{"id":"https://openalex.org/W4408320497","doi":"https://doi.org/10.1155/cplx/9007322","title":"Prevention of EMT\u2010Mediated Metastasis via Optimal Modulation Strategies for the Dysregulated WNT Pathway Interacting With TGF\u2010\u03b2","display_name":"Prevention of EMT\u2010Mediated Metastasis via Optimal Modulation Strategies for the Dysregulated WNT Pathway Interacting With TGF\u2010\u03b2","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4408320497","doi":"https://doi.org/10.1155/cplx/9007322"},"language":"en","primary_location":{"id":"doi:10.1155/cplx/9007322","is_oa":true,"landing_page_url":"https://doi.org/10.1155/cplx/9007322","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/cplx/9007322","source":{"id":"https://openalex.org/S207319443","display_name":"Complexity","issn_l":"1076-2787","issn":["1076-2787","1099-0526"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Complexity","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/cplx/9007322","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082388635","display_name":"Sooyoun Choi","orcid":"https://orcid.org/0000-0002-7422-677X"},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sooyoun Choi","raw_affiliation_strings":["Department of Mathematics ,  Pusan National University ,  Busan ,  46241 ,  Republic of Korea , pusan.ac.kr"],"raw_orcid":"https://orcid.org/0000-0002-7422-677X","affiliations":[{"raw_affiliation_string":"Department of Mathematics ,  Pusan National University ,  Busan ,  46241 ,  Republic of Korea , pusan.ac.kr","institution_ids":["https://openalex.org/I4921948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054682918","display_name":"Yunil Roh","orcid":"https://orcid.org/0000-0003-1191-0336"},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yunil Roh","raw_affiliation_strings":["Department of Mathematics ,  Pusan National University ,  Busan ,  46241 ,  Republic of Korea , pusan.ac.kr"],"raw_orcid":"https://orcid.org/0000-0003-1191-0336","affiliations":[{"raw_affiliation_string":"Department of Mathematics ,  Pusan National University ,  Busan ,  46241 ,  Republic of Korea , pusan.ac.kr","institution_ids":["https://openalex.org/I4921948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025243108","display_name":"Yong Dam Jeong","orcid":"https://orcid.org/0000-0002-3970-7690"},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yong Dam Jeong","raw_affiliation_strings":["Interdisciplinary Biology Laboratory (iBLab) ,  Division of Biological Science ,  Graduate School of Science ,  Nagoya University ,  Nagoya ,  Japan , nagoya-u.ac.jp"],"raw_orcid":"https://orcid.org/0000-0002-3970-7690","affiliations":[{"raw_affiliation_string":"Interdisciplinary Biology Laboratory (iBLab) ,  Division of Biological Science ,  Graduate School of Science ,  Nagoya University ,  Nagoya ,  Japan , nagoya-u.ac.jp","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067871964","display_name":"Il Hyo Jung","orcid":"https://orcid.org/0000-0002-6086-5124"},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Il Hyo Jung","raw_affiliation_strings":["Department of Mathematics ,  Pusan National University ,  Busan ,  46241 ,  Republic of Korea , pusan.ac.kr","Finance Fishery Manufacture Industrial Mathematics Center on BigData ,  Pusan National University ,  Busan ,  46241 ,  Republic of Korea , pusan.ac.kr","Institute of Mathematical Sciences ,  Pusan National University ,  Busan ,  46241 ,  Republic of Korea , imsc.res.in"],"raw_orcid":"https://orcid.org/0000-0002-6086-5124","affiliations":[{"raw_affiliation_string":"Department of Mathematics ,  Pusan National University ,  Busan ,  46241 ,  Republic of Korea , pusan.ac.kr","institution_ids":["https://openalex.org/I4921948"]},{"raw_affiliation_string":"Finance Fishery Manufacture Industrial Mathematics Center on BigData ,  Pusan National University ,  Busan ,  46241 ,  Republic of Korea , pusan.ac.kr","institution_ids":["https://openalex.org/I4921948"]},{"raw_affiliation_string":"Institute of Mathematical Sciences ,  Pusan National University ,  Busan ,  46241 ,  Republic of Korea , imsc.res.in","institution_ids":["https://openalex.org/I4921948"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5067871964"],"corresponding_institution_ids":["https://openalex.org/I4921948"],"apc_list":{"value":2550,"currency":"USD","value_usd":2550},"apc_paid":{"value":2550,"currency":"USD","value_usd":2550},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04954979,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2025","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wnt-signaling-pathway","display_name":"Wnt signaling pathway","score":0.7508872151374817},{"id":"https://openalex.org/keywords/metastasis","display_name":"Metastasis","score":0.7122585773468018},{"id":"https://openalex.org/keywords/transforming-growth-factor","display_name":"Transforming growth