{"id":"https://openalex.org/W3105871342","doi":"https://doi.org/10.1155/2020/8836493","title":"Identification of Prognostic Biomarkers of Cutaneous Melanoma Based on Analysis of Tumor Mutation Burden","display_name":"Identification of Prognostic Biomarkers of Cutaneous Melanoma Based on Analysis of Tumor Mutation Burden","publication_year":2020,"publication_date":"2020-11-16","ids":{"openalex":"https://openalex.org/W3105871342","doi":"https://doi.org/10.1155/2020/8836493","mag":"3105871342","pmid":"https://pubmed.ncbi.nlm.nih.gov/33273963"},"language":"en","primary_location":{"id":"doi:10.1155/2020/8836493","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2020/8836493","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2020/8836493.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/cmmm/2020/8836493.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088332991","display_name":"Jiaqiong Lin","orcid":"https://orcid.org/0000-0002-7094-159X"},"institutions":[{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaqiong Lin","raw_affiliation_strings":["Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-7094-159X","affiliations":[{"raw_affiliation_string":"Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100741532","display_name":"Yan Lin","orcid":"https://orcid.org/0000-0003-3802-2988"},"institutions":[{"id":"https://openalex.org/I4210092091","display_name":"Third Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00fb35g87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092091"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Lin","raw_affiliation_strings":["Department of Nephrology, Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China"],"raw_orcid":"https://orcid.org/0000-0003-3802-2988","affiliations":[{"raw_affiliation_string":"Department of Nephrology, Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210092091","https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102006267","display_name":"Zena Huang","orcid":"https://orcid.org/0000-0002-0642-3675"},"institutions":[{"id":"https://openalex.org/I4210145693","display_name":"Guangdong Academy of Medical Sciences","ror":"https://ror.org/0432p8t34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210145693"]},{"id":"https://openalex.org/I4210153930","display_name":"Guangdong Provincial People's Hospital","ror":"https://ror.org/045kpgw45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zena Huang","raw_affiliation_strings":["Department of General Medicine, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China"],"raw_orcid":"https://orcid.org/0000-0002-0642-3675","affiliations":[{"raw_affiliation_string":"Department of General Medicine, Guangdong Provincial People\u2019s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China","institution_ids":["https://openalex.org/I4210145693","https://openalex.org/I4210153930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100673952","display_name":"Xiaoyong Li","orcid":"https://orcid.org/0000-0001-7754-731X"},"institutions":[{"id":"https://openalex.org/I4210092091","display_name":"Third Affiliated Hospital of Guangzhou Medical University","ror":"https://ror.org/00fb35g87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092091"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaoyong Li","raw_affiliation_strings":["Department of General Surgery, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China"],"raw_orcid":"https://orcid.org/0000-0001-7754-731X","affiliations":[{"raw_affiliation_string":"Department of General Surgery, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I4210092091","https://openalex.org/I92039509"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100673952"],"corresponding_institution_ids":["https://openalex.org/I4210092091","https://openalex.org/I92039509"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":0.4211,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.64821169,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"2020","issue":null,"first_page":"1","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5526999831199646,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5526999831199646,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.2624000012874603,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.07680000364780426,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.6777631640434265},{"id":"https://openalex.org/keywords/melanoma","display_name":"Melanoma","score":0.6333258748054504},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.5455881357192993},{"id":"https://openalex.org/keywords/mutation-testing","display_name":"Mutation testing","score":0.5077806115150452},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4799359440803528},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.45998185873031616},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.39463716745376587},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3811896741390228},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.36695343255996704},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.36297208070755005},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2700861692428589},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10603362321853638}],"concepts":[{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6777631640434265},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6333258748054504},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5455881357192993},{"id":"https://openalex.org/C163565370","wikidata":"https://www.wikidata.org/wiki/Q4308623","display_name":"Mutation testing","level":4,"score":0.5077806115150452},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4799359440803528},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45998185873031616},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39463716745376587},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3811896741390228},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.36695343255996704},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36297208070755005},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2700861692428589},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10603362321853638},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016246","descriptor_name":"Lymphocytes, Tumor-Infiltrating","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1155/2020/8836493","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2020/8836493","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2020/8836493.