{"id":"https://openalex.org/W3092872515","doi":"https://doi.org/10.1155/2020/8834651","title":"Simulations of Myenteric Neuron Dynamics in Response to Mechanical Stretch","display_name":"Simulations of Myenteric Neuron Dynamics in Response to Mechanical Stretch","publication_year":2020,"publication_date":"2020-10-13","ids":{"openalex":"https://openalex.org/W3092872515","doi":"https://doi.org/10.1155/2020/8834651","mag":"3092872515","pmid":"https://pubmed.ncbi.nlm.nih.gov/33123188"},"language":"en","primary_location":{"id":"doi:10.1155/2020/8834651","is_oa":true,"landing_page_url":"http://doi.org/10.1155/2020/8834651","pdf_url":"https://downloads.hindawi.com/journals/cin/2020/8834651.pdf","source":{"id":"https://openalex.org/S72372694","display_name":"Computational Intelligence and Neuroscience","issn_l":"1687-5265","issn":["1687-5265","1687-5273"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Intelligence and Neuroscience","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/cin/2020/8834651.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004311292","display_name":"Donghua Liao","orcid":"https://orcid.org/0000-0003-3908-6537"},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2799976261","display_name":"Aalborg University Hospital","ror":"https://ror.org/02jk5qe80","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799976261"]},{"id":"https://openalex.org/I4210112798","display_name":"Mech-Sense","ror":"https://ror.org/02akzdv37","country_code":"DK","type":"facility","lineage":["https://openalex.org/I4210112798"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Donghua Liao","raw_affiliation_strings":["Giome Academia, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","Mech-Sense, Department of Gastroenterology, Aalborg University Hospital, Aalborg, Denmark"],"raw_orcid":"https://orcid.org/0000-0003-3908-6537","affiliations":[{"raw_affiliation_string":"Giome Academia, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Mech-Sense, Department of Gastroenterology, Aalborg University Hospital, Aalborg, Denmark","institution_ids":["https://openalex.org/I2799976261","https://openalex.org/I4210112798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077415554","display_name":"Jingbo Zhao","orcid":"https://orcid.org/0000-0002-4430-4829"},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]},{"id":"https://openalex.org/I2799976261","display_name":"Aalborg University Hospital","ror":"https://ror.org/02jk5qe80","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799976261"]},{"id":"https://openalex.org/I4210112798","display_name":"Mech-Sense","ror":"https://ror.org/02akzdv37","country_code":"DK","type":"facility","lineage":["https://openalex.org/I4210112798"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jingbo Zhao","raw_affiliation_strings":["Giome Academia, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","Mech-Sense, Department of Gastroenterology, Aalborg University Hospital, Aalborg, Denmark","Standard (Chongqing) Pathological Diagnosis Center, No. 8 Xiyuan North Road Shapingba District, Chongqing, China"],"raw_orcid":"https://orcid.org/0000-0002-4430-4829","affiliations":[{"raw_affiliation_string":"Giome Academia, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]},{"raw_affiliation_string":"Mech-Sense, Department of Gastroenterology, Aalborg University Hospital, Aalborg, Denmark","institution_ids":["https://openalex.org/I2799976261","https://openalex.org/I4210112798"]},{"raw_affiliation_string":"Standard (Chongqing) Pathological Diagnosis Center, No. 8 Xiyuan North Road Shapingba District, Chongqing, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060244358","display_name":"Hans Gregersen","orcid":"https://orcid.org/0000-0002-5792-2845"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hans Gregersen","raw_affiliation_strings":["Calmi2, San Diego, CA, USA","GIOME, Discovery Bay, Hong Kong"],"raw_orcid":"https://orcid.org/0000-0002-5792-2845","affiliations":[{"raw_affiliation_string":"Calmi2, San Diego, CA, USA","institution_ids":[]},{"raw_affiliation_string":"GIOME, Discovery Bay, Hong Kong","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5004311292"],"corresponding_institution_ids":["https://openalex.org/I204337017","https://openalex.org/I2799976261","https://openalex.org/I4210112798"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11339886,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2020","issue":null,"first_page":"1","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9943000078201294,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9943000078201294,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.9781000018119812,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9681000113487244,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dynamics","display_name":"Dynamics (music)","score":0.6681259870529175},{"id":"https://openalex.org/keywords/neuron","display_name":"Neuron","score":0.5362374782562256},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.47279590368270874},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.4274669885635376},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.417027086019516},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.2719752788543701},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22872549295425415},{"id":"https://openalex.org/keywords/acoustics","display_name":"Acoustics","score":0.20392900705337524}],"concepts":[{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.6681259870529175},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.5362374782562256},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.47279590368270874},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4274669885635376},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.417027086019516},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2719752788543701},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22872549295425415},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.20392900705337524}],"mesh":[{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009475","descriptor_name":"Neurons, Afferent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009475","descriptor_name":"Neurons, Afferent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009475","descriptor_name":"Neurons, Afferent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1155/2020/8834651","is_oa":true,"landing_page_url":"http://doi.org/10.1155/2020/8834651","pdf_url":"https://downloads.hindawi.com/journals/cin/2020/8834651.pdf","source":{"id":"https://openalex.org/S72372694","display_name":"Computational Intelligence and Neuroscience","issn_l":"1687-5265","issn":["1687-5265","1687-5273"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Intelligence and Neuroscience","raw_type":"journal-article"},{"id":"pmid:33123188","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33123188","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational intelligence and neuroscience","raw_type":null},{"id":"pmh:oai:pure.atira.dk:openaire/018a3ff1-cfa7-4902-be12-25dbc2f27996","is_oa":true,"landing_page_url":"https://vbn.aau.dk/da/publications/018a3ff1-cfa7-4902-be12-25dbc2f27996","pdf_url":null,"source":{"id":"https://openalex.org/S4306401731","display_name":"VBN Forskningsportal (Aalborg Universitet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I891191580","host_organization_name":"Aalborg University","host_organization_lineage":["https://openalex.org/I891191580"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Liao, D, Zhao, J & Gregersen, H 2020, 'Simulations of Myenteric Neuron Dynamics in Response to Mechanical Stretch', Computational Intelligence and Neuroscience, vol. 2020, 8834651. https://doi.org/10.1155/2020/8834651","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:d998208d66624beeb3f95401ce49da7f","is_oa":false,"landing_page_url":"https://doaj.org/article/d998208d66624beeb3f95401ce49da7f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computational Intelligence and Neuroscience, Vol 2020 (2020)","raw_type":"article"},{"id":"pmh:oai:hindawi.com:10.1155/2020/8834651","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2020/8834651","pdf_url":null,"source":{"id":"https://openalex.org/S4306400340","display_name":"Hindawi Journal of Chemistry (Hindawi)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210126990","host_organization_name":"Hindawi (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210126990"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Research Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7582074","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7582074","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Comput Intell Neurosci","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:publications/1af615f4-157f-4ad9-a47f-39e101b42076","is_oa":false,"landing_page_url":"https://pure.au.dk/portal/en/publications/1af615f4-157f-4ad9-a47f-39e101b42076","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Liao, D, Zhao, J & Gregersen, H 2020, 'Simulations of Myenteric Neuron Dynamics in Response to Mechanical Stretch', Computational Intelligence and Neuroscience, vol. 2020, 8834651. https://doi.org/10.1155/2020/8834651","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"doi:10.1155/2020/8834651","is_oa":true,"landing_page_url":"http://doi.org/10.1155/2020/8834651","pdf_url":"https://downloads.hindawi.com/journals/cin/2020/8834651.pdf","source":{"id":"https://openalex.org/S72372694","display_name":"Computational