{"id":"https://openalex.org/W3156328755","doi":"https://doi.org/10.1155/2021/5526179","title":"The Novel Regulatory Role of lncRNA-miRNA-mRNA Axis in Amyotrophic Lateral Sclerosis: An Integrated Bioinformatics Analysis","display_name":"The Novel Regulatory Role of lncRNA-miRNA-mRNA Axis in Amyotrophic Lateral Sclerosis: An Integrated Bioinformatics Analysis","publication_year":2021,"publication_date":"2021-04-15","ids":{"openalex":"https://openalex.org/W3156328755","doi":"https://doi.org/10.1155/2021/5526179","mag":"3156328755","pmid":"https://pubmed.ncbi.nlm.nih.gov/33953791"},"language":"en","primary_location":{"id":"doi:10.1155/2021/5526179","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/5526179","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2021/5526179.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/cmmm/2021/5526179.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101618695","display_name":"Dingsheng Liu","orcid":"https://orcid.org/0000-0003-2712-0988"},"institutions":[{"id":"https://openalex.org/I4210135985","display_name":"Shanghai University of Medicine and Health Sciences","ror":"https://ror.org/03ns6aq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210135985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dingsheng Liu","raw_affiliation_strings":["Department of Oncology and Hematology, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Department of Oncology and Hematology, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China","institution_ids":["https://openalex.org/I4210135985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051374683","display_name":"Xiaojia Zuo","orcid":"https://orcid.org/0000-0002-1838-9312"},"institutions":[{"id":"https://openalex.org/I4210135985","display_name":"Shanghai University of Medicine and Health Sciences","ror":"https://ror.org/03ns6aq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210135985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojia Zuo","raw_affiliation_strings":["Department of Oncology and Hematology, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Department of Oncology and Hematology, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China","institution_ids":["https://openalex.org/I4210135985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100364207","display_name":"Peng Zhang","orcid":"https://orcid.org/0000-0002-9997-2576"},"institutions":[{"id":"https://openalex.org/I4210135985","display_name":"Shanghai University of Medicine and Health Sciences","ror":"https://ror.org/03ns6aq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210135985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Peng Zhang","raw_affiliation_strings":["Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China","institution_ids":["https://openalex.org/I4210135985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100684039","display_name":"Rui Zhao","orcid":"https://orcid.org/0000-0002-6602-6583"},"institutions":[{"id":"https://openalex.org/I4210135985","display_name":"Shanghai University of Medicine and Health Sciences","ror":"https://ror.org/03ns6aq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210135985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Zhao","raw_affiliation_strings":["Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China","institution_ids":["https://openalex.org/I4210135985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019212481","display_name":"Donglin Lai","orcid":null},"institutions":[{"id":"https://openalex.org/I4210135985","display_name":"Shanghai University of Medicine and Health Sciences","ror":"https://ror.org/03ns6aq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210135985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Donglin Lai","raw_affiliation_strings":["Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China","institution_ids":["https://openalex.org/I4210135985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077184154","display_name":"Kai\u2010Jie Chen","orcid":"https://orcid.org/0000-0001-7581-6571"},"institutions":[{"id":"https://openalex.org/I4210135985","display_name":"Shanghai University of Medicine and Health Sciences","ror":"https://ror.org/03ns6aq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210135985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaijie Chen","raw_affiliation_strings":["Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China","institution_ids":["https://openalex.org/I4210135985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101587348","display_name":"Yuru Han","orcid":"https://orcid.org/0000-0001-8378-9120"},"institutions":[{"id":"https://openalex.org/I4210135985","display_name":"Shanghai University of Medicine and Health Sciences","ror":"https://ror.org/03ns6aq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210135985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuru Han","raw_affiliation_strings":["Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China","institution_ids":["https://openalex.org/I4210135985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003748017","display_name":"Guoqing Wan","orcid":null},"institutions":[{"id":"https://openalex.org/I4210135985","display_name":"Shanghai University of Medicine and Health Sciences","ror":"https://ror.org/03ns6aq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210135985"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guoqing Wan","raw_affiliation_strings":["Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China","institution_ids":["https://openalex.org/I4210135985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025569891","display_name":"Yanjun Zheng","orcid":"https://orcid.org/0000-0002-1943-5106"},"institutions":[{"id":"https://openalex.org/I4210135985","display_name":"Shanghai University of Medicine and Health