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},{"id":"pmid:33273963","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33273963","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and mathematical methods in medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:4cb842bfc67a4d4f8b6afbf525bed7b5","is_oa":true,"landing_page_url":"https://doaj.org/article/4cb842bfc67a4d4f8b6afbf525bed7b5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computational and Mathematical Methods in Medicine, Vol 2020 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7683164","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7683164","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Comput Math Methods Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1155/2020/8836493","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2020/8836493","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2020/8836493.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6299999952316284}],"awards":[{"id":"https://openalex.org/G1487794332","display_name":null,"funder_award_id":"2019, 81902831","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5789698369","display_name":null,"funder_award_id":"81902831","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3105871342.pdf","grobid_xml":"https://content.openalex.org/works/W3105871342.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1607316259","https://openalex.org/W1904795858","https://openalex.org/W1979538859","https://openalex.org/W1997834038","https://openalex.org/W2022495797","https://openalex.org/W2030467932","https://openalex.org/W2040935952","https://openalex.org/W2044563319","https://openalex.org/W2066671159","https://openalex.org/W2074737893","https://openalex.org/W2076011743","https://openalex.org/W2093762704","https://openalex.org/W2094381069","https://openalex.org/W2129234309","https://openalex.org/W2158734599","https://openalex.org/W2171490333","https://openalex.org/W2560367415","https://openalex.org/W2578528809","https://openalex.org/W2590166853","https://openalex.org/W2606495925","https://openalex.org/W2635951006","https://openalex.org/W2747774814","https://openalex.org/W2754454631","https://openalex.org/W2779221466","https://openalex.org/W2787895089","https://openalex.org/W2797675588","https://openalex.org/W2797855256","https://openalex.org/W2885139325","https://openalex.org/W2889646458","https://openalex.org/W2900082702","https://openalex.org/W2900657494","https://openalex.org/W2909679049","https://openalex.org/W2920353660","https://openalex.org/W2921349646","https://openalex.org/W2922870792","https://openalex.org/W2956286257","https://openalex.org/W2957861560","https://openalex.org/W2981147981","https://openalex.org/W3015039969","https://openalex.org/W4244068819","https://openalex.org/W4248444041"],"related_works":["https://openalex.org/W2123958666","https://openalex.org/W2546792321","https://openalex.org/W2951506308","https://openalex.org/W2488011889","https://openalex.org/W2165310406","https://openalex.org/W2139763472","https://openalex.org/W2546441935","https://openalex.org/W2047943031","https://openalex.org/W2126723155","https://openalex.org/W2232482475"],"abstract_inverted_index":{"BACKGROUND:":[0],"Immunotherapy":[1],"offers":[2],"a":[3,51,177,209,255,268,280],"novel":[4],"approach":[5],"for":[6,17,90,196,284],"the":[7,13,23,36,42,55,116,120,127,134,146,217,234,247],"treatment":[8,197],"of":[9,22,29,39,54,64,108,181,202,212,220,239],"cutaneous":[10,66,265],"melanoma,":[11],"but":[12],"clinical":[14],"efficiency":[15],"varies":[16],"individual":[18],"patients.":[19],"In":[20,215],"consideration":[21],"high":[24],"cost":[25],"and":[26,60,82,99,110,143,150,172,222,228,241,274],"adverse":[27],"effects":[28],"immunotherapy,":[30],"it":[31],"is":[32],"essential":[33],"to":[34,78,125,190],"explore":[35],"predictive":[37,52],"biomarkers":[38],"outcomes.":[40],"Recently,":[41],"tumor":[43],"mutation":[44,62,80],"burden":[45],"(TMB)":[46],"has":[47],"been":[48],"proposed":[49],"as":[50],"prognosticator":[53],"immune":[56,111,130,213,218,275],"response.":[57],"METHOD:":[58],"RNA-seq":[59],"somatic":[61],"datasets":[63],"472":[65],"melanoma":[67],"patients":[68],"were":[69,88,95,145,162,231,244],"downloaded":[70],"from":[71,115],"The":[72,104,199],"Cancer":[73],"Genome":[74],"Atlas":[75],"(TCGA)":[76],"database":[77],"analyze":[79],"type":[81],"TMB.":[83],"Differently":[84],"expressed":[85],"genes":[86,184,205],"(DEGs)":[87],"identified":[89,96],"functional":[91],"analysis.":[92,103],"TMB-related":[93,183,204],"signatures":[94,109],"via":[97],"LASSO":[98],"multivariate":[100],"Cox":[101],"regression":[102],"association":[105,270],"between":[106,271],"mutants":[107],"cells":[112],"was":[113,123,185,188,206,258,277],"evaluated":[114],"TIMER":[117],"database.":[118],"Furthermore,":[119,176],"Wilcox":[121],"test":[122],"applied":[124],"assess":[126],"difference":[128],"in":[129,137,165,233,246,264],"infiltration":[131,276],"calculated":[132],"by":[133],"CIBERSORT":[135],"algorithm":[136],"risk":[138,194],"groupings.":[139],"RESULTS:":[140],"C>T":[141],"substitutions":[142],"TTN":[144],"most":[147],"common":[148],"SNV":[149],"mutated":[151],"gene,":[152],"respectively.":[153],"Patients":[154],"with":[155,208,260],"low":[156,210],"TMB":[157,257],"presented":[158],"poor":[159],"prognosis.":[160],"DEGs":[161],"mainly":[163],"implicated":[164],"skin":[166],"development,":[167],"cell":[168],"cycle,":[169],"DNA":[170],"replication,":[171],"immune-associated":[173],"crosstalk":[174],"pathways.":[175],"prognostic":[178,272],"model":[179,273],"consisting":[180],"eight":[182,203],"developed,":[186],"which":[187],"found":[189],"be":[191],"an":[192],"independent":[193],"factor":[195],"outcome.":[198],"mutational":[200],"status":[201],"associated":[207,259],"level":[211],"infiltration.":[214],"addition,":[216],"infiltrates":[219],"CD4+":[221],"CD8+":[223],"T":[224],"cells,":[225,227],"NK":[226],"M1":[229],"macrophages":[230,243],"higher":[232,245,256],"low-risk":[235],"group,":[236],"while":[237],"those":[238],"M0":[240],"M2":[242],"high-risk":[248],"group.":[249],"CONCLUSION:":[250],"Our":[251],"study":[252],"demonstrated":[253],"that":[254],"favorable":[261],"survival":[262],"outcome":[263],"melanoma.":[266],"Moreover,":[267],"close":[269],"identified,":[278],"providing":[279],"new":[281],"potential":[282],"target":[283],"immunotherapy.":[285]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
