{"id":"https://openalex.org/W2922568594","doi":"https://doi.org/10.1155/2019/1035974","title":"Reachability Analysis of Low\u2010Order Discrete State Reaction Networks Obeying Conservation Laws","display_name":"Reachability Analysis of Low\u2010Order Discrete State Reaction Networks Obeying Conservation Laws","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2922568594","doi":"https://doi.org/10.1155/2019/1035974","mag":"2922568594"},"language":"en","primary_location":{"id":"doi:10.1155/2019/1035974","is_oa":true,"landing_page_url":"http://doi.org/10.1155/2019/1035974","pdf_url":"https://downloads.hindawi.com/journals/complexity/2019/1035974.pdf","source":{"id":"https://openalex.org/S207319443","display_name":"Complexity","issn_l":"1076-2787","issn":["1076-2787","1099-0526"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Complexity","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://downloads.hindawi.com/journals/complexity/2019/1035974.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068998099","display_name":"Gergely Szlobodnyik","orcid":"https://orcid.org/0000-0003-2825-0645"},"institutions":[{"id":"https://openalex.org/I31882830","display_name":"P\u00e1zm\u00e1ny P\u00e9ter Catholic University","ror":"https://ror.org/05v9kya57","country_code":"HU","type":"education","lineage":["https://openalex.org/I31882830"]}],"countries":["HU"],"is_corresponding":true,"raw_author_name":"Gergely Szlobodnyik","raw_affiliation_strings":["Faculty of Information Technology and Bionics, Pzmny Pter Catholic University, Prter u. 50/a, H-1083 Budapest, Hungary","Faculty of Information Technology and Bionics, P\u00e1zm\u00e1ny P\u00e9ter Catholic University, Pr\u00e1ter u. 50/a, H-1083 Budapest"],"affiliations":[{"raw_affiliation_string":"Faculty of Information Technology and Bionics, Pzmny Pter Catholic University, Prter u. 50/a, H-1083 Budapest, Hungary","institution_ids":["https://openalex.org/I31882830"]},{"raw_affiliation_string":"Faculty of Information Technology and Bionics, P\u00e1zm\u00e1ny P\u00e9ter Catholic University, Pr\u00e1ter u. 50/a, H-1083 Budapest","institution_ids":["https://openalex.org/I31882830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048317569","display_name":"G\u00e1bor Szederk\u00e9nyi","orcid":"https://orcid.org/0000-0003-4199-6089"},"institutions":[{"id":"https://openalex.org/I31882830","display_name":"P\u00e1zm\u00e1ny P\u00e9ter Catholic University","ror":"https://ror.org/05v9kya57","country_code":"HU","type":"education","lineage":["https://openalex.org/I31882830"]},{"id":"https://openalex.org/I4210117195","display_name":"Institute for Computer Science and Control","ror":"https://ror.org/0249v7n71","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4210117195","https://openalex.org/I7597260"]},{"id":"https://openalex.org/I7597260","display_name":"Hungarian Academy of Sciences","ror":"https://ror.org/02ks8qq67","country_code":"HU","type":"government","lineage":["https://openalex.org/I7597260"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"G\u00e1bor Szederk\u00e9nyi","raw_affiliation_strings":["Faculty of Information Technology and Bionics, P\u00e1zm\u00e1ny P\u00e9ter Catholic University, Pr\u00e1ter u. 50/a, H-1083 Budapest","Systems and Control Laboratory, Institute for Computer Science and Control (MTA SZTAKI) of the Hungarian Academy of Sciences, Kende u. 13-17, H-1111 Budapest"],"affiliations":[{"raw_affiliation_string":"Faculty of Information Technology and Bionics, P\u00e1zm\u00e1ny P\u00e9ter Catholic University, Pr\u00e1ter u. 50/a, H-1083 Budapest","institution_ids":["https://openalex.org/I31882830"]},{"raw_affiliation_string":"Systems and Control Laboratory, Institute for Computer Science and Control (MTA SZTAKI) of the Hungarian Academy of Sciences, Kende u. 13-17, H-1111 Budapest","institution_ids":["https://openalex.org/I4210117195","https://openalex.org/I7597260"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5068998099"],"corresponding_institution_ids":["https://openalex.org/I31882830"],"apc_list":{"value":2300,"currency":"USD","value_usd":2300},"apc_paid":{"value":2300,"currency":"USD","value_usd":2300},"fwci":0.0859,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.45887965,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"2019","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10409","display_name":"Fuel Cells and Related Materials","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reachability","display_name":"Reachability","score":0.9472965002059937},{"id":"https://openalex.org/keywords/bounded-function","display_name":"Bounded function","score":0.689470648765564},{"id":"https://openalex.org/keywords/reachability-problem","display_name":"Reachability problem","score":0.6512929201126099},{"id":"https://openalex.org/keywords/state","display_name":"State (computer science)","score":0.5865813493728638},{"id":"https://openalex.org/keywords/integer","display_name":"Integer (computer science)","score":0.5495681166648865},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.519585132598877},{"id":"https://openalex.org/keywords/integer-programming","display_name":"Integer programming","score":0.48444464802742004},{"id":"https://openalex.org/keywords/state-space","display_name":"State