{"id":"https://openalex.org/W2882981046","doi":"https://doi.org/10.1155/2018/1613290","title":"The Application of Dynamic Models to the Exploration of <mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" id=\"M1\"><mml:mrow><mml:msub><mml:mrow><mml:mi>\u03b2</mml:mi></mml:mrow><mml:mrow><mml:mn fontstyle=\"italic\">1</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>-AR Overactivation as a Cause of Heart Failure","display_name":"The Application of Dynamic Models to the Exploration of <mml:math xmlns:mml=\"http://www.w3.org/1998/Math/MathML\" id=\"M1\"><mml:mrow><mml:msub><mml:mrow><mml:mi>\u03b2</mml:mi></mml:mrow><mml:mrow><mml:mn fontstyle=\"italic\">1</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>-AR Overactivation as a Cause of Heart Failure","publication_year":2018,"publication_date":"2018-07-30","ids":{"openalex":"https://openalex.org/W2882981046","doi":"https://doi.org/10.1155/2018/1613290","mag":"2882981046","pmid":"https://pubmed.ncbi.nlm.nih.gov/30154911"},"language":"lv","primary_location":{"id":"doi:10.1155/2018/1613290","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2018/1613290","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2018/1613290.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/cmmm/2018/1613290.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100447905","display_name":"Xiaoyun Wang","orcid":"https://orcid.org/0000-0001-5174-8076"},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]},{"id":"https://openalex.org/I9086337","display_name":"Taiyuan University of Technology","ror":"https://ror.org/03kv08d37","country_code":"CN","type":"education","lineage":["https://openalex.org/I9086337"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Xiaoyun Wang","raw_affiliation_strings":["College of Mathematics, Taiyuan University of Technology, Taiyuan, Shanxi, China","Department of Scientific Computing, Florida State University, Tallahassee, FL, USA"],"raw_orcid":"https://orcid.org/0000-0001-5174-8076","affiliations":[{"raw_affiliation_string":"College of Mathematics, Taiyuan University of Technology, Taiyuan, Shanxi, China","institution_ids":["https://openalex.org/I9086337"]},{"raw_affiliation_string":"Department of Scientific Computing, Florida State University, Tallahassee, FL, USA","institution_ids":["https://openalex.org/I103163165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085843574","display_name":"Min Zhao","orcid":"https://orcid.org/0000-0001-7722-318X"},"institutions":[{"id":"https://openalex.org/I9086337","display_name":"Taiyuan University of Technology","ror":"https://ror.org/03kv08d37","country_code":"CN","type":"education","lineage":["https://openalex.org/I9086337"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Zhao","raw_affiliation_strings":["College of Mathematics, Taiyuan University of Technology, Taiyuan, Shanxi, China"],"raw_orcid":"https://orcid.org/0000-0001-7722-318X","affiliations":[{"raw_affiliation_string":"College of Mathematics, Taiyuan University of Technology, Taiyuan, Shanxi, China","institution_ids":["https://openalex.org/I9086337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100626803","display_name":"Xiaoqiang Wang","orcid":"https://orcid.org/0000-0003-0960-521X"},"institutions":[{"id":"https://openalex.org/I103163165","display_name":"Florida State University","ror":"https://ror.org/05g3dte14","country_code":"US","type":"education","lineage":["https://openalex.org/I103163165"]},{"id":"https://openalex.org/I9086337","display_name":"Taiyuan University of Technology","ror":"https://ror.org/03kv08d37","country_code":"CN","type":"education","lineage":["https://openalex.org/I9086337"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Xiaoqiang Wang","raw_affiliation_strings":["College of Mathematics, Taiyuan University of Technology, Taiyuan, Shanxi, China","Department of Scientific Computing, Florida State University, Tallahassee, FL, USA"],"raw_orcid":"https://orcid.org/0000-0003-0960-521X","affiliations":[{"raw_affiliation_string":"College of Mathematics, Taiyuan University of Technology, Taiyuan, Shanxi, China","institution_ids":["https://openalex.org/I9086337"]},{"raw_affiliation_string":"Department of Scientific Computing, Florida State University, Tallahassee, FL, USA","institution_ids":["https://openalex.org/I103163165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100735634","display_name":"Shuping Li","orcid":"https://orcid.org/0000-0001-9908-4678"},"institutions":[{"id":"https://openalex.org/I135714990","display_name":"North University of China","ror":"https://ror.org/047bp1713","country_code":"CN","type":"education","lineage":["https://openalex.org/I135714990"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuping Li","raw_affiliation_strings":["Department of Mathematics, North University of China, Taiyuan, Shanxi, China"],"raw_orcid":"https://orcid.org/0000-0001-9908-4678","affiliations":[{"raw_affiliation_string":"Department of Mathematics, North University of