{"id":"https://openalex.org/W4407313423","doi":"https://doi.org/10.1155/int/9994758","title":"Comprehensive Network Analysis of Lung Cancer Biomarkers Identifying Key Genes Through RNA\u2010Seq Data and PPI Networks","display_name":"Comprehensive Network Analysis of Lung Cancer Biomarkers Identifying Key Genes Through RNA\u2010Seq Data and PPI Networks","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4407313423","doi":"https://doi.org/10.1155/int/9994758"},"language":"en","primary_location":{"id":"doi:10.1155/int/9994758","is_oa":true,"landing_page_url":"https://doi.org/10.1155/int/9994758","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/int/9994758","source":{"id":"https://openalex.org/S57950554","display_name":"International Journal of Intelligent Systems","issn_l":"0884-8173","issn":["0884-8173","1098-111X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Intelligent Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/int/9994758","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006122294","display_name":"Meshrif Alruily","orcid":"https://orcid.org/0000-0002-9479-1848"},"institutions":[{"id":"https://openalex.org/I199702508","display_name":"Jouf University","ror":"https://ror.org/02zsyt821","country_code":"SA","type":"education","lineage":["https://openalex.org/I199702508"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Meshrif Alruily","raw_affiliation_strings":["Department of Computer Science ,  College of Computer and Information Sciences ,  Jouf University ,  Sakaka ,  72388 ,  Saudi Arabia , ju.edu.sa"],"raw_orcid":"https://orcid.org/0000-0002-9479-1848","affiliations":[{"raw_affiliation_string":"Department of Computer Science ,  College of Computer and Information Sciences ,  Jouf University ,  Sakaka ,  72388 ,  Saudi Arabia , ju.edu.sa","institution_ids":["https://openalex.org/I199702508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022674647","display_name":"Murtada K. Elbashir","orcid":"https://orcid.org/0000-0003-3431-6604"},"institutions":[{"id":"https://openalex.org/I199702508","display_name":"Jouf University","ror":"https://ror.org/02zsyt821","country_code":"SA","type":"education","lineage":["https://openalex.org/I199702508"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Murtada K. Elbashir","raw_affiliation_strings":["Information Systems Department ,  College of Computer and Information Sciences ,  Jouf University ,  Sakaka ,  72388 ,  Saudi Arabia , ju.edu.sa"],"raw_orcid":"https://orcid.org/0000-0003-3431-6604","affiliations":[{"raw_affiliation_string":"Information Systems Department ,  College of Computer and Information Sciences ,  Jouf University ,  Sakaka ,  72388 ,  Saudi Arabia , ju.edu.sa","institution_ids":["https://openalex.org/I199702508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024732617","display_name":"Mohamed Ezz","orcid":"https://orcid.org/0000-0001-8571-8828"},"institutions":[{"id":"https://openalex.org/I199702508","display_name":"Jouf University","ror":"https://ror.org/02zsyt821","country_code":"SA","type":"education","lineage":["https://openalex.org/I199702508"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Mohamed Ezz","raw_affiliation_strings":["Department of Computer Science ,  College of Computer and Information Sciences ,  Jouf University ,  Sakaka ,  72388 ,  Saudi Arabia , ju.edu.sa"],"raw_orcid":"https://orcid.org/0000-0001-8571-8828","affiliations":[{"raw_affiliation_string":"Department of Computer Science ,  College of Computer and Information Sciences ,  Jouf University ,  Sakaka ,  72388 ,  Saudi Arabia , ju.edu.sa","institution_ids":["https://openalex.org/I199702508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044331344","display_name":"Bader Aldughayfiq","orcid":"https://orcid.org/0000-0001-9584-0560"},"institutions":[{"id":"https://openalex.org/I199702508","display_name":"Jouf University","ror":"https://ror.org/02zsyt821","country_code":"SA","type":"education","lineage":["https://openalex.org/I199702508"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Bader Aldughayfiq","raw_affiliation_strings":["Information Systems Department ,  College of Computer and Information Sciences ,  Jouf University ,  Sakaka ,  72388 ,  Saudi Arabia , ju.edu.sa"],"raw_orcid":"https://orcid.org/0000-0001-9584-0560","affiliations":[{"raw_affiliation_string":"Information Systems Department ,  College of Computer and Information Sciences ,  Jouf University ,  Sakaka ,  72388 ,  