{"id":"https://openalex.org/W3165785886","doi":"https://doi.org/10.1155/2021/5576808","title":"Ghrelin Regulates Cyclooxygenase-2 Expression and Promotes Gastric Cancer Cell Progression","display_name":"Ghrelin Regulates Cyclooxygenase-2 Expression and Promotes Gastric Cancer Cell Progression","publication_year":2021,"publication_date":"2021-05-22","ids":{"openalex":"https://openalex.org/W3165785886","doi":"https://doi.org/10.1155/2021/5576808","mag":"3165785886","pmid":"https://pubmed.ncbi.nlm.nih.gov/34122616"},"language":"en","primary_location":{"id":"doi:10.1155/2021/5576808","is_oa":true,"landing_page_url":"http://doi.org/10.1155/2021/5576808","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2021/5576808.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/cmmm/2021/5576808.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027406363","display_name":"Huanqing Li","orcid":"https://orcid.org/0000-0002-1933-2211"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210101358","display_name":"Minhang District Central Hospital","ror":"https://ror.org/00p0n9a62","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210101358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huanqing Li","raw_affiliation_strings":["Endoscopy Center, Minhang District Central Hospital of Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Endoscopy Center, Minhang District Central Hospital of Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210101358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100330102","display_name":"Xiaohong Zhang","orcid":"https://orcid.org/0000-0001-5419-0899"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210101358","display_name":"Minhang District Central Hospital","ror":"https://ror.org/00p0n9a62","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210101358"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaohong Zhang","raw_affiliation_strings":["Endoscopy Center, Minhang District Central Hospital of Fudan University, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0001-5419-0899","affiliations":[{"raw_affiliation_string":"Endoscopy Center, Minhang District Central Hospital of Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210101358"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100381521","display_name":"Li Feng","orcid":"https://orcid.org/0000-0002-5309-8975"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210101358","display_name":"Minhang District Central Hospital","ror":"https://ror.org/00p0n9a62","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210101358"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Li Feng","raw_affiliation_strings":["Endoscopy Center, Minhang District Central Hospital of Fudan University, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0002-5309-8975","affiliations":[{"raw_affiliation_string":"Endoscopy Center, Minhang District Central Hospital of Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210101358"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100330102","https://openalex.org/A5100381521"],"corresponding_institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210101358"],"apc_list":{"value":2550,"currency":"USD","value_usd":2550},"apc_paid":{"value":2550,"currency":"USD","value_usd":2550},"fwci":0.7189,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.63375859,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"2021","issue":null,"first_page":"1","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9296000003814697,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.9296000003814697,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-kinase-b","display_name":"Protein kinase B","score":0.8250038623809814},{"id":"https://openalex.org/keywords/apoptosis","display_name":"Apoptosis","score":0.7264143824577332},{"id":"https://openalex.org/keywords/pi3k/akt/mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.7167441844940186},{"id":"https://openalex.org/keywords/ghrelin","display_name":"Ghrelin","score":0.6191542148590088},{"id":"https://openalex.org/keywords/western-blot","display_name":"Western blot","score":0.5425305366516113},{"id":"https://openalex.org/keywords/cyclooxygenase","display_name":"Cyclooxygenase","score":0.48851263523101807},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.4812193214893341},{"id":"https://openalex.org/keywords/cell-growth","display_name":"Cell growth","score":0.43710511922836304},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.42212796211242676},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.4214913845062256},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.36381930112838745},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.33799049258232117},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.31063252687454224},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.26181650161743164},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.16010066866874695},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.08702284097671509},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.04209616780281067}],"concepts":[{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.8250038623809814},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7264143824577332},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7167441844940186},{"id":"https://openalex.org/C2779357093","wikidata":"https://www.wikidata.org/wiki/Q422269","display_name":"Ghrelin","level":3,"score":0.6191542148590088},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5425305366516113},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.48851263523101807},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4812193214893341},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.43710511922836304},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42212796211242676},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4214913845062256},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36381930112838745},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33799049258232117},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31063252687454224},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.26181650161743164},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16010066866874695},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08702284097671509},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.04209616780281067},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009578","descriptor_name":"Nitrobenzenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009578","descriptor_name":"Nitrobenzenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009578","descriptor_name":"Nitrobenzenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052246","descriptor_name":"Cyclooxygenase 