space","score":0.42088595032691956},{"id":"https://openalex.org/keywords/discrete-mathematics","display_name":"Discrete mathematics","score":0.3523469567298889},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3387511968612671},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.2670862078666687},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.25389766693115234},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.09708088636398315},{"id":"https://openalex.org/keywords/mathematical-analysis","display_name":"Mathematical analysis","score":0.07348832488059998}],"concepts":[{"id":"https://openalex.org/C136643341","wikidata":"https://www.wikidata.org/wiki/Q1361526","display_name":"Reachability","level":2,"score":0.9472965002059937},{"id":"https://openalex.org/C34388435","wikidata":"https://www.wikidata.org/wiki/Q2267362","display_name":"Bounded function","level":2,"score":0.689470648765564},{"id":"https://openalex.org/C2777669093","wikidata":"https://www.wikidata.org/wiki/Q17141570","display_name":"Reachability problem","level":3,"score":0.6512929201126099},{"id":"https://openalex.org/C48103436","wikidata":"https://www.wikidata.org/wiki/Q599031","display_name":"State (computer science)","level":2,"score":0.5865813493728638},{"id":"https://openalex.org/C97137487","wikidata":"https://www.wikidata.org/wiki/Q729138","display_name":"Integer (computer science)","level":2,"score":0.5495681166648865},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.519585132598877},{"id":"https://openalex.org/C56086750","wikidata":"https://www.wikidata.org/wiki/Q6042592","display_name":"Integer programming","level":2,"score":0.48444464802742004},{"id":"https://openalex.org/C72434380","wikidata":"https://www.wikidata.org/wiki/Q230930","display_name":"State space","level":2,"score":0.42088595032691956},{"id":"https://openalex.org/C118615104","wikidata":"https://www.wikidata.org/wiki/Q121416","display_name":"Discrete mathematics","level":1,"score":0.3523469567298889},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3387511968612671},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.2670862078666687},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.25389766693115234},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.09708088636398315},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.07348832488059998},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1155/2019/1035974","is_oa":true,"landing_page_url":"http://doi.org/10.1155/2019/1035974","pdf_url":"https://downloads.hindawi.com/journals/complexity/2019/1035974.pdf","source":{"id":"https://openalex.org/S207319443","display_name":"Complexity","issn_l":"1076-2787","issn":["1076-2787","1099-0526"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Complexity","raw_type":"journal-article"},{"id":"pmh:oai:RePEc:hin:complx:1035974","is_oa":false,"landing_page_url":"http://downloads.hindawi.com/journals/8503/2019/1035974.xml","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:15f967b0f243441682cc34b8520edd99","is_oa":true,"landing_page_url":"https://doaj.org/article/15f967b0f243441682cc34b8520edd99","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Complexity, Vol 2019 (2019)","raw_type":"article"},{"id":"pmh:oai:eprints.sztaki.hu:9668","is_oa":false,"landing_page_url":"http://eprints.sztaki.hu/9668/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401907","display_name":"SZTAKI Publication Repository (Hungarian Academy of Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I7597260","host_organization_name":"Hungarian Academy of Sciences","host_organization_lineage":["https://openalex.org/I7597260"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:hindawi.com:10.1155/2019/1035974","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2019/1035974","pdf_url":null,"source":{"id":"https://openalex.org/S4306400340","display_name":"Hindawi Journal of Chemistry (Hindawi)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210126990","host_organization_name":"Hindawi (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210126990"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Research Article"}],"best_oa_location":{"id":"doi:10.1155/2019/1035974","is_oa":true,"landing_page_url":"http://doi.org/10.1155/2019/1035974","pdf_url":"https://downloads.hindawi.com/journals/complexity/2019/1035974.pdf","source":{"id":"https://openalex.org/S207319443","display_name":"Complexity","issn_l":"1076-2787","issn":["1076-2787","1099-0526"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Complexity","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.75}],"awards":[{"id":"https://openalex.org/G1234428117","display_name":null,"funder_award_id":"EFOP-3.6.3-VEKOP-16-2017-00002","funder_id":"https://openalex.org/F4320326762","funder_display_name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal"},{"id":"https://openalex.org/G1748000517","display_name":null,"funder_award_id":"NKFIH","funder_id":"https://openalex.org/F4320336675","funder_display_name":"National Research, Development and Innovation Office"},{"id":"https://openalex.org/G2715829889","display_name":null,"funder_award_id":"125739","funder_id":"https://openalex.org/F4320326762","funder_display_name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal"},{"id":"https://openalex.org/G3011850684","display_name":null,"funder_award_id":"EFOP-3.6.3-VEKOP-16-2017-00002","funder_id":"https://openalex.org/F4320338080","funder_display_name":"European