{"id":"https://openalex.org/W3155838537","doi":"https://doi.org/10.1155/2021/5576933","title":"Systematic Identification of Survival-Associated Alternative Splicing Events in Kidney Renal Clear Cell Carcinoma","display_name":"Systematic Identification of Survival-Associated Alternative Splicing Events in Kidney Renal Clear Cell Carcinoma","publication_year":2021,"publication_date":"2021-04-19","ids":{"openalex":"https://openalex.org/W3155838537","doi":"https://doi.org/10.1155/2021/5576933","mag":"3155838537","pmid":"https://pubmed.ncbi.nlm.nih.gov/33959190"},"language":"en","primary_location":{"id":"doi:10.1155/2021/5576933","is_oa":true,"landing_page_url":"http://doi.org/10.1155/2021/5576933","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2021/5576933.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/cmmm/2021/5576933.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054973475","display_name":"Yubin Wei","orcid":"https://orcid.org/0000-0001-5277-2318"},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yubin Wei","raw_affiliation_strings":["Department of Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, China","Laboratory of Tissue and Cell Biology, Experimental Teaching and Management Center, Chongqing Medical University, Chongqing, China"],"raw_orcid":"https://orcid.org/0000-0001-5277-2318","affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"Laboratory of Tissue and Cell Biology, Experimental Teaching and Management Center, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100459087","display_name":"Zheng Zhang","orcid":"https://orcid.org/0000-0002-0062-517X"},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zheng Zhang","raw_affiliation_strings":["Department of Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, China"],"raw_orcid":"https://orcid.org/0000-0002-0062-517X","affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085728589","display_name":"Rui Peng","orcid":"https://orcid.org/0000-0003-1551-9334"},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Peng","raw_affiliation_strings":["Department of Bioinformatics, Chongqing Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026082024","display_name":"Yan Sun","orcid":"https://orcid.org/0000-0003-2595-0961"},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Sun","raw_affiliation_strings":["Department of Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, China"],"raw_orcid":"https://orcid.org/0000-0003-2595-0961","affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102833765","display_name":"Luyu Zhang","orcid":"https://orcid.org/0009-0000-2361-5014"},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Luyu Zhang","raw_affiliation_strings":["Department of Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000701402","display_name":"Handeng Liu","orcid":"https://orcid.org/0000-0001-9994-165X"},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Handeng Liu","raw_affiliation_strings":["Department of Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, China","Laboratory of Tissue and Cell Biology, Experimental Teaching and Management Center, Chongqing Medical University, Chongqing, China"],"raw_orcid":"https://orcid.org/0000-0001-9994-165X","affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"Laboratory of Tissue and Cell Biology, Experimental Teaching and Management Center, Chongqing Medical University, Chongqing, China","institution_ids":["https://openalex.org/I87780372"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5000701402"],"corresponding_institution_ids":["https://openalex.org/I87780372"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":0.1586,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.46713298,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"2021","issue":null,"first_page":"1","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6101667881011963},{"id":"https://openalex.org/keywords/rna-splicing","display_name":"RNA splicing","score":0.6056339144706726},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"Alternative splicing","score":0.5449364185333252},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5245890021324158},{"id":"https://openalex.org/keywords/proportional-hazards-model","display_name":"Proportional hazards model","score":0.5105546712875366},{"id":"https://openalex.org/keywords/exon","display_name":"Exon","score":0.442362904548645},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3893125355243683},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.27612078189849854},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2730436325073242},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2599707841873169},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2063276469707489},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.15592217445373535}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6101667881011963},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.6056339144706726},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.5449364185333252},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5245890021324158},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5105546712875366},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.442362904548645},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3893125355243683},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27612078189849854},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2730436325073242},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2599707841873169},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2063276469707489},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.15592217445373535}],"mesh":[{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1155/2021/5576933","is_oa":true,"landing_page_url":"http://doi.org/10.1155/2021/5576933","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2021/5576933.