{"id":"https://openalex.org/W3092294391","doi":"https://doi.org/10.1155/2020/8081973","title":"Transcriptome Analysis Identifies Novel Prognostic Genes in Osteosarcoma","display_name":"Transcriptome Analysis Identifies Novel Prognostic Genes in Osteosarcoma","publication_year":2020,"publication_date":"2020-10-05","ids":{"openalex":"https://openalex.org/W3092294391","doi":"https://doi.org/10.1155/2020/8081973","mag":"3092294391","pmid":"https://pubmed.ncbi.nlm.nih.gov/33082842"},"language":"en","primary_location":{"id":"doi:10.1155/2020/8081973","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2020/8081973","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2020/8081973.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/cmmm/2020/8081973.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100426695","display_name":"Junfeng Chen","orcid":"https://orcid.org/0000-0002-0779-4435"},"institutions":[{"id":"https://openalex.org/I4210139608","display_name":"The First People's Hospital of Tianmen","ror":"https://ror.org/0305gdg87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139608"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junfeng Chen","raw_affiliation_strings":["Department of Orthopedics, Tianmen First People\u2019s Hospital, Tianmen, Hubei 431700, China"],"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Tianmen First People\u2019s Hospital, Tianmen, Hubei 431700, China","institution_ids":["https://openalex.org/I4210139608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078191766","display_name":"Xiaojun Guo","orcid":"https://orcid.org/0000-0003-0139-3486"},"institutions":[{"id":"https://openalex.org/I4210139608","display_name":"The First People's Hospital of Tianmen","ror":"https://ror.org/0305gdg87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139608"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojun Guo","raw_affiliation_strings":["Department of Orthopedics, Tianmen First People\u2019s Hospital, Tianmen, Hubei 431700, China"],"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Tianmen First People\u2019s Hospital, Tianmen, Hubei 431700, China","institution_ids":["https://openalex.org/I4210139608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000922793","display_name":"Guangjun Zeng","orcid":null},"institutions":[{"id":"https://openalex.org/I4210139608","display_name":"The First People's Hospital of Tianmen","ror":"https://ror.org/0305gdg87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139608"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guangjun Zeng","raw_affiliation_strings":["Department of Orthopedics, Tianmen First People\u2019s Hospital, Tianmen, Hubei 431700, China"],"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Tianmen First People\u2019s Hospital, Tianmen, Hubei 431700, China","institution_ids":["https://openalex.org/I4210139608"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029683139","display_name":"Jianhua Liu","orcid":"https://orcid.org/0000-0003-1165-9348"},"institutions":[{"id":"https://openalex.org/I4210139608","display_name":"The First People's Hospital of Tianmen","ror":"https://ror.org/0305gdg87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139608"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianhua Liu","raw_affiliation_strings":["Department of Orthopedics, Tianmen First People\u2019s Hospital, Tianmen, Hubei 431700, China"],"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, Tianmen First People\u2019s Hospital, Tianmen, Hubei 431700, China","institution_ids":["https://openalex.org/I4210139608"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101785474","display_name":"Bin Zhao","orcid":"https://orcid.org/0000-0001-5133-7365"},"institutions":[{"id":"https://openalex.org/I4210093544","display_name":"Wuhan Puai Hospital","ror":"https://ror.org/00qavst65","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093544"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bin Zhao","raw_affiliation_strings":["Department of Foot and Ankle Surgery, Wuhan Fourth Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China"],"affiliations":[{"raw_affiliation_string":"Department of Foot and Ankle Surgery, Wuhan Fourth Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China","institution_ids":["https://openalex.org/I47720641","https://openalex.org/I4210093544"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5101785474"],"corresponding_institution_ids":["https://openalex.org/I4210093544","https://openalex.org/I47720641"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":0.3995,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.5402383,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"2020","issue":null,"first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proportional-hazards-model","display_name":"Proportional hazards model","score":0.6867573261260986},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"Osteosarcoma","score":0.6559158563613892},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.5739806294441223},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.5468038320541382},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.49820780754089355},{"id":"https://openalex.org/keywords/survival-analysis","display_name":"Survival analysis","score":0.4804672598838806},{"id":"https://openalex.org/keywords/prognostic-model","display_name":"Prognostic model","score":0.45366886258125305},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.44634246826171875},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.4405134618282318},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.42521244287490845},{"id":"https://openalex.org/keywords/candidate-gene","display_name":"Candidate gene","score":0.4195701479911804},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.41210079193115234},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.34163331985473633},{"id":"https://openalex.org/keywords/overall-survival","display_name":"Overall survival","score":0.3252549171447754},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.31322383880615234},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.21959659457206726},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.14545297622680664},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.09822165966033936}],"concepts":[{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.6867573261260986},{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.6559158563613892},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5739806294441223},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5468038320541382},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49820780754089355},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.4804672598838806},{"id":"https://openalex.org/C2993277928","wikidata":"https://www.wikidata.org/wiki/Q7248370","display_name":"Prognostic