China, Taiyuan, Shanxi, China","institution_ids":["https://openalex.org/I135714990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017031516","display_name":"Ning Cao","orcid":"https://orcid.org/0000-0003-3961-3819"},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ning Cao","raw_affiliation_strings":["Beijing Key Laboratory of Metabolic Disorders Related Cardiovascular Diseases, Capital Medical University, Beijing, China","Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0003-3961-3819","affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Metabolic Disorders Related Cardiovascular Diseases, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381"]},{"raw_affiliation_string":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053882190","display_name":"Huirong Liu","orcid":"https://orcid.org/0000-0002-8178-2950"},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huirong Liu","raw_affiliation_strings":["Beijing Key Laboratory of Metabolic Disorders Related Cardiovascular Diseases, Capital Medical University, Beijing, China","Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0002-8178-2950","affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Metabolic Disorders Related Cardiovascular Diseases, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381"]},{"raw_affiliation_string":"Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5053882190","https://openalex.org/A5100447905","https://openalex.org/A5100626803"],"corresponding_institution_ids":["https://openalex.org/I103163165","https://openalex.org/I183519381","https://openalex.org/I9086337"],"apc_list":{"value":2550,"currency":"USD","value_usd":2550},"apc_paid":{"value":2550,"currency":"USD","value_usd":2550},"fwci":0.0824,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.42894599,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"2018","issue":null,"first_page":"1","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13338","display_name":"Pharmacological Effects and Assays","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/akaike-information-criterion","display_name":"Akaike information criterion","score":0.8251103758811951},{"id":"https://openalex.org/keywords/heart-failure","display_name":"Heart failure","score":0.5824708342552185},{"id":"https://openalex.org/keywords/isoprenaline","display_name":"Isoprenaline","score":0.49851465225219727},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.47006091475486755},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.38745877146720886},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3741752505302429},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.34775036573410034},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.25847312808036804},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.23278942704200745}],"concepts":[{"id":"https://openalex.org/C126674687","wikidata":"https://www.wikidata.org/wiki/Q1662573","display_name":"Akaike information criterion","level":2,"score":0.8251103758811951},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5824708342552185},{"id":"https://openalex.org/C2776090920","wikidata":"https://www.wikidata.org/wiki/Q415550","display_name":"Isoprenaline","level":3,"score":0.49851465225219727},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.47006091475486755},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.38745877146720886},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3741752505302429},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34775036573410034},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.25847312808036804},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.23278942704200745},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018342","descriptor_name":"Receptors, Adrenergic, beta-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018342","descriptor_name":"Receptors, Adrenergic, beta-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018342","descriptor_name":"Receptors, Adrenergic, beta-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018343","descriptor_name":"Receptors, Adrenergic, beta-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018343","descriptor_name":"Receptors, Adrenergic, beta-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018343","descriptor_name":"Receptors, Adrenergic, beta-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1155/2018/1613290","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2018/1613290","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2018/1613290.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},{"id":"pmid:30154911","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30154911","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and mathematical methods in medicine","raw_type":null},{"id":"pmh:oai:diginole.lib.fsu.edu:fsu_710012","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306401638","display_name":"DigiNole (Florida State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I103163165","host_organization_name":"Florida State University","host_organization_lineage":["https://openalex.org/I103163165"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:europepmc.org:5053861","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6091447","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1155/2018/1613290","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2018/1613290","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2018/1613290.