Sciences","ror":"https://ror.org/03ns6aq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210135985"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yanjun Zheng","raw_affiliation_strings":["Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China","institution_ids":["https://openalex.org/I4210135985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066446906","display_name":"Changlian Lu","orcid":"https://orcid.org/0000-0002-0812-9162"},"institutions":[{"id":"https://openalex.org/I4210135985","display_name":"Shanghai University of Medicine and Health Sciences","ror":"https://ror.org/03ns6aq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210135985"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Changlian Lu","raw_affiliation_strings":["Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China","institution_ids":["https://openalex.org/I4210135985"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081353139","display_name":"Xuefeng Gu","orcid":"https://orcid.org/0000-0002-8718-2067"},"institutions":[{"id":"https://openalex.org/I4210135985","display_name":"Shanghai University of Medicine and Health Sciences","ror":"https://ror.org/03ns6aq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210135985"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xuefeng Gu","raw_affiliation_strings":["Research Department, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China","Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China"],"affiliations":[{"raw_affiliation_string":"Research Department, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China","institution_ids":["https://openalex.org/I4210135985"]},{"raw_affiliation_string":"Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China","institution_ids":["https://openalex.org/I4210135985"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5025569891","https://openalex.org/A5066446906","https://openalex.org/A5081353139"],"corresponding_institution_ids":["https://openalex.org/I4210135985"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":0.9796,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.78140569,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"2021","issue":null,"first_page":"1","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12400","display_name":"Neurogenetic and Muscular Disorders Research","score":0.982699990272522,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":0.955299973487854,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/competing-endogenous-rna","display_name":"Competing endogenous RNA","score":0.9239793419837952},{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"Amyotrophic lateral sclerosis","score":0.8739196062088013},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.7555723190307617},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7309518456459045},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"Pathogenesis","score":0.5986928343772888},{"id":"https://openalex.org/keywords/messenger-rna","display_name":"Messenger RNA","score":0.5332339406013489},{"id":"https://openalex.org/keywords/malat1","display_name":"MALAT1","score":0.5189292430877686},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4466646611690521},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3886316418647766},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.36534565687179565},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.3509542942047119},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"Long non-coding RNA","score":0.3425534963607788},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.33673736453056335},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3275229334831238},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.1954323947429657},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.16905862092971802},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.10062524676322937}],"concepts":[{"id":"https://openalex.org/C60365752","wikidata":"https://www.wikidata.org/wiki/Q5156306","display_name":"Competing endogenous RNA","level":5,"score":0.9239793419837952},{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.8739196062088013},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7555723190307617},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7309518456459045},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5986928343772888},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5332339406013489},{"id":"https://openalex.org/C2779134362","wikidata":"https://www.wikidata.org/wiki/Q18056223","display_name":"MALAT1","level":5,"score":0.5189292430877686},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4466646611690521},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3886316418647766},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.36534565687179565},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.3509542942047119},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.3425534963607788},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.33673736453056335},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3275229334831238},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1954323947429657},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16905862092971802},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.10062524676322937}],"mesh":[{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D062085","descriptor_name":"RNA, Long Noncoding","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1155/2021/5526179","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/5526179","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2021/5526179.