model","level":3,"score":0.45366886258125305},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44634246826171875},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4405134618282318},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42521244287490845},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.4195701479911804},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41210079193115234},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34163331985473633},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.3252549171447754},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31322383880615234},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.21959659457206726},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14545297622680664},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09822165966033936},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016259","descriptor_name":"Genes, myc","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016259","descriptor_name":"Genes, myc","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016259","descriptor_name":"Genes, myc","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055641","descriptor_name":"Mathematical Concepts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055641","descriptor_name":"Mathematical Concepts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055641","descriptor_name":"Mathematical Concepts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056444","descriptor_name":"Axonemal Dyneins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056444","descriptor_name":"Axonemal Dyneins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056444","descriptor_name":"Axonemal Dyneins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1155/2020/8081973","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2020/8081973","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2020/8081973.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},{"id":"pmid:33082842","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33082842","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and mathematical methods in medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:e305bfdafb3047389036278653c348e8","is_oa":true,"landing_page_url":"https://doaj.org/article/e305bfdafb3047389036278653c348e8","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computational and Mathematical Methods in Medicine, Vol 2020 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7559853","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7559853","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Comput Math Methods Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1155/2020/8081973","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2020/8081973","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2020/8081973.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3092294391.pdf","grobid_xml":"https://content.openalex.org/works/W3092294391.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1675595217","https://openalex.org/W1843769190","https://openalex.org/W1967159277","https://openalex.org/W1980088710","https://openalex.org/W1999914295","https://openalex.org/W2000173637","https://openalex.org/W2008217999","https://openalex.org/W2020920713","https://openalex.org/W2021536610","https://openalex.org/W2101802836","https://openalex.org/W2106409672","https://openalex.org/W2107929386","https://openalex.org/W2110256992","https://openalex.org/W2139373232","https://openalex.org/W2178308549","https://openalex.org/W2317833459","https://openalex.org/W2329218644","https://openalex.org/W2335561432","https://openalex.org/W2342335701","https://openalex.org/W2492397079","https://openalex.org/W2571046561","https://openalex.org/W2588167481","https://openalex.org/W2758160127","https://openalex.org/W2789924919","https://openalex.org/W2901827276","https://openalex.org/W2950595506","https://openalex.org/W3002266378","https://openalex.org/W3013416758","https://openalex.org/W3026912741","https://openalex.org/W3032949839","https://openalex.org/W3147586197","https://openalex.org/W4211062330"],"related_works":["https://openalex.org/W2353768080","https://openalex.org/W2068236691","https://openalex.org/W837686567","https://openalex.org/W3135804592","https://openalex.org/W2146367717","https://openalex.org/W2970162846","https://openalex.org/W4362347072","https://openalex.org/W2362802330","https://openalex.org/W2102964659","https://openalex.org/W3014256949"],"abstract_inverted_index":{"Osteosarcoma":[0],"(OS),":[1],"a":[2,143,151,179],"malignant":[3],"primary":[4],"bone":[5],"tumor":[6],"often":[7],"seen":[8],"in":[9,17,42,169,221,238],"young":[10],"adults,":[11],"is":[12],"highly":[13],"aggressive.":[14],"The":[15,164],"improvements":[16],"high-throughput":[18],"technologies":[19],"have":[20],"accelerated":[21],"the":[22,38,55,61,64,79,84,88,94,101,106,120,134,156,170,187,215,226],"identification":[23,216],"of":[24,40,57,67,98,105,161,190,217,228,233],"various":[25],"prognostic":[26,85,107,121,219],"biomarkers":[27,220],"for":[28,87,166],"cancer":[29],"survival":[30,90,230],"prediction.":[31],"However,":[32],"only":[33],"few":[34],"studies":[35],"focus":[36],"on":[37,142],"prediction":[39,227],"prognosis":[41],"OS":[43,69,89,157,167,222,229],"patients":[44,158,168],"using":[45],"gene":[46],"expression":[47],"data":[48,66],"due":[49],"to":[50],"small":[51],"sample":[52],"size":[53],"and":[54,117,131,154,198,209,231],"lack":[56],"public":[58],"datasets.":[59],"In":[60,182,213],"present":[62],"study,":[63],"RNA-seq":[65],"82":[68],"samples,":[70],"along":[71],"with":[72,123,206],"their":[73],"clinical":[74],"information,":[75],"were":[76,111,203],"collected":[77],"from":[78],"TARGET":[80],"database.":[81],"To":[82],"identify":[83],"genes":[86,97,104,193,202],"prediction,":[91],"we":[92,148,184],"selected":[93],"top":[95],"50":[96],"contribution":[99],"as":[100],"initial":[102],"candidate":[103],"risk":[108,196],"model,":[109,116,147],"which":[110,237],"ranked":[112],"by":[113],"random":[114],"forest":[115],"found":[118,199],"that":[119,175,200],"model":[122,177],"five":[124],"predictors":[125],"including":[126],"<i>CD180</i>,":[127],"<i>MYC</i>,":[128],"<i>PROSER2</i>,":[129],"<i>DNAI1</i>,":[130],"<i>FATE1</i>":[132],"was":[133],"optimal":[135],"multivariable":[136,144],"Cox":[137,145],"regression":[138,146],"model.":[139],"Moreover,":[140],"based":[141],"also":[149,185],"developed":[150],"scoring":[152],"method":[153],"stratified":[155],"into":[159],"groups":[160,197],"different":[162],"risks.":[163],"stratification":[165],"validation":[171],"set":[172],"further":[173],"demonstrated":[174],"our":[176],"has":[178],"robust":[180],"performance.":[181],"addition,":[183],"investigated":[186],"biological":[188,207],"function":[189],"differentially":[191],"expressed":[192],"between":[194],"two":[195],"those":[201],"mainly":[204],"involved":[205],"pathways":[208],"processes":[210],"regarding":[211],"immunity.":[212],"summary,":[214],"novel":[218],"would":[223],"greatly":[224],"assist":[225],"development":[232],"molecularly":[234],"targeted":[235],"therapies,":[236],"turn":[239],"benefit":[240],"patients'":[241],"survival.":[242]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}