{"id":"https://openalex.org/W2944584222","doi":"https://doi.org/10.1155/2019/9287120","title":"Continuous Readout versus Titer-Based Assays of Influenza Vaccine Trials: Sensitivity, Specificity, and False Discovery Rates","display_name":"Continuous Readout versus Titer-Based Assays of Influenza Vaccine Trials: Sensitivity, Specificity, and False Discovery Rates","publication_year":2019,"publication_date":"2019-05-08","ids":{"openalex":"https://openalex.org/W2944584222","doi":"https://doi.org/10.1155/2019/9287120","mag":"2944584222","pmid":"https://pubmed.ncbi.nlm.nih.gov/31205481"},"language":"en","primary_location":{"id":"doi:10.1155/2019/9287120","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2019/9287120","pdf_url":"http://downloads.hindawi.com/journals/cmmm/2019/9287120.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://downloads.hindawi.com/journals/cmmm/2019/9287120.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100417601","display_name":"Dongmei Li","orcid":"https://orcid.org/0000-0001-9140-2483"},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medical Center","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dongmei Li","raw_affiliation_strings":["Informatics Core, Clinical and Translational Science Institute, University of Rochester Medical Center, Rochester, NY, USA"],"raw_orcid":"https://orcid.org/0000-0001-9140-2483","affiliations":[{"raw_affiliation_string":"Informatics Core, Clinical and Translational Science Institute, University of Rochester Medical Center, Rochester, NY, USA","institution_ids":["https://openalex.org/I28792581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081333357","display_name":"Jiong Wang","orcid":"https://orcid.org/0000-0002-4938-5074"},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medical Center","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiong Wang","raw_affiliation_strings":["Department of Medicine, Division of Nephrology, University of Rochester Medical Center, Rochester, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-4938-5074","affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Nephrology, University of Rochester Medical Center, Rochester, NY, USA","institution_ids":["https://openalex.org/I28792581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000752583","display_name":"Jessica Garigen","orcid":null},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medical Center","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica Garigen","raw_affiliation_strings":["Department of Medicine, Division of Nephrology, University of Rochester Medical Center, Rochester, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Nephrology, University of Rochester Medical Center, Rochester, NY, USA","institution_ids":["https://openalex.org/I28792581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083732628","display_name":"John J. Treanor","orcid":null},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medical Center","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John J. Treanor","raw_affiliation_strings":["Department of Medicine, Division of Infectious Diseases, University of Rochester Medical Center, Rochester, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Infectious Diseases, University of Rochester Medical Center, Rochester, NY, USA","institution_ids":["https://openalex.org/I28792581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076140837","display_name":"Martin S. Zand","orcid":"https://orcid.org/0000-0002-7095-8682"},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medical Center","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Martin S. Zand","raw_affiliation_strings":["Department of Medicine, Division of Nephrology, University of Rochester Medical Center, Rochester, NY, USA","Informatics Core, Clinical and Translational Science Institute, University of Rochester Medical Center, Rochester, NY, USA","Rochester Center for Health Informatics, University of Rochester Medical Center, Rochester, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-7095-8682","affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Nephrology, University of Rochester Medical Center, Rochester, NY, USA","institution_ids":["https://openalex.org/I28792581"]},{"raw_affiliation_string":"Informatics Core, Clinical and Translational Science Institute, University of Rochester Medical Center, Rochester, NY, USA","institution_ids":["https://openalex.org/I28792581"]},{"raw_affiliation_string":"Rochester Center for Health Informatics, University of Rochester Medical Center, Rochester, NY, USA","institution_ids":["https://openalex.org/I28792581"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5076140837","https://openalex.org/A5100417601"],"corresponding_institution_ids":["https://openalex.org/I28792581"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":1.5969,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.83074767,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"2019","issue":null,"first_page":"1","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.9868999719619751,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/false-discovery-rate","display_name":"False discovery rate","score":0.6712229251861572},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.5632848143577576},{"id":"https://openalex.org/keywords/titer","display_name":"Titer","score":0.5184983015060425},{"id":"https://openalex.org/keywords/sensitivity","display_name":"Sensitivity (control systems)","score":0.4741244316101074},{"id":"https://openalex.org/keywords/influenza-vaccine","display_name":"Influenza vaccine","score":0.4689728021621704},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.45363694429397583},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3568766713142395},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.35422229766845703},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.34911200404167175},{"id":"https://openalex.org/keywords/vaccination","display_name":"Vaccination","score":0.34265682101249695},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.12116965651512146},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.07302087545394897}],"concepts":[{"id":"https://openalex.org/C193244246","wikidata":"https://www.wikidata.org/wiki/Q5432696","display_name":"False discovery rate","level":3,"score":0.6712229251861572},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5632848143577576},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.5184983015060425},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.4741244316101074},{"id":"https://openalex.org/C2780689484","wikidata":"https://www.wikidata.org/wiki/Q383260","display_name":"Influenza vaccine","level":3,"score":0.4689728021621704},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45363694429397583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3568766713142395},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35422229766845703},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34911200404167175},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.34265682101249695},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.12116965651512146},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07302087545394897},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C24326235","wikidata":"https://www.wikidata.org/wiki/Q126095","display_name":"Electronic engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005189","descriptor_name":"False Positive Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D007251","descriptor_name":"Influenza, Human","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D007252","descriptor_name":"Influenza Vaccines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007252","descriptor_name":"Influenza Vaccines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007252","descriptor_name":"Influenza Vaccines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007252","descriptor_name":"Influenza Vaccines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D009500","descriptor_name":"Neutralization Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009500","descriptor_name":"Neutralization Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009500","descriptor_name":"Neutralization Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009500","descriptor_name":"Neutralization Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019267","descriptor_name":"Hemagglutinin Glycoproteins, Influenza Virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019267","descriptor_name":"Hemagglutinin Glycoproteins, Influenza Virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019267","descriptor_name":"Hemagglutinin Glycoproteins, Influenza Virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019267","descriptor_name":"Hemagglutinin Glycoproteins, Influenza Virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1155/2019/9287120","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2019/9287120","pdf_url":"http://downloads.hindawi.com/journals/cmmm/2019/9287120.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},{"id":"pmid:31205481","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31205481","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and mathematical methods in medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:52c0ffbf80d04d11abf6c6da6c734ed2","is_oa":true,"landing_page_url":"https://doaj.org/article/52c0ffbf80d04d11abf6c6da6c734ed2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computational and Mathematical Methods in Medicine, Vol 2019 (2019)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5542158","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6530215","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1155/2019/9287120","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2019/9287120","pdf_url":"http://downloads.hindawi.com/journals/cmmm/2019/9287120.