{"id":"https://openalex.org/W1964970753","doi":"https://doi.org/10.1155/2014/867289","title":"Systematic Analysis of Time-Series Gene Expression Data on Tumor Cell-Selective Apoptotic Responses to HDAC Inhibitors","display_name":"Systematic Analysis of Time-Series Gene Expression Data on Tumor Cell-Selective Apoptotic Responses to HDAC Inhibitors","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W1964970753","doi":"https://doi.org/10.1155/2014/867289","mag":"1964970753","pmid":"https://pubmed.ncbi.nlm.nih.gov/25371703"},"language":"en","primary_location":{"id":"doi:10.1155/2014/867289","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2014/867289","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2014/867289.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/cmmm/2014/867289.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101398997","display_name":"Yunfeng Qi","orcid":"https://orcid.org/0000-0002-2704-6792"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun-feng Qi","raw_affiliation_strings":["National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020070866","display_name":"Yanxin Huang","orcid":"https://orcid.org/0000-0002-4913-8161"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan-xin Huang","raw_affiliation_strings":["National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007535547","display_name":"Yan Dong","orcid":"https://orcid.org/0000-0003-1622-5354"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Dong","raw_affiliation_strings":["National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China","School of Computer Science and Information Technology, Northeast Normal University, Changchun 130117, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China","institution_ids":["https://openalex.org/I184983240"]},{"raw_affiliation_string":"School of Computer Science and Information Technology, Northeast Normal University, Changchun 130117, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087757321","display_name":"Lihua Zheng","orcid":"https://orcid.org/0000-0001-5380-2021"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li-hua Zheng","raw_affiliation_strings":["National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008609733","display_name":"Yongli Bao","orcid":"https://orcid.org/0000-0002-5972-1983"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong-li Bao","raw_affiliation_strings":["National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055401764","display_name":"Luguo Sun","orcid":"https://orcid.org/0000-0002-0895-8120"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu-guo Sun","raw_affiliation_strings":["National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101076058","display_name":"Yin Wu","orcid":"https://orcid.org/0000-0001-7369-8612"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yin Wu","raw_affiliation_strings":["National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106467070","display_name":"Chunlei Yu","orcid":null},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chun-lei Yu","raw_affiliation_strings":["National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, China","institution_ids":["https://openalex.org/I184983240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024214452","display_name":"Hongyu Jiang","orcid":"https://orcid.org/0000-0001-5774-6258"},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210125137","display_name":"First Hospital of Jilin University","ror":"https://ror.org/034haf133","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210125137"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hong-yu Jiang","raw_affiliation_strings":["Department of General Internal Medicine, First Hospital of Jilin University, Changchun 130021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Internal Medicine, First Hospital of Jilin University, Changchun 130021, China","institution_ids":["https://openalex.org/I4210125137","https://openalex.org/I194450716"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100321614","display_name":"Yuxin Li","orcid":"https://orcid.org/0000-0001-9739-9860"},"institutions":[{"id":"https://openalex.org/I184983240","display_name":"Northeast Normal University","ror":"https://ror.org/02rkvz144","country_code":"CN","type":"education","lineage":["https://openalex.org/I184983240"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yu-xin Li","raw_affiliation_strings":["Research Center of Agriculture and Medicine Gene Engineering of Ministry of Education, Northeast Normal University, Changchun 130024, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center of Agriculture and Medicine Gene Engineering of Ministry of Education, Northeast Normal University, Changchun 130024, China","institution_ids":["https://openalex.org/I184983240"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5020070866","https://openalex.org/A5024214452","https://openalex.org/A5100321614"],"corresponding_institution_ids":["https://openalex.org/I184983240","https://openalex.org/I194450716","https://openalex.org/I4210125137"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":0.2846,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.58322048,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"2014","issue":null,"first_page":"1","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vorinostat","display_name":"Vorinostat","score":0.8658084869384766},{"id":"https://openalex.org/keywords/apoptosis","display_name":"Apoptosis","score":0.7123183608055115},{"id":"https://openalex.org/keywords/acetylation","display_name":"Acetylation","score":0.7094447016716003},{"id":"https://openalex.org/keywords/histone-deacetylase","display_name":"Histone