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},{"id":"pmid:33953791","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33953791","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and mathematical methods in medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:700b08b83f0740a39de1cbd2d848847b","is_oa":true,"landing_page_url":"https://doaj.org/article/700b08b83f0740a39de1cbd2d848847b","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computational and Mathematical Methods in Medicine, Vol 2021 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8067776","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8067776","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Comput Math Methods Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1155/2021/5526179","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/5526179","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2021/5526179.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.47999998927116394}],"awards":[{"id":"https://openalex.org/G1098290666","display_name":null,"funder_award_id":"PWZzk2017-31","funder_id":"https://openalex.org/F4320321881","funder_display_name":"Shanghai Municipal Education Commission"},{"id":"https://openalex.org/G1121271761","display_name":null,"funder_award_id":"Program","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1276829693","display_name":null,"funder_award_id":"Shanghai","funder_id":"https://openalex.org/F4320321881","funder_display_name":"Shanghai Municipal Education Commission"},{"id":"https://openalex.org/G1537283964","display_name":null,"funder_award_id":"81830052","funder_id":"https://openalex.org/F4320328941","funder_display_name":"Shanghai University of Medicine and Health Sciences"},{"id":"https://openalex.org/G1860089911","display_name":null,"funder_award_id":"81830052","funder_id":"https://openalex.org/F4320321881","funder_display_name":"Shanghai Municipal Education Commission"},{"id":"https://openalex.org/G2087396116","display_name":null,"funder_award_id":"China","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2229998227","display_name":null,"funder_award_id":"18DZ2260400","funder_id":"https://openalex.org/F4320328940","funder_display_name":"Shanghai Key Laboratory of Molecular Imaging"},{"id":"https://openalex.org/G2794167913","display_name":null,"funder_award_id":"PWZzk2017-31","funder_id":"https://openalex.org/F4320328940","funder_display_name":"Shanghai Key Laboratory of Molecular Imaging"},{"id":"https://openalex.org/G2799683801","display_name":null,"funder_award_id":"ZZJKYX19009","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2802911279","display_name":null,"funder_award_id":"Young","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3085993365","display_name":null,"funder_award_id":"(Grant No.","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3317480652","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3549359564","display_name":null,"funder_award_id":"PWZzk2017-31","funder_id":"https://openalex.org/F4320328941","funder_display_name":"Shanghai University of Medicine and Health Sciences"},{"id":"https://openalex.org/G391238517","display_name":null,"funder_award_id":", and","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4020255992","display_name":null,"funder_award_id":"Project","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G404194601","display_name":null,"funder_award_id":"81772829","funder_id":"https://openalex.org/F4320321881","funder_display_name":"Shanghai Municipal Education Commission"},{"id":"https://openalex.org/G453427909","display_name":null,"funder_award_id":"ZZJKYX19009","funder_id":"https://openalex.org/F4320321881","funder_display_name":"Shanghai Municipal Education Commission"},{"id":"https://openalex.org/G4549446626","display_name":null,"funder_award_id":"81772829","funder_id":"https://openalex.org/F4320328941","funder_display_name":"Shanghai University of Medicine and Health Sciences"},{"id":"https://openalex.org/G4811203239","display_name":null,"funder_award_id":"2018-2020","funder_id":"https://openalex.org/F4320321881","funder_display_name":"Shanghai Municipal Education Commission"},{"id":"https://openalex.org/G4825087165","display_name":null,"funder_award_id":"81830052","funder_id":"https://openalex.org/F4320328940","funder_display_name":"Shanghai Key Laboratory of Molecular Imaging"},{"id":"https://openalex.org/G5209807430","display_name":null,"funder_award_id":"ZZJKYX19009","funder_id":"https://openalex.org/F4320328940","funder_display_name":"Shanghai Key Laboratory of Molecular Imaging"},{"id":"https://openalex.org/G5353599981","display_name":null,"funder_award_id":"2018-2020","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5760752404","display_name":null,"funder_award_id":"Projects","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5939423041","display_name":null,"funder_award_id":"Technology","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5994120800","display_name":null,"funder_award_id":"Natural","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5994494637","display_name":null,"funder_award_id":"and 81","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G651947439","display_name":null,"funder_award_id":"81830052","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6572595324","display_name":null,"funder_award_id":"81772829","funder_id":"https://openalex.org/F4320328940","funder_display_name":"Shanghai Key Laboratory of Molecular Imaging"},{"id":"https://openalex.org/G6877722829","display_name":null,"funder_award_id":"PWZzk2017-31","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6939601970","display_name":null,"funder_award_id":"ZZJKYX19009","funder_id":"https://openalex.org/F4320328941","funder_display_name":"Shanghai University of Medicine and Health Sciences"},{"id":"https://openalex.org/G7608752429","display_name":null,"funder_award_id":"Talent","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7726157001","display_name":null,"funder_award_id":"Grant No.","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7781739151","display_name":null,"funder_award_id":"18DZ2260400","funder_id":"https://openalex.org/F4320328941","funder_display_name":"Shanghai