Intelligence and Neuroscience","issn_l":"1687-5265","issn":["1687-5265","1687-5273"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Intelligence and Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3659761258","display_name":null,"funder_award_id":"903959","funder_id":"https://openalex.org/F4320322314","funder_display_name":"Karen Elise Jensens Fond"},{"id":"https://openalex.org/G4330852888","display_name":null,"funder_award_id":"NNF18OC0052045","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G4386533100","display_name":null,"funder_award_id":"903959","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G6333441402","display_name":null,"funder_award_id":"NNF18OC0052045","funder_id":"https://openalex.org/F4320322314","funder_display_name":"Karen Elise Jensens Fond"}],"funders":[{"id":"https://openalex.org/F4320322314","display_name":"Karen Elise Jensens Fond","ror":"https://ror.org/00kaqnj29"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3092872515.pdf","grobid_xml":"https://content.openalex.org/works/W3092872515.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1965121027","https://openalex.org/W1981562838","https://openalex.org/W1985977003","https://openalex.org/W1997556359","https://openalex.org/W1999015709","https://openalex.org/W1999763069","https://openalex.org/W2002297978","https://openalex.org/W2004982499","https://openalex.org/W2009046255","https://openalex.org/W2011396633","https://openalex.org/W2011826381","https://openalex.org/W2045898764","https://openalex.org/W2059306679","https://openalex.org/W2063717098","https://openalex.org/W2068032958","https://openalex.org/W2073181263","https://openalex.org/W2075147334","https://openalex.org/W2076340469","https://openalex.org/W2077587321","https://openalex.org/W2078950386","https://openalex.org/W2082316468","https://openalex.org/W2093946239","https://openalex.org/W2097609518","https://openalex.org/W2098267014","https://openalex.org/W2100260601","https://openalex.org/W2142465720","https://openalex.org/W2161855647","https://openalex.org/W2198139982","https://openalex.org/W2308244353","https://openalex.org/W2336119436","https://openalex.org/W2467338282","https://openalex.org/W2519687820","https://openalex.org/W2807113328"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2949058385","https://openalex.org/W4281997648"],"abstract_inverted_index":{"Background.":[0],"Intestinal":[1],"sensitivity":[2],"to":[3,16,26,59,74,81,90,161],"mechanical":[4,49,83,153],"stimuli":[5,19,84],"has":[6],"been":[7],"studied":[8],"intensively":[9],"in":[10,20,120,173,186],"visceral":[11],"pain":[12],"studies.":[13],"The":[14,112,118,156,178],"ability":[15],"sense":[17],"different":[18],"the":[21,31,41,44,66,78,98,102,121,136,139,143,147,169],"gut":[22],"and":[23,33,47,132,151,164,196],"translate":[24],"these":[25],"physiological":[27,171],"outcomes":[28],"relies":[29],"on":[30],"mechanosensory":[32],"transductive":[34],"capacity":[35],"of":[36,43,69,77,97,129,146,166,168,191],"intrinsic":[37,192],"intestinal":[38,61],"nerves.":[39],"However,":[40],"nature":[42],"mechanosensitive":[45,52],"channels":[46],"principal":[48],"stimulus":[50],"for":[51],"receptors":[53],"are":[54,85],"unknown.":[55],"To":[56],"be":[57,181],"able":[58],"characterize":[60],"mechanoelectrical":[62],"transduction,":[63],"that":[64],"is,":[65],"molecular":[67],"basis":[68],"mechanosensation,":[70],"comprehensive":[71],"mathematical":[72,95],"models":[73],"predict":[75,162],"responses":[76],"sensory":[79],"neurons":[80,149,195],"controlled":[82],"needed.":[86],"This":[87],"study":[88],"aims":[89],"develop":[91],"a":[92,127,159],"biophysically":[93],"based":[94],"model":[96,115,122,140,157,179],"myenteric":[99,148,175],"neuron":[100,176],"with":[101,150],"parameters":[103,119],"constrained":[104],"by":[105,125],"learning":[106],"from":[107],"existing":[108],"experimental":[109],"data.":[110],"Findings.":[111],"conductance-based":[113],"single-compartment":[114],"was":[116],"selected.":[117],"were":[123],"optimized":[124,137],"using":[126],"combination":[128],"hand":[130],"tuning":[131],"automated":[133],"estimation.":[134],"Using":[135],"parameters,":[138],"successfully":[141],"predicted":[142],"electrophysiological":[144],"features":[145,163],"without":[152],"stimulation.":[154],"Conclusions.":[155],"provides":[158],"method":[160],"levels":[165],"detail":[167],"underlying":[170],"system":[172],"generating":[174],"responses.":[177],"could":[180],"used":[182],"as":[183],"building":[184],"blocks":[185],"future":[187],"large-scale":[188],"network":[189],"simulations":[190],"primary":[193],"afferent":[194],"their":[197],"network.":[198]},"counts_by_year":[],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