deacetylase","score":0.6868352293968201},{"id":"https://openalex.org/keywords/histone","display_name":"Histone","score":0.6720080375671387},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"Cell cycle","score":0.5621123909950256},{"id":"https://openalex.org/keywords/chromatin","display_name":"Chromatin","score":0.5341410040855408},{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.528761088848114},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitor","display_name":"Histone deacetylase inhibitor","score":0.5072081089019775},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.48624885082244873},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4759601950645447},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.4534896910190582},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.45060089230537415},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.42167437076568604},{"id":"https://openalex.org/keywords/cell-cycle-checkpoint","display_name":"Cell cycle checkpoint","score":0.4200063943862915},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.41621142625808716},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4016115069389343},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.24433431029319763},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.20189878344535828}],"concepts":[{"id":"https://openalex.org/C2776262904","wikidata":"https://www.wikidata.org/wiki/Q905901","display_name":"Vorinostat","level":5,"score":0.8658084869384766},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7123183608055115},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.7094447016716003},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.6868352293968201},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.6720080375671387},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5621123909950256},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.5341410040855408},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.528761088848114},{"id":"https://openalex.org/C2776202225","wikidata":"https://www.wikidata.org/wiki/Q3569101","display_name":"Histone deacetylase inhibitor","level":5,"score":0.5072081089019775},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48624885082244873},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4759601950645447},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4534896910190582},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45060089230537415},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.42167437076568604},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.4200063943862915},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.41621142625808716},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4016115069389343},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24433431029319763},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20189878344535828}],"mesh":[{"descriptor_ui":"D000077337","descriptor_name":"Vorinostat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077337","descriptor_name":"Vorinostat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077337","descriptor_name":"Vorinostat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006877","descriptor_name":"Hydroxamic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006877","descriptor_name":"Hydroxamic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006877","descriptor_name":"Hydroxamic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1155/2014/867289","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2014/867289","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2014/867289.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},{"id":"pmid:25371703","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25371703","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and mathematical methods in medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:7c5194fc83f345ff9cef383689e69a8e","is_oa":true,"landing_page_url":"https://doaj.org/article/7c5194fc83f345ff9cef383689e69a8e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computational and Mathematical Methods in Medicine, Vol 2014 (2014)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4211306","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4211306","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Comput Math Methods Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1155/2014/867289","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2014/867289","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2014/867289.