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},{"id":"pmid:33959190","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33959190","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and mathematical methods in medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:311486f1adff49e4803789575b89b4b9","is_oa":false,"landing_page_url":"https://doaj.org/article/311486f1adff49e4803789575b89b4b9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computational and Mathematical Methods in Medicine, Vol 2021 (2021)","raw_type":"article"},{"id":"pmh:oai:hindawi.com:10.1155/2021/5576933","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/5576933","pdf_url":null,"source":{"id":"https://openalex.org/S4306400340","display_name":"Hindawi Journal of Chemistry (Hindawi)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210126990","host_organization_name":"Hindawi (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210126990"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Research Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8075682","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8075682","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Comput Math Methods Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1155/2021/5576933","is_oa":true,"landing_page_url":"http://doi.org/10.1155/2021/5576933","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2021/5576933.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5899999737739563,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1608939687","display_name":null,"funder_award_id":"20180112","funder_id":"https://openalex.org/F4320327865","funder_display_name":"Chongqing Research Program of Basic Research and Frontier Technology"},{"id":"https://openalex.org/G7068503243","display_name":null,"funder_award_id":"cstc2017jcyjAX0113","funder_id":"https://openalex.org/F4320327865","funder_display_name":"Chongqing Research Program of Basic Research and Frontier Technology"}],"funders":[{"id":"https://openalex.org/F4320327865","display_name":"Chongqing Research Program of Basic Research and Frontier Technology","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3155838537.pdf","grobid_xml":"https://content.openalex.org/works/W3155838537.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W1883773314","https://openalex.org/W1970108031","https://openalex.org/W1986077139","https://openalex.org/W1987450903","https://openalex.org/W2004778652","https://openalex.org/W2004894621","https://openalex.org/W2024036230","https://openalex.org/W2040870350","https://openalex.org/W2045232151","https://openalex.org/W2053382318","https://openalex.org/W2081604575","https://openalex.org/W2095473486","https://openalex.org/W2098215003","https://openalex.org/W2105037453","https://openalex.org/W2109936378","https://openalex.org/W2123402634","https://openalex.org/W2123664981","https://openalex.org/W2138564158","https://openalex.org/W2148974484","https://openalex.org/W2155804510","https://openalex.org/W2176981778","https://openalex.org/W2181830444","https://openalex.org/W2465758996","https://openalex.org/W2513371636","https://openalex.org/W2515668871","https://openalex.org/W2604847258","https://openalex.org/W2612976808","https://openalex.org/W2750771238","https://openalex.org/W2786680569","https://openalex.org/W2789597829","https://openalex.org/W2790576796","https://openalex.org/W2800987064","https://openalex.org/W2890052597","https://openalex.org/W2890979201","https://openalex.org/W2902200003","https://openalex.org/W2927089236","https://openalex.org/W2955557725","https://openalex.org/W2980543348","https://openalex.org/W2980949872","https://openalex.org/W2987107881"],"related_works":["https://openalex.org/W2130439870","https://openalex.org/W2800537687","https://openalex.org/W2147652847","https://openalex.org/W178291922","https://openalex.org/W1976843764","https://openalex.org/W2000278701","https://openalex.org/W3215633333","https://openalex.org/W2349910028","https://openalex.org/W1671586832","https://openalex.org/W2151954452"],"abstract_inverted_index":{"There":[0],"is":[1,9],"growing":[2],"evidence":[3],"that":[4,111,176],"aberrant":[5],"alternative":[6],"splicing":[7,52,102,156],"(AS)":[8],"highly":[10,159],"correlated":[11,160],"with":[12,50,68,206],"driving":[13],"tumorigenesis,":[14],"but":[15],"its":[16],"function":[17],"in":[18,124,141,191,224],"kidney":[19],"renal":[20],"clear":[21],"cell":[22],"carcinoma":[23],"(KIRC)":[24],"remains":[25],"to":[26,88,137,161,217],"be":[27],"discovered.":[28],"In":[29],"this":[30],"study,":[31],"we":[32,60,77,174,194],"obtained":[33],"the":[34,51,62,69,79,90,98,146,167,170,180,207,219],"level-3":[35],"RNA":[36],"sequencing":[37],"and":[38,71,82,105,185,199],"clinical":[39],"data":[40],"of":[41,92,101,114,119,130,150,169,182,222],"KIRC":[42,67,126],"from":[43,56],"The":[44],"Cancer":[45],"Genome":[46],"Atlas":[47],"(TGCA).":[48],"Combining":[49],"event":[53],"detail":[54],"information":[55],"TGCA":[57],"SpliceSeq":[58],"database,":[59],"established":[61,200],"independent":[63],"prognosis":[64,93,131,201],"signatures":[65,132,202],"for":[66,203],"univariate":[70],"multivariate":[72],"Cox":[73],"regression":[74],"analyses.":[75],"Then,":[76],"used":[78],"Kaplan-Meier":[80],"analysis":[81],"receiver":[83],"operating":[84],"characteristic":[85],"curves":[86],"(ROCs)":[87],"assess":[89],"accuracy":[91],"signatures.":[94],"We":[95],"also":[96],"constructed":[97],"regulatory":[99],"network":[100],"factors":[103,157],"(SFs)":[104,158],"AS":[106,117,162,184,197,223],"events.":[107],"Our":[108],"results":[109],"showed":[110],"a":[112,134,188,214],"total":[113],"12029":[115],"survival-associated":[116,196],"events":[118,163,198],"5761":[120],"genes":[121],"were":[122,164],"found":[123,175],"524":[125],"patients.":[127],"All":[128],"types":[129],"displayed":[133],"satisfactory":[135],"ability":[136],"reliably":[138],"predict,":[139],"especially":[140],"exon":[142],"skip":[143],"model":[144],"which":[145,211],"area":[147],"under":[148],"curve":[149],"ROC":[151],"was":[152],"0.802.":[153],"Moreover,":[154],"18":[155],"identified.":[165],"With":[166],"construction":[168],"SF-AS":[171,208],"interactive":[172,209],"network,":[173,210],"SF":[177],"powerfully":[178],"promotes":[179],"occurrence":[181],"abnormal":[183],"may":[186],"have":[187],"profound":[189],"role":[190],"KIRC.":[192,225],"Collectively,":[193],"screened":[195],"KIRC,":[204],"coupling":[205],"might":[212],"provide":[213],"key":[215],"perspective":[216],"clarify":[218],"potential":[220],"mechanism":[221]},"counts_by_year":[{"year":2022,"cited_by_count":2}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}