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7900000214576721,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G2364539194","display_name":null,"funder_award_id":"HHSN266200700008C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3343546770","display_name":null,"funder_award_id":"UL1 TR002001","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3380008563","display_name":null,"funder_award_id":"AI069351","funder_id":"https://openalex.org/F4320310246","funder_display_name":"University of Rochester"},{"id":"https://openalex.org/G4411448324","display_name":null,"funder_award_id":"UL1 TR002001","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G625544220","display_name":null,"funder_award_id":"UL1 TR002001","funder_id":"https://openalex.org/F4320310246","funder_display_name":"University of Rochester"},{"id":"https://openalex.org/G6422398712","display_name":null,"funder_award_id":"TR002001","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G674291738","display_name":null,"funder_award_id":"TR002001","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G700200469","display_name":null,"funder_award_id":"TR002001","funder_id":"https://openalex.org/F4320310246","funder_display_name":"University of Rochester"},{"id":"https://openalex.org/G7112637443","display_name":null,"funder_award_id":"AI098112","funder_id":"https://openalex.org/F4320310246","funder_display_name":"University of Rochester"},{"id":"https://openalex.org/G7217925772","display_name":null,"funder_award_id":"R21AI138500","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7979507054","display_name":null,"funder_award_id":"AI098112","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7982150927","display_name":null,"funder_award_id":"AI069351","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G909747981","display_name":null,"funder_award_id":"R21AI138500","funder_id":"https://openalex.org/F4320310246","funder_display_name":"University of Rochester"}],"funders":[{"id":"https://openalex.org/F4320310246","display_name":"University of Rochester","ror":"https://ror.org/022kthw22"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2944584222.pdf","grobid_xml":"https://content.openalex.org/works/W2944584222.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1532337562","https://openalex.org/W1956219364","https://openalex.org/W1979158913","https://openalex.org/W1983140192","https://openalex.org/W1997343899","https://openalex.org/W2025333144","https://openalex.org/W2036236122","https://openalex.org/W2081283602","https://openalex.org/W2121361343","https://openalex.org/W2127890221","https://openalex.org/W2146512944","https://openalex.org/W2146755591","https://openalex.org/W2152617913","https://openalex.org/W2153756547","https://openalex.org/W2153923124","https://openalex.org/W2155467153","https://openalex.org/W2168274941","https://openalex.org/W2288929640","https://openalex.org/W2339080478","https://openalex.org/W2557207823","https://openalex.org/W2573825602","https://openalex.org/W2588356986","https://openalex.org/W2604646618","https://openalex.org/W2769050466","https://openalex.org/W2769745607","https://openalex.org/W2789756931","https://openalex.org/W2796989115","https://openalex.org/W3099018540","https://openalex.org/W4243315578"],"related_works":["https://openalex.org/W2389124870","https://openalex.org/W1921844237","https://openalex.org/W2168149717","https://openalex.org/W200978175","https://openalex.org/W2178204436","https://openalex.org/W2113356685","https://openalex.org/W4300887971","https://openalex.org/W4293336298","https://openalex.org/W2467227750","https://openalex.org/W2967314070"],"abstract_inverted_index":{"The":[0,143],"current":[1],"gold":[2],"standard":[3],"for":[4,42],"measuring":[5,51],"antibody-based":[6],"immunity":[7],"to":[8,31,47,128,152,173],"influenza":[9,96,111,165],"viruses":[10],"relies":[11],"on":[12],"the":[13,22,79,117,157,174,186],"hemagglutinin":[14],"inhibition":[15],"assay":[16,24],"(HAI),":[17],"an":[18,110,164],"80-year-old":[19],"technology,":[20],"and":[21,62,68,102,139,197],"microneutralization":[23],"(MN).":[25],"Both":[26],"assays":[27,133,149,191],"use":[28],"serial":[29],"dilution":[30],"provide":[32,208],"a":[33,57,135,140],"discrete,":[34,124],"ranked":[35],"readout":[36,59,125,130,190],"of":[37,50,81,119,159,163,177,194,204],"8-14":[38],"categorical":[39],"titer":[40,93],"values":[41],"each":[43],"sample.":[44],"In":[45,74],"contrast":[46],"other":[48],"methods":[49,65,214],"vaccine":[52,97,112,166],"antibody":[53],"levels":[54],"that":[55,146,202],"produce":[56],"continuous":[58,90,129],"(i.e.,":[60],"mPLEX-Flu":[61],"ELISA),":[63],"titering":[64,132,148],"introduce":[66],"imprecision":[67],"increase":[69],"false":[70],"discovery":[71],"rates":[72],"(FDR).":[73],"this":[75,195],"paper,":[76],"we":[77,181,216],"assess":[78],"degree":[80],"such":[82],"statistical":[83,137,169],"errors,":[84],"first":[85],"with":[86,92,211],"simulation":[87,187],"studies":[88],"comparing":[89],"data":[91,94,108],"in":[95,156,183,185,219],"study":[98,205],"group":[99],"comparison":[100,158],"analyses":[101],"then":[103],"by":[104],"analyzing":[105],"actual":[106],"sample":[107],"from":[109],"trial.":[113,167],"Our":[114],"results":[115,144,210],"show":[116],"superiority":[118],"using":[120],"continuous,":[121],"rather":[122],"than":[123],"assays.":[126],"Compared":[127],"assays,":[131,179],"have":[134,217],"lower":[136],"precision":[138],"higher":[141],"FDR.":[142],"suggested":[145],"traditional":[147],"could":[150,207],"lead":[151],"increased":[153],"Type-II":[154],"errors":[155],"different":[160,209],"therapeutic":[161],"arms":[162],"These":[168],"issues":[170],"are":[171,192],"related":[172],"mathematical":[175],"nature":[176],"titer-based":[178],"which":[180],"examine":[182],"detail":[184],"studies.":[188],"Continuous":[189],"free":[193],"issue,":[196],"thus":[198],"it":[199],"is":[200],"possible":[201],"comparisons":[203],"groups":[206],"these":[212],"two":[213],"as":[215],"shown":[218],"our":[220],"case":[221],"study.":[222]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
