{"id":"https://openalex.org/W3163945882","doi":"https://doi.org/10.1155/2021/5529389","title":"Using Recursive Feature Selection with Random Forest to Improve Protein Structural Class Prediction for Low-Similarity Sequences","display_name":"Using Recursive Feature Selection with Random Forest to Improve Protein Structural Class Prediction for Low-Similarity Sequences","publication_year":2021,"publication_date":"2021-05-07","ids":{"openalex":"https://openalex.org/W3163945882","doi":"https://doi.org/10.1155/2021/5529389","mag":"3163945882","pmid":"https://pubmed.ncbi.nlm.nih.gov/34055035"},"language":"en","primary_location":{"id":"doi:10.1155/2021/5529389","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/5529389","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2021/5529389.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/cmmm/2021/5529389.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010223665","display_name":"Yaoxin Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I1328775524","display_name":"Zhejiang Sci-Tech University","ror":"https://ror.org/03893we55","country_code":"CN","type":"education","lineage":["https://openalex.org/I1328775524"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaoxin Wang","raw_affiliation_strings":["College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China","institution_ids":["https://openalex.org/I1328775524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103235374","display_name":"Yingjie Xu","orcid":"https://orcid.org/0000-0003-2462-1840"},"institutions":[{"id":"https://openalex.org/I1328775524","display_name":"Zhejiang Sci-Tech University","ror":"https://ror.org/03893we55","country_code":"CN","type":"education","lineage":["https://openalex.org/I1328775524"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingjie Xu","raw_affiliation_strings":["Qixin School, Zhejiang Sci-Tech University, Hangzhou 310018, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qixin School, Zhejiang Sci-Tech University, Hangzhou 310018, China","institution_ids":["https://openalex.org/I1328775524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070303785","display_name":"Zhenyu Yang","orcid":"https://orcid.org/0000-0002-7137-2552"},"institutions":[{"id":"https://openalex.org/I1328775524","display_name":"Zhejiang Sci-Tech University","ror":"https://ror.org/03893we55","country_code":"CN","type":"education","lineage":["https://openalex.org/I1328775524"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenyu Yang","raw_affiliation_strings":["College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China","institution_ids":["https://openalex.org/I1328775524"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100320534","display_name":"Xiaoqing Liu","orcid":"https://orcid.org/0000-0001-9272-5102"},"institutions":[{"id":"https://openalex.org/I50760025","display_name":"Hangzhou Dianzi University","ror":"https://ror.org/0576gt767","country_code":"CN","type":"education","lineage":["https://openalex.org/I50760025"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoqing Liu","raw_affiliation_strings":["College of Sciences, Hangzhou Dianzi University, Hangzhou 310018, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Sciences, Hangzhou Dianzi University, Hangzhou 310018, China","institution_ids":["https://openalex.org/I50760025"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013729700","display_name":"Qi Dai","orcid":"https://orcid.org/0000-0003-2675-6511"},"institutions":[{"id":"https://openalex.org/I1328775524","display_name":"Zhejiang Sci-Tech University","ror":"https://ror.org/03893we55","country_code":"CN","type":"education","lineage":["https://openalex.org/I1328775524"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qi Dai","raw_affiliation_strings":["College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China"],"raw_orcid":"https://orcid.org/0000-0003-2675-6511","affiliations":[{"raw_affiliation_string":"College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China","institution_ids":["https://openalex.org/I1328775524"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5013729700"],"corresponding_institution_ids":["https://openalex.org/I1328775524"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":3.2513,"has_fulltext":true,"cited_by_count":53,"citation_normalized_percentile":{"value":0.93403826,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"2021","issue":null,"first_page":"1","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/random-forest","display_name":"Random forest","score":0.772566556930542},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.7547438144683838},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6497668027877808},{"id":"https://openalex.org/keywords/redundancy","display_name":"Redundancy (engineering)","score":0.581021249294281},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.5558451414108276},{"id":"https://openalex.org/keywords/class","display_name":"Class (philosophy)","score":0.5436349511146545},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.5315506458282471},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.5210899114608765},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5174751281738281},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5079012513160706},{"id":"https://openalex.org/keywords/structural-similarity","display_name":"Structural similarity","score":0.49896836280822754},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4839351773262024},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.459760844707489},{"id":"https://openalex.org/keywords/protein-structure-prediction","display_name":"Protein structure prediction","score":0.4444771707057953},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.20254942774772644},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.06632205843925476}],"concepts":[{"id":"https://openalex.org/C169258074","wikidata":"https://www.wikidata.org/wiki/Q245748","display_name":"Random forest","level":2,"score":0.772566556930542},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.7547438144683838},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6497668027877808},{"id":"https://openalex.org/C152124472","wikidata":"https://www.wikidata.org/wiki/Q1204361","display_name":"Redundancy (engineering)","level":2,"score":0.581021249294281},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.5558451414108276},{"id":"https://openalex.org/C2777212361","wikidata":"https://www.wikidata.org/wiki/Q5127848","display_name":"Class (philosophy)","level":2,"score":0.5436349511146545},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.5315506458282471},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.5210899114608765},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5174751281738281},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5079012513160706},{"id":"https://openalex.org/C139489369","wikidata":"https://www.wikidata.org/wiki/Q770846","display_name":"Structural