{"id":"https://openalex.org/W2466708836","doi":"https://doi.org/10.1155/2016/2460184","title":"A Canonical Correlation Analysis of AIDS Restriction Genes and Metabolic Pathways Identifies Purine Metabolism as a Key Cooperator","display_name":"A Canonical Correlation Analysis of AIDS Restriction Genes and Metabolic Pathways Identifies Purine Metabolism as a Key Cooperator","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2466708836","doi":"https://doi.org/10.1155/2016/2460184","mag":"2466708836","pmid":"https://pubmed.ncbi.nlm.nih.gov/27462363"},"language":"en","primary_location":{"id":"doi:10.1155/2016/2460184","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2016/2460184","pdf_url":"http://downloads.hindawi.com/journals/cmmm/2016/2460184.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://downloads.hindawi.com/journals/cmmm/2016/2460184.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033738107","display_name":"Hanhui Ye","orcid":"https://orcid.org/0000-0003-0769-5223"},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210115910","display_name":"Mengchao Hepatobiliary Hospital","ror":"https://ror.org/029w49918","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115910"]},{"id":"https://openalex.org/I4210124931","display_name":"Fuzhou Pulmonary Hospital of Fujian","ror":"https://ror.org/03d5yat74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124931"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hanhui Ye","raw_affiliation_strings":["Infectious Diseases Hospital of Fuzhou, Fuzhou 350025, China","The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Hospital of Fuzhou, Fuzhou 350025, China","institution_ids":["https://openalex.org/I4210124931"]},{"raw_affiliation_string":"The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, China","institution_ids":["https://openalex.org/I4210115910","https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016091749","display_name":"Jinjin Yuan","orcid":null},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210115910","display_name":"Mengchao Hepatobiliary Hospital","ror":"https://ror.org/029w49918","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115910"]},{"id":"https://openalex.org/I4210124931","display_name":"Fuzhou Pulmonary Hospital of Fujian","ror":"https://ror.org/03d5yat74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124931"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinjin Yuan","raw_affiliation_strings":["Infectious Diseases Hospital of Fuzhou, Fuzhou 350025, China","The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Hospital of Fuzhou, Fuzhou 350025, China","institution_ids":["https://openalex.org/I4210124931"]},{"raw_affiliation_string":"The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, China","institution_ids":["https://openalex.org/I4210115910","https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005215197","display_name":"Zhengwu Wang","orcid":"https://orcid.org/0000-0002-3946-0974"},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210115910","display_name":"Mengchao Hepatobiliary Hospital","ror":"https://ror.org/029w49918","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115910"]},{"id":"https://openalex.org/I4210124931","display_name":"Fuzhou Pulmonary Hospital of Fujian","ror":"https://ror.org/03d5yat74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124931"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhengwu Wang","raw_affiliation_strings":["Infectious Diseases Hospital of Fuzhou, Fuzhou 350025, China","The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Hospital of Fuzhou, Fuzhou 350025, China","institution_ids":["https://openalex.org/I4210124931"]},{"raw_affiliation_string":"The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, China","institution_ids":["https://openalex.org/I4210115910","https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109641478","display_name":"Aiqiong Huang","orcid":null},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210115910","display_name":"Mengchao Hepatobiliary Hospital","ror":"https://ror.org/029w49918","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115910"]},{"id":"https://openalex.org/I4210124931","display_name":"Fuzhou Pulmonary Hospital of Fujian","ror":"https://ror.org/03d5yat74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124931"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Aiqiong Huang","raw_affiliation_strings":["Infectious Diseases Hospital of Fuzhou, Fuzhou 350025, China","The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Hospital of Fuzhou, Fuzhou 350025, China","institution_ids":["https://openalex.org/I4210124931"]},{"raw_affiliation_string":"The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, China","institution_ids":["https://openalex.org/I4210115910","https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100393815","display_name":"Xiaolong Liu","orcid":"https://orcid.org/0000-0002-3096-4981"},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210115910","display_name":"Mengchao Hepatobiliary Hospital","ror":"https://ror.org/029w49918","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115910"]},{"id":"https://openalex.org/I4210124931","display_name":"Fuzhou Pulmonary Hospital of Fujian","ror":"https://ror.org/03d5yat74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124931"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaolong Liu","raw_affiliation_strings":["Infectious Diseases Hospital of Fuzhou, Fuzhou 350025, China","The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Hospital of Fuzhou, Fuzhou 350025, China","institution_ids":["https://openalex.org/I4210124931"]},{"raw_affiliation_string":"The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, China","institution_ids":["https://openalex.org/I4210115910","https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057229639","display_name":"Xiao Han","orcid":"https://orcid.org/0000-0002-4557-1304"},"institutions":[{"id":"https://openalex.org/I4210138501","display_name":"Chinese Academy of Agricultural Sciences","ror":"https://ror.org/0313jb750","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210167153","display_name":"Biotechnology Research Institute","ror":"https://ror.org/05vm76w92","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210127390","https://openalex.org/I4210138501","https://openalex.org/I4210151987","https://openalex.org/I4210167153"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiao Han","raw_affiliation_strings":["Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China","institution_ids":["https://openalex.org/I4210138501","https://openalex.org/I4210167153"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045270019","display_name":"Yahong Chen","orcid":"https://orcid.org/0000-0003-3258-8032"},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210115910","display_name":"Mengchao Hepatobiliary Hospital","ror":"https://ror.org/029w49918","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115910"]},{"id":"https://openalex.org/I4210124931","display_name":"Fuzhou