{"id":"https://openalex.org/W2236171162","doi":"https://doi.org/10.1155/2016/7904693","title":"Systems Medicine of Cancer: Bringing Together Clinical Data and Nonlinear Dynamics of Genetic Networks","display_name":"Systems Medicine of Cancer: Bringing Together Clinical Data and Nonlinear Dynamics of Genetic Networks","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2236171162","doi":"https://doi.org/10.1155/2016/7904693","mag":"2236171162","pmid":"https://pubmed.ncbi.nlm.nih.gov/26881011"},"language":"en","primary_location":{"id":"doi:10.1155/2016/7904693","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2016/7904693","pdf_url":"http://downloads.hindawi.com/journals/cmmm/2016/7904693.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"type":"editorial","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://downloads.hindawi.com/journals/cmmm/2016/7904693.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043056880","display_name":"Konstantin B. Blyuss","orcid":"https://orcid.org/0000-0003-3542-1908"},"institutions":[{"id":"https://openalex.org/I162608824","display_name":"University of Sussex","ror":"https://ror.org/00ayhx656","country_code":"GB","type":"education","lineage":["https://openalex.org/I162608824"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Konstantin B. Blyuss","raw_affiliation_strings":["Department of Mathematics, University of Sussex, Falmer, Brighton BN1 9QH, UK"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of Sussex, Falmer, Brighton BN1 9QH, UK","institution_ids":["https://openalex.org/I162608824"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027945638","display_name":"Ranjit Manchanda","orcid":"https://orcid.org/0000-0003-3381-5057"},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ranjit Manchanda","raw_affiliation_strings":["Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK"],"affiliations":[{"raw_affiliation_string":"Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085207296","display_name":"J\u00fcrgen Kurths","orcid":"https://orcid.org/0000-0002-5926-4276"},"institutions":[{"id":"https://openalex.org/I60200437","display_name":"Potsdam Institute for Climate Impact Research","ror":"https://ror.org/03e8s1d88","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I60200437"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00fcrgen Kurths","raw_affiliation_strings":["Potsdam Institute for Climate Impact Research, 14473 Potsdam, Germany"],"affiliations":[{"raw_affiliation_string":"Potsdam Institute for Climate Impact Research, 14473 Potsdam, Germany","institution_ids":["https://openalex.org/I60200437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108681726","display_name":"Ahmed Alsaedi","orcid":"https://orcid.org/0000-0003-3452-8922"},"institutions":[{"id":"https://openalex.org/I185163786","display_name":"King Abdulaziz University","ror":"https://ror.org/02ma4wv74","country_code":"SA","type":"education","lineage":["https://openalex.org/I185163786"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Ahmed Alsaedi","raw_affiliation_strings":["Department of Mathematics, King AbdulAziz University, Jeddah 21589, Saudi Arabia"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics, King AbdulAziz University, Jeddah 21589, Saudi Arabia","institution_ids":["https://openalex.org/I185163786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029926969","display_name":"Alexey Zaikin","orcid":"https://orcid.org/0000-0001-7540-1130"},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I79563041","display_name":"N. I. Lobachevsky State University of Nizhny Novgorod","ror":"https://ror.org/01bb1zm18","country_code":"RU","type":"education","lineage":["https://openalex.org/I79563041"]}],"countries":["GB","RU"],"is_corresponding":true,"raw_author_name":"Alexey Zaikin","raw_affiliation_strings":["Institute for Women\u2019s Health and Department of Mathematics, University College London, London WC1E 6AU, UK","Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod 603950, Russia","Institute for Women's Health and Department of Mathematics, University College London, London WC1E 6AU, UK"],"affiliations":[{"raw_affiliation_string":"Institute for Women\u2019s Health and Department of Mathematics, University College London, London WC1E 6AU, UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"Lobachevsky