2 Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D052246","descriptor_name":"Cyclooxygenase 2 Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D052246","descriptor_name":"Cyclooxygenase 2 Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D054439","descriptor_name":"Ghrelin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054439","descriptor_name":"Ghrelin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054439","descriptor_name":"Ghrelin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1155/2021/5576808","is_oa":true,"landing_page_url":"http://doi.org/10.1155/2021/5576808","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2021/5576808.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},{"id":"pmid:34122616","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34122616","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and mathematical methods in medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:518cf2e9b0ed4f1e9002231f6643b469","is_oa":true,"landing_page_url":"https://doaj.org/article/518cf2e9b0ed4f1e9002231f6643b469","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computational and Mathematical Methods in Medicine, Vol 2021 (2021)","raw_type":"article"},{"id":"pmh:oai:hindawi.com:10.1155/2021/5576808","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/5576808","pdf_url":null,"source":{"id":"https://openalex.org/S4306400340","display_name":"Hindawi Journal of Chemistry (Hindawi)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210126990","host_organization_name":"Hindawi (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210126990"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Research Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8166482","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8166482","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Comput Math Methods Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1155/2021/5576808","is_oa":true,"landing_page_url":"http://doi.org/10.1155/2021/5576808","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2021/5576808.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6200000047683716,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3165785886.pdf","grobid_xml":"https://content.openalex.org/works/W3165785886.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W123990481","https://openalex.org/W1766737321","https://openalex.org/W1888331147","https://openalex.org/W1911222162","https://openalex.org/W1966406941","https://openalex.org/W1983232559","https://openalex.org/W1983843748","https://openalex.org/W2008646871","https://openalex.org/W2017392274","https://openalex.org/W2034407136","https://openalex.org/W2034912653","https://openalex.org/W2045016464","https://openalex.org/W2049083712","https://openalex.org/W2055053845","https://openalex.org/W2068268408","https://openalex.org/W2074601711","https://openalex.org/W2076253305","https://openalex.org/W2078240720","https://openalex.org/W2094018565","https://openalex.org/W2101105397","https://openalex.org/W2115203110","https://openalex.org/W2160738204","https://openalex.org/W2163865122","https://openalex.org/W2279427065","https://openalex.org/W2286340588","https://openalex.org/W2404557660","https://openalex.org/W2409612333","https://openalex.org/W2522738905","https://openalex.org/W2781525129","https://openalex.org/W3012148640","https://openalex.org/W3025405022","https://openalex.org/W3146736758","https://openalex.org/W4254329876"],"related_works":["https://openalex.org/W3183179750","https://openalex.org/W2070783513","https://openalex.org/W2024933597","https://openalex.org/W3116479654","https://openalex.org/W4205189596","https://openalex.org/W2916964185","https://openalex.org/W2422815049","https://openalex.org/W2098584395","https://openalex.org/W2019551003","https://openalex.org/W2982360817"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"research":[2],"the":[3,25,40,79,110,119,136,142,150,172,189],"molecular":[4,190],"mechanism":[5],"of":[6,13,27,42,51,81,97,113,139,152,174,188],"ghrelin":[7,90],"in":[8,75,94,164,176,192],"apoptosis,":[9],"migratory,":[10,121],"and":[11,20,34,45,58,65,71,100,116,118,123,141,145,162],"invasion":[12,59,72,146],"gastric":[14],"cancer":[15],"(GC)":[16],"cells.":[17],"METHODS:":[18],"M),":[19],"Akt":[21,107],"inhibitor":[22,108,134],"perifosine":[23],"(10uM),":[24],"rates":[26,80,151],"apoptosis":[28,82,124,153,163],"were":[29,60,73,83,104,125,130,147,154],"detected":[30,61],"by":[31,48,62,179],"TUNEL":[32],"assay":[33],"flow":[35],"cytometry":[36],"assay.":[37],"We":[38],"assessed":[39],"expressions":[41],"PI3K,":[43,99,115],"p-Akt,":[44,98,114],"COX-2":[46,117,140,175],"proteins":[47],"making":[49],"use":[50],"Western":[52],"blot":[53],"analysis.":[54,67],"The":[55,69],"cell":[56,120,143,159],"migratory":[57,70,144],"using":[63],"wound-healing":[64],"transwell":[66],"RESULTS:":[68],"increased":[74],"ghrelin-treated":[76],"cells,":[77],"while":[78,149],"decreased.":[84],"GC":[85,165,177],"AGS":[86],"cells":[87,103,129,166,178],"treated":[88,105,131],"with":[89,106,132],"showed":[91],"an":[92],"increase":[93],"protein":[95,111,137],"expression":[96,112,138,173],"COX-2.":[101],"After":[102,128],"perifosine,":[109],"invasion,":[122,161],"partly":[126],"recovered.":[127],"cyclooxygenase-2":[133],"NS398,":[135],"decreased,":[148],"increased.":[155],"CONCLUSION:":[156],"Ghrelin":[157,170,182],"regulates":[158],"migration,":[160],"through":[167],"targeting":[168,180],"PI3K/Akt/COX-2.":[169],"increases":[171],"PI3K/Akt.":[181],"is":[183],"suggested":[184],"to":[185],"be":[186],"one":[187],"targets":[191],"GC.":[193]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}