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1860353089","display_name":null,"funder_award_id":"201601D021015","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2044722261","display_name":null,"funder_award_id":"2015MS033","funder_id":"https://openalex.org/F4320322666","funder_display_name":"Natural Science Foundation of Shanxi Province"},{"id":"https://openalex.org/G2110799724","display_name":null,"funder_award_id":"201601D102002","funder_id":"https://openalex.org/F4320322666","funder_display_name":"Natural Science Foundation of Shanxi Province"},{"id":"https://openalex.org/G2256995849","display_name":null,"funder_award_id":"2015MS033","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3108889583","display_name":null,"funder_award_id":"201601D021015","funder_id":"https://openalex.org/F4320322666","funder_display_name":"Natural Science Foundation of Shanxi Province"},{"id":"https://openalex.org/G3121598983","display_name":null,"funder_award_id":"91539205","funder_id":"https://openalex.org/F4320322725","funder_display_name":"China Scholarship Council"},{"id":"https://openalex.org/G3909044794","display_name":null,"funder_award_id":"91539205","funder_id":"https://openalex.org/F4320324098","funder_display_name":"Taiyuan University of Technology"},{"id":"https://openalex.org/G4537720414","display_name":null,"funder_award_id":"201601D102002","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4940991747","display_name":null,"funder_award_id":"201601D021015","funder_id":"https://openalex.org/F4320322725","funder_display_name":"China Scholarship Council"},{"id":"https://openalex.org/G5424552573","display_name":null,"funder_award_id":"91539205","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5920030905","display_name":null,"funder_award_id":"201601D102002","funder_id":"https://openalex.org/F4320322725","funder_display_name":"China Scholarship Council"},{"id":"https://openalex.org/G6240093065","display_name":null,"funder_award_id":"91539205","funder_id":"https://openalex.org/F4320322666","funder_display_name":"Natural Science Foundation of Shanxi Province"},{"id":"https://openalex.org/G6558775001","display_name":null,"funder_award_id":"2015MS033","funder_id":"https://openalex.org/F4320322725","funder_display_name":"China Scholarship Council"},{"id":"https://openalex.org/G6663313247","display_name":null,"funder_award_id":"201601D102002","funder_id":"https://openalex.org/F4320324098","funder_display_name":"Taiyuan University of Technology"},{"id":"https://openalex.org/G7193219842","display_name":null,"funder_award_id":"tyut-rc201317a","funder_id":"https://openalex.org/F4320322666","funder_display_name":"Natural Science Foundation of Shanxi Province"},{"id":"https://openalex.org/G7594537673","display_name":null,"funder_award_id":"tyut-rc201317a","funder_id":"https://openalex.org/F4320324098","funder_display_name":"Taiyuan University of Technology"},{"id":"https://openalex.org/G8012905776","display_name":null,"funder_award_id":"tyut-rc201317a","funder_id":"https://openalex.org/F4320322725","funder_display_name":"China Scholarship Council"},{"id":"https://openalex.org/G8363548301","display_name":null,"funder_award_id":"201601D021015","funder_id":"https://openalex.org/F4320324098","funder_display_name":"Taiyuan University of Technology"},{"id":"https://openalex.org/G8624586432","display_name":null,"funder_award_id":"2015MS033","funder_id":"https://openalex.org/F4320324098","funder_display_name":"Taiyuan University of Technology"},{"id":"https://openalex.org/G8885438815","display_name":null,"funder_award_id":"tyut-rc201317a","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322666","display_name":"Natural Science Foundation of Shanxi Province","ror":null},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"},{"id":"https://openalex.org/F4320324098","display_name":"Taiyuan University of Technology","ror":"https://ror.org/03kv08d37"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2882981046.pdf","grobid_xml":"https://content.openalex.org/works/W2882981046.