{"id":"https://openalex.org/W3086570168","doi":"https://doi.org/10.1155/2020/8750167","title":"A Computational Model to Investigate GABA-Activated Astrocyte Modulation of Neuronal Excitation","display_name":"A Computational Model to Investigate GABA-Activated Astrocyte Modulation of Neuronal Excitation","publication_year":2020,"publication_date":"2020-09-15","ids":{"openalex":"https://openalex.org/W3086570168","doi":"https://doi.org/10.1155/2020/8750167","mag":"3086570168","pmid":"https://pubmed.ncbi.nlm.nih.gov/33014120"},"language":"en","primary_location":{"id":"doi:10.1155/2020/8750167","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2020/8750167","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2020/8750167.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/cmmm/2020/8750167.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034246785","display_name":"Licong Li","orcid":"https://orcid.org/0000-0001-8288-2243"},"institutions":[{"id":"https://openalex.org/I43337087","display_name":"Hebei University","ror":"https://ror.org/01p884a79","country_code":"CN","type":"education","lineage":["https://openalex.org/I43337087"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Licong Li","raw_affiliation_strings":["College of Physics Science and Technology, Hebei University, Baoding 071002, China","Key Laboratory of Digital Medical Engineering of Hebei Province, Hebei University, Baoding 071002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Physics Science and Technology, Hebei University, Baoding 071002, China","institution_ids":["https://openalex.org/I43337087"]},{"raw_affiliation_string":"Key Laboratory of Digital Medical Engineering of Hebei Province, Hebei University, Baoding 071002, China","institution_ids":["https://openalex.org/I43337087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078971922","display_name":"Jin Zhou","orcid":"https://orcid.org/0000-0003-3128-407X"},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin Zhou","raw_affiliation_strings":["Department of Neural Engineering and Biological Interdisciplinary Studies, Institute of Military Cognition and Brain Sciences, Academy of Military Medical Sciences, Beijing 100850, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neural Engineering and Biological Interdisciplinary Studies, Institute of Military Cognition and Brain Sciences, Academy of Military Medical Sciences, Beijing 100850, China","institution_ids":["https://openalex.org/I2802541053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102657466","display_name":"Hongji Sun","orcid":"https://orcid.org/0000-0002-1712-8030"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112150","display_name":"Institute of Automation","ror":"https://ror.org/022c3hy66","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112150"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongji Sun","raw_affiliation_strings":["Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China","institution_ids":["https://openalex.org/I4210112150","https://openalex.org/I19820366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100748634","display_name":"Jing Liu","orcid":"https://orcid.org/0000-0002-2217-0372"},"institutions":[{"id":"https://openalex.org/I43337087","display_name":"Hebei University","ror":"https://ror.org/01p884a79","country_code":"CN","type":"education","lineage":["https://openalex.org/I43337087"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Liu","raw_affiliation_strings":["Key Laboratory of Digital Medical Engineering of Hebei Province, Hebei University, Baoding 071002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Digital Medical Engineering of Hebei Province, Hebei University, Baoding 071002, China","institution_ids":["https://openalex.org/I43337087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101810550","display_name":"Hongrui Wang","orcid":"https://orcid.org/0000-0002-2916-8849"},"institutions":[{"id":"https://openalex.org/I43337087","display_name":"Hebei University","ror":"https://ror.org/01p884a79","country_code":"CN","type":"education","lineage":["https://openalex.org/I43337087"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongrui Wang","raw_affiliation_strings":["Key Laboratory of Digital Medical Engineering of Hebei Province, Hebei University, Baoding 071002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Digital Medical Engineering of Hebei Province, Hebei University, Baoding 071002, China","institution_ids":["https://openalex.org/I43337087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006890334","display_name":"Xiuling Liu","orcid":"https://orcid.org/0000-0002-1871-1017"},"institutions":[{"id":"https://openalex.org/I43337087","display_name":"Hebei University","ror":"https://ror.org/01p884a79","country_code":"CN","type":"education","lineage":["https://openalex.org/I43337087"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiuling Liu","raw_affiliation_strings":["Key Laboratory of Digital Medical Engineering of Hebei Province, Hebei University, Baoding 071002, China"],"raw_orcid":"https://orcid.org/0000-0002-1871-1017","affiliations":[{"raw_affiliation_string":"Key Laboratory of Digital Medical Engineering of Hebei Province, Hebei University, Baoding 071002, China","institution_ids":["https://openalex.org/I43337087"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011166808","display_name":"Changyong Wang","orcid":"https://orcid.org/0000-0002-3350-8623"},"institutions":[{"id":"https://openalex.org/I2802541053","display_name":"Academy of Military Medical Sciences","ror":"https://ror.org/02bv3c993","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2802541053"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Changyong Wang","raw_affiliation_strings":["Department of Neural Engineering and Biological Interdisciplinary Studies, Institute of Military Cognition and Brain Sciences, Academy of Military