State University of Nizhny Novgorod, Nizhny Novgorod 603950, Russia","institution_ids":["https://openalex.org/I79563041"]},{"raw_affiliation_string":"Institute for Women's Health and Department of Mathematics, University College London, London WC1E 6AU, UK","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5029926969"],"corresponding_institution_ids":["https://openalex.org/I45129253","https://openalex.org/I79563041"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00169934,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2016","issue":null,"first_page":"1","last_page":"2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9776999950408936,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9380000233650208,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dynamics","display_name":"Dynamics (music)","score":0.48783376812934875},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.4566373825073242},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.44209614396095276},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.42585331201553345},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.34471744298934937},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.33601778745651245},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.18388184905052185},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.1781889796257019},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.0859820544719696}],"concepts":[{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.48783376812934875},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.4566373825073242},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44209614396095276},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.42585331201553345},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34471744298934937},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33601778745651245},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18388184905052185},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.1781889796257019},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0859820544719696},{"id":"https://openalex.org/C19417346","wikidata":"https://www.wikidata.org/wiki/Q7922","display_name":"Pedagogy","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013597","descriptor_name":"Systems Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013597","descriptor_name":"Systems Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013597","descriptor_name":"Systems Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013597","descriptor_name":"Systems Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1155/2016/7904693","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2016/7904693","pdf_url":"http://downloads.hindawi.com/journals/cmmm/2016/7904693.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},{"id":"pmid:26881011","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26881011","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and mathematical methods in medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:2bada568fce845408f29124ee9772e58","is_oa":true,"landing_page_url":"https://doaj.org/article/2bada568fce845408f29124ee9772e58","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computational and Mathematical Methods in Medicine, Vol 2016 (2016)","raw_type":"article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1475079","is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/1475079/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"   Computational and Mathematical Methods in Medicine , 2016     , Article 7904693. (2016)      ","raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4737019","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4737019","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Comput Math Methods Med","raw_type":"Text"},{"id":"pmh:oai:qmro.qmul.ac.uk:123456789/11154","is_oa":true,"landing_page_url":"http://qmro.qmul.ac.uk/xmlui/handle/123456789/11154","pdf_url":null,"source":{"id":"https://openalex.org/S4306400530","display_name":"Queen Mary Research Online (Queen Mary University of London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I166337079","host_organization_name":"Queen Mary University of London","host_organization_lineage":["https://openalex.org/I166337079"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1155/2016/7904693","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2016/7904693","pdf_url":"http://downloads.hindawi.com/journals/cmmm/2016/7904693.