{"id":"https://openalex.org/W4205668459","doi":"https://doi.org/10.1155/2022/7549894","title":"Identification of Key Genes and Pathways in Osteosarcoma by Bioinformatics Analysis","display_name":"Identification of Key Genes and Pathways in Osteosarcoma by Bioinformatics Analysis","publication_year":2022,"publication_date":"2022-01-15","ids":{"openalex":"https://openalex.org/W4205668459","doi":"https://doi.org/10.1155/2022/7549894"},"language":"en","primary_location":{"id":"doi:10.1155/2022/7549894","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2022/7549894","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2022/7549894.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/cmmm/2022/7549894.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056536492","display_name":"Xiujin Chen","orcid":"https://orcid.org/0000-0003-2522-7992"},"institutions":[{"id":"https://openalex.org/I4210098630","display_name":"Xi'an Honghui Hospital","ror":"https://ror.org/015bnwc11","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098630"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiujin Chen","raw_affiliation_strings":["Department of Orthopaedic Oncology, Hong Hui Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, 710054 Shaanxi Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Oncology, Hong Hui Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, 710054 Shaanxi Province, China","institution_ids":["https://openalex.org/I4210098630","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100331222","display_name":"Nan Zhang","orcid":"https://orcid.org/0000-0001-6518-2501"},"institutions":[{"id":"https://openalex.org/I4210098630","display_name":"Xi'an Honghui Hospital","ror":"https://ror.org/015bnwc11","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098630"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nan Zhang","raw_affiliation_strings":["Department of Pathology, Hong Hui Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, 710054 Shaanxi Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Hong Hui Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, 710054 Shaanxi Province, China","institution_ids":["https://openalex.org/I4210098630","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101664956","display_name":"Yuanyuan Zheng","orcid":"https://orcid.org/0000-0003-2942-474X"},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Zheng","raw_affiliation_strings":["Geriatric Cardiovascular Department, The Second Affiliated Hospital of Xi'an Jiaotong University (Xibei Hospital), Xi\u2019an, Shaanxi Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geriatric Cardiovascular Department, The Second Affiliated Hospital of Xi'an Jiaotong University (Xibei Hospital), Xi\u2019an, Shaanxi Province, China","institution_ids":["https://openalex.org/I4210131893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101106270","display_name":"Zhichao Tong","orcid":null},"institutions":[{"id":"https://openalex.org/I4210098630","display_name":"Xi'an Honghui Hospital","ror":"https://ror.org/015bnwc11","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098630"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhichao Tong","raw_affiliation_strings":["Department of Orthopaedic Oncology, Hong Hui Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, 710054 Shaanxi Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Oncology, Hong Hui Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, 710054 Shaanxi Province, China","institution_ids":["https://openalex.org/I4210098630","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100302739","display_name":"Tuanmin Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210098630","display_name":"Xi'an Honghui Hospital","ror":"https://ror.org/015bnwc11","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098630"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tuanmin Yang","raw_affiliation_strings":["Department of Orthopaedic Oncology, Hong Hui Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, 710054 Shaanxi Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Oncology, Hong Hui Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, 710054 Shaanxi Province, China","institution_ids":["https://openalex.org/I4210098630","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101582111","display_name":"Xin Kang","orcid":"https://orcid.org/0000-0001-6080-9619"},"institutions":[{"id":"https://openalex.org/I4210098630","display_name":"Xi'an Honghui Hospital","ror":"https://ror.org/015bnwc11","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098630"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xin