factor","score":0.6388163566589355},{"id":"https://openalex.org/keywords/modulation","display_name":"Modulation (music)","score":0.5547946095466614},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.47153884172439575},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.41003215312957764},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.38182130455970764},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.35234934091567993},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3240772485733032},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.15592432022094727},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1301865577697754},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.09904474020004272}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.7508872151374817},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.7122585773468018},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.6388163566589355},{"id":"https://openalex.org/C123079801","wikidata":"https://www.wikidata.org/wiki/Q750240","display_name":"Modulation (music)","level":2,"score":0.5547946095466614},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47153884172439575},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.41003215312957764},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38182130455970764},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35234934091567993},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3240772485733032},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.15592432022094727},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1301865577697754},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09904474020004272},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1155/cplx/9007322","is_oa":true,"landing_page_url":"https://doi.org/10.1155/cplx/9007322","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/cplx/9007322","source":{"id":"https://openalex.org/S207319443","display_name":"Complexity","issn_l":"1076-2787","issn":["1076-2787","1099-0526"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Complexity","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:2fce238ce4964aa2940f419c9d1dd3e0","is_oa":true,"landing_page_url":"https://doaj.org/article/2fce238ce4964aa2940f419c9d1dd3e0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Complexity, Vol 2025 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/cplx/9007322","is_oa":true,"landing_page_url":"https://doi.org/10.1155/cplx/9007322","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/cplx/9007322","source":{"id":"https://openalex.org/S207319443","display_name":"Complexity","issn_l":"1076-2787","issn":["1076-2787","1099-0526"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Complexity","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2353471013","display_name":null,"funder_award_id":"RS-2024-00407832","funder_id":"https://openalex.org/F4320322030","funder_display_name":"Ministry of Science, ICT and Future Planning"},{"id":"https://openalex.org/G4274620313","display_name":null,"funder_award_id":"RS-2024-00411733","funder_id":"https://openalex.org/F4320322030","funder_display_name":"Ministry of Science, ICT and Future Planning"},{"id":"https://openalex.org/G4502279026","display_name":null,"funder_award_id":"2022R1A5A1033624","funder_id":"https://openalex.org/F4320322030","funder_display_name":"Ministry of Science, ICT and Future Planning"},{"id":"https://openalex.org/G5407483848","display_name":null,"funder_award_id":"2022R1A5A1033624","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"},{"id":"https://openalex.org/G5586844261","display_name":null,"funder_award_id":"RS-2024-00345478","funder_id":"https://openalex.org/F4320322030","funder_display_name":"Ministry of Science, ICT and Future Planning"},{"id":"https://openalex.org/G5820875047","display_name":null,"funder_award_id":"2022R1A5A1033624)","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G6066198193","display_name":null,"funder_award_id":"RS-2024-00342113","funder_id":"https://openalex.org/F4320322030","funder_display_name":"Ministry of Science, ICT and Future Planning"},{"id":"https://openalex.org/G6433000349","display_name":null,"funder_award_id":"RS-2024-00342113","funder_id":"https://openalex.org/F4320328359","funder_display_name":"Ministry of Science and ICT, South Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322030","display_name":"Ministry of Science, ICT and Future Planning","ror":"https://ror.org/032e49973"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320328359","display_name":"Ministry of Science and ICT, South Korea","ror":"https://ror.org/01wpjm123"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4408320497.pdf","grobid_xml":"https://content.openalex.org/works/W4408320497.