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2236171162.pdf","grobid_xml":"https://content.openalex.org/works/W2236171162.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W2586801360","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W2604872355"],"abstract_inverted_index":{"The":[0,287],"last":[1],"few":[2],"years":[3],"have":[4,37,602],"witnessed":[5],"major":[6],"developments":[7,149],"in":[8,150,164,198,346,363,513,589,597,623,634,691,710],"experimental":[9],"techniques":[10,84,229,277,709],"for":[11,244,399,404,414,479,615,665,679,716,721],"analysis":[12,83,96,123,157,483,715],"of":[13,20,30,42,49,58,91,95,97,114,121,136,145,153,167,184,195,201,207,216,218,230,256,262,274,283,293,303,324,338,368,374,396,435,440,451,454,484,497,505,522,532,537,558,566,569,575,584,592,610,629,643,653,668,725],"cancer,":[14,669],"including":[15],"full":[16,340],"genome":[17],"sequencing,":[18],"measurement":[19],"multiple":[21],"oncomarkers,":[22],"DNA":[23,379,391,397],"methylation":[24],"profile,":[25,27],"genomic":[26],"or":[28,677],"transcriptome":[29],"the":[31,47,56,67,93,119,130,134,146,151,165,185,199,228,238,281,291,308,317,322,325,336,339,351,356,394,408,463,485,498,509,523,533,564,573,581,590,627,650,684,688,718,723],"pathological":[32],"tissue.":[33],"Whilst":[34],"these":[35,62,559],"advances":[36],"provided":[38],"some":[39,144],"additional":[40],"understanding":[41],"cancer":[43,50,98,406,416,436,516],"onset":[44,719],"and":[45,66,76,104,110,128,138,158,162,178,188,205,233,248,295,299,307,316,348,360,421,428,458,470,527,554,572,600,607,612,632,663,696,700,707,713,720],"development,":[46],"problem":[48,94,247],"is":[51,100,447,466],"far":[52],"from":[53,61,107,382,508],"solved.":[54],"Since":[55],"amounts":[57],"data":[59,68,82,99,160,714],"emerging":[60,381],"are":[63,117,493,518],"very":[64],"substantial,":[65],"itself":[69],"can":[70,386],"be":[71,387],"extremely":[72],"heterogeneous":[73],"(qualitative,":[74],"quantitative,":[75],"verbal":[77],"descriptions),":[78],"this":[79,115,246,480,644,666,692,697],"makes":[80],"standard":[81],"not":[85],"practically":[86],"applicable.":[87],"One":[88],"promising":[89],"direction":[90],"addressing":[92],"to":[101,180,189,279,342,349,605,613],"use":[102],"modern":[103,585],"sophisticated":[105,543],"methods":[106,587],"systems":[108,452,598,711],"biology":[109,599,712],"cybernetics.":[111],"Some":[112],"challenges":[113],"approach":[116,243],"connecting":[118],"results":[120,434],"mathematical":[122,156,276],"with":[124,252,335,402,552],"real":[125],"clinical":[126],"data,":[127],"bridging":[129],"existing":[131,275],"gaps":[132],"between":[133],"communities":[135],"clinicians":[137],"applied":[139],"mathematicians.\r\n\r\nThis":[140],"special":[141,693],"issue":[142,694],"showcases":[143],"most":[147,534],"recent":[148],"areas":[152],"nonlinear":[154],"dynamics,":[155],"modeling,":[159],"analysis,":[161],"simulations":[163,255],"area":[166],"cancer.":[168,455],"Having":[169],"received":[170],"11":[171],"submissions,":[172],"six":[173],"best":[174],"papers":[175,689],"were":[176],"chosen":[177],"published":[179,690],"provide":[181,271,640],"an":[182,224,234,272,448,494,503,641],"overview":[183,273],"research":[186,645,703],"field":[187],"motivate":[190],"further":[191,702],"study.\r\n\r\nIn":[192],"\u201cOptimal":[193],"Placement":[194],"Irradiation":[196],"Sources":[197],"Planning":[200],"Radiotherapy:":[202],"Mathematical":[203],"Models":[204,261],"Methods":[206],"Solving,\u201d":[208],"O.":[209,576],"Blyuss":[210],"et":[211,269,578,621],"al.":[212,270,579,622],"analyse":[213,606],"optimal":[214],"choice":[215],"placement":[217],"irradiation":[219],"sources":[220],"during":[221],"radiotherapy":[222],"as":[223,329],"optimization":[225,232],"problem.":[226],"Using":[227,647],"nondifferentiable":[231],"approximate":[235],"Klepper's":[236],"algorithm,":[237],"authors":[239,288,409],"derive":[240,410],"a":[241,332,477],"new":[242,616,706],"solving":[245],"illustrate":[249,343],"their":[250,364,624],"methodology":[251],"actual":[253],"numerical":[254,487],"different":[257,304],"scenarios.