{"id":"https://openalex.org/W2105191443","doi":"https://doi.org/10.1155/2014/481935","title":"Computer Implementation of a New Therapeutic Model for GBM Tumor","display_name":"Computer Implementation of a New Therapeutic Model for GBM Tumor","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2105191443","doi":"https://doi.org/10.1155/2014/481935","mag":"2105191443","pmid":"https://pubmed.ncbi.nlm.nih.gov/25221615"},"language":"en","primary_location":{"id":"doi:10.1155/2014/481935","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2014/481935","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2014/481935.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/cmmm/2014/481935.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062448684","display_name":"Ali Jamali Nazari","orcid":"https://orcid.org/0000-0002-9427-121X"},"institutions":[{"id":"https://openalex.org/I155419210","display_name":"Islamic Azad University, Science and Research Branch","ror":"https://ror.org/03187yj51","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433","https://openalex.org/I155419210"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Ali Jamali Nazari","raw_affiliation_strings":["Department of Medical Radiation Engineering, Islamic Azad University, Tehran Science and Research Branch, Tehran 14515-775, Iran"],"raw_orcid":"https://orcid.org/0000-0002-9427-121X","affiliations":[{"raw_affiliation_string":"Department of Medical Radiation Engineering, Islamic Azad University, Tehran Science and Research Branch, Tehran 14515-775, Iran","institution_ids":["https://openalex.org/I155419210"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011568499","display_name":"Dariush Sardari","orcid":"https://orcid.org/0000-0002-9400-8243"},"institutions":[{"id":"https://openalex.org/I155419210","display_name":"Islamic Azad University, Science and Research Branch","ror":"https://ror.org/03187yj51","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433","https://openalex.org/I155419210"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Dariush Sardari","raw_affiliation_strings":["Department of Medical Radiation Engineering, Islamic Azad University, Tehran Science and Research Branch, Tehran 14515-775, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Radiation Engineering, Islamic Azad University, Tehran Science and Research Branch, Tehran 14515-775, Iran","institution_ids":["https://openalex.org/I155419210"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102092588","display_name":"Ahmad Reza Vali","orcid":null},"institutions":[{"id":"https://openalex.org/I78323350","display_name":"Malek Ashtar University of Technology","ror":"https://ror.org/0043ezw98","country_code":"IR","type":"education","lineage":["https://openalex.org/I78323350"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Ahmad Reza Vali","raw_affiliation_strings":["Electrical Engineering Department, Control Engineering Group, Malek Ashtar University of Technology, Tehran, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Electrical Engineering Department, Control Engineering Group, Malek Ashtar University of Technology, Tehran, Iran","institution_ids":["https://openalex.org/I78323350"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035978702","display_name":"Keivan Maghooli","orcid":"https://orcid.org/0000-0003-0980-0154"},"institutions":[{"id":"https://openalex.org/I155419210","display_name":"Islamic Azad University, Science and Research Branch","ror":"https://ror.org/03187yj51","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433","https://openalex.org/I155419210"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Keivan Maghooli","raw_affiliation_strings":["Department of Biomedical Engineering, Islamic Azad University, Science and Research Branch, Tehran, Iran","Department of Biomedical Engineering, Islamic Azad University Science and Research Branch, Tehran, Iran#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Islamic Azad University, Science and Research Branch, Tehran, Iran","institution_ids":["https://openalex.org/I155419210"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Islamic Azad University Science and Research Branch, Tehran, Iran#TAB#","institution_ids":["https://openalex.org/I155419210"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":0.5055,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.68061187,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"2014","issue":null,"first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9889000058174133,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.5669780373573303},{"id":"https://openalex.org/keywords/acceleration","display_name":"Acceleration","score":0.5146804451942444},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5012116432189941},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"Glioblastoma","score":0.48216623067855835},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.4540380835533142},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.33888623118400574},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.24933621287345886},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2153441607952118},