{"id":"https://openalex.org/W3116983079","doi":"https://doi.org/10.1155/2020/7397132","title":"Prognostic Correlation of an Autophagy-Related Gene Signature in Patients with Head and Neck Squamous Cell Carcinoma","display_name":"Prognostic Correlation of an Autophagy-Related Gene Signature in Patients with Head and Neck Squamous Cell Carcinoma","publication_year":2020,"publication_date":"2020-12-28","ids":{"openalex":"https://openalex.org/W3116983079","doi":"https://doi.org/10.1155/2020/7397132","mag":"3116983079","pmid":"https://pubmed.ncbi.nlm.nih.gov/33456497"},"language":"en","primary_location":{"id":"doi:10.1155/2020/7397132","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2020/7397132","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2020/7397132.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/cmmm/2020/7397132.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055324725","display_name":"Cai Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210132950","display_name":"Stomatology Hospital","ror":"https://ror.org/041yj5753","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132950"]},{"id":"https://openalex.org/I4391768043","display_name":"State Key Laboratory of Oral Diseases","ror":"https://ror.org/00pvqk557","country_code":null,"type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768043"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cai Yang","raw_affiliation_strings":["Department of Orthodontics, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, State Key Laboratory of Oral Diseases, Chengdu 610041, China"],"affiliations":[{"raw_affiliation_string":"Department of Orthodontics, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, State Key Laboratory of Oral Diseases, Chengdu 610041, China","institution_ids":["https://openalex.org/I4210132950","https://openalex.org/I24185976","https://openalex.org/I4391768043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046449951","display_name":"Hongxiang Mei","orcid":"https://orcid.org/0000-0002-8462-638X"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210132950","display_name":"Stomatology Hospital","ror":"https://ror.org/041yj5753","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132950"]},{"id":"https://openalex.org/I4391768043","display_name":"State Key Laboratory of Oral Diseases","ror":"https://ror.org/00pvqk557","country_code":null,"type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768043"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongxiang Mei","raw_affiliation_strings":["Department of Orthodontics, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, State Key Laboratory of Oral Diseases, Chengdu 610041, China"],"affiliations":[{"raw_affiliation_string":"Department of Orthodontics, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, State Key Laboratory of Oral Diseases, Chengdu 610041, China","institution_ids":["https://openalex.org/I4210132950","https://openalex.org/I24185976","https://openalex.org/I4391768043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100612023","display_name":"Liang Peng","orcid":"https://orcid.org/0000-0002-9831-2787"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Peng","raw_affiliation_strings":["Intelligent Information Technologies and Applications Lab (IIT), School of Information and Software Engineering, University of Electronic Science and Technology of China, Chengdu 610041, China"],"affiliations":[{"raw_affiliation_string":"Intelligent Information Technologies and Applications Lab (IIT), School of Information and Software Engineering, University of Electronic Science and Technology of China, Chengdu 610041, China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001275547","display_name":"Fulin Jiang","orcid":"https://orcid.org/0000-0003-1332-6504"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210132950","display_name":"Stomatology Hospital","ror":"https://ror.org/041yj5753","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132950"]},{"id":"https://openalex.org/I4391768043","display_name":"State Key Laboratory of Oral Diseases","ror":"https://ror.org/00pvqk557","country_code":null,"type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768043"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fulin Jiang","raw_affiliation_strings":["Department of Orthodontics, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, State Key Laboratory of Oral Diseases, Chengdu 610041, China"],"affiliations":[{"raw_affiliation_string":"Department of Orthodontics, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, State Key Laboratory of Oral Diseases, Chengdu 610041, China","institution_ids":["https://openalex.org/I4210132950","https://openalex.org/I24185976","https://openalex.org/I4391768043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062152355","display_name":"Bingjie Xie","orcid":"https://orcid.org/0000-0003-2916-3359"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210132950","display_name":"Stomatology Hospital","ror":"https://ror.org/041yj5753","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132950"]},{"id":"https://openalex.org/I4391768043","display_name":"State Key Laboratory of Oral Diseases","ror":"https://ror.org/00pvqk557","country_code":null,"type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768043"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bingjie Xie","raw_affiliation_strings":["Department of Orthodontics, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, State Key Laboratory of Oral Diseases, Chengdu 610041, China"],"affiliations":[{"raw_affiliation_string":"Department of Orthodontics, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, State Key Laboratory of Oral Diseases, Chengdu 610041, China","institution_ids":["https://openalex.org/I4210132950","https://openalex.org/I24185976","https://openalex.org/I4391768043"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100420987","display_name":"Juan