{"id":"https://openalex.org/W2907402578","doi":"https://doi.org/10.1155/2019/9079104","title":"Dynamic Modeling of the Angiogenic Switch and Its Inhibition by Bevacizumab","display_name":"Dynamic Modeling of the Angiogenic Switch and Its Inhibition by Bevacizumab","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2907402578","doi":"https://doi.org/10.1155/2019/9079104","mag":"2907402578"},"language":"en","primary_location":{"id":"doi:10.1155/2019/9079104","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2019/9079104","pdf_url":"https://downloads.hindawi.com/journals/complexity/2019/9079104.pdf","source":{"id":"https://openalex.org/S207319443","display_name":"Complexity","issn_l":"1076-2787","issn":["1076-2787","1099-0526"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Complexity","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://downloads.hindawi.com/journals/complexity/2019/9079104.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071839699","display_name":"D\u00e1vid Csercsik","orcid":"https://orcid.org/0000-0002-5917-1352"},"institutions":[{"id":"https://openalex.org/I103356709","display_name":"Obuda University","ror":"https://ror.org/00ax71d21","country_code":"HU","type":"education","lineage":["https://openalex.org/I103356709"]},{"id":"https://openalex.org/I31882830","display_name":"P\u00e1zm\u00e1ny P\u00e9ter Catholic University","ror":"https://ror.org/05v9kya57","country_code":"HU","type":"education","lineage":["https://openalex.org/I31882830"]}],"countries":["HU"],"is_corresponding":true,"raw_author_name":"D\u00e1vid Csercsik","raw_affiliation_strings":["Physiological Controls Research Center, University Research, Innovation and Service Center, buda University, Budapest, Hungary","Pzmny Pter Catholic University, Faculty of Information Technology and Bionics, P.O. Box 278, 1444 Budapest, Hungary","Physiological Controls Research Center, University Research, Innovation and Service Center, \u00d3buda University, Budapest","P\u00e1zm\u00e1ny P\u00e9ter Catholic University, Faculty of Information Technology and Bionics, P.O. Box 278, 1444 Budapest"],"raw_orcid":"https://orcid.org/0000-0002-5917-1352","affiliations":[{"raw_affiliation_string":"Physiological Controls Research Center, University Research, Innovation and Service Center, buda University, Budapest, Hungary","institution_ids":["https://openalex.org/I103356709"]},{"raw_affiliation_string":"Pzmny Pter Catholic University, Faculty of Information Technology and Bionics, P.O. Box 278, 1444 Budapest, Hungary","institution_ids":["https://openalex.org/I31882830"]},{"raw_affiliation_string":"Physiological Controls Research Center, University Research, Innovation and Service Center, \u00d3buda University, Budapest","institution_ids":["https://openalex.org/I103356709"]},{"raw_affiliation_string":"P\u00e1zm\u00e1ny P\u00e9ter Catholic University, Faculty of Information Technology and Bionics, P.O. Box 278, 1444 Budapest","institution_ids":["https://openalex.org/I31882830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021051122","display_name":"Levente Kov\u00e1cs","orcid":"https://orcid.org/0000-0002-3188-0800"},"institutions":[{"id":"https://openalex.org/I103356709","display_name":"Obuda University","ror":"https://ror.org/00ax71d21","country_code":"HU","type":"education","lineage":["https://openalex.org/I103356709"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Levente Kov\u00e1cs","raw_affiliation_strings":["Physiological Controls Research Center, University Research, Innovation and Service Center, \u00d3buda University, Budapest"],"raw_orcid":"https://orcid.org/0000-0002-3188-0800","affiliations":[{"raw_affiliation_string":"Physiological Controls Research Center, University Research, Innovation and Service Center, \u00d3buda University, Budapest","institution_ids":["https://openalex.org/I103356709"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5071839699"],"corresponding_institution_ids":["https://openalex.org/I103356709","https://openalex.org/I31882830"],"apc_list":{"value":2300,"currency":"USD","value_usd":2300},"apc_paid":{"value":2300,"currency":"USD","value_usd":2300},"fwci":1.0226,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.74197512,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"2019","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bevacizumab","display_name":"Bevacizumab","score":0.7760062217712402},{"id":"https://openalex.org/keywords/vascular-tumor","display_name":"Vascular