{"id":"https://openalex.org/W1519246313","doi":"https://doi.org/10.1155/2015/528097","title":"Tyrosine Kinase Ligand-Receptor Pair Prediction by Using Support Vector Machine","display_name":"Tyrosine Kinase Ligand-Receptor Pair Prediction by Using Support Vector Machine","publication_year":2015,"publication_date":"2015-08-11","ids":{"openalex":"https://openalex.org/W1519246313","doi":"https://doi.org/10.1155/2015/528097","mag":"1519246313","pmid":"https://pubmed.ncbi.nlm.nih.gov/26347773"},"language":"en","primary_location":{"id":"doi:10.1155/2015/528097","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2015/528097","pdf_url":"https://downloads.hindawi.com/archive/2015/528097.pdf","source":{"id":"https://openalex.org/S146125958","display_name":"Advances in Bioinformatics","issn_l":"1687-8027","issn":["1687-8027","1687-8035"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/archive/2015/528097.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015180119","display_name":"Masayuki Yarimizu","orcid":null},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayuki Yarimizu","raw_affiliation_strings":["Department of Biotechnology, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan","Department of Biotechnology, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-Ku, Tokyo 113-8657, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Biotechnology, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-Ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100694029","display_name":"Wei Cao","orcid":"https://orcid.org/0000-0001-9617-0984"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Cao Wei","raw_affiliation_strings":["Department of Biotechnology, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan","Department of Biotechnology, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-Ku, Tokyo 113-8657, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Biotechnology, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-Ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080222397","display_name":"Yusuke Komiyama","orcid":"https://orcid.org/0000-0001-6468-3718"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yusuke Komiyama","raw_affiliation_strings":["Department of Biotechnology, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan","Department of Biotechnology, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-Ku, Tokyo 113-8657, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Biotechnology, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-Ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090239771","display_name":"Kokoro Ueki","orcid":null},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kokoro Ueki","raw_affiliation_strings":["Department of Biotechnology, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan","Department of Biotechnology, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-Ku, Tokyo 113-8657, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Biotechnology, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-Ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059004826","display_name":"Shugo Nakamura","orcid":"https://orcid.org/0000-0003-0851-7437"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shugo Nakamura","raw_affiliation_strings":["Department of Biotechnology, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan","Department of Biotechnology, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-Ku, Tokyo 113-8657, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Biotechnology, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-Ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022580065","display_name":"Kazuya Sumikoshi","orcid":null},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuya Sumikoshi","raw_affiliation_strings":["Department of Biotechnology, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan","Department of Biotechnology, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-Ku, Tokyo 113-8657, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Biotechnology, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-Ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052407958","display_name":"Tohru Terada","orcid":"https://orcid.org/0000-0002-7091-0646"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tohru Terada","raw_affiliation_strings":["Department of Biotechnology, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan","Department of Biotechnology, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-Ku, Tokyo 113-8657, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Biotechnology, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-Ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102746753","display_name":"Kentaro Shimizu","orcid":"https://orcid.org/0000-0002-3245-0052"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kentaro Shimizu","raw_affiliation_strings":["Department of Biotechnology, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan","Department of Biotechnology, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-Ku, Tokyo 113-8657, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Biotechnology, The University of Tokyo, 1-1-1, Yayoi, Bunkyo-Ku, Tokyo 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5102746753"],"corresponding_institution_ids":["https://openalex.org/I74801974"],"apc_list":null,"apc_paid":null,"fwci":1.0915,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.78270363,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"2015","issue":null,"first_page":"1","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/receptor-tyrosine-kinase","display_name":"Receptor tyrosine kinase","score":0.6228798627853394},{"id":"https://openalex.org/keywords/tyrosine-kinase","display_name":"Tyrosine kinase","score":0.585983395576477},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5655049681663513},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.5051911473274231},{"id":"https://openalex.org/keywords/ror1","display_name":"ROR1","score":0.500652551651001},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.49468323588371277},{"id":"https://openalex.org/keywords/tyrosine","display_name":"Tyrosine","score":0.4554857313632965},{"id":"https://openalex.org/keywords/tropomyosin-receptor-kinase-c","display_name":"Tropomyosin receptor kinase C","score":0.4363701343536377},{"id":"https://openalex.org/keywords/protein-kinase-domain","display_name":"Protein kinase