{"id":"https://openalex.org/W2954292398","doi":"https://doi.org/10.1155/2019/6912914","title":"<i>In Silico</i>Screening of Aptamers Configuration against Hepatitis B Surface Antigen","display_name":"<i>In Silico</i>Screening of Aptamers Configuration against Hepatitis B Surface Antigen","publication_year":2019,"publication_date":"2019-06-26","ids":{"openalex":"https://openalex.org/W2954292398","doi":"https://doi.org/10.1155/2019/6912914","mag":"2954292398","pmid":"https://pubmed.ncbi.nlm.nih.gov/31346332"},"language":"en","primary_location":{"id":"doi:10.1155/2019/6912914","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2019/6912914","pdf_url":"https://downloads.hindawi.com/archive/2019/6912914.pdf","source":{"id":"https://openalex.org/S146125958","display_name":"Advances in Bioinformatics","issn_l":"1687-8027","issn":["1687-8027","1687-8035"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/archive/2019/6912914.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004258831","display_name":"Mohamad Zulkeflee Sabri","orcid":"https://orcid.org/0000-0002-1005-5043"},"institutions":[{"id":"https://openalex.org/I4528857","display_name":"University of Kuala Lumpur","ror":"https://ror.org/026wwrx19","country_code":"MY","type":"education","lineage":["https://openalex.org/I4528857"]}],"countries":["MY"],"is_corresponding":true,"raw_author_name":"Mohamad Zulkeflee Sabri","raw_affiliation_strings":["Bioengineering Section, Universiti Kuala Lumpur Malaysian Institute of Chemical and Bioengineering Technology (UniKL MICET), Lot 1988, Bandar Vendor Taboh Naning, 78000 Alor Gajah, Melaka, Malaysia"],"raw_orcid":"https://orcid.org/0000-0002-1005-5043","affiliations":[{"raw_affiliation_string":"Bioengineering Section, Universiti Kuala Lumpur Malaysian Institute of Chemical and Bioengineering Technology (UniKL MICET), Lot 1988, Bandar Vendor Taboh Naning, 78000 Alor Gajah, Melaka, Malaysia","institution_ids":["https://openalex.org/I4528857"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001585387","display_name":"Azzmer Azzar Abdul Hamid","orcid":"https://orcid.org/0000-0003-2404-6890"},"institutions":[{"id":"https://openalex.org/I4164984","display_name":"International Islamic University Malaysia","ror":"https://ror.org/03s9hs139","country_code":"MY","type":"education","lineage":["https://openalex.org/I4164984"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Azzmer Azzar Abdul Hamid","raw_affiliation_strings":["Department of Biotechnology, Kulliyyah of Science, International Islamic University Malaysia (IIUM), Bandar Indera Mahkota, 25200 Kuantan, Pahang, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Kulliyyah of Science, International Islamic University Malaysia (IIUM), Bandar Indera Mahkota, 25200 Kuantan, Pahang, Malaysia","institution_ids":["https://openalex.org/I4164984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057489973","display_name":"Sharifah Mariam Sayed Hitam","orcid":null},"institutions":[{"id":"https://openalex.org/I4528857","display_name":"University of Kuala Lumpur","ror":"https://ror.org/026wwrx19","country_code":"MY","type":"education","lineage":["https://openalex.org/I4528857"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Sharifah Mariam Sayed Hitam","raw_affiliation_strings":["Bioengineering Section, Universiti Kuala Lumpur Malaysian Institute of Chemical and Bioengineering Technology (UniKL MICET), Lot 1988, Bandar Vendor Taboh Naning, 78000 Alor Gajah, Melaka, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioengineering Section, Universiti Kuala Lumpur Malaysian Institute of Chemical and Bioengineering Technology (UniKL MICET), Lot 1988, Bandar Vendor Taboh Naning, 78000 Alor Gajah, Melaka, Malaysia","institution_ids":["https://openalex.org/I4528857"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051488830","display_name":"Mohd Zulkhairi Abdul Rahim","orcid":"https://orcid.org/0000-0002-8692-8277"},"institutions":[{"id":"https://openalex.org/I4528857","display_name":"University of Kuala Lumpur","ror":"https://ror.org/026wwrx19","country_code":"MY","type":"education","lineage":["https://openalex.org/I4528857"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Mohd. Zulkhairi Abdul Rahim","raw_affiliation_strings":["Technical Foundation Section, Universiti Kuala Lumpur Malaysian Institute of Chemical and Bioengineering Technology (UniKL MICET), Lot 1988, Bandar Vendor Taboh Naning, 78000 Alor Gajah, Melaka, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technical Foundation Section, Universiti Kuala Lumpur Malaysian Institute of Chemical and Bioengineering Technology (UniKL MICET), Lot 1988, Bandar Vendor Taboh Naning, 78000 Alor