similarity","level":2,"score":0.49896836280822754},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4839351773262024},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.459760844707489},{"id":"https://openalex.org/C18051474","wikidata":"https://www.wikidata.org/wiki/Q899656","display_name":"Protein structure prediction","level":3,"score":0.4444771707057953},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.20254942774772644},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06632205843925476},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000072416","descriptor_name":"Protein Structural Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072416","descriptor_name":"Protein Structural Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072416","descriptor_name":"Protein Structural Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072416","descriptor_name":"Protein Structural Elements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1155/2021/5529389","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/5529389","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2021/5529389.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},{"id":"pmid:34055035","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34055035","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and mathematical methods in medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:667ec7d2688b464f9dde4de46fa8c4a5","is_oa":false,"landing_page_url":"https://doaj.org/article/667ec7d2688b464f9dde4de46fa8c4a5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computational and Mathematical Methods in Medicine, Vol 2021 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8123985","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8123985","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Comput Math Methods Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1155/2021/5529389","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/5529389","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2021/5529389.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6899999976158142,"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15"}],"awards":[{"id":"https://openalex.org/G1365109037","display_name":"\u8010\u836f\u6027\u6761\u4ef6\u81f4\u75c5\u83cc\u57fa\u56e0\u7ec4\u5c9b\u7684\u591a\u5c3a\u5ea6\u8bc6\u522b\u6a21\u578b\u7814\u7a76","funder_award_id":"61772028","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1936496632","display_name":null,"funder_award_id":"LY20F020016","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3771145995","display_name":null,"funder_award_id":"LY20F020016","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G4452349165","display_name":null,"funder_award_id":"61772028","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3163945882.pdf","grobid_xml":"https://content.openalex.org/works/W3163945882.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W278909723","https://openalex.org/W1480577415","https://openalex.org/W1975371732","https://openalex.org/W1975670646","https://openalex.org/W1977927254","https://openalex.org/W1981532526","https://openalex.org/W1984437717","https://openalex.org/W1986913015","https://openalex.org/W1989447327","https://openalex.org/W1990678622","https://openalex.org/W1991059126","https://openalex.org/W1998354148","https://openalex.org/W2000264668","https://openalex.org/W2008767404","https://openalex.org/W2012121247","https://openalex.org/W2017229033","https://openalex.org/W2020117329","https://openalex.org/W2020580483","https://openalex.org/W2028492942","https://openalex.org/W2029759111","https://openalex.org/W2030793934","https://openalex.org/W2038020595","https://openalex.org/W2040183015","https://openalex.org/W2044143373","https://openalex.org/W2049934106","https://openalex.org/W2053427692","https://openalex.org/W2055848950","https://openalex.org/W2061068513","https://openalex.org/W2070753511","https://openalex.org/W2072168663","https://openalex.org/W2073718013","https://openalex.org/W2076460489","https://openalex.org/W2083501076","https://openalex.org/W2085277871","https://openalex.org/W2087317522","https://openalex.org/W2094279491","https://openalex.org/W2104332903","https://openalex.org/W2105634619","https://openalex.org/W2108432201","https://openalex.org/W2117825194","https://openalex.org/W2118615504","https://openalex.org/W2121910469","https://openalex.org/W2125725297","https://openalex.org/W2153187042","https://openalex.org/W2157142295","https://openalex.org/W2158877088","https://openalex.org/W2163449716","https://openalex.org/W2204012452","https://openalex.org/W2513786151","https://openalex.org/W2804549231","https://openalex.org/W4230674625","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W3193043704","https://openalex.org/W4386259002","https://openalex.org/W1546989560","https://openalex.org/W4388745254","https://openalex.org/W2980082554","https://openalex.org/W1517228774","https://openalex.org/W2767419625","https://openalex.org/W2156571267","https://openalex.org/W2389704471","https://openalex.org/W2747166117"],"abstract_inverted_index":{"Many":[0],"combinations":[1],"of":[2,76],"protein":[3,9,42,77,100,127],"features":[4,26,85,101,109],"are":[5,86],"used":[6,118],"to":[7,22,40,119],"improve":[8,41],"structural":[10,43,78,108,128],"class":[11,44,79],"prediction,":[12],"but":[13,88],"the":[14,24,48,58,67,74,89,105,111,126],"information":[15],"redundancy":[16],"is":[17,92],"often":[18],"ignored.":[19],"In":[20],"order":[21],"select":[23],"important":[25],"with":[27,37,51,57],"strong":[28],"classification":[29],"ability,":[30],"we":[31],"proposed":[32,49,68],"a":[33],"recursive":[34],"feature":[35,69],"selection":[36,70],"random":[38],"forest":[39],"prediction.":[45,80],"We":[46,96],"evaluated":[47],"method":[50,71],"four":[52],"experiments":[53],"and":[54,102],"compared":[55,98],"it":[56],"available":[59],"competing":[60],"prediction":[61,90,123],"methods.":[62],"The":[63],"results":[64],"indicate":[65],"that":[66,104],"effectively":[72],"improves":[73],"efficiency":[75],"Only":[81],"less":[82],"than":[83],"5%":[84],"used,":[87],"accuracy":[91],"improved":[93],"by":[94],"4.6-13.3%.":[95],"further":[97],"different":[99],"found":[103],"predicted":[106],"secondary":[107],"achieve":[110],"best":[112],"performance.":[113],"This":[114],"understanding":[115],"can":[116],"be":[117],"design":[120],"more":[121],"powerful":[122],"methods":[124],"for":[125],"class.":[129]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":2}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}