Medical Sciences, Beijing 100850, China"],"raw_orcid":"https://orcid.org/0000-0002-3350-8623","affiliations":[{"raw_affiliation_string":"Department of Neural Engineering and Biological Interdisciplinary Studies, Institute of Military Cognition and Brain Sciences, Academy of Military Medical Sciences, Beijing 100850, China","institution_ids":["https://openalex.org/I2802541053"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5006890334","https://openalex.org/A5011166808"],"corresponding_institution_ids":["https://openalex.org/I2802541053","https://openalex.org/I43337087"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":0.5192,"has_fulltext":true,"cited_by_count":14,"citation_normalized_percentile":{"value":0.58874347,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"2020","issue":null,"first_page":"1","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/excitatory-postsynaptic-potential","display_name":"Excitatory postsynaptic potential","score":0.8662822842597961},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.8201818466186523},{"id":"https://openalex.org/keywords/inhibitory-postsynaptic-potential","display_name":"Inhibitory postsynaptic potential","score":0.7972787618637085},{"id":"https://openalex.org/keywords/glutamatergic","display_name":"Glutamatergic","score":0.7936774492263794},{"id":"https://openalex.org/keywords/glutamate-receptor","display_name":"Glutamate receptor","score":0.7409133315086365},{"id":"https://openalex.org/keywords/astrocyte","display_name":"Astrocyte","score":0.6715778112411499},{"id":"https://openalex.org/keywords/postsynaptic-potential","display_name":"Postsynaptic potential","score":0.5564410090446472},{"id":"https://openalex.org/keywords/premovement-neuronal-activity","display_name":"Premovement neuronal activity","score":0.5352718234062195},{"id":"https://openalex.org/keywords/postsynaptic-current","display_name":"Postsynaptic Current","score":0.521605372428894},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.425688236951828},{"id":"https://openalex.org/keywords/gamma-aminobutyric-acid","display_name":"gamma-Aminobutyric acid","score":0.4168434739112854},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3656805455684662},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"Central nervous system","score":0.22787466645240784},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.14991867542266846},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.09031760692596436}],"concepts":[{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.8662822842597961},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.8201818466186523},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.7972787618637085},{"id":"https://openalex.org/C2780648746","wikidata":"https://www.wikidata.org/wiki/Q28208871","display_name":"Glutamatergic","level":4,"score":0.7936774492263794},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.7409133315086365},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.6715778112411499},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.5564410090446472},{"id":"https://openalex.org/C74254510","wikidata":"https://www.wikidata.org/wiki/Q7240508","display_name":"Premovement neuronal activity","level":2,"score":0.5352718234062195},{"id":"https://openalex.org/C2910581834","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Postsynaptic Current","level":4,"score":0.521605372428894},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.425688236951828},{"id":"https://openalex.org/C2777771985","wikidata":"https://www.wikidata.org/wiki/Q210021","display_name":"gamma-Aminobutyric acid","level":3,"score":0.4168434739112854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3656805455684662},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.22787466645240784},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.14991867542266846},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09031760692596436}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055592","descriptor_name":"Biophysical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055592","descriptor_name":"Biophysical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055592","descriptor_name":"Biophysical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055641","descriptor_name":"Mathematical Concepts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055641","descriptor_name":"Mathematical Concepts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055641","descriptor_name":"Mathematical Concepts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1155/2020/8750167","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2020/8750167","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2020/8750167.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},{"id":"pmid:33014120","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33014120","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and mathematical methods in medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:55d6c457a08240dfbd8dc95ef91481b1","is_oa":false,"landing_page_url":"https://doaj.org/article/55d6c457a08240dfbd8dc95ef91481b1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computational and Mathematical Methods in Medicine, Vol 2020 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7512075","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7512075","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Comput Math Methods Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1155/2020/8750167","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2020/8750167","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2020/8750167.