Gajah, Melaka, Malaysia","institution_ids":["https://openalex.org/I4528857"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5004258831"],"corresponding_institution_ids":["https://openalex.org/I4528857"],"apc_list":null,"apc_paid":null,"fwci":1.7095,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.8481282,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"2019","issue":null,"first_page":"1","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aptamer","display_name":"Aptamer","score":0.9851537942886353},{"id":"https://openalex.org/keywords/hbsag","display_name":"HBsAg","score":0.6859371066093445},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.6746214032173157},{"id":"https://openalex.org/keywords/systematic-evolution-of-ligands-by-exponential-enrichment","display_name":"Systematic evolution of ligands by exponential enrichment","score":0.5943873524665833},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.46186524629592896},{"id":"https://openalex.org/keywords/molecular-mechanics","display_name":"Molecular mechanics","score":0.43396297097206116},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3569062054157257},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.3515715003013611},{"id":"https://openalex.org/keywords/combinatorial-chemistry","display_name":"Combinatorial chemistry","score":0.3228338360786438},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.25080883502960205},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.23611611127853394},{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"Hepatitis B virus","score":0.20574232935905457},{"id":"https://openalex.org/keywords/molecular-biology","display_name":"Molecular biology","score":0.19768407940864563},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.17656022310256958},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.12723666429519653},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.08998352289199829}],"concepts":[{"id":"https://openalex.org/C128972844","wikidata":"https://www.wikidata.org/wiki/Q418722","display_name":"Aptamer","level":2,"score":0.9851537942886353},{"id":"https://openalex.org/C2777410769","wikidata":"https://www.wikidata.org/wiki/Q2282887","display_name":"HBsAg","level":4,"score":0.6859371066093445},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6746214032173157},{"id":"https://openalex.org/C122682173","wikidata":"https://www.wikidata.org/wiki/Q907101","display_name":"Systematic evolution of ligands by exponential enrichment","level":4,"score":0.5943873524665833},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46186524629592896},{"id":"https://openalex.org/C25057246","wikidata":"https://www.wikidata.org/wiki/Q1344441","display_name":"Molecular mechanics","level":3,"score":0.43396297097206116},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3569062054157257},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.3515715003013611},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3228338360786438},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25080883502960205},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23611611127853394},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.20574232935905457},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.19768407940864563},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.17656022310256958},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.12723666429519653},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.08998352289199829},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1155/2019/6912914","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2019/6912914","pdf_url":"https://downloads.hindawi.com/archive/2019/6912914.pdf","source":{"id":"https://openalex.org/S146125958","display_name":"Advances in Bioinformatics","issn_l":"1687-8027","issn":["1687-8027","1687-8035"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:31346332","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31346332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in bioinformatics","raw_type":null},{"id":"pmh:oai:generic.eprints.org:73863","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306400713","display_name":"The International Islamic University Malaysia Repository (The International Islamic University Malaysia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4164984","host_organization_name":"International Islamic University Malaysia","host_organization_lineage":["https://openalex.org/I4164984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"pmh:oai:doaj.org/article:628162a3647b43649dd00710331c30a2","is_oa":false,"landing_page_url":"https://doaj.org/article/628162a3647b43649dd00710331c30a2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Advances