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.10861063003540039}],"concepts":[{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.5669780373573303},{"id":"https://openalex.org/C117896860","wikidata":"https://www.wikidata.org/wiki/Q11376","display_name":"Acceleration","level":2,"score":0.5146804451942444},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5012116432189941},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.48216623067855835},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4540380835533142},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33888623118400574},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.24933621287345886},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2153441607952118},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10861063003540039},{"id":"https://openalex.org/C74650414","wikidata":"https://www.wikidata.org/wiki/Q11397","display_name":"Classical mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011829","descriptor_name":"Radiation Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011829","descriptor_name":"Radiation Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011829","descriptor_name":"Radiation Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1155/2014/481935","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2014/481935","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2014/481935.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},{"id":"pmid:25221615","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25221615","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and mathematical methods in medicine","raw_type":null},{"id":"pmh:oai:europepmc.org:3133126","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC4144396","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4144396","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4144396","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Comput Math Methods Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1155/2014/481935","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2014/481935","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2014/481935.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7599999904632568}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2105191443.pdf","grobid_xml":"https://content.openalex.org/works/W2105191443.grobid-xml"},"referenced_works_count":11,"referenced_works":["https://openalex.org/W193018420","https://openalex.org/W196969224","https://openalex.org/W1501347617","https://openalex.org/W1970295573","https://openalex.org/W1975817152","https://openalex.org/W2019438752","https://openalex.org/W2068316689","https://openalex.org/W2097571405","https://openalex.org/W2105491572","https://openalex.org/W2139899744","https://openalex.org/W4243694527"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725"],"abstract_inverted_index":{"Modeling":[0],"the":[1,5,21,25,52,67,81,88,124,130,133,140,144,152,156,164,171,183,188,190],"tumor":[2,41,58,134,215],"behavior":[3],"in":[4,20,27,37,51,66,84,151,220],"host":[6],"organ":[7],"as":[8,70,96,115],"function":[9],"of":[10,29,54,57,123,132,146,154,160,205],"time":[11],"and":[12,31,35,121,135,148,158,166,203],"radiation":[13],"dose":[14,63,161],"has":[15,109,192],"been":[16,111,193],"a":[17,47,97,167],"major":[18],"study":[19],"previous":[22,200],"decades.":[23],"Here":[24],"effort":[26],"estimation":[28],"cancerous":[30,149],"normal":[32,136,147,180],"cell":[33,181],"proliferation":[34],"growth":[36,216],"glioblastoma":[38],"multiform":[39],"(GBM)":[40],"is":[42,100,177],"presented.":[43],"This":[44],"paper":[45],"introduces":[46],"new":[48,98],"mathematical":[49],"model":[50,61,108,128,191,211],"form":[53],"differential":[55],"equation":[56],"growth.":[59],"The":[60,106,127,209],"contains":[62],"delivery":[64,162],"amount":[65,159],"treatment":[68,82,141,218,223],"scheme":[69],"an":[71,116],"input":[72],"term.":[73],"It":[74],"also":[75,110],"can":[76,225],"be":[77,226],"utilized":[78],"to":[79,86,113,163,213],"optimize":[80],"process":[83,142,219],"order":[85],"increase":[87],"patient":[89],"survival":[90],"period.":[91],"Gene":[92],"expression":[93],"programming":[94],"(GEP)":[95],"concept":[99],"used":[101],"for":[102,179],"estimating":[103],"this":[104],"model.":[105],"LQ":[107],"applied":[112],"GEP":[114],"initial":[117],"value,":[118],"causing":[119],"acceleration":[120],"improvement":[122],"algorithm":[125],"estimation.":[126],"shows":[129],"number":[131],"brain":[137,172],"cells":[138,150],"during":[139,217],"using":[143],"status":[145],"initiation":[153],"treatment,":[155],"timing":[157],"patient,":[165],"coefficient":[168],"that":[169],"describes":[170],"condition.":[173],"A":[174],"critical":[175],"level":[176],"defined":[178],"when":[182],"patient's":[184],"death":[185],"occurs.":[186],"In":[187],"end":[189],"verified":[194],"by":[195],"clinical":[196],"data":[197],"obtained":[198],"from":[199],"accepted":[201],"formulae":[202],"some":[204],"our":[206],"experimental":[207],"resources.":[208],"proposed":[210],"helps":[212],"predict":[214],"which":[221],"further":[222],"processes":[224],"controlled.":[227]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}
