{"id":"https://openalex.org/W3152867406","doi":"https://doi.org/10.1155/2021/6697848","title":"Identification of Molecular Regulatory Features and Markers for Acute Type A Aortic Dissection","display_name":"Identification of Molecular Regulatory Features and Markers for Acute Type A Aortic Dissection","publication_year":2021,"publication_date":"2021-04-12","ids":{"openalex":"https://openalex.org/W3152867406","doi":"https://doi.org/10.1155/2021/6697848","mag":"3152867406","pmid":"https://pubmed.ncbi.nlm.nih.gov/33953793"},"language":"en","primary_location":{"id":"doi:10.1155/2021/6697848","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/6697848","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2021/6697848.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/cmmm/2021/6697848.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100662076","display_name":"Rui Lian","orcid":"https://orcid.org/0000-0001-9445-3075"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801051648","display_name":"China-Japan Friendship Hospital","ror":"https://ror.org/037cjxp13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801051648"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Lian","raw_affiliation_strings":["Emergency Department, China-Japan Friendship Hospital, Beijing, China","Graduate School of Peking Union Medical College, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0001-9445-3075","affiliations":[{"raw_affiliation_string":"Emergency Department, China-Japan Friendship Hospital, Beijing, China","institution_ids":["https://openalex.org/I2801051648"]},{"raw_affiliation_string":"Graduate School of Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I2801228662","https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100669897","display_name":"Guochao Zhang","orcid":"https://orcid.org/0000-0002-9531-8374"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801051648","display_name":"China-Japan Friendship Hospital","ror":"https://ror.org/037cjxp13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801051648"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guochao Zhang","raw_affiliation_strings":["Department of General Surgery, China-Japan Friendship Hospital, Beijing, China","Emergency Department, China-Japan Friendship Hospital, Beijing, China","Graduate School of Peking Union Medical College, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, China-Japan Friendship Hospital, Beijing, China","institution_ids":["https://openalex.org/I2801051648"]},{"raw_affiliation_string":"Emergency Department, China-Japan Friendship Hospital, Beijing, China","institution_ids":["https://openalex.org/I2801051648"]},{"raw_affiliation_string":"Graduate School of Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I2801228662","https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101464990","display_name":"Shengtao Yan","orcid":"https://orcid.org/0000-0003-3011-0051"},"institutions":[{"id":"https://openalex.org/I2801051648","display_name":"China-Japan Friendship Hospital","ror":"https://ror.org/037cjxp13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801051648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shengtao Yan","raw_affiliation_strings":["Emergency Department, China-Japan Friendship Hospital, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0003-3011-0051","affiliations":[{"raw_affiliation_string":"Emergency Department, China-Japan Friendship Hospital, Beijing, China","institution_ids":["https://openalex.org/I2801051648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102714473","display_name":"Lichao Sun","orcid":"https://orcid.org/0000-0003-0551-1080"},"institutions":[{"id":"https://openalex.org/I2801051648","display_name":"China-Japan Friendship Hospital","ror":"https://ror.org/037cjxp13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801051648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lichao Sun","raw_affiliation_strings":["Emergency Department, China-Japan Friendship Hospital, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0003-0551-1080","affiliations":[{"raw_affiliation_string":"Emergency Department, China-Japan Friendship Hospital, Beijing, China","institution_ids":["https://openalex.org/I2801051648"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100392500","display_name":"Guoqiang Zhang","orcid":"https://orcid.org/0000-0003-1728-3847"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801051648","display_name":"China-Japan Friendship Hospital","ror":"https://ror.org/037cjxp13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801051648"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guoqiang Zhang","raw_affiliation_strings":["Department of General Surgery, China-Japan Friendship Hospital, Beijing, China","Emergency Department, China-Japan Friendship Hospital, Beijing, China","Graduate School of Peking Union Medical College, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0003-1728-3847","affiliations":[{"raw_affiliation_string":"Department of General Surgery, China-Japan Friendship Hospital, Beijing, China","institution_ids":["https://openalex.org/I2801051648"]},{"raw_affiliation_string":"Emergency