Pulmonary Hospital of Fujian","ror":"https://ror.org/03d5yat74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124931"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yahong Chen","raw_affiliation_strings":["Infectious Diseases Hospital of Fuzhou, Fuzhou 350025, China","The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Diseases Hospital of Fuzhou, Fuzhou 350025, China","institution_ids":["https://openalex.org/I4210124931"]},{"raw_affiliation_string":"The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, China","institution_ids":["https://openalex.org/I4210115910","https://openalex.org/I129708740"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5045270019","https://openalex.org/A5057229639"],"corresponding_institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210115910","https://openalex.org/I4210124931","https://openalex.org/I4210138501","https://openalex.org/I4210167153"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":0.5342,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.68894563,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"2016","issue":null,"first_page":"1","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7538946866989136},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.7516472339630127},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.7030718326568604},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5428282618522644},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.48528429865837097},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.4534603953361511},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4491368532180786},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.4231218695640564},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.4032418727874756}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7538946866989136},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7516472339630127},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7030718326568604},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5428282618522644},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.48528429865837097},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4534603953361511},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4491368532180786},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.4231218695640564},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4032418727874756},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011687","descriptor_name":"Purines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1155/2016/2460184","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2016/2460184","pdf_url":"http://downloads.hindawi.com/journals/cmmm/2016/2460184.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},{"id":"pmid:27462363","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27462363","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and mathematical methods in medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:5e54b665fecf4c50a017a7ab53225fb7","is_oa":false,"landing_page_url":"https://doaj.org/article/5e54b665fecf4c50a017a7ab53225fb7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computational and Mathematical Methods in Medicine, Vol 2016 (2016)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:3922384","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4947641","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1155/2016/2460184","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2016/2460184","pdf_url":"http://downloads.hindawi.com/journals/cmmm/2016/2460184.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8299999833106995,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2466708836.pdf","grobid_xml":"https://content.openalex.org/works/W2466708836.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W172055262","https://openalex.org/W1564172809","https://openalex.org/W1842765029","https://openalex.org/W1925884925","https://openalex.org/W1963813930","https://openalex.org/W1977193326","https://openalex.org/W1993953434","https://openalex.org/W1995453338","https://openalex.org/W1998581214","https://openalex.org/W1998993816","https://openalex.org/W2002113368","https://openalex.org/W2007021820","https://openalex.org/W2010189440","https://openalex.org/W2011465764","https://openalex.org/W2016076533","https://openalex.org/W2016299030","https://openalex.org/W2024702568","https://openalex.org/W2031830279","https://openalex.org/W2038217719","https://openalex.org/W2046385005","https://openalex.org/W2057068045","https://openalex.org/W2058321555","https://openalex.org/W2070676224","https://openalex.org/W2089487951","https://openalex.org/W2096130477","https://openalex.org/W2106915606","https://openalex.org/W2115202379","https://openalex.org/W2118897675","https://openalex.org/W2123584222","https://openalex.org/W2130438504","https://openalex.org/W2140821112","https://openalex.org/W2140865115","https://openalex.org/W2141606491","https://openalex.org/W2143965041","https://openalex.org/W2146999068","https://openalex.org/W2160175784","https://openalex.org/W2161443949","https://openalex.org/W2168909179","https://openalex.org/W2312581928"],"related_works":["https://openalex.org/W2399513595","https://openalex.org/W4388386498","https://openalex.org/W2374855950","https://openalex.org/W2363311673","https://openalex.org/W2388669904","https://openalex.org/W2041374557","https://openalex.org/W2365629105","https://openalex.org/W2114409792","https://openalex.org/W2170854597","https://openalex.org/W2367539286"],"abstract_inverted_index":{"Human":[0],"immunodeficiency":[1],"virus":[2,25],"causes":[3],"a":[4,47,102,109],"severe":[5],"disease":[6],"in":[7,35,80],"humans,":[8],"referred":[9],"to":[10,45,53,112],"as":[11],"immune":[12],"deficiency":[13],"syndrome.":[14],"Studies":[15],"on":[16],"the":[17,24,36,55,86,114],"interaction":[18],"between":[19,57],"host":[20,92],"genetic":[21,42],"factors":[22,43,93],"and":[23,60],"have":[26],"revealed":[27],"dozens":[28],"of":[29],"genes":[30,77],"that":[31,68,94],"impact":[32],"diverse":[33],"processes":[34],"AIDS":[37,58,75,98],"disease.":[38],"To":[39],"resolve":[40],"more":[41],"related":[44],"AIDS,":[46],"canonical":[48,103],"correlation":[49,56,104],"analysis":[50,105],"was":[51],"used":[52],"determine":[54],"restriction":[59,76,99],"metabolic":[61],"pathway":[62,89],"gene":[63],"expression.":[64],"The":[65],"results":[66],"show":[67],"HIV-1":[69],"postentry":[70],"cellular":[71],"viral":[72],"cofactors":[73],"from":[74],"are":[78,95],"coexpressed":[79,96],"human":[81],"transcriptome":[82],"microarray":[83],"datasets.":[84],"Further,":[85],"purine":[87],"metabolism":[88],"comprises":[90],"novel":[91],"with":[97],"genes.":[100],"Using":[101],"for":[106],"expression":[107],"is":[108],"reliable":[110],"approach":[111],"exploring":[113],"mechanism":[115],"underlying":[116],"AIDS.":[117]},"counts_by_year":[{"year":2018,"cited_by_count":3}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}