Kang","raw_affiliation_strings":["Department of Sports Medicine, Hong Hui Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, 710054 Shaanxi Province, China"],"raw_orcid":"https://orcid.org/0000-0001-6080-9619","affiliations":[{"raw_affiliation_string":"Department of Sports Medicine, Hong Hui Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, 710054 Shaanxi Province, China","institution_ids":["https://openalex.org/I4210098630","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103164612","display_name":"Yan He","orcid":"https://orcid.org/0000-0002-4128-3444"},"institutions":[{"id":"https://openalex.org/I4210098630","display_name":"Xi'an Honghui Hospital","ror":"https://ror.org/015bnwc11","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098630"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan He","raw_affiliation_strings":["Department of Magnetic Resonance Imaging, Hong Hui Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, 710054 Shaanxi Province, China"],"raw_orcid":"https://orcid.org/0000-0002-4128-3444","affiliations":[{"raw_affiliation_string":"Department of Magnetic Resonance Imaging, Hong Hui Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, 710054 Shaanxi Province, China","institution_ids":["https://openalex.org/I4210098630","https://openalex.org/I87445476"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030004775","display_name":"Liang Dong","orcid":"https://orcid.org/0000-0001-8655-8854"},"institutions":[{"id":"https://openalex.org/I4210098630","display_name":"Xi'an Honghui Hospital","ror":"https://ror.org/015bnwc11","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210098630"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liang Dong","raw_affiliation_strings":["Department of Cervical Spine Surgery, Hong Hui Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, 710054 Shaanxi Province, China"],"raw_orcid":"https://orcid.org/0000-0001-8655-8854","affiliations":[{"raw_affiliation_string":"Department of Cervical Spine Surgery, Hong Hui Hospital of Xi\u2019an Jiaotong University, Xi\u2019an, 710054 Shaanxi Province, China","institution_ids":["https://openalex.org/I4210098630","https://openalex.org/I87445476"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5030004775","https://openalex.org/A5101582111","https://openalex.org/A5103164612"],"corresponding_institution_ids":["https://openalex.org/I4210098630","https://openalex.org/I87445476"],"apc_list":{"value":2550,"currency":"USD","value_usd":2550},"apc_paid":{"value":2550,"currency":"USD","value_usd":2550},"fwci":1.0088,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.72672862,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"2022","issue":null,"first_page":"1","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9921000003814697,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kegg","display_name":"KEGG","score":0.7013596296310425},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6862236261367798},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6719052791595459},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.5061735510826111},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4826813042163849},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.4207855463027954},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.42063748836517334},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3905089795589447},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.3272472023963928}],"concepts":[{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.7013596296310425},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6862236261367798},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6719052791595459},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.5061735510826111},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4826813042163849},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4207855463027954},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.42063748836517334},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3905089795589447},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.3272472023963928}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1155/2022/7549894","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2022/7549894","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2022/7549894.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:da1438ba58a34f308bfd3f12c4d1508d","is_oa":true,"landing_page_url":"https://doaj.org/article/da1438ba58a34f308bfd3f12c4d1508d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computational and Mathematical Methods in Medicine, Vol 2022 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2022/7549894","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2022/7549894","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2022/7549894.