tumor","score":0.558621883392334},{"id":"https://openalex.org/keywords/simple","display_name":"Simple (philosophy)","score":0.5459770560264587},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5012814998626709},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.47723010182380676},{"id":"https://openalex.org/keywords/cytotoxic-t-cell","display_name":"Cytotoxic T cell","score":0.4605625569820404},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"Angiogenesis","score":0.4528525471687317},{"id":"https://openalex.org/keywords/extension","display_name":"Extension (predicate logic)","score":0.43901512026786804},{"id":"https://openalex.org/keywords/tumor-cells","display_name":"Tumor cells","score":0.42901816964149475},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.3176455497741699},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.24538597464561462},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22055187821388245},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.16128090023994446},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.12995252013206482},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.11941364407539368},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.08221209049224854},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.0727967917919159}],"concepts":[{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.7760062217712402},{"id":"https://openalex.org/C2991707464","wikidata":"https://www.wikidata.org/wiki/Q25422732","display_name":"Vascular tumor","level":2,"score":0.558621883392334},{"id":"https://openalex.org/C2780586882","wikidata":"https://www.wikidata.org/wiki/Q7520643","display_name":"Simple (philosophy)","level":2,"score":0.5459770560264587},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5012814998626709},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.47723010182380676},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.4605625569820404},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.4528525471687317},{"id":"https://openalex.org/C2778029271","wikidata":"https://www.wikidata.org/wiki/Q5421931","display_name":"Extension (predicate logic)","level":2,"score":0.43901512026786804},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.42901816964149475},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3176455497741699},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24538597464561462},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22055187821388245},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16128090023994446},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.12995252013206482},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11941364407539368},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08221209049224854},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0727967917919159},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1155/2019/9079104","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2019/9079104","pdf_url":"https://downloads.hindawi.com/journals/complexity/2019/9079104.pdf","source":{"id":"https://openalex.org/S207319443","display_name":"Complexity","issn_l":"1076-2787","issn":["1076-2787","1099-0526"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Complexity","raw_type":"journal-article"},{"id":"pmh:oai:real.mtak.hu:91434","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306400081","display_name":"Repository of the Academy's Library (Library of the Hungarian Academy of Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210140733","host_organization_name":"Library and Information Centre of the Hungarian Academy of Sciences","host_organization_lineage":["https://openalex.org/I4210140733"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:RePEc:hin:complx:9079104","is_oa":false,"landing_page_url":"http://downloads.hindawi.com/journals/8503/2019/9079104.xml","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:2524683d294f4557a77f405804235f91","is_oa":true,"landing_page_url":"https://doaj.org/article/2524683d294f4557a77f405804235f91","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Complexity, Vol 2019 (2019)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2019/9079104","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2019/9079104","pdf_url":"https://downloads.hindawi.com/journals/complexity/2019/9079104.pdf","source":{"id":"https://openalex.org/S207319443","display_name":"Complexity","issn_l":"1076-2787","issn":["1076-2787","1099-0526"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Complexity","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7400000095367432,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1352750399","display_name":"Personalized