Department, China-Japan Friendship Hospital, Beijing, China","institution_ids":["https://openalex.org/I2801051648"]},{"raw_affiliation_string":"Graduate School of Peking Union Medical College, Beijing, China","institution_ids":["https://openalex.org/I2801228662","https://openalex.org/I200296433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100392500"],"corresponding_institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801051648","https://openalex.org/I2801228662"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":1.7492,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.85271417,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"2021","issue":null,"first_page":"1","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10618","display_name":"Aortic Disease and Treatment Approaches","score":0.3093000054359436,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10618","display_name":"Aortic Disease and Treatment Approaches","score":0.3093000054359436,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.1371999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research","score":0.12559999525547028,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.723272979259491},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6003050804138184},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.481101930141449},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.39078661799430847},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.37235721945762634},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3549097776412964},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.3215515613555908}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.723272979259491},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6003050804138184},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.481101930141449},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39078661799430847},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37235721945762634},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3549097776412964},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3215515613555908}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000784","descriptor_name":"Aortic Dissection","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000784","descriptor_name":"Aortic Dissection","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000784","descriptor_name":"Aortic Dissection","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000784","descriptor_name":"Aortic Dissection","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000784","descriptor_name":"Aortic Dissection","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000784","descriptor_name":"Aortic Dissection","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000784","descriptor_name":"Aortic Dissection","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000784","descriptor_name":"Aortic Dissection","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001014","descriptor_name":"Aortic Aneurysm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001014","descriptor_name":"Aortic Aneurysm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001014","descriptor_name":"Aortic Aneurysm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001014","descriptor_name":"Aortic Aneurysm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001014","descriptor_name":"Aortic Aneurysm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001014","descriptor_name":"Aortic Aneurysm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001014","descriptor_name":"Aortic Aneurysm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001014","descriptor_name":"Aortic Aneurysm","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1155/2021/6697848","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/6697848","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2021/6697848.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},{"id":"pmid:33953793","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33953793","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and mathematical methods in medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:a1d20c0ef50b498aab93a65463cf5724","is_oa":false,"landing_page_url":"https://doaj.org/article/a1d20c0ef50b498aab93a65463cf5724","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computational and Mathematical Methods in Medicine, Vol 2021 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8057891","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8057891","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Comput Math Methods Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1155/2021/6697848","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/6697848","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2021/6697848.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7699999809265137}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3152867406.pdf","grobid_xml":"https://content.openalex.org/works/W3152867406.