{"id":"https://openalex.org/W3089027679","doi":"https://doi.org/10.1155/2020/8694821","title":"Dynamics of a Virological Model for Cancer Therapy with Innate Immune Response","display_name":"Dynamics of a Virological Model for Cancer Therapy with Innate Immune Response","publication_year":2020,"publication_date":"2020-09-27","ids":{"openalex":"https://openalex.org/W3089027679","doi":"https://doi.org/10.1155/2020/8694821","mag":"3089027679"},"language":"en","primary_location":{"id":"doi:10.1155/2020/8694821","is_oa":true,"landing_page_url":"http://doi.org/10.1155/2020/8694821","pdf_url":"https://downloads.hindawi.com/journals/complexity/2020/8694821.pdf","source":{"id":"https://openalex.org/S207319443","display_name":"Complexity","issn_l":"1076-2787","issn":["1076-2787","1099-0526"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Complexity","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://downloads.hindawi.com/journals/complexity/2020/8694821.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057461613","display_name":"Ayoub Nouni","orcid":null},"institutions":[{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Ayoub Nouni","raw_affiliation_strings":["Laboratory of Analysis, Modeling and Simulation (LAMS), Faculty of Sciences Ben M\u2019sik, Hassan II University of Casablanca, P.O. Box 7955 Sidi Othman, Casablanca, Morocco"],"affiliations":[{"raw_affiliation_string":"Laboratory of Analysis, Modeling and Simulation (LAMS), Faculty of Sciences Ben M\u2019sik, Hassan II University of Casablanca, P.O. Box 7955 Sidi Othman, Casablanca, Morocco","institution_ids":["https://openalex.org/I99297268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072861693","display_name":"Khalid Hattaf","orcid":"https://orcid.org/0000-0002-5032-3639"},"institutions":[{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":true,"raw_author_name":"Khalid Hattaf","raw_affiliation_strings":["Centre R\u00e9gional des M\u00e9tiers de l\u2019Education et de la Formation (CRMEF), 20340 Derb Ghalef, Casablanca, Morocco","Laboratory of Analysis, Modeling and Simulation (LAMS), Faculty of Sciences Ben M\u2019sik, Hassan II University of Casablanca, P.O. Box 7955 Sidi Othman, Casablanca, Morocco"],"affiliations":[{"raw_affiliation_string":"Centre R\u00e9gional des M\u00e9tiers de l\u2019Education et de la Formation (CRMEF), 20340 Derb Ghalef, Casablanca, Morocco","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Analysis, Modeling and Simulation (LAMS), Faculty of Sciences Ben M\u2019sik, Hassan II University of Casablanca, P.O. Box 7955 Sidi Othman, Casablanca, Morocco","institution_ids":["https://openalex.org/I99297268"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090815657","display_name":"Noura Yousfi","orcid":"https://orcid.org/0000-0001-8435-5981"},"institutions":[{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Noura Yousfi","raw_affiliation_strings":["Laboratory of Analysis, Modeling and Simulation (LAMS), Faculty of Sciences Ben M\u2019sik, Hassan II University of Casablanca, P.O. Box 7955 Sidi Othman, Casablanca, Morocco"],"affiliations":[{"raw_affiliation_string":"Laboratory of Analysis, Modeling and Simulation (LAMS), Faculty of Sciences Ben M\u2019sik, Hassan II University of Casablanca, P.O. Box 7955 Sidi Othman, Casablanca, Morocco","institution_ids":["https://openalex.org/I99297268"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5072861693"],"corresponding_institution_ids":["https://openalex.org/I99297268"],"apc_list":{"value":2300,"currency":"USD","value_usd":2300},"apc_paid":{"value":2300,"currency":"USD","value_usd":2300},"fwci":0.297,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.54814091,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"2020","issue":null,"first_page":"1","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hopf-bifurcation","display_name":"Hopf bifurcation","score":0.6637860536575317},{"id":"https://openalex.org/keywords/lytic-cycle","display_name":"Lytic cycle","score":0.5835776925086975},{"id":"https://openalex.org/keywords/innate-immune-system","display_name":"Innate immune system","score":0.5685321092605591},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"Cancer therapy","score":0.535467803478241},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.4912659525871277},{"id":"https://openalex.org/keywords/antiviral-therapy","display_name":"Antiviral therapy","score":0.44651874899864197},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.31615790724754333},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3067588210105896},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.3059431314468384},{"id":"https://openalex.org/keywords/bifurcation","display_name":"Bifurcation","score":0.3030209541320801},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.2783058285713196},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.14744412899017334},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.0977872908115387},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.06837517023086548}],"concepts":[{"id":"https://openalex.org/C172435161","wikidata":"https://www.wikidata.org/wiki/Q531126","display_name":"Hopf bifurcation","level":4,"score":0.6637860536575317},{"id":"https://openalex.org/C182615771","wikidata":"https://www.wikidata.org/wiki/Q1369386","display_name":"Lytic