Li","orcid":"https://orcid.org/0000-0001-8320-2406"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]},{"id":"https://openalex.org/I4210132950","display_name":"Stomatology Hospital","ror":"https://ror.org/041yj5753","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132950"]},{"id":"https://openalex.org/I4391768043","display_name":"State Key Laboratory of Oral Diseases","ror":"https://ror.org/00pvqk557","country_code":null,"type":"facility","lineage":["https://openalex.org/I24185976","https://openalex.org/I4391768043"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Juan Li","raw_affiliation_strings":["Department of Orthodontics, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, State Key Laboratory of Oral Diseases, Chengdu 610041, China"],"affiliations":[{"raw_affiliation_string":"Department of Orthodontics, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, State Key Laboratory of Oral Diseases, Chengdu 610041, China","institution_ids":["https://openalex.org/I4210132950","https://openalex.org/I24185976","https://openalex.org/I4391768043"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5100420987"],"corresponding_institution_ids":["https://openalex.org/I24185976","https://openalex.org/I4210132950","https://openalex.org/I4391768043"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":2.4727,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.90515657,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"2020","issue":null,"first_page":"1","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"Head and neck squamous-cell carcinoma","score":0.6997687816619873},{"id":"https://openalex.org/keywords/autophagy","display_name":"Autophagy","score":0.5858892202377319},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.5830408334732056},{"id":"https://openalex.org/keywords/cdkn2a","display_name":"CDKN2A","score":0.5175113677978516},{"id":"https://openalex.org/keywords/proportional-hazards-model","display_name":"Proportional hazards model","score":0.4893037974834442},{"id":"https://openalex.org/keywords/survival-analysis","display_name":"Survival analysis","score":0.48140549659729004},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.47052252292633057},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.4484352469444275},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4463226795196533},{"id":"https://openalex.org/keywords/gene-signature","display_name":"Gene signature","score":0.43765944242477417},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"Head and neck cancer","score":0.40970712900161743},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4079095721244812},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3670693039894104},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.3263119161128998},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.23729515075683594},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1017647385597229},{"id":"https://openalex.org/keywords/apoptosis","display_name":"Apoptosis","score":0.08091095089912415}],"concepts":[{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.6997687816619873},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.5858892202377319},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5830408334732056},{"id":"https://openalex.org/C2780265364","wikidata":"https://www.wikidata.org/wiki/Q5009957","display_name":"CDKN2A","level":3,"score":0.5175113677978516},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4893037974834442},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.48140549659729004},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47052252292633057},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4484352469444275},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4463226795196533},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.43765944242477417},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.40970712900161743},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4079095721244812},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3670693039894104},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3263119161128998},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.23729515075683594},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1017647385597229},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.08091095089912415}],"mesh":[{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000077195","descriptor_name":"Squamous Cell Carcinoma of Head and Neck","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063990","descriptor_name":"Gene Ontology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1155/2020/7397132","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2020/7397132","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2020/7397132.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},{"id":"pmid:33456497","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33456497","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and mathematical methods in medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:b5a936ebd05d4f1f82ea3ef9c336772c","is_oa":true,"landing_page_url":"https://doaj.org/article/b5a936ebd05d4f1f82ea3ef9c336772c","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computational and Mathematical Methods in Medicine, Vol 2020 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7785385","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7785385","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Comput Math Methods Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1155/2020/7397132","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2020/7397132","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2020/7397132.