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W1686570201","https://openalex.org/W1966107523","https://openalex.org/W1966327575","https://openalex.org/W1987925623","https://openalex.org/W1992521055","https://openalex.org/W2000642767","https://openalex.org/W2018782206","https://openalex.org/W2024264687","https://openalex.org/W2035618305","https://openalex.org/W2047837955","https://openalex.org/W2049175174","https://openalex.org/W2057462930","https://openalex.org/W2081929579","https://openalex.org/W2089807183","https://openalex.org/W2105621610","https://openalex.org/W2112248448","https://openalex.org/W2145139438","https://openalex.org/W2146512944","https://openalex.org/W2147487806","https://openalex.org/W2155248983","https://openalex.org/W2161722088","https://openalex.org/W2170330896","https://openalex.org/W2288473292","https://openalex.org/W2403458246","https://openalex.org/W2424211800","https://openalex.org/W2466879592","https://openalex.org/W2501496023","https://openalex.org/W2510700837","https://openalex.org/W2564433691","https://openalex.org/W2585706781","https://openalex.org/W2590574894","https://openalex.org/W2607486178","https://openalex.org/W2745417329","https://openalex.org/W2765416597","https://openalex.org/W2790781434","https://openalex.org/W2791665828","https://openalex.org/W2796325516","https://openalex.org/W2797663627","https://openalex.org/W2883694215","https://openalex.org/W2891674642","https://openalex.org/W2901361157","https://openalex.org/W2901425401","https://openalex.org/W2901827276","https://openalex.org/W2911016540","https://openalex.org/W2915308361","https://openalex.org/W2977538778","https://openalex.org/W2981101270","https://openalex.org/W3004562536","https://openalex.org/W3010938347","https://openalex.org/W3011221555","https://openalex.org/W3015234388","https://openalex.org/W3022538096","https://openalex.org/W3024209145","https://openalex.org/W3025567596","https://openalex.org/W3040374709","https://openalex.org/W3044950542","https://openalex.org/W3045823656","https://openalex.org/W3048645885","https://openalex.org/W3048772400","https://openalex.org/W3092230054","https://openalex.org/W3095571996","https://openalex.org/W3119659946","https://openalex.org/W4211116063"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2357948923","https://openalex.org/W4211132779","https://openalex.org/W4313472242","https://openalex.org/W2332159055","https://openalex.org/W2030500189","https://openalex.org/W2419188526","https://openalex.org/W2144422987","https://openalex.org/W2018938924","https://openalex.org/W3171722058"],"abstract_inverted_index":{"BACKGROUND:":[0],"Acute":[1],"type":[2],"A":[3],"aortic":[4,77],"dissection":[5,78],"(ATAAD)":[6],"is":[7],"one":[8],"of":[9,46,140,221],"the":[10,51,100,106,181,219,237],"most":[11],"lethal":[12],"cardiovascular":[13],"diseases,":[14],"and":[15,28,40,79,121,130,143,159,190,216,226,240],"its":[16],"molecular":[17,238],"mechanism":[18],"remains":[19],"unclear.":[20],"METHODS:":[21],"Differentially":[22],"expressed":[23],"genes":[24,60,104,134,208],"(DEGs)":[25],"between":[26,76,119],"ATAAD":[27,66,120,222],"control":[29,80,122],"were":[30,62,81,109,135,149,168,177],"detected":[31],"by":[32,50,83,125,214],"limma":[33],"R":[34,69],"package":[35],"in":[36,152,203,218],"GSE52093,":[37],"GSE153434,":[38,131],"GSE98770,":[39],"GSE84827,":[41],"respectively.":[42],"The":[43,103,206,230],"coexpression":[44],"network":[45,95],"DEGs":[47],"was":[48,56,96,123],"identified":[49,82,110,124,185,197,210],"WGCNA":[52],"package.":[53,70,85],"Enrichment":[54],"analysis":[55],"performed":[57],"for":[58,243],"module":[59,133],"that":[61],"positively":[63],"correlated":[64],"with":[65,88,105,137,146],"using":[67],"clusterProfiler":[68],"In":[71,162],"addition,":[72,163],"differentially":[73,165,199],"methylated":[74,166],"markers":[75,167,176],"ChAMP":[84],"After":[86],"comparing":[87],"ATAAD-related":[89,178],"genes,":[90],"a":[91],"protein-protein":[92],"interaction":[93],"(PPI)":[94],"established":[97],"based":[98],"on":[99],"STRING":[101],"database.":[102],"highest":[107],"connectivity":[108],"as":[111,192],"hub":[112,193,207],"genes.":[113,194],"Finally,":[114,195],"differential":[115,141],"immune":[116,201,224],"cell":[117,154,160],"infiltration":[118],"ssGSEA.":[126],"RESULTS:":[127],"From":[128],"GSE52093":[129],"268":[132],"obtained":[136,169],"consistent":[138],"direction":[139],"expression":[142],"high":[144],"correlation":[145],"ATAAD.":[147,204,244],"They":[148],"significantly":[150,198],"enriched":[151],"T":[153],"activation,":[155],"HIF-1":[156],"signaling":[157],"pathway,":[158],"cycle.":[161],"2060":[164],"from":[170],"GSE84827.":[171],"Among":[172],"them,":[173],"77":[174],"methylation":[175,215],"DEGs.":[179],"Using":[180],"PPI":[182],"network,":[183],"we":[184,196,209],"MYC,":[186],"ITGA2,":[187],"RND3,":[188],"BCL2,":[189],"PHLPP2":[191],"infiltrated":[200],"cells":[202],"CONCLUSION:":[205],"may":[211,232],"be":[212],"regulated":[213],"participate":[217],"development":[220],"through":[223],"inflammation":[225],"oxidative":[227],"stress":[228],"response.":[229],"findings":[231],"provide":[233],"new":[234],"insights":[235],"into":[236],"mechanisms":[239],"therapeutic":[241],"targets":[242]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}