{"id":"https://openalex.org/W2137927364","doi":"https://doi.org/10.1162/089976603321192086","title":"Spike-Driven Synaptic Dynamics Generating Working Memory States","display_name":"Spike-Driven Synaptic Dynamics Generating Working Memory States","publication_year":2003,"publication_date":"2003-02-27","ids":{"openalex":"https://openalex.org/W2137927364","doi":"https://doi.org/10.1162/089976603321192086","mag":"2137927364","pmid":"https://pubmed.ncbi.nlm.nih.gov/12620158"},"language":"en","primary_location":{"id":"doi:10.1162/089976603321192086","is_oa":false,"landing_page_url":"https://doi.org/10.1162/089976603321192086","pdf_url":null,"source":{"id":"https://openalex.org/S207023548","display_name":"Neural Computation","issn_l":"0899-7667","issn":["0899-7667","1530-888X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315718","host_organization_name":"The MIT Press","host_organization_lineage":["https://openalex.org/P4310315718"],"host_organization_lineage_names":["The MIT Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Computation","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112799021","display_name":"Daniel J. Amit","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Daniel J. Amit","raw_affiliation_strings":["Dipartimento di Fisica, Universita' di Roma, La Sapienza, 00185 Rome, Italy, and Racah Institute of Physics, Hebrew University, Jerusalem, Israel,"],"affiliations":[{"raw_affiliation_string":"Dipartimento di Fisica, Universita' di Roma, La Sapienza, 00185 Rome, Italy, and Racah Institute of Physics, Hebrew University, Jerusalem, Israel,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020750894","display_name":"Gianluigi Mongillo","orcid":"https://orcid.org/0000-0002-6885-9394"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gianluigi Mongillo","raw_affiliation_strings":["Dipartimento di Fisica, Universita' di Roma, La Sapienza, 00185 Rome, Italy, and Racah Institute of Physics, Hebrew University, Jerusalem, Israel,"],"affiliations":[{"raw_affiliation_string":"Dipartimento di Fisica, Universita' di Roma, La Sapienza, 00185 Rome, Italy, and Racah Institute of Physics, Hebrew University, Jerusalem, Israel,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112799021"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.5635,"has_fulltext":false,"cited_by_count":74,"citation_normalized_percentile":{"value":0.96161413,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"15","issue":"3","first_page":"565","last_page":"596"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10502","display_name":"Advanced Memory and Neural Computing","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10502","display_name":"Advanced Memory and Neural Computing","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spike","display_name":"Spike (software development)","score":0.6974012851715088},{"id":"https://openalex.org/keywords/dynamics","display_name":"Dynamics (music)","score":0.506923258304596},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.4779079854488373},{"id":"https://openalex.org/keywords/working-memory","display_name":"Working memory","score":0.45924073457717896},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4430388808250427},{"id":"https://openalex.org/keywords/spike-train","display_name":"Spike train","score":0.42125698924064636},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.36709946393966675},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.32324323058128357},{"id":"https://openalex.org/keywords/cognition","display_name":"Cognition","score":0.1916796863079071}],"concepts":[{"id":"https://openalex.org/C2781390188","wikidata":"https://www.wikidata.org/wiki/Q25203449","display_name":"Spike (software development)","level":2,"score":0.6974012851715088},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.506923258304596},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4779079854488373},{"id":"https://openalex.org/C21963081","wikidata":"https://www.wikidata.org/wiki/Q11337567","display_name":"Working memory","level":3,"score":0.45924073457717896},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4430388808250427},{"id":"https://openalex.org/C2909946758","wikidata":"https://www.wikidata.org/wiki/Q194277","display_name":"Spike train","level":3,"score":0.42125698924064636},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.36709946393966675},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.32324323058128357},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.1916796863079071},{"id":"https://openalex.org/C19417346","wikidata":"https://www.wikidata.org/wiki/Q7922","display_name":"Pedagogy","level":1,"score":0.0},{"id":"https://openalex.org/C115903868","wikidata":"https://www.wikidata.org/wiki/Q80993","display_name":"Software engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008568","descriptor_name":"Memory","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1162/089976603321192086","is_oa":false,"landing_page_url":"https://doi.org/10.1162/089976603321192086","pdf_url":null,"source":{"id":"https://openalex.org/S207023548","display_name":"Neural