\r\n\r\nThe":[258],"paper":[259,365,625],"\u201cTime-Delayed":[260],"Gene":[263],"Regulatory":[264],"Networks\u201d":[265],"by":[266,331,355,371,389,468],"K.":[267],"Parmar":[268],"applicable":[278],"modeling":[280],"dynamics":[282,323,337],"gene":[284,441],"regulatory":[285,442],"networks.":[286],"focus":[289],"on":[290,313,418,547,563,704],"effects":[292,492],"transcriptional":[294],"translational":[296],"time":[297,318,357],"delays":[298],"demonstrate":[300],"how":[301,378,462],"stability":[302],"steady":[305],"states":[306],"associated":[309],"behavior":[310],"change":[311],"depending":[312],"system":[314,341],"parameters":[315],"delays.":[319],"They":[320],"contrast":[321],"fast":[326],"mRNA":[327],"regime,":[328],"described":[330],"reduced":[333],"model,":[334],"possible":[344,674],"differences":[345],"behaviour":[347],"highlight":[350],"important":[352],"role":[353],"played":[354],"delays.\r\n\r\nH.":[358],"Namazi":[359],"M.":[361],"Kiminezhadmalale":[362],"titled":[366],"\u201cDiagnosis":[367],"Lung":[369],"Cancer":[370],"Fractal":[372],"Analysis":[373],"Damaged":[375],"DNA\u201d":[376],"discuss":[377],"sequences":[380],"patient":[383],"blood":[384],"plasma":[385],"studied":[388],"analysing":[390],"walks.":[392],"Comparing":[393],"features":[395],"profiles":[398],"healthy":[400],"individuals":[401],"those":[403],"lung":[405,415],"patients,":[407],"several":[411],"predictive":[412],"criteria":[413],"based":[417,546],"Hurst":[419],"exponents":[420],"fractal":[422],"dimension.\r\n\r\nThe":[423],"circadian":[424,445,464,499],"physiology,":[425],"clock":[426,465,500],"genes,":[427],"cell":[429,511,636,638],"cycle":[430],"may":[431],"critically":[432],"affect":[433],"chronotherapeutics;":[437],"hence,":[438],"investigation":[439],"networks":[443,609,657],"controlling":[444],"rhythms":[446],"irreplaceable":[449],"part":[450],"medicine":[453,601],"R.":[456],"Heussen":[457],"D.":[459],"Whitmore":[460],"study":[461],"entrained":[467],"light,":[469],"they":[471,658],"experimentally":[472],"investigate":[473],"whether":[474],"there":[475],"exists":[476],"threshold":[478],"synchronization.":[481],"Moreover,":[482],"constructed":[486],"model":[488],"shows":[489],"that":[490,501,683],"stochastic":[491],"essential":[495],"feature":[496],"provides":[502],"explanation":[504],"signal":[506],"decay":[507],"zebrafish":[510],"lines":[512],"prolonged":[514],"darkness.\r\n\r\nSome":[515],"types":[517,536],"especially":[519],"dangerous":[520],"because":[521],"high":[524],"progression":[525,724],"rate,":[526],"malignant":[528],"gliomas":[529],"represent":[530],"one":[531],"severe":[535],"tumors.":[538],"Modern":[539],"medical":[540],"approaches":[541],"offer":[542],"treatment":[544],"procedures,":[545],"microsurgical":[548],"tumor":[549,594],"removal":[550],"combined":[551],"radio-":[553],"chemotherapy.":[555],"A":[556],"success":[557],"surgical":[560],"resection":[561],"depends":[562],"clarity":[565],"intraoperative":[567],"diagnostics":[568],"human":[570],"gliomas,":[571],"review":[574],"Tyurikova":[577],"surveys":[580],"wide":[582],"diversity":[583],"diagnostic":[586],"used":[588],"course":[591],"glial":[593],"resections.\r\n\r\nRecent":[595],"development":[596],"enabled":[603],"us":[604],"infer":[608],"interactions":[611],"search":[614],"network":[617],"oncomarkers.":[618],"S.-M.":[619],"Wang":[620],"about":[626],"identification":[628],"dysregulated":[630,651,661],"genes":[631,662],"pathways":[633,664],"clear":[635],"renal":[637],"carcinoma":[639],"example":[642],"direction.":[646],"systematic":[648],"tracking":[649],"modules":[652],"reweighted":[654],"protein-protein":[655],"interaction":[656],"successfully":[659],"identified":[660],"type":[667],"thus":[670],"gaining":[671],"insights":[672],"into":[673],"biological":[675],"markers":[676],"targets":[678],"drug":[680],"development.\r\n\r\nWe":[681],"hope":[682],"readers":[685],"will":[686,698],"find":[687],"interesting,":[695],"encourage":[699],"foster":[701],"developing":[705],"efficient":[708],"predicting":[717],"monitoring":[722],"cancer.\r\n\r\n\r\nKonstantin":[726],"B.":[727],"Blyuss\r\n\r\nRanjit":[728],"Manchanda\r\n\r\nJurgen":[729],"Kurths\r\n\r\nAhmed":[730],"Alsaedi\r\n\r\nAlexey":[731],"Zaikin":[732]},"counts_by_year":[],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}