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5252224160","display_name":"\u7ec6\u80de\u51cb\u4ea1\u4fe1\u53f7\u8f6c\u5bfc\u7f51\u7edc\u591a\u5c3a\u5ea6\u5efa\u6a21\u53ca\u5176\u5728\u65b0\u6297\u80bf\u7624\u836f\u7269\u9776\u6807\u8bc6\u522b\u65b9\u9762\u7684\u5e94\u7528\u7814\u7a76","funder_award_id":"61172183","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5740865938","display_name":null,"funder_award_id":"20130101148JC","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8417801252","display_name":null,"funder_award_id":"12ZX55","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320310121","display_name":"Natural Science Foundation of Jilin Province","ror":null},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322174","display_name":"People's Government of Jilin Province","ror":"https://ror.org/02fzqav45"},{"id":"https://openalex.org/F4320325913","display_name":"Changchun Science and Technology Bureau","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1964970753.pdf","grobid_xml":"https://content.openalex.org/works/W1964970753.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W138485792","https://openalex.org/W143763378","https://openalex.org/W1749479308","https://openalex.org/W1920958927","https://openalex.org/W1935931925","https://openalex.org/W1975856746","https://openalex.org/W1977037602","https://openalex.org/W1980947442","https://openalex.org/W1982772122","https://openalex.org/W1993021532","https://openalex.org/W1995487754","https://openalex.org/W1996834020","https://openalex.org/W2001533493","https://openalex.org/W2004338948","https://openalex.org/W2004980848","https://openalex.org/W2008054969","https://openalex.org/W2010457001","https://openalex.org/W2014364284","https://openalex.org/W2015047229","https://openalex.org/W2022811243","https://openalex.org/W2031249942","https://openalex.org/W2033176001","https://openalex.org/W2033675587","https://openalex.org/W2036694038","https://openalex.org/W2040957529","https://openalex.org/W2045185694","https://openalex.org/W2057358066","https://openalex.org/W2057625439","https://openalex.org/W2063683286","https://openalex.org/W2067818013","https://openalex.org/W2069019880","https://openalex.org/W2071999296","https://openalex.org/W2075582843","https://openalex.org/W2075625882","https://openalex.org/W2075984614","https://openalex.org/W2083482432","https://openalex.org/W2099118364","https://openalex.org/W2101142880","https://openalex.org/W2103017472","https://openalex.org/W2106323366","https://openalex.org/W2108436181","https://openalex.org/W2119571991","https://openalex.org/W2120211376","https://openalex.org/W2121378134","https://openalex.org/W2125718095","https://openalex.org/W2126689485","https://openalex.org/W2130410032","https://openalex.org/W2131989143","https://openalex.org/W2144807742","https://openalex.org/W2148014174","https://openalex.org/W2150372654","https://openalex.org/W2158217645","https://openalex.org/W2158313623","https://openalex.org/W2159482845","https://openalex.org/W2163856173","https://openalex.org/W2164713773","https://openalex.org/W2312983841","https://openalex.org/W2341182633","https://openalex.org/W3141920145","https://openalex.org/W4233171904","https://openalex.org/W4242404314"],"related_works":["https://openalex.org/W1043690502","https://openalex.org/W2043322963","https://openalex.org/W4392685193","https://openalex.org/W4200528065","https://openalex.org/W1483077634","https://openalex.org/W3137354716","https://openalex.org/W2145470144","https://openalex.org/W2380036341","https://openalex.org/W4362418352","https://openalex.org/W3151757475"],"abstract_inverted_index":{"SAHA":[0,23,42,104],"(suberoylanilide":[1],"hydroxamic":[2],"acid":[3],"or":[4],"vorinostat)":[5],"is":[6,52],"the":[7,16,50,90,107,137],"first":[8],"nonselective":[9],"histone":[10,25],"deacetylase":[11],"(HDAC)":[12],"inhibitor":[13],"approved":[14],"by":[15,72,98],"US":[17],"Food":[18],"and":[19,29,115],"Drug":[20],"Administration":[21],"(FDA).":[22],"affects":[24],"acetylation":[26],"in":[27],"chromatin":[28],"a":[30,83,130],"variety":[31],"of":[32,46,58,89,92,118],"nonhistone":[33],"substrates,":[34],"thus":[35],"influencing":[36],"many":[37],"cellular":[38],"processes.":[39],"In":[40],"particularly,":[41],"induces":[43],"selective":[44,123],"apoptosis":[45,95],"tumor":[47,66,93,119,124],"cells,":[48],"although":[49],"mechanism":[51,91],"not":[53],"well":[54],"understood.":[55],"A":[56],"series":[57],"microarray":[59],"experiments":[60],"was":[61],"recently":[62],"conducted":[63],"to":[64,121],"investigate":[65],"cell-selective":[67],"proapoptotic":[68],"transcriptional":[69],"responses":[70],"induced":[71,97],"SAHA.":[73,99],"Based":[74],"on":[75],"that":[76,103],"gene":[77],"expression":[78],"time":[79],"series,":[80],"we":[81],"propose":[82],"novel":[84],"framework":[85],"for":[86],"detailed":[87],"analysis":[88],"cell":[94,111,125],"selectively":[96,105],"Our":[100,127,134],"analyses":[101],"indicated":[102],"disrupted":[106],"DNA":[108],"damage":[109],"response,":[110],"cycle,":[112],"p53":[113],"expression,":[114],"mitochondrial":[116],"integrity":[117],"samples":[120],"induce":[122],"apoptosis.":[126],"results":[128],"suggest":[129],"possible":[131],"regulation":[132],"network.":[133],"research":[135],"extends":[136],"existing":[138],"research.":[139]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-06-06T09:05:17.133730","created_date":"2025-10-10T00:00:00"}