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1508748501","https://openalex.org/W1536067283","https://openalex.org/W1963501822","https://openalex.org/W1964847767","https://openalex.org/W1972212024","https://openalex.org/W1972429412","https://openalex.org/W1989770075","https://openalex.org/W2001620484","https://openalex.org/W2004100213","https://openalex.org/W2006472255","https://openalex.org/W2007500813","https://openalex.org/W2014036889","https://openalex.org/W2015567417","https://openalex.org/W2021586841","https://openalex.org/W2028642586","https://openalex.org/W2038504801","https://openalex.org/W2068745993","https://openalex.org/W2091669278","https://openalex.org/W2094535521","https://openalex.org/W2094650757","https://openalex.org/W2098891057","https://openalex.org/W2103641729","https://openalex.org/W2120925536","https://openalex.org/W2133877095","https://openalex.org/W2135535700","https://openalex.org/W2140595402","https://openalex.org/W2158812368","https://openalex.org/W2170331002","https://openalex.org/W2170619426","https://openalex.org/W2185657910","https://openalex.org/W2192684627","https://openalex.org/W2333848322","https://openalex.org/W2438447375","https://openalex.org/W2520611244","https://openalex.org/W2573970795","https://openalex.org/W2630701056","https://openalex.org/W2755285110","https://openalex.org/W2756115418","https://openalex.org/W2896546058","https://openalex.org/W2940057770","https://openalex.org/W2957934662","https://openalex.org/W2963267964","https://openalex.org/W2979492661","https://openalex.org/W3020208951","https://openalex.org/W3108389912","https://openalex.org/W3112064419","https://openalex.org/W3116374128","https://openalex.org/W4205498896","https://openalex.org/W4224112383","https://openalex.org/W4243493776","https://openalex.org/W4245893543","https://openalex.org/W4280638650","https://openalex.org/W4378078317","https://openalex.org/W4391033302","https://openalex.org/W4396916306","https://openalex.org/W7046543776"],"related_works":["https://openalex.org/W2165132828","https://openalex.org/W4234806968","https://openalex.org/W2937181318","https://openalex.org/W2543202296","https://openalex.org/W2507081987","https://openalex.org/W3148046299","https://openalex.org/W2055808176","https://openalex.org/W2365516742","https://openalex.org/W2383757887","https://openalex.org/W3030570121"],"abstract_inverted_index":{"Cancer":[0],"metastasis":[1,27,55,217],"is":[2,19],"one":[3],"of":[4,8,14,25,33,62,78,92,147,154,174,194,210,224],"the":[5,15,23,58,71,76,88,123,126,145,152,159,168,179,208,211,222],"leading":[6,29],"causes":[7],"death":[9],"in":[10,67,86,95,136],"cancer":[11,26,216],"patients.":[12],"Dysregulation":[13],"WNT":[16,127],"signaling":[17,80,128,213],"pathway":[18,129],"known":[20],"to":[21,30,53,75,103,112,150,204,221],"increase":[22],"risk":[24],"by":[28,56,107,191],"excessive":[31],"accumulation":[32],"\u03b2\u2010catenin,":[34,63],"which":[35],"activates":[36],"epithelial\u2013mesenchymal":[37],"transition":[38],"(EMT)":[39],"mechanisms":[40],"that":[41,120,183],"induce":[42],"cell":[43,79],"motility.":[44],"Although":[45],"mono":[46],"and":[47,69,130,156,197],"combination":[48,90,96,161],"therapies":[49],"are":[50,65,202],"being":[51],"developed":[52],"prevent":[54,151],"controlling":[57],"abnormally":[59],"elevated":[60],"levels":[61],"there":[64],"limitations":[66],"comparing":[68],"predicting":[70],"treatment":[72],"effects":[73],"due":[74],"complexity":[77],"pathways.":[81],"In":[82,98],"addition,":[83],"uncertainty":[84],"exists":[85],"determining":[87],"optimal":[89,109,140,160,180],"ratio":[91,162],"each":[93],"therapy":[94,181],"treatments.":[97],"this":[99],"study,":[100],"we":[101,177],"aim":[102],"address":[104],"these":[105],"challenges":[106],"investigating":[108],"modulation":[110],"strategies":[111,149],"minimize":[113],"\u03b2\u2010catenin":[114,155],"concentration,":[115],"using":[116],"a":[117],"mathematical":[118],"model":[119],"comprehensively":[121],"describes":[122],"interactions":[124],"between":[125],"transforming":[131],"growth":[132],"factor\u2010\u03b2":[133],"(TGF\u2010\u03b2)":[134],"involved":[135],"EMT,":[137,165],"along":[138],"with":[139],"control":[141,195],"theory.":[142],"We":[143],"analyze":[144],"efficacy":[146,190],"monotherapy":[148],"hyperactivation":[153],"quantitatively":[157],"determine":[158],"for":[163],"preventing":[164],"based":[166],"on":[167],"E\u2010cadherin":[169],"biomarker":[170],"as":[171],"an":[172],"indicator":[173],"EMT.":[175],"Furthermore,":[176],"identify":[178],"protocol":[182],"minimizes":[184],"patient":[185],"burden":[186],"while":[187],"maximizing":[188],"therapeutic":[189,226],"incorporating":[192],"considerations":[193],"sequences":[196],"delay":[198],"times.":[199],"Our":[200],"findings":[201],"expected":[203],"not":[205],"only":[206],"enhance":[207],"understanding":[209],"complex":[212],"pathways":[214],"underlying":[215],"but":[218],"also":[219],"contribute":[220],"development":[223],"novel":[225],"approaches.":[227]},"counts_by_year":[],"updated_date":"2026-08-15T07:11:24.734988","created_date":"2025-10-10T00:00:00"}