Cancer Therapy by Model-based Optimal Robust Control Algorithm","funder_award_id":"679681","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"},{"id":"https://openalex.org/G3039771339","display_name":"Personalized Cancer Therapy by Model-based Optimal Robust Control Algorithm","funder_award_id":"679681","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2907402578.pdf","grobid_xml":"https://content.openalex.org/works/W2907402578.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W7317053","https://openalex.org/W47680732","https://openalex.org/W65153156","https://openalex.org/W96301413","https://openalex.org/W602693067","https://openalex.org/W626649172","https://openalex.org/W1588998206","https://openalex.org/W1598145845","https://openalex.org/W1603230122","https://openalex.org/W1964615735","https://openalex.org/W1972414315","https://openalex.org/W1980681154","https://openalex.org/W1985804036","https://openalex.org/W1992560794","https://openalex.org/W1997585819","https://openalex.org/W2000292756","https://openalex.org/W2000791857","https://openalex.org/W2001273174","https://openalex.org/W2020160984","https://openalex.org/W2021587795","https://openalex.org/W2022451981","https://openalex.org/W2026691590","https://openalex.org/W2030524855","https://openalex.org/W2030892741","https://openalex.org/W2033783472","https://openalex.org/W2050499474","https://openalex.org/W2056392188","https://openalex.org/W2068072750","https://openalex.org/W2074952300","https://openalex.org/W2081440473","https://openalex.org/W2081633887","https://openalex.org/W2088383307","https://openalex.org/W2089901886","https://openalex.org/W2109175747","https://openalex.org/W2109962618","https://openalex.org/W2121929569","https://openalex.org/W2122746292","https://openalex.org/W2122752792","https://openalex.org/W2122913894","https://openalex.org/W2129331774","https://openalex.org/W2130149982","https://openalex.org/W2139098221","https://openalex.org/W2157520030","https://openalex.org/W2161590805","https://openalex.org/W2296094736","https://openalex.org/W2313083023","https://openalex.org/W2405101378","https://openalex.org/W2488890990","https://openalex.org/W2586479532","https://openalex.org/W2597548790","https://openalex.org/W2607436811","https://openalex.org/W2619490433","https://openalex.org/W2768806839","https://openalex.org/W2772955743","https://openalex.org/W2782661788","https://openalex.org/W2784168042","https://openalex.org/W2898962282","https://openalex.org/W4205660969","https://openalex.org/W4210796035","https://openalex.org/W4250428608","https://openalex.org/W6600308229"],"related_works":["https://openalex.org/W3142026086","https://openalex.org/W2028827184","https://openalex.org/W2146312028","https://openalex.org/W2767564966","https://openalex.org/W1983068147","https://openalex.org/W3146277049","https://openalex.org/W3209693064","https://openalex.org/W4246588393","https://openalex.org/W4200337742","https://openalex.org/W4405329451"],"abstract_inverted_index":{"We":[0,43],"formulate":[1],"a":[2,72],"dynamic":[3],"model":[4,22,46,59,77],"of":[5,13,30,75,80],"vascular":[6,14],"tumor":[7,17],"growth,":[8],"in":[9,89],"which":[10],"the":[11,24,28,31,45,58,76],"interdependence":[12],"dynamics":[15],"with":[16],"volume":[18,48],"is":[19,78],"considered.":[20],"The":[21],"describes":[23],"angiogenic":[25],"switch;":[26],"thus":[27],"inhibition":[29],"vascularization":[32],"process":[33],"by":[34],"antiangiogenic":[35,84],"drugs":[36,85],"may":[37],"be":[38],"taken":[39],"into":[40],"account":[41],"explicitly.":[42],"validate":[44],"against":[47],"measurement":[49],"data":[50],"originating":[51],"from":[52],"experiments":[53],"on":[54],"mice":[55],"and":[56,83],"analyze":[57],"behavior":[60],"assuming":[61],"different":[62,66,91],"inputs":[63,87],"corresponding":[64],"to":[65],"therapies.":[67],"Furthermore,":[68],"we":[69],"show":[70],"that":[71],"simple":[73],"extension":[74],"capable":[79],"considering":[81],"cytotoxic":[82],"as":[86],"simultaneously":[88],"qualitatively":[90],"ways.":[92]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4}],"updated_date":"2026-06-27T08:28:00.272161","created_date":"2025-10-10T00:00:00"}