domain","score":0.41306808590888977},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.40614941716194153},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3302880823612213},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3277057409286499},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3238416314125061},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.3226854205131531},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3221670389175415},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor-receptor","display_name":"Platelet-derived growth factor receptor","score":0.32096347212791443},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.3184063136577606},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2871825695037842},{"id":"https://openalex.org/keywords/growth-factor","display_name":"Growth factor","score":0.10615125298500061}],"concepts":[{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.6228798627853394},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.585983395576477},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5655049681663513},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.5051911473274231},{"id":"https://openalex.org/C23440912","wikidata":"https://www.wikidata.org/wiki/Q18030230","display_name":"ROR1","level":5,"score":0.500652551651001},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.49468323588371277},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.4554857313632965},{"id":"https://openalex.org/C79186569","wikidata":"https://www.wikidata.org/wiki/Q14897880","display_name":"Tropomyosin receptor kinase C","level":5,"score":0.4363701343536377},{"id":"https://openalex.org/C32619005","wikidata":"https://www.wikidata.org/wiki/Q24768234","display_name":"Protein kinase domain","level":4,"score":0.41306808590888977},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.40614941716194153},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3302880823612213},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3277057409286499},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3238416314125061},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3226854205131531},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3221670389175415},{"id":"https://openalex.org/C180361614","wikidata":"https://www.wikidata.org/wiki/Q7202242","display_name":"Platelet-derived growth factor receptor","level":4,"score":0.32096347212791443},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3184063136577606},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2871825695037842},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.10615125298500061},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1155/2015/528097","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2015/528097","pdf_url":"https://downloads.hindawi.com/archive/2015/528097.pdf","source":{"id":"https://openalex.org/S146125958","display_name":"Advances in Bioinformatics","issn_l":"1687-8027","issn":["1687-8027","1687-8035"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:26347773","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26347773","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:3539099","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4548105","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1155/2015/528097","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2015/528097","pdf_url":"https://downloads.hindawi.com/archive/2015/528097.pdf","source":{"id":"https://openalex.org/S146125958","display_name":"Advances in Bioinformatics","issn_l":"1687-8027","issn":["1687-8027","1687-8035"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6200000047683716,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1519246313.pdf","grobid_xml":"https://content.openalex.org/works/W1519246313.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1964477815","https://openalex.org/W1971369226","https://openalex.org/W1995240259","https://openalex.org/W1995819749","https://openalex.org/W2020816856","https://openalex.org/W2022446852","https://openalex.org/W2028415754","https://openalex.org/W2032359283","https://openalex.org/W2048771637","https://openalex.org/W2055043387","https://openalex.org/W2108649941","https://openalex.org/W2119821739","https://openalex.org/W2130687290","https://openalex.org/W2138072853","https://openalex.org/W2153635508","https://openalex.org/W2167851075","https://openalex.org/W2605068739","https://openalex.org/W4239510810"],"related_works":["https://openalex.org/W2057499670","https://openalex.org/W2172112093","https://openalex.org/W2023447434","https://openalex.org/W2044148403","https://openalex.org/W2752691130","https://openalex.org/W1986363374","https://openalex.org/W1977179627","https://openalex.org/W1969206533","https://openalex.org/W2395338823","https://openalex.org/W2410549645"],"abstract_inverted_index":{"Receptor":[0],"tyrosine":[1,59,70,121],"kinases":[2],"are":[3,15],"essential":[4],"proteins":[5],"involved":[6,17],"in":[7,12,18],"cellular":[8,44],"differentiation":[9],"and":[10,14,22,46,81,89,98,113,126,128,136],"proliferation":[11],"vivo":[13],"heavily":[16],"allergic":[19],"diseases,":[20],"diabetes,":[21],"onset/proliferation":[23],"of":[24,31,43,77,100,148],"cancerous":[25],"cells.":[26],"Identifying":[27],"the":[28,75,130,149,152],"interacting":[29],"partner":[30],"this":[32,51],"protein,":[33],"a":[34,40,55,93],"growth":[35],"factor":[36],"ligand,":[37],"will":[38],"provide":[39],"deeper":[41],"understanding":[42],"proliferation/differentiation":[45],"other":[47],"cell":[48],"processes.":[49],"In":[50],"study,":[52],"we":[53,114,145],"developed":[54],"method":[56,105],"for":[57,95,120,123],"predicting":[58],"kinase":[60,71,122],"ligand-receptor":[61,72],"pairs":[62,73],"from":[63,74,140,164],"their":[64],"amino":[65],"acid":[66],"sequences.":[67],"We":[68],"collected":[69],"Database":[76],"Interacting":[78],"Proteins":[79],"(DIP)":[80],"UniProtKB,":[82],"filtered":[83],"them":[84,91],"by":[85],"removing":[86],"sequence":[87,133],"redundancy,":[88],"used":[90],"as":[92,142],"dataset":[94],"machine":[96,124],"learning":[97,125],"assessment":[99],"predictive":[101],"performance.":[102],"Our":[103],"prediction":[104],"is":[106,159],"based":[107],"on":[108],"support":[109],"vector":[110],"machines":[111],"(SVMs),":[112],"evaluated":[115],"several":[116],"input":[117,143],"features":[118],"suitable":[119],"compared":[127],"analyzed":[129],"results.":[131],"Using":[132],"pattern":[134],"information":[135,138],"domain":[137],"extracted":[139],"sequences":[141],"features,":[144],"obtained":[146,163],"0.996":[147],"area":[150],"under":[151],"receiver":[153],"operating":[154],"characteristic":[155],"curve.":[156],"This":[157],"accuracy":[158],"higher":[160],"than":[161],"that":[162],"general":[165],"protein-protein":[166],"interaction":[167],"pair":[168],"predictions.":[169]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-03-10T16:38:18.471706","created_date":"2025-10-10T00:00:00"}