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W62323985","https://openalex.org/W1513721194","https://openalex.org/W1638437879","https://openalex.org/W1892143536","https://openalex.org/W1976937534","https://openalex.org/W1989222595","https://openalex.org/W2003794640","https://openalex.org/W2029078217","https://openalex.org/W2031034134","https://openalex.org/W2057648840","https://openalex.org/W2096242050","https://openalex.org/W2100366210","https://openalex.org/W2142635246","https://openalex.org/W2167923245","https://openalex.org/W2414008377","https://openalex.org/W2524702909","https://openalex.org/W2562903659","https://openalex.org/W2605638302","https://openalex.org/W2623078573","https://openalex.org/W2801872744","https://openalex.org/W3022903251","https://openalex.org/W4210949901","https://openalex.org/W4242207978"],"related_works":["https://openalex.org/W1987464952","https://openalex.org/W2735932032","https://openalex.org/W2028169157","https://openalex.org/W2172884470","https://openalex.org/W2188061941","https://openalex.org/W2148077962","https://openalex.org/W2030252680","https://openalex.org/W4253044522","https://openalex.org/W1980950130","https://openalex.org/W2040889573"],"abstract_inverted_index":{"High":[0],"titer":[1],"of":[2,64,75,112,181,195,209,219],"<mml:math":[3,24,54,82,125,134,139,223],"xmlns:mml=\"http://www.w3.org/1998/Math/MathML\"":[4,9,25,30,55,83,126,135,140,145,224],"id=\"M2\"><mml:mrow><mml:msub><mml:mrow><mml:mi>\u03b2</mml:mi></mml:mrow><mml:mrow><mml:mn":[5],"mathvariant=\"normal\">1</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>-adrenoreceptor":[6],"autoantibodies":[7],"(<mml:math":[8,29,144],"id=\"M3\"><mml:mrow><mml:msub><mml:mrow><mml:mi>\u03b2</mml:mi></mml:mrow><mml:mrow><mml:mn":[10],"mathvariant=\"normal\">1</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>-AA)":[11],"has":[12],"been":[13],"reported":[14],"to":[15,36,49,96,174,185,199],"appear":[16],"in":[17,94,103,116,124],"heart":[18,37,182],"failure":[19,38,183],"patients.":[20],"It":[21],"induces":[22],"sustained":[23],"id=\"M4\"><mml:mrow><mml:msub><mml:mrow><mml:mi>\u03b2</mml:mi></mml:mrow><mml:mrow><mml:mn":[26],"mathvariant=\"normal\">1</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>-adrenergic":[27],"receptor":[28],"id=\"M5\"><mml:mrow><mml:msub><mml:mrow><mml:mi>\u03b2</mml:mi></mml:mrow><mml:mrow><mml:mn":[31],"mathvariant=\"normal\">1</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>-AR)":[32],"activation":[33],"which":[34],"leads":[35],"(HF),":[39],"but":[40],"the":[41,51,61,65,87,99,129,149,162,166,176,179,196,206,220,236],"mechanism":[42,177],"is":[43],"as":[44],"yet":[45],"unclear.":[46],"In":[47],"order":[48,95],"investigate":[50],"mechanisms":[52],"causing":[53],"id=\"M6\"><mml:mrow><mml:msub><mml:mrow><mml:mi>\u03b2</mml:mi></mml:mrow><mml:mrow><mml:mn":[56],"mathvariant=\"normal\">1</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>-AR":[57,137],"non-desensitization,":[58],"we":[59,159],"studied":[60],"beating":[62],"frequency":[63],"neonatal":[66],"rat":[67],"cardiomyocytes":[68],"(NRCMs)":[69],"under":[70],"different":[71],"conditions":[72],"(an":[73],"injection":[74],"isoprenaline":[76],"(ISO)":[77],"for":[78,86,178,189,205],"one":[79,106,119],"group":[80,111],"and":[81,89,138,152,184,191,227],"id=\"M7\"><mml:mrow><mml:msub><mml:mrow><mml:mi>\u03b2</mml:mi></mml:mrow><mml:mrow><mml:mn":[84],"mathvariant=\"normal\">1</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>-AA":[85,226],"other)":[88],"established":[90],"three":[91],"dynamic":[92],"models":[93],"best":[97],"describe":[98],"true":[100],"relationships":[101],"shown":[102],"medical":[104],"experiments;":[105],"model":[107,164],"used":[108,171],"a":[109,201,232],"control":[110],"healthy":[113],"rats;":[114],"then":[115],"HF":[117],"rats":[118],"focused":[120],"on":[121,235],"conformation":[122],"changes":[123],"id=\"M8\"><mml:mrow><mml:msub><mml:mrow><mml:mi>\u03b2</mml:mi></mml:mrow><mml:mrow><mml:mn":[127],"mathvariant=\"normal\">1</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>-AR;":[128],"other":[130],"examined":[131],"interaction":[132,163],"between":[133],"id=\"M9\"><mml:mrow><mml:msub><mml:mrow><mml:mi>\u03b2</mml:mi></mml:mrow><mml:mrow><mml:mn":[136],"id=\"M10\"><mml:mrow><mml:msub><mml:mrow><mml:mi>\u03b2</mml:mi></mml:mrow><mml:mrow><mml:mn":[141],"mathvariant=\"normal\">2</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>-adrenergic":[142],"receptors":[143],"id=\"M11\"><mml:mrow><mml:msub><mml:mrow><mml:mi>\u03b2</mml:mi></mml:mrow><mml:mrow><mml:mn":[146],"mathvariant=\"normal\">2</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>-AR).":[147],"Comparing":[148],"experimental":[150],"data":[151],"corresponding":[153],"Akaike":[154],"information":[155],"criterion":[156],"(AIC)":[157],"values,":[158],"concluded":[160],"that":[161,229],"was":[165,198],"most":[167],"likely":[168],"mechanism.":[169],"We":[170,213],"mathematical":[172],"methods":[173],"explore":[175],"development":[180,208],"find":[186],"potential":[187],"targets":[188],"prevention":[190],"treatment.":[192],"The":[193],"aim":[194],"paper":[197],"provide":[200],"strong":[202],"theoretical":[203],"basis":[204],"clinical":[207],"personalized":[210],"treatment":[211],"programs.":[212],"also":[214],"carried":[215],"out":[216],"sensitivity":[217],"analysis":[218],"initial":[221],"concentration":[222],"id=\"M12\"><mml:mrow><mml:msub><mml:mrow><mml:mi>\u03b2</mml:mi></mml:mrow><mml:mrow><mml:mn":[225],"found":[228],"they":[230],"had":[231],"noticeable":[233],"effect":[234],"fitting":[237],"results.":[238]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2018-08-03T00:00:00"}