University of Medicine and Health Sciences"},{"id":"https://openalex.org/G8386195870","display_name":null,"funder_award_id":"18DZ2260400","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8656187453","display_name":null,"funder_award_id":"18DZ2260400","funder_id":"https://openalex.org/F4320321881","funder_display_name":"Shanghai Municipal Education Commission"},{"id":"https://openalex.org/G8978869799","display_name":null,"funder_award_id":"81772829","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321881","display_name":"Shanghai Municipal Education Commission","ror":"https://ror.org/05tewj457"},{"id":"https://openalex.org/F4320322438","display_name":"Nanjing University of Aeronautics and Astronautics","ror":"https://ror.org/01scyh794"},{"id":"https://openalex.org/F4320324852","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760"},{"id":"https://openalex.org/F4320328940","display_name":"Shanghai Key Laboratory of Molecular Imaging","ror":null},{"id":"https://openalex.org/F4320328941","display_name":"Shanghai University of Medicine and Health Sciences","ror":"https://ror.org/03ns6aq57"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3156328755.pdf","grobid_xml":"https://content.openalex.org/works/W3156328755.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1965286266","https://openalex.org/W1974448552","https://openalex.org/W2012065499","https://openalex.org/W2016332933","https://openalex.org/W2018934739","https://openalex.org/W2027642546","https://openalex.org/W2032669538","https://openalex.org/W2037976498","https://openalex.org/W2046387002","https://openalex.org/W2048813950","https://openalex.org/W2050373464","https://openalex.org/W2072981065","https://openalex.org/W2076313803","https://openalex.org/W2083964855","https://openalex.org/W2084987853","https://openalex.org/W2100111801","https://openalex.org/W2105149510","https://openalex.org/W2121820194","https://openalex.org/W2127861463","https://openalex.org/W2127938800","https://openalex.org/W2136949432","https://openalex.org/W2139849649","https://openalex.org/W2141645735","https://openalex.org/W2152119060","https://openalex.org/W2162978926","https://openalex.org/W2169769531","https://openalex.org/W2350314468","https://openalex.org/W2473312868","https://openalex.org/W2510868781","https://openalex.org/W2523970725","https://openalex.org/W2532542819","https://openalex.org/W2537943818","https://openalex.org/W2593544935","https://openalex.org/W2599301666","https://openalex.org/W2604770955","https://openalex.org/W2616121238","https://openalex.org/W2624634543","https://openalex.org/W2764015132","https://openalex.org/W2783774884","https://openalex.org/W2806572652","https://openalex.org/W2883099175","https://openalex.org/W2900029705","https://openalex.org/W2904034429","https://openalex.org/W2910657247","https://openalex.org/W2910883404","https://openalex.org/W2911659806","https://openalex.org/W2914644978","https://openalex.org/W2916470469","https://openalex.org/W2920958771","https://openalex.org/W2933052407","https://openalex.org/W2948661768","https://openalex.org/W2953843495","https://openalex.org/W2969461081","https://openalex.org/W2982331205","https://openalex.org/W2995128297","https://openalex.org/W2999849842","https://openalex.org/W3003739613","https://openalex.org/W3004599404","https://openalex.org/W3018111778","https://openalex.org/W3025879039","https://openalex.org/W3026019136","https://openalex.org/W3026892791","https://openalex.org/W3030546965","https://openalex.org/W3037856171"],"related_works":["https://openalex.org/W3108443692","https://openalex.org/W2400832891","https://openalex.org/W3110530940","https://openalex.org/W2962733257","https://openalex.org/W2617692178","https://openalex.org/W4399497420","https://openalex.org/W4387653368","https://openalex.org/W2901590794","https://openalex.org/W2912601922","https://openalex.org/W3162111133"],"abstract_inverted_index":{"Amyotrophic":[0],"lateral":[1],"sclerosis":[2],"(ALS)":[3],"is":[4],"an":[5],"incurable":[6],"neurodegenerative":[7],"disease":[8],"that":[9,61,127],"primarily":[10],"affects":[11],"motor":[12],"neurons,":[13],"causing":[14],"muscle":[15],"atrophy,":[16],"bulbar":[17],"palsy,":[18],"and":[19,26,56,68,72,110,139,151],"pyramidal":[20],"tract":[21],"signs.":[22],"However,":[23],"the":[24,49,83,95,104,108,128,133,147,158],"aetiology":[25],"pathogenesis":[27,148,159],"of":[28,52,98,122,149,160],"ALS":[29,66,109],"have":[30],"not":[31],"been":[32],"elucidated":[33],"to":[34,81,86,93,156],"date.":[35],"In":[36],"this":[37],"study,":[38],"a":[39,74],"competitive":[40],"endogenous":[41],"RNA":[42],"(ceRNA)":[43],"network":[44,78],"was":[45,79,91],"constructed":[46,80],"by":[47,64,132],"analyzing":[48],"expression":[50],"profiles":[51],"messenger":[53],"RNAs":[54,59],"(mRNAs)":[55],"long":[57],"noncoding":[58],"(lncRNAs)":[60],"were":[62,119],"matched":[63],"7":[65],"samples":[67],"4":[69],"control":[70,111],"samples,":[71],"then":[73],"protein-protein":[75],"interaction":[76],"(PPI)":[77],"identify":[82],"genes":[84,141],"related":[85],"ALS.":[87,161],"Gene":[88],"Ontology":[89],"(GO)":[90],"used":[92],"study":[94],"potential":[96,114],"functions":[97],"differentially":[99],"expressed":[100],"mRNAs":[101],"(DEmRNAs)":[102],"in":[103,146],"ceRNA":[105,116],"network.":[106],"For":[107],"groups,":[112],"247177":[113],"lncRNA-mRNA":[115],"relationship":[117,124],"pairs":[118,125],"screened.":[120],"Analysis":[121],"significant":[123],"demonstrated":[126],"PPI":[129],"modules":[130],"formed":[131],"<i>MALAT1</i>-regulated":[134],"<i>SYNRG</i>,":[135],"<i>ITSN2</i>,":[136],"<i>PICALM</i>,":[137],"<i>AP3B1</i>,":[138],"<i>AAK1</i>":[140],"may":[142,154],"play":[143],"important":[144],"roles":[145],"ALS,":[150],"these":[152],"results":[153],"help":[155],"characterize":[157]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}