":[143],"constructed":[145],"model":[147,176],"microcolumn":[151],"which":[153],"GABA":[154,165,198],"inhibition":[155,166],"subtracts":[156],"controls":[160,167],"sustained":[162],"response,":[163],"response":[169],"transient":[171],"suprathreshold":[173],"inputs.":[174],"The":[175],"fits":[177],"based":[180],"stimulation":[182],"with":[183],"drifting":[184],"sine-wave":[185],"gratings":[186],"as":[187,189],"flashed":[190],"bars,":[191],"explains":[192],"counterintuitive":[194],"property":[195],"conductance,":[199],"suboptimal":[202],"submaximal":[205],"contrasts":[206],"produces":[207],"exponential":[209],"distribution":[210],"firing":[212],"frequencies.":[213]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