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5299999713897705}],"awards":[{"id":"https://openalex.org/G4207073069","display_name":null,"funder_award_id":"F2018201070","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7994072155","display_name":null,"funder_award_id":"61703133","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8248491097","display_name":null,"funder_award_id":"61673158","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3086570168.pdf","grobid_xml":"https://content.openalex.org/works/W3086570168.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W1574905387","https://openalex.org/W1861463350","https://openalex.org/W1940417817","https://openalex.org/W1963763563","https://openalex.org/W1966907942","https://openalex.org/W1966982646","https://openalex.org/W1976738367","https://openalex.org/W1977294596","https://openalex.org/W1982950909","https://openalex.org/W1990737444","https://openalex.org/W1994253577","https://openalex.org/W1998041052","https://openalex.org/W1998229125","https://openalex.org/W2006338283","https://openalex.org/W2008595762","https://openalex.org/W2018027127","https://openalex.org/W2020487122","https://openalex.org/W2022607753","https://openalex.org/W2030127292","https://openalex.org/W2032730787","https://openalex.org/W2037125063","https://openalex.org/W2042681276","https://openalex.org/W2044730840","https://openalex.org/W2045465808","https://openalex.org/W2048383480","https://openalex.org/W2049071740","https://openalex.org/W2049517487","https://openalex.org/W2049594669","https://openalex.org/W2050452462","https://openalex.org/W2052957998","https://openalex.org/W2053079477","https://openalex.org/W2057724638","https://openalex.org/W2062549338","https://openalex.org/W2065705799","https://openalex.org/W2077187035","https://openalex.org/W2079150153","https://openalex.org/W2095923239","https://openalex.org/W2104417933","https://openalex.org/W2109078104","https://openalex.org/W2111547035","https://openalex.org/W2123609069","https://openalex.org/W2126143811","https://openalex.org/W2131802146","https://openalex.org/W2135328571","https://openalex.org/W2135426390","https://openalex.org/W2142961412","https://openalex.org/W2148654448","https://openalex.org/W2154100802","https://openalex.org/W2154233987","https://openalex.org/W2154323800","https://openalex.org/W2167719316","https://openalex.org/W2168617417","https://openalex.org/W2171437709","https://openalex.org/W2291352574","https://openalex.org/W2339728065","https://openalex.org/W2513197021","https://openalex.org/W2562109833","https://openalex.org/W2596360620","https://openalex.org/W2620558082","https://openalex.org/W2754276445","https://openalex.org/W2781911216","https://openalex.org/W2782344173","https://openalex.org/W2786310594","https://openalex.org/W2789902842","https://openalex.org/W2790639275","https://openalex.org/W2791212118","https://openalex.org/W2796453918","https://openalex.org/W2799844935","https://openalex.org/W2802487994","https://openalex.org/W2807684261","https://openalex.org/W2967265650","https://openalex.org/W3098581270","https://openalex.org/W3105906856","https://openalex.org/W4210553920","https://openalex.org/W4247763225"],"related_works":["https://openalex.org/W1996815194","https://openalex.org/W2137197598","https://openalex.org/W2748185513","https://openalex.org/W4225147667","https://openalex.org/W4394876835","https://openalex.org/W2080708567","https://openalex.org/W4284706549","https://openalex.org/W3182878900","https://openalex.org/W3002370256","https://openalex.org/W4319299256"],"abstract_inverted_index":{"Gamma-aminobutyric":[0],"acid":[1],"(GABA)":[2],"is":[3],"critical":[4],"for":[5,197],"proper":[6],"neural":[7],"network":[8,59],"function":[9],"and":[10,70,91,124,154],"can":[11,34,113],"activate":[12],"astrocytes":[13,23,46,66,90,112,164,183],"to":[14,27,39,61,75,102,116,147,176],"induce":[15],"neuronal":[16,48,58,137,185],"excitability;":[17],"however,":[18],"the":[19,51,63,85,96,167,173,180,199],"mechanism":[20],"by":[21,119,162],"which":[22,145,193],"transform":[24],"inhibitory":[25,168],"signaling":[26],"excitatory":[28,68,92],"enhancement":[29],"remains":[30],"unclear.":[31],"Computational":[32],"modeling":[33],"be":[35,195],"a":[36,56],"powerful":[37],"tool":[38],"provide":[40],"further":[41],"understanding":[42],"of":[43,65,78,87,98,170,182,191,201],"how":[44],"GABA-activated":[45,163],"modulate":[47],"excitation.":[49],"In":[50],"present":[52],"study,":[53],"we":[54],"implemented":[55],"biophysical":[57],"model":[60,82,174],"investigate":[62],"effects":[64,86,200],"on":[67,89],"pre-":[69],"postsynaptic":[71,155],"terminals":[72,94],"following":[73],"exposure":[74],"increasing":[76],"concentrations":[77,132],"external":[79],"GABA.":[80,171],"The":[81],"completely":[83],"describes":[84],"GABA":[88,118,131],"presynaptic":[93,152],"within":[95],"framework":[97],"glutamatergic":[99],"gliotransmission":[100],"according":[101],"neurophysiological":[103],"findings.":[104],"Utilizing":[105],"this":[106],"model,":[107],"our":[108],"results":[109],"show":[110],"that":[111],"rapidly":[114],"respond":[115],"incoming":[117],"inducing":[120],"Ca":[121],"2+":[122],"oscillations":[123],"subsequent":[125],"gliotransmitter":[126],"glutamate":[127,143],"release.":[128],"Elevation":[129],"in":[130,150,184],"not":[133],"only":[134],"naturally":[135],"decreases":[136],"spikes":[138],"but":[139],"also":[140],"enhances":[141],"astrocytic":[142],"release,":[144],"leads":[146],"an":[148],"increase":[149,177],"astrocyte-mediated":[151],"release":[153],"slow":[156],"inward":[157],"currents.":[158],"Neuronal":[159],"excitation":[160],"induced":[161],"partly":[165],"counteracts":[166],"effect":[169],"Overall,":[172],"helps":[175],"knowledge":[178],"regarding":[179],"involvement":[181],"regulation":[186],"using":[187],"simulated":[188],"bath":[189],"perfusion":[190],"GABA,":[192],"may":[194],"useful":[196],"exploring":[198],"GABA-type":[202],"antiepileptic":[203],"drugs.":[204]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3}],"updated_date":"2026-05-21T09:19:25.381259","created_date":"2025-10-10T00:00:00"}