Social Fund"},{"id":"https://openalex.org/G3718615213","display_name":null,"funder_award_id":"\u00daNKP-18-3","funder_id":"https://openalex.org/F4320326762","funder_display_name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal"},{"id":"https://openalex.org/G3998201246","display_name":null,"funder_award_id":"Social","funder_id":"https://openalex.org/F4320338080","funder_display_name":"European Social Fund"},{"id":"https://openalex.org/G4693063966","display_name":null,"funder_award_id":"EFOP-3","funder_id":"https://openalex.org/F4320338080","funder_display_name":"European Social Fund"},{"id":"https://openalex.org/G5374134968","display_name":null,"funder_award_id":"European Social Fund","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6551428496","display_name":null,"funder_award_id":"00002","funder_id":"https://openalex.org/F4320338080","funder_display_name":"European Social Fund"},{"id":"https://openalex.org/G7101391507","display_name":null,"funder_award_id":"EFOP-3.6.3-VEKOP-16","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8725523790","display_name":null,"funder_award_id":"EFOP-3.6.3-VEKOP-16","funder_id":"https://openalex.org/F4320338080","funder_display_name":"European Social Fund"},{"id":"https://openalex.org/G972092959","display_name":null,"funder_award_id":"EFOP-3.6.3-VEKOP-16-2017-00002","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320326762","display_name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","ror":null},{"id":"https://openalex.org/F4320336675","display_name":"National Research, Development and Innovation Office","ror":null},{"id":"https://openalex.org/F4320338080","display_name":"European Social Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2922568594.pdf","grobid_xml":"https://content.openalex.org/works/W2922568594.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W172803389","https://openalex.org/W201532216","https://openalex.org/W562988859","https://openalex.org/W897674100","https://openalex.org/W1545252802","https://openalex.org/W1621944155","https://openalex.org/W1638844320","https://openalex.org/W1965692670","https://openalex.org/W1967723742","https://openalex.org/W1976443948","https://openalex.org/W1981296835","https://openalex.org/W1996109622","https://openalex.org/W2010265885","https://openalex.org/W2011495892","https://openalex.org/W2016440384","https://openalex.org/W2033084216","https://openalex.org/W2033711351","https://openalex.org/W2044760528","https://openalex.org/W2100440346","https://openalex.org/W2114616381","https://openalex.org/W2129740858","https://openalex.org/W2131241947","https://openalex.org/W2136336342","https://openalex.org/W2145387969","https://openalex.org/W2147543317","https://openalex.org/W2160273855","https://openalex.org/W2171280873","https://openalex.org/W2276916781","https://openalex.org/W2501206750","https://openalex.org/W2573359569","https://openalex.org/W2611053392","https://openalex.org/W2737500437","https://openalex.org/W2762468599","https://openalex.org/W2805468500","https://openalex.org/W3099885922","https://openalex.org/W3125224867"],"related_works":["https://openalex.org/W4253760428","https://openalex.org/W2047831585","https://openalex.org/W3208672221","https://openalex.org/W3017277461","https://openalex.org/W4287199681","https://openalex.org/W3172202899","https://openalex.org/W4224983736","https://openalex.org/W2060144422","https://openalex.org/W2011495892","https://openalex.org/W4389158950"],"abstract_inverted_index":{"In":[0],"this":[1,116],"paper":[2],"we":[3],"study":[4],"the":[5,49,71,81,86,91,103,110,118,132,138,148,154,167],"reachability":[6,39,50,92,119,139],"problem":[7,40,120],"of":[8,32,41,51,59,94,105,109,134,150,156,164],"sub\u2010":[9,95],"and":[10,66,88,96,152,158],"superconservative":[11,34,42,97],"discrete":[12],"state":[13,28,113],"chemical":[14],"reaction":[15,43,98],"networks":[16,44,99],"(d\u2010CRNs).":[17],"It":[18],"is":[19,36,45,121],"known":[20],"that":[21,31],"a":[22,33,76],"subconservative":[23,52],"network":[24,56],"has":[25],"bounded":[26],"reachable":[27],"space,":[29],"while":[30],"one":[35,64,67],"unbounded.":[37],"The":[38],"traced":[46],"back":[47],"to":[48,102],"ones.":[53],"We":[54,74],"consider":[55],"structures":[57],"composed":[58],"reactions":[60,82,165],"having":[61],"at":[62],"most":[63],"input":[65],"output":[68],"species":[69,151],"beyond":[70],"possible":[72],"catalyzers.":[73],"give":[75],"proof":[77],"that,":[78],"assuming":[79,161],"all":[80],"are":[83,100],"charged":[84],"in":[85,144,147,153,166],"initial":[87,157],"target":[89,159],"states,":[90,160],"problems":[93],"equivalent":[101],"existence":[104],"nonnegative":[106],"integer":[107],"solution":[108],"corresponding":[111],"d\u2010CRN":[112],"equations.":[114],"Using":[115],"result,":[117],"reformulated":[122],"as":[123],"an":[124],"Integer":[125],"Linear":[126],"Programming":[127],"(ILP)":[128],"feasibility":[129],"problem.":[130],"Therefore,":[131],"number":[133,149,163],"feasible":[135],"trajectories":[136],"satisfying":[137],"relation":[140],"can":[141],"be":[142],"counted":[143],"polynomial":[145],"time":[146],"distance":[155],"fixed":[162],"system.":[168]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}