{"id":"https://openalex.org/W3124978598","doi":"https://doi.org/10.1155/2021/6648834","title":"Qu Feng Xuan Bi Formula Alleviates Airway Inflammation and Guides Clinical Treatment by Improving Bronchial Immune Balance in the Asthma Model","display_name":"Qu Feng Xuan Bi Formula Alleviates Airway Inflammation and Guides Clinical Treatment by Improving Bronchial Immune Balance in the Asthma Model","publication_year":2021,"publication_date":"2021-01-21","ids":{"openalex":"https://openalex.org/W3124978598","doi":"https://doi.org/10.1155/2021/6648834","mag":"3124978598"},"language":"en","primary_location":{"id":"doi:10.1155/2021/6648834","is_oa":true,"landing_page_url":"http://doi.org/10.1155/2021/6648834","pdf_url":"https://downloads.hindawi.com/journals/sp/2021/6648834.pdf","source":{"id":"https://openalex.org/S166774750","display_name":"Scientific Programming","issn_l":"1058-9244","issn":["1058-9244","1875-919X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Programming","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/sp/2021/6648834.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102718224","display_name":"Po Hu","orcid":"https://orcid.org/0009-0001-2932-0775"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Po Hu","raw_affiliation_strings":["The First Clinical Medical College, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Clinical Medical College, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101595157","display_name":"Suofang Shi","orcid":"https://orcid.org/0000-0002-1447-7059"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Suofang Shi","raw_affiliation_strings":["Department of Respiratory Diseases, The First Affiliation Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, China"],"raw_orcid":"https://orcid.org/0000-0002-1447-7059","affiliations":[{"raw_affiliation_string":"Department of Respiratory Diseases, The First Affiliation Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100418899","display_name":"Li Liu","orcid":"https://orcid.org/0000-0003-2314-8756"},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Liu","raw_affiliation_strings":["Department of Molecular Biology, The First Affiliation Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, The First Affiliation Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, China","institution_ids":["https://openalex.org/I131434179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041025191","display_name":"Shuomiao Yin","orcid":null},"institutions":[{"id":"https://openalex.org/I37987034","display_name":"Guangzhou University","ror":"https://ror.org/05ar8rn06","country_code":"CN","type":"education","lineage":["https://openalex.org/I37987034"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuomiao Yin","raw_affiliation_strings":["The First Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong 510006, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong 510006, China","institution_ids":["https://openalex.org/I37987034"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047014422","display_name":"Lingfu Wang","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lingfu Wang","raw_affiliation_strings":["The First Clinical Medical College, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Clinical Medical College, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5101595157"],"corresponding_institution_ids":[],"apc_list":{"value":1800,"currency":"USD","value_usd":1800},"apc_paid":{"value":1800,"currency":"USD","value_usd":1800},"fwci":0.2425,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.51696961,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"2021","issue":null,"first_page":"1","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9861999750137329,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9861999750137329,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9854999780654907,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9563000202178955,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asthma","display_name":"Asthma","score":0.7810418605804443},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.6363533139228821},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.630471408367157},{"id":"https://openalex.org/keywords/inflammation","display_name":"Inflammation","score":0.5613704919815063},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"Traditional Chinese medicine","score":0.5229259729385376},{"id":"https://openalex.org/keywords/mapk/erk-pathway","display_name":"MAPK/ERK pathway","score":0.5222833156585693},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.4833507239818573},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.4686065912246704},{"id":"https://openalex.org/keywords/balance","display_name":"Balance (ability)","score":0.4322133958339691},{"id":"https://openalex.org/keywords/toll-like-receptor","display_name":"Toll-like receptor","score":0.4245191812515259},{"id":"https://openalex.org/keywords/innate-immune-system","display_name":"Innate immune system","score":0.29544389247894287},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.288814514875412},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.21263572573661804},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.11844748258590698},{"id":"https://openalex.org/keywords/physical-therapy","display_name":"Physical therapy","score":0.09161791205406189}],"concepts":[{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.7810418605804443},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6363533139228821},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.630471408367157},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5613704919815063},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.5229259729385376},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5222833156585693},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4833507239818573},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4686065912246704},{"id":"https://openalex.org/C168031717","wikidata":"https://www.wikidata.org/wiki/Q1530280","display_name":"Balance (ability)","level":2,"score":0.4322133958339691},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.4245191812515259},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.29544389247894287},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.288814514875412},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21263572573661804},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11844748258590698},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.09161791205406189},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1155/2021/6648834","is_oa":true,"landing_page_url":"http://doi.org/10.1155/2021/6648834","pdf_url":"https://downloads.hindawi.com/journals/sp/2021/6648834.pdf","source":{"id":"https://openalex.org/S166774750","display_name":"Scientific Programming","issn_l":"1058-9244","issn":["1058-9244","1875-919X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Programming","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:233eabd1d52b436792a222cf46aab983","is_oa":false,"landing_page_url":"https://doaj.org/article/233eabd1d52b436792a222cf46aab983","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific Programming, Vol 2021 (2021)","raw_type":"article"},{"id":"pmh:oai:hindawi.com:10.1155/2021/6648834","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/6648834","pdf_url":null,"source":{"id":"https://openalex.org/S4306400340","display_name":"Hindawi Journal of Chemistry (Hindawi)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210126990","host_organization_name":"Hindawi (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210126990"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Research Article"}],"best_oa_location":{"id":"doi:10.1155/2021/6648834","is_oa":true,"landing_page_url":"http://doi.org/10.1155/2021/6648834","pdf_url":"https://downloads.hindawi.com/journals/sp/2021/6648834.pdf","source":{"id":"https://openalex.org/S166774750","display_name":"Scientific Programming","issn_l":"1058-9244","issn":["1058-9244","1875-919X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Programming","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"awards":[{"id":"https://openalex.org/G2503361640","display_name":null,"funder_award_id":"81774267","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G971440153","display_name":null,"funder_award_id":"BK20141502","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3124978598.pdf","grobid_xml":"https://content.openalex.org/works/W3124978598.grobid-xml"},"referenced_works_count":21,"referenced_works":["https://openalex.org/W196974270","https://openalex.org/W1504695357","https://openalex.org/W1547938117","https://openalex.org/W1603862958","https://openalex.org/W1669866646","https://openalex.org/W1995744610","https://openalex.org/W2023718084","https://openalex.org/W2026314011","https://openalex.org/W2028171970","https://openalex.org/W2033715939","https://openalex.org/W2034220219","https://openalex.org/W2040211909","https://openalex.org/W2048654643","https://openalex.org/W2115643744","https://openalex.org/W2132525268","https://openalex.org/W2142590472","https://openalex.org/W2151729760","https://openalex.org/W2153274446","https://openalex.org/W2161663577","https://openalex.org/W2314310745","https://openalex.org/W4312898948"],"related_works":["https://openalex.org/W2196358948","https://openalex.org/W1075988649","https://openalex.org/W4382298417","https://openalex.org/W2763069634","https://openalex.org/W2395336337","https://openalex.org/W2035331892","https://openalex.org/W1524220139","https://openalex.org/W2792401660","https://openalex.org/W2970486894","https://openalex.org/W74624318"],"abstract_inverted_index":{"Network":[0],"pharmacology":[1],"analysis":[2],"has":[3],"shown":[4],"that":[5,73,111],"Qu":[6],"Feng":[7],"Xuan":[8],"Bi":[9],"Formula":[10],"(QFXBF)":[11],"is":[12],"a":[13,123],"traditional":[14],"Chinese":[15],"herbal":[16],"medicine":[17],"used":[18],"to":[19,42],"treat":[20],"bronchial":[21,34,138],"asthma,":[22],"with":[23,137],"demonstrated":[24],"remarkable":[25],"effects;":[26],"however,":[27],"its":[28],"effects":[29],"on":[30],"airway":[31],"inflammation":[32],"and":[33,54,88,90,105,133,140],"asthma":[35,139],"alleviation":[36],"remain":[37],"unclear.":[38],"This":[39],"study":[40],"aimed":[41],"explore":[43],"the":[44,55,63,67,74,83,96,112,131],"underlying":[45,125],"mechanism":[46,124],"of":[47,66,77,135],"QFXBF":[48,78,98,102],"by":[49],"assessing":[50],"toll-like":[51],"receptor-9":[52],"(TLR-9)":[53],"downstream":[56,84],"MAPK":[57],"signaling":[58],"pathway":[59],"as":[60,62,118],"well":[61],"immune":[64,114],"modulation":[65],"Th1/Th2":[68,113],"balance.":[69],"The":[70],"results":[71],"showed":[72],"aqueous":[75],"extract":[76],"increased":[79],"TLR-9":[80],"expression,":[81],"regulated":[82],"genes":[85],"AP-1,":[86],"JNK,":[87],"ERK1/2,":[89],"reduced":[91],"serum":[92],"IL-5":[93],"levels":[94,107],"in":[95],"high-dose":[97],"group;":[99],"meanwhile,":[100],"following":[101],"treatment,":[103],"IFN-\u03b3":[104],"TNF-\u03b1":[106],"were":[108],"increased,":[109],"indicating":[110],"balance":[115],"was":[116],"reversed":[117],"predicted.":[119],"These":[120],"findings":[121],"provide":[122],"QFXBF\u2019s":[126],"effects,":[127],"which":[128],"significantly":[129],"improves":[130],"treatment":[132],"management":[134],"patients":[136],"profoundly":[141],"impacts":[142],"medical":[143],"information":[144],"processing.":[145]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}