Saudi Arabia , ju.edu.sa","institution_ids":["https://openalex.org/I199702508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083138497","display_name":"Majed Abdullah Alrowaily","orcid":"https://orcid.org/0000-0002-8537-8795"},"institutions":[{"id":"https://openalex.org/I199702508","display_name":"Jouf University","ror":"https://ror.org/02zsyt821","country_code":"SA","type":"education","lineage":["https://openalex.org/I199702508"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Majed Abdullah Alrowaily","raw_affiliation_strings":["Department of Computer Science ,  College of Computer and Information Sciences ,  Jouf University ,  Sakaka ,  72388 ,  Saudi Arabia , ju.edu.sa"],"raw_orcid":"https://orcid.org/0000-0002-8537-8795","affiliations":[{"raw_affiliation_string":"Department of Computer Science ,  College of Computer and Information Sciences ,  Jouf University ,  Sakaka ,  72388 ,  Saudi Arabia , ju.edu.sa","institution_ids":["https://openalex.org/I199702508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088543490","display_name":"Hisham Allahem","orcid":"https://orcid.org/0000-0002-0433-1478"},"institutions":[{"id":"https://openalex.org/I199702508","display_name":"Jouf University","ror":"https://ror.org/02zsyt821","country_code":"SA","type":"education","lineage":["https://openalex.org/I199702508"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Hisham Allahem","raw_affiliation_strings":["Information Systems Department ,  College of Computer and Information Sciences ,  Jouf University ,  Sakaka ,  72388 ,  Saudi Arabia , ju.edu.sa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Information Systems Department ,  College of Computer and Information Sciences ,  Jouf University ,  Sakaka ,  72388 ,  Saudi Arabia , ju.edu.sa","institution_ids":["https://openalex.org/I199702508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058527975","display_name":"Mohanad Mohammed","orcid":"https://orcid.org/0000-0001-5336-0286"},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Mohanad Mohammed","raw_affiliation_strings":["Department of Mathematics ,  School of Mathematics ,  Statistics and Computer Science ,  University of KwaZulu-Natal , Pietermaritzburg Private Bag X01,  Scottsville ,  3209 ,  South Africa , ukzn.ac.za"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics ,  School of Mathematics ,  Statistics and Computer Science ,  University of KwaZulu-Natal , Pietermaritzburg Private Bag X01,  Scottsville ,  3209 ,  South Africa , ukzn.ac.za","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102735427","display_name":"Elsayed Mostafa","orcid":null},"institutions":[{"id":"https://openalex.org/I4210095597","display_name":"King Abdullah International Medical Research Center","ror":"https://ror.org/009p8zv69","country_code":"SA","type":"facility","lineage":["https://openalex.org/I4210095597"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Elsayed Mostafa","raw_affiliation_strings":["Engineering & Research International (ERI) ,  Riyadh ,  Saudi Arabia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Engineering & Research International (ERI) ,  Riyadh ,  Saudi Arabia","institution_ids":["https://openalex.org/I4210095597"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006869294","display_name":"Ayman Mohamed Mostafa","orcid":"https://orcid.org/0000-0002-8951-4096"},"institutions":[{"id":"https://openalex.org/I199702508","display_name":"Jouf University","ror":"https://ror.org/02zsyt821","country_code":"SA","type":"education","lineage":["https://openalex.org/I199702508"]}],"countries":["SA"],"is_corresponding":true,"raw_author_name":"Ayman Mohamed Mostafa","raw_affiliation_strings":["Information Systems Department ,  College of Computer and Information Sciences ,  Jouf University ,  Sakaka ,  72388 ,  Saudi Arabia , ju.edu.sa"],"raw_orcid":"https://orcid.org/0000-0002-8951-4096","affiliations":[{"raw_affiliation_string":"Information Systems Department ,  College of Computer and Information Sciences ,  Jouf University ,  Sakaka ,  72388 ,  Saudi Arabia , ju.edu.sa","institution_ids":["https://openalex.org/I199702508"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5006869294"],"corresponding_institution_ids":["https://openalex.org/I199702508"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2500,"currency":"USD","value_usd":2500},"fwci":1.9472,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.84310538,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"2025","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/key","display_name":"Key (lock)","score":0.6999871134757996},{"id":"https://openalex.org/keywords/rna-seq","display_name":"RNA-Seq","score":0.6101794838905334},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5781132578849792},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.5094414353370667},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.501136302947998},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.481010764837265},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.44916871190071106},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3943934440612793},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2736654281616211},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.21798580884933472},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1789570152759552},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.15223148465156555},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.1472093164920807},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.11331149935722351},{"id":"https://openalex.org/keywords/computer-security","display_name":"Computer security","score":0.08082506060600281}],"concepts":[{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.6999871134757996},{"id":"https://openalex.org/C107397762","wikidata":"https://www.wikidata.org/wiki/Q2542347","display_name":"RNA-Seq","level":5,"score":0.6101794838905334},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5781132578849792},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5094414353370667},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.501136302947998},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.481010764837265},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44916871190071106},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3943934440612793},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2736654281616211},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21798580884933472},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1789570152759552},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.15223148465156555},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.1472093164920807},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.11331149935722351},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.08082506060600281}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1155/int/9994758","is_oa":true,"landing_page_url":"https://doi.org/10.1155/int/9994758","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/int/9994758","source":{"id":"https://openalex.org/S57950554","display_name":"International Journal of Intelligent Systems","issn_l":"0884-8173","issn":["0884-8173","1098-111X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Intelligent Systems","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1155/int/9994758","is_oa":true,"landing_page_url":"https://doi.org/10.1155/int/9994758","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/int/9994758","source":{"id":"https://openalex.org/S57950554","display_name":"International Journal of Intelligent Systems","issn_l":"0884-8173","issn":["0884-8173","1098-111X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Intelligent Systems","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5941669782","display_name":null,"funder_award_id":"223202","funder_id":"https://openalex.org/F4320327296","funder_display_name":"Ministry of Education \u2013 Kingdom of Saudi Arabi"}],"funders":[{"id":"https://openalex.org/F4320327296","display_name":"Ministry of Education \u2013 Kingdom of Saudi Arabi","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4407313423.pdf","grobid_xml":"https://content.openalex.org/works/W4407313423.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1989215255","https://openalex.org/W1994219871","https://openalex.org/W2022531767","https://openalex.org/W2055137027","https://openalex.org/W2060902443","https://openalex.org/W2070050178","https://openalex.org/W2072319964","https://openalex.org/W2076983043","https://openalex.org/W2088654426","https://openalex.org/W2122528459","https://openalex.org/W2145502099","https://openalex.org/W2158485828","https://openalex.org/W2165341580","https://openalex.org/W2230320310","https://openalex.org/W2773619385","https://openalex.org/W3001414569","https://openalex.org/W3105613063","https://openalex.org/W3108814108","https://openalex.org/W3124379712","https://openalex.org/W3154489565","https://openalex.org/W3216731583","https://openalex.org/W4234236664","https://openalex.org/W4311959699","https://openalex.org/W4366587704","https://openalex.org/W4377221069","https://openalex.org/W4385633776","https://openalex.org/W4386746828","https://openalex.org/W4388617176","https://openalex.org/W4392352213","https://openalex.org/W4395661563","https://openalex.org/W6603835122","https://openalex.org/W6691434200"],"related_works":["https://openalex.org/W4394426846","https://openalex.org/W4200033037","https://openalex.org/W4394543623","https://openalex.org/W3213655218","https://openalex.org/W4394560977","https://openalex.org/W2064573700","https://openalex.org/W2140798747","https://openalex.org/W2948169060","https://openalex.org/W4394488504","https://openalex.org/W4394163355"],"abstract_inverted_index":{"This":[0,250],"study":[1,251],"addresses":[2],"the":[3,32,77,80,101,132,156,188,214,255],"pressing":[4],"need":[5],"for":[6,34,79,141,274],"improved":[7],"lung":[8,106,126,142,165,234,266],"cancer":[9,22,127,166,235,267],"diagnosis":[10,268],"and":[11,17,38,47,55,69,117,153,168,173,178,195,205,217,260,269,278],"treatment":[12],"by":[13,98],"leveraging":[14],"computational":[15,258],"methods":[16,87,259],"omics":[18,89,261],"data":[19,64,72,90,116,262],"analysis.":[20],"Lung":[21],"remains":[23],"a":[24,110,221,240],"leading":[25],"cause":[26],"of":[27,82,134,176,187,257],"cancer\u2010related":[28],"deaths":[29],"globally,":[30],"highlighting":[31],"urgency":[33],"more":[35],"effective":[36],"diagnostic":[37,42],"therapeutic":[39],"approaches.":[40],"Current":[41],"methods,":[43],"such":[44,61,147],"as":[45,62,148,239],"imaging":[46],"biopsies,":[48],"suffer":[49],"from":[50],"limitations":[51,75],"in":[52,71,94,105,137,233,264],"sensitivity,":[53],"specificity,":[54],"accessibility,":[56],"often":[57],"due":[58],"to":[59,124,159],"factors":[60],"poor":[63],"quality,":[65],"small":[66],"sample":[67],"sizes,":[68],"variability":[70],"sources.":[73],"These":[74],"highlight":[76],"necessity":[78],"development":[81,167],"advanced":[83],"noninvasive":[84],"techniques.":[85],"Computational":[86],"utilizing":[88],"have":[91],"shown":[92],"promise":[93],"overcoming":[95],"these":[96],"challenges":[97],"comprehensively":[99],"understanding":[100],"molecular":[102],"pathways":[103],"involved":[104],"cancer.":[107],"We":[108],"propose":[109],"novel":[111],"approach":[112,136],"that":[113],"utilizes":[114],"RNA\u2010Seq":[115],"employs":[118],"LASSO":[119],"regression":[120],"with":[121,164,191,226],"attention":[122],"mechanisms":[123],"identify":[125],"biomarkers.":[128],"Our":[129],"results":[130],"demonstrate":[131],"effectiveness":[133],"this":[135],"identifying":[138],"potential":[139,256],"biomarkers":[140],"cancer,":[143],"including":[144,197],"well\u2010known":[145],"genes":[146,162,190,229],"TP53,":[149],"EGFR,":[150],"KRAS,":[151],"ALK,":[152],"PIK3CA,":[154],"validating":[155],"model\u2019s":[157],"ability":[158],"uncover":[160],"key":[161],"associated":[163],"progression.":[169,236],"Gene":[170],"Ontology":[171],"(GO)":[172],"Kyoto":[174],"Encyclopedia":[175],"Genes":[177],"Genomes":[179],"(KEGG)":[180],"pathway":[181],"enrichment":[182],"analyses":[183],"revealed":[184],"significant":[185],"associations":[186],"identified":[189,245],"critical":[192],"biological":[193],"processes":[194],"pathways,":[196],"protein":[198],"synthesis,":[199],"folding,":[200],"cell":[201],"adhesion,":[202],"gene":[203],"regulation,":[204],"immune":[206],"responses.":[207],"The":[208],"PPI":[209],"network":[210],"analysis,":[211],"constructed":[212],"using":[213],"STRING":[215],"database":[216],"Cytoscape":[218],"application,":[219],"highlighted":[220],"highly":[222],"interconnected":[223],"interaction":[224],"landscape,":[225],"central":[227],"hub":[228,242],"playing":[230],"pivotal":[231],"roles":[232],"RPSA":[237],"emerged":[238],"crucial":[241],"gene,":[243],"consistently":[244],"across":[246],"different":[247],"centrality":[248],"measures.":[249],"sheds":[252],"light":[253],"on":[254],"analysis":[263],"improving":[265],"treatment,":[270],"offering":[271],"new":[272],"insights":[273],"future":[275],"research":[276],"directions":[277],"personalized":[279],"medicine":[280],"strategies.":[281]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2}],"updated_date":"2026-06-15T08:34:33.830935","created_date":"2025-10-10T00:00:00"}