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.800000011920929,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G3004345782","display_name":null,"funder_award_id":"2017JY0228","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3317480652","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5939423041","display_name":null,"funder_award_id":"Technology","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5994120800","display_name":null,"funder_award_id":"Natural","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7428242387","display_name":null,"funder_award_id":"31670","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7544166594","display_name":null,"funder_award_id":"31971240","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8011863576","display_name":null,"funder_award_id":"31670951","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8208342437","display_name":null,"funder_award_id":"1 and","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3116983079.pdf","grobid_xml":"https://content.openalex.org/works/W3116983079.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1520172057","https://openalex.org/W1767858921","https://openalex.org/W1900990988","https://openalex.org/W1970159404","https://openalex.org/W1986241711","https://openalex.org/W1987367583","https://openalex.org/W2007649418","https://openalex.org/W2045122835","https://openalex.org/W2048500195","https://openalex.org/W2062312459","https://openalex.org/W2076029531","https://openalex.org/W2088434373","https://openalex.org/W2096906078","https://openalex.org/W2101234009","https://openalex.org/W2108836663","https://openalex.org/W2110664940","https://openalex.org/W2116123484","https://openalex.org/W2118441422","https://openalex.org/W2124363070","https://openalex.org/W2142309458","https://openalex.org/W2156382128","https://openalex.org/W2165741636","https://openalex.org/W2235523093","https://openalex.org/W2259438076","https://openalex.org/W2339083295","https://openalex.org/W2347431815","https://openalex.org/W2496353082","https://openalex.org/W2517107066","https://openalex.org/W2517211727","https://openalex.org/W2524192596","https://openalex.org/W2529817763","https://openalex.org/W2532987289","https://openalex.org/W2560322684","https://openalex.org/W2562415788","https://openalex.org/W2595134239","https://openalex.org/W2625989536","https://openalex.org/W2747774814","https://openalex.org/W2755864984","https://openalex.org/W2756947021","https://openalex.org/W2792640665","https://openalex.org/W2805423897","https://openalex.org/W2903493423","https://openalex.org/W2909477364","https://openalex.org/W2913401162","https://openalex.org/W2915793996","https://openalex.org/W2922870792","https://openalex.org/W2940038159","https://openalex.org/W2994619449","https://openalex.org/W3085791571","https://openalex.org/W3211488171","https://openalex.org/W6675354045"],"related_works":["https://openalex.org/W4389729033","https://openalex.org/W2002235770","https://openalex.org/W4368360105","https://openalex.org/W4385623635","https://openalex.org/W4379279831","https://openalex.org/W4225270205","https://openalex.org/W4387267272","https://openalex.org/W4205754828","https://openalex.org/W4387120015","https://openalex.org/W3132581975"],"abstract_inverted_index":{"Considerable":[0],"evidence":[1],"indicates":[2],"that":[3,70,121],"autophagy":[4,217],"plays":[5],"a":[6,118,201],"vital":[7],"role":[8],"in":[9,30,95,136,150,218],"the":[10,24,126,173,184],"biological":[11,86],"processes":[12],"of":[13,18,27,88,152,172,209,216],"various":[14],"cancers.":[15],"The":[16,48,175],"aim":[17],"this":[19,198],"study":[20,199],"is":[21],"to":[22,65,84,116],"evaluate":[23],"prognostic":[25,68,110,148,176],"value":[26,135],"autophagy-related":[28,67,91,203],"genes":[29,69,92],"patients":[31,124,141,211],"with":[32,74,108],"head":[33],"and":[34,43,61,105,128,142,169,190,212],"neck":[35],"squamous":[36],"cell":[37],"carcinoma":[38],"(HNSCC).":[39],"Transcriptome":[40],"expression":[41],"profiles":[42],"clinical":[44,157],"data":[45,182],"acquired":[46],"from":[47,183],"Cancer":[49,192],"Genome":[50,193],"Atlas":[51],"(TCGA)":[52],"database":[53,189],"were":[54,71,82,114],"analyzed":[55],"by":[56,181],"Cox":[57],"proportional":[58],"hazards":[59],"model":[60],"Kaplan-Meier":[62],"survival":[63],"analysis":[64],"screen":[66],"significantly":[72,109],"correlated":[73],"HNSCC":[75,96,113,140,210],"patients'":[76],"overall":[77],"survival.":[78],"Functional":[79],"enrichment":[80],"analyses":[81],"performed":[83],"explore":[85],"functions":[87],"differentially":[89],"expressed":[90],"(ARGs)":[93],"identified":[94,107],"patients.":[97],"Six":[98],"ARGs":[99],"(EGFR,":[100],"HSPB8,":[101],"PRKN,":[102],"CDKN2A,":[103],"FADD,":[104],"ITGA3)":[106],"values":[111],"for":[112,139,206],"used":[115],"construct":[117],"risk":[119],"signature":[120,132,177,205],"could":[122],"stratify":[123],"into":[125],"high-risk":[127],"low-risk":[129],"groups.":[130],"This":[131],"demonstrated":[133],"great":[134],"predicting":[137,207],"prognosis":[138,208],"was":[143,178],"indicated":[144],"as":[145],"an":[146],"independent":[147],"factor":[149],"terms":[151],"clinicopathological":[153],"characteristics":[154],"(sex,":[155],"age,":[156],"stage,":[158],"histological":[159],"grade,":[160],"anatomic":[161],"subdivision,":[162],"alcohol":[163],"history,":[164],"smoking":[165],"status,":[166,168],"HPV":[167],"mutational":[170],"status":[171],"samples).":[174],"also":[179],"validated":[180],"Gene":[185],"Expression":[186],"Omnibus":[187],"(GEO)":[188],"International":[191],"Consortium":[194],"(ICGC).":[195],"In":[196],"conclusion,":[197],"provides":[200],"novel":[202],"gene":[204],"gives":[213],"molecular":[214],"insights":[215],"HNSCC.":[219]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5}],"updated_date":"2026-04-16T08:26:57.006410","created_date":"2025-10-10T00:00:00"}