in Bioinformatics, Vol 2019 (2019)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5604313","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6617924","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1155/2019/6912914","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2019/6912914","pdf_url":"https://downloads.hindawi.com/archive/2019/6912914.pdf","source":{"id":"https://openalex.org/S146125958","display_name":"Advances in Bioinformatics","issn_l":"1687-8027","issn":["1687-8027","1687-8035"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323757","display_name":"University of Kuala Lumpur","ror":"https://ror.org/026wwrx19"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2954292398.pdf","grobid_xml":"https://content.openalex.org/works/W2954292398.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1962510714","https://openalex.org/W1966078827","https://openalex.org/W1975580333","https://openalex.org/W1982140052","https://openalex.org/W1986191025","https://openalex.org/W1987134040","https://openalex.org/W1992192767","https://openalex.org/W1996075279","https://openalex.org/W2004210936","https://openalex.org/W2007135643","https://openalex.org/W2036910435","https://openalex.org/W2044172327","https://openalex.org/W2051580523","https://openalex.org/W2055359274","https://openalex.org/W2056215929","https://openalex.org/W2060079863","https://openalex.org/W2070753604","https://openalex.org/W2071995736","https://openalex.org/W2075369230","https://openalex.org/W2119803195","https://openalex.org/W2133777396","https://openalex.org/W2134967712","https://openalex.org/W2141157874","https://openalex.org/W2143871350","https://openalex.org/W2144574197","https://openalex.org/W2147283902","https://openalex.org/W2148893085","https://openalex.org/W2150040556","https://openalex.org/W2152301430","https://openalex.org/W2168630917","https://openalex.org/W2336040088","https://openalex.org/W2417008923","https://openalex.org/W2521640490","https://openalex.org/W2606133359","https://openalex.org/W2783351753","https://openalex.org/W2807416178"],"related_works":["https://openalex.org/W4313237059","https://openalex.org/W2146864995","https://openalex.org/W2077323385","https://openalex.org/W2392306680","https://openalex.org/W2918405227","https://openalex.org/W2095052940","https://openalex.org/W3093450845","https://openalex.org/W4283324873","https://openalex.org/W3108749156","https://openalex.org/W4304099287"],"abstract_inverted_index":{"Aptamer":[0],"has":[1],"been":[2],"long":[3],"studied":[4,85],"as":[5,144],"a":[6],"substitute":[7],"of":[8,19,48,56,155],"antibodies":[9],"for":[10,45,181],"many":[11],"purposes.":[12],"However,":[13],"due":[14],"to":[15],"the":[16,20,36,57,116,121,131,145,171,178],"exceeded":[17],"length":[18,58,180],"aptamers":[21,46,65,77,106,141,175],"obtained":[22,60],"in":[23,28,164,173],"vitro":[24,174],",":[25],"difficulties":[26],"arise":[27],"its":[29,32,182],"manipulation":[30],"during":[31],"molecular":[33,87,89],"conjugation":[34],"on":[35,42,108],"matrix":[37],"surfaces.":[38],"Current":[39,167],"study":[40,168],"focuses":[41],"computational":[43,153],"improvement":[44],"screening":[47],"hepatitis":[49],"B":[50],"surface":[51],"antigen":[52],"(HBsAg)":[53],"through":[54,161],"optimization":[55],"sequences":[59],"from":[61],"SELEX.":[62],"Three":[63],"original":[64],"with":[66,130,138],"affinity":[67,80],"against":[68,81],"HBsAg":[69,82,109],"were":[70,142],"truncated":[71,105],"into":[72],"five":[73,140],"short":[74],"hairpin":[75],"structured":[76],"and":[78,93,125,149],"their":[79],"was":[83],"thoroughly":[84],"by":[86,115,176],"docking,":[88],"dynamics":[90],"(MD)":[91],"simulation,":[92],"Molecular":[94],"Mechanics":[95],"Poisson-Boltzmann":[96],"Surface":[97],"Area":[98],"(MMPBSA)":[99],"method.":[100],"The":[101,152],"result":[102],"shows":[103],"that":[104],"binding":[107,123,147,157],"\u201ca\u201d":[110],"determinant":[111],"region":[112],"are":[113],"stabilized":[114],"dynamic":[117],"H-bond":[118],"formation":[119],"between":[120],"active":[122,146],"residues":[124,129,148],"nucleotides.":[126],"Amino":[127],"acids":[128],"highest":[132],"hydrogen":[133,135],"bonds":[134],"bond":[136],"interactions":[137],"all":[139],"determined":[143],"further":[150],"characterized.":[151],"prediction":[154],"complexes":[156],"will":[158,169],"include":[159],"validations":[160],"experimental":[162],"assays":[163],"future":[165],"studies.":[166],"improve":[170],"current":[172],"minimizing":[177],"aptamer":[179],"easy":[183],"manipulation.":[184]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":4}],"updated_date":"2026-05-16T08:24:45.110214","created_date":"2025-10-10T00:00:00"}