Computation","issn_l":"0899-7667","issn":["0899-7667","1530-888X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310315718","host_organization_name":"The MIT Press","host_organization_lineage":["https://openalex.org/P4310315718"],"host_organization_lineage_names":["The MIT Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Computation","raw_type":"journal-article"},{"id":"pmid:12620158","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12620158","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural computation","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/8","display_name":"Decent work and economic growth","score":0.5099999904632568}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1543249864","https://openalex.org/W1575022561","https://openalex.org/W1907121963","https://openalex.org/W1916896154","https://openalex.org/W1986246844","https://openalex.org/W1989512479","https://openalex.org/W2002249797","https://openalex.org/W2007369064","https://openalex.org/W2008284899","https://openalex.org/W2012074763","https://openalex.org/W2015647735","https://openalex.org/W2031543773","https://openalex.org/W2040124307","https://openalex.org/W2043487837","https://openalex.org/W2054296371","https://openalex.org/W2056785468","https://openalex.org/W2061405268","https://openalex.org/W2062807288","https://openalex.org/W2071137742","https://openalex.org/W2074391612","https://openalex.org/W2083910902","https://openalex.org/W2095283212","https://openalex.org/W2101222204","https://openalex.org/W2104782380","https://openalex.org/W2108154271","https://openalex.org/W2108250347","https://openalex.org/W2113345172","https://openalex.org/W2120004185","https://openalex.org/W2120259469","https://openalex.org/W2129841439","https://openalex.org/W2140783889","https://openalex.org/W2143373656","https://openalex.org/W2143553955","https://openalex.org/W2147101007","https://openalex.org/W2160340450","https://openalex.org/W2162652458","https://openalex.org/W2162921217","https://openalex.org/W2167080053","https://openalex.org/W2185212694","https://openalex.org/W2194648315","https://openalex.org/W4234028443","https://openalex.org/W4245564453","https://openalex.org/W4248914143"],"related_works":["https://openalex.org/W2383615955","https://openalex.org/W2056756835","https://openalex.org/W2062974934","https://openalex.org/W2187212244","https://openalex.org/W2775582103","https://openalex.org/W2329992713","https://openalex.org/W1558157446","https://openalex.org/W2173049006","https://openalex.org/W2014837149","https://openalex.org/W2114811586"],"abstract_inverted_index":{"The":[0,42,200],"collective":[1],"behavior":[2],"of":[3,10,30,38,45,48,60,76,91,100,104,115,120,127,134,137,143,175,183,193,208,218],"a":[4,7,27,46,74,88,112,125],"network,":[5],"modeling":[6],"cortical":[8],"module":[9],"spiking":[11,31],"neurons":[12,39,105],"connected":[13],"by":[14],"plastic":[15],"synapses":[16,101],"is":[17,24,51,71,111,147,158,165,203],"studied.":[18],"A":[19],"detailed":[20],"spike-driven":[21],"synaptic":[22,69,178,201],"dynamics":[23,37,70,202],"simulated":[25],"in":[26,82,96,191,205],"large":[28],"network":[29,56],"neurons,":[32],"implementing":[33],"the":[34,55,58,68,92,132,135,138,144,152,154,173,176,181,194,197,206],"full":[35],"double":[36],"and":[40,78,180,215],"synapses.":[41],"repeated":[43],"presentation":[44],"set":[47,99],"external":[49],"stimuli":[50],"shown":[52],"to":[53,57,124,151,172],"structure":[54,179],"point":[59],"sustaining":[61],"working":[62,163],"memory":[63,164],"(selective":[64],"delay":[65],"activity).":[66],"When":[67,141],"analyzed":[72],"as":[73,117,119],"function":[75],"pre-":[77],"postsynaptic":[79],"spike":[80,212],"rates":[81],"functionally":[83],"defined":[84],"populations,":[85],"it":[86,167],"reveals":[87],"novel":[89],"variation":[90],"Hebbian":[93,156],"plasticity":[94],"paradigm:":[95],"any":[97],"functional":[98],"between":[102],"pairs":[103],"(e.g.,":[106],"stimulated-stimulated,":[107],"stimulated-delay,":[108],"stimulated-spontaneous),":[109],"there":[110],"finite":[113],"probability":[114],"potentiation":[116,128],"well":[118],"depression.":[121],"This":[122],"leads":[123],"saturation":[126],"or":[129],"depression":[130],"at":[131],"level":[133],"ratio":[136],"two":[139,145],"probabilities.":[140],"one":[142],"probabilities":[146],"very":[148],"high":[149],"relative":[150],"other,":[153],"familiar":[155],"mechanism":[157],"recovered.":[159],"But":[160],"where":[161],"correlated":[162],"formed,":[166],"prevents":[168],"overlearning.":[169],"Constraints":[170],"relevant":[171],"stability":[174],"acquired":[177],"regimes":[182],"global":[184],"activity":[185],"allowing":[186],"for":[187],"structuring":[188],"are":[189],"expressed":[190],"terms":[192],"parameters":[195],"describing":[196],"single-synapse":[198],"dynamics.":[199],"discussed":[204],"light":[207],"experiments":[209],"observing":[210],"precise":[211],"timing":[213],"effects":[214],"related":[216],"issues":[217],"biological":[219],"plausibility.":[220]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}