cycle","level":3,"score":0.5835776925086975},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.5685321092605591},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.535467803478241},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4912659525871277},{"id":"https://openalex.org/C2993512173","wikidata":"https://www.wikidata.org/wiki/Q846227","display_name":"Antiviral therapy","level":4,"score":0.44651874899864197},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.31615790724754333},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3067588210105896},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3059431314468384},{"id":"https://openalex.org/C2781349735","wikidata":"https://www.wikidata.org/wiki/Q4904824","display_name":"Bifurcation","level":3,"score":0.3030209541320801},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2783058285713196},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.14744412899017334},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0977872908115387},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.06837517023086548},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C3020491458","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Chronic hepatitis","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1155/2020/8694821","is_oa":true,"landing_page_url":"http://doi.org/10.1155/2020/8694821","pdf_url":"https://downloads.hindawi.com/journals/complexity/2020/8694821.pdf","source":{"id":"https://openalex.org/S207319443","display_name":"Complexity","issn_l":"1076-2787","issn":["1076-2787","1099-0526"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Complexity","raw_type":"journal-article"},{"id":"pmh:oai:RePEc:hin:complx:8694821","is_oa":false,"landing_page_url":"http://downloads.hindawi.com/journals/8503/2020/8694821.xml","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:8973059a208e49c1b74b74d073cf4994","is_oa":true,"landing_page_url":"https://doaj.org/article/8973059a208e49c1b74b74d073cf4994","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Complexity, Vol 2020 (2020)","raw_type":"article"},{"id":"pmh:oai:hindawi.com:10.1155/2020/8694821","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2020/8694821","pdf_url":null,"source":{"id":"https://openalex.org/S4306400340","display_name":"Hindawi Journal of Chemistry (Hindawi)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210126990","host_organization_name":"Hindawi (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210126990"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Research Article"}],"best_oa_location":{"id":"doi:10.1155/2020/8694821","is_oa":true,"landing_page_url":"http://doi.org/10.1155/2020/8694821","pdf_url":"https://downloads.hindawi.com/journals/complexity/2020/8694821.pdf","source":{"id":"https://openalex.org/S207319443","display_name":"Complexity","issn_l":"1076-2787","issn":["1076-2787","1099-0526"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Complexity","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.699999988079071}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3089027679.pdf","grobid_xml":"https://content.openalex.org/works/W3089027679.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W1975337895","https://openalex.org/W1987119981","https://openalex.org/W2025822934","https://openalex.org/W2042627536","https://openalex.org/W2063512646","https://openalex.org/W2158630456","https://openalex.org/W2169331901","https://openalex.org/W2773251671","https://openalex.org/W2798876257","https://openalex.org/W2990232165","https://openalex.org/W4211238487"],"related_works":["https://openalex.org/W3104145505","https://openalex.org/W2199233783","https://openalex.org/W2802879296","https://openalex.org/W2912177355","https://openalex.org/W4377819193","https://openalex.org/W2808548176","https://openalex.org/W2473020030","https://openalex.org/W3046818880","https://openalex.org/W1984628064","https://openalex.org/W2794805289"],"abstract_inverted_index":{"The":[0,23],"aim":[1],"of":[2,30,43,127],"this":[3,58],"work":[4],"is":[5],"to":[6,56,71],"present":[7],"a":[8,31],"virological":[9],"model":[10,25,57,83],"for":[11,40,66],"cancer":[12],"therapy":[13,92,97,102,118],"that":[14,80],"includes":[15],"the":[16,28,41,44,50,63,67,81,89,94,99,106,115,124,130],"innate":[17,107],"immune":[18,108,121],"response":[19,109],"and":[20,35,114,129],"saturation":[21],"effect.":[22],"presented":[24],"combines":[26],"both":[27],"evolution":[29],"logistic":[32],"growing":[33],"tumor":[34,69],"time":[36,59,64],"delay":[37,51],"which":[38,60,87],"stands":[39],"period":[42],"viral":[45,76],"lytic":[46],"cycle.":[47],"We":[48,78],"use":[49],"differential":[52],"equation":[53],"in":[54],"order":[55],"also":[61],"means":[62],"needed":[65],"infected":[68],"cells":[70],"produce":[72],"new":[73],"virions":[74],"after":[75],"entry.":[77],"show":[79],"delayed":[82],"has":[84,110],"four":[85],"equilibria":[86,128],"are":[88,133],"desired":[90],"outcome":[91],"equilibrium,":[93,98],"complete":[95],"failure":[96],"partial":[100,116],"success":[101,117],"free-immune":[103],"equilibrium":[104,119],"when":[105],"not":[111],"been":[112],"established,":[113],"with":[120],"response.":[122],"Furthermore,":[123],"stability":[125],"analysis":[126],"Hopf":[131],"bifurcation":[132],"properly":[134],"exhibited.":[135]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}