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5899999737739563,"id":"https://metadata.un.org/sdg/1","display_name":"No poverty"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4205668459.pdf","grobid_xml":"https://content.openalex.org/works/W4205668459.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W181426613","https://openalex.org/W1270834676","https://openalex.org/W1986550373","https://openalex.org/W2013881151","https://openalex.org/W2028264252","https://openalex.org/W2035873826","https://openalex.org/W2077149593","https://openalex.org/W2083239828","https://openalex.org/W2086584353","https://openalex.org/W2087025987","https://openalex.org/W2105951972","https://openalex.org/W2114309015","https://openalex.org/W2130410032","https://openalex.org/W2159941442","https://openalex.org/W2341128841","https://openalex.org/W2418831213","https://openalex.org/W2550400579","https://openalex.org/W2552171096","https://openalex.org/W2620556559","https://openalex.org/W2762414284","https://openalex.org/W2767053399","https://openalex.org/W2781034938","https://openalex.org/W2795389019","https://openalex.org/W2797890752","https://openalex.org/W2806176286","https://openalex.org/W2895113642","https://openalex.org/W2948656673","https://openalex.org/W2970107612","https://openalex.org/W2994964009","https://openalex.org/W3014352023"],"related_works":["https://openalex.org/W2297026197","https://openalex.org/W3089173564","https://openalex.org/W1976510917","https://openalex.org/W1974573031","https://openalex.org/W1986669422","https://openalex.org/W2073305407","https://openalex.org/W2052655934","https://openalex.org/W104645380","https://openalex.org/W2183420549","https://openalex.org/W2027213253"],"abstract_inverted_index":{"Purpose.":[0],"Osteosarcoma":[1],"(OS)":[2],"is":[3,210],"the":[4,13,36,41,56,78,96,100,108,194,204],"most":[5],"primary":[6],"bone":[7],"malignant":[8],"tumor":[9,27],"in":[10,132],"adolescents.":[11],"Although":[12],"treatment":[14],"of":[15,55,67,102,147,208],"OS":[16,148,200,209],"has":[17],"made":[18],"great":[19],"progress,":[20],"patients\u2019":[21],"prognosis":[22],"remains":[23],"poor":[24],"due":[25],"to":[26],"invasion":[28],"and":[29,32,69,71,80,91,123,140,157,176,191,197,203],"metastasis.":[30],"Materials":[31],"Methods.":[33],"We":[34,46],"downloaded":[35],"expression":[37,110],"profile":[38,111],"GSE12865":[39],"from":[40],"Gene":[42,63,72],"Expression":[43],"Omnibus":[44],"database.":[45],"screened":[47,92],"differential":[48],"expressed":[49],"genes":[50,94,121,125,146,196],"(DEGs)":[51],"by":[52],"making":[53],"use":[54],"R":[57],"limma":[58],"software":[59],"package.":[60],"Based":[61],"on":[62],"Ontology,":[64],"Kyoto":[65],"Encyclopedia":[66],"Genes":[68],"Genomes,":[70],"Set":[73],"Enrichment":[74],"Analysis,":[75],"we":[76,85,113],"performed":[77],"function":[79],"pathway":[81],"enrichment":[82],"analyses.":[83],"Then,":[84],"constructed":[86],"a":[87],"Protein-Protein":[88],"Interaction":[89],"network":[90,161],"hub":[93,145,195],"through":[95,159,187],"Search":[97],"Tool":[98],"for":[99],"Retrieval":[101],"Interacting":[103],"Genes.":[104],"Result.":[105],"By":[106],"analyzing":[107,188],"gene":[109],"GSE12865,":[112],"obtained":[114],"703":[115],"OS-related":[116],"DEGs,":[117],"which":[118],"contained":[119],"166":[120],"upregulated":[122],"537":[124],"downregulated.":[126],"The":[127,144],"DEGs":[128],"were":[129,149,179],"primarily":[130],"abundant":[131],"ribosome,":[133],"cell":[134,168],"adhesion":[135,169,178],"molecules,":[136,170],"ubiquitin-ubiquitin":[137],"ligase":[138],"activity,":[139],"p53":[141],"signaling":[142],"pathway.":[143],"KDR,":[150],"CDH5,":[151],"CD34,":[152],"CDC42,":[153],"RBX1,":[154],"POLR2C,":[155],"PPP2CA,":[156],"RPS2":[158],"PPI":[160],"analysis.":[162],"Finally,":[163],"GSEA":[164],"analysis":[165],"showed":[166],"that":[167],"chemokine":[171],"signal":[172],"pathway,":[173],"transendothelial":[174],"migration,":[175],"focal":[177],"associated":[180],"with":[181],"OS.":[182],"Conclusion.":[183],"In":[184],"this":[185],"study,":[186],"microarray":[189],"technology":[190],"bioinformatics":[192],"analysis,":[193],"pathways":[198],"about":[199],"are":[201],"identified,":[202],"new":[205],"molecular":[206],"mechanism":[207],"clarified.":[211]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4}],"updated_date":"2026-07-29T09:40:50.615796","created_date":"2025-10-10T00:00:00"}
