{"id":"https://openalex.org/W2078539405","doi":"https://doi.org/10.1155/2013/989307","title":"Understanding the Pathogenesis of Kawasaki Disease by Network and Pathway Analysis","display_name":"Understanding the Pathogenesis of Kawasaki Disease by Network and Pathway Analysis","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2078539405","doi":"https://doi.org/10.1155/2013/989307","mag":"2078539405","pmid":"https://pubmed.ncbi.nlm.nih.gov/23533546"},"language":"en","primary_location":{"id":"doi:10.1155/2013/989307","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2013/989307","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2013/989307.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/cmmm/2013/989307.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040898387","display_name":"Yu-wen Lv","orcid":null},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-wen Lv","raw_affiliation_strings":["Department of Pediatric Cardiology, Children's Hospital of Soochow University, Suzhou 215003, China"],"affiliations":[{"raw_affiliation_string":"Department of Pediatric Cardiology, Children's Hospital of Soochow University, Suzhou 215003, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115602722","display_name":"Jing Wang","orcid":"https://orcid.org/0000-0002-2670-719X"},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Wang","raw_affiliation_strings":["Center for Systems Biology, Soochow University, Suzhou 215006, China"],"affiliations":[{"raw_affiliation_string":"Center for Systems Biology, Soochow University, Suzhou 215006, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075788332","display_name":"Ling Sun","orcid":"https://orcid.org/0000-0001-6444-9470"},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Sun","raw_affiliation_strings":["Department of Pediatric Cardiology, Children's Hospital of Soochow University, Suzhou 215003, China"],"affiliations":[{"raw_affiliation_string":"Department of Pediatric Cardiology, Children's Hospital of Soochow University, Suzhou 215003, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100444675","display_name":"Jianmin Zhang","orcid":"https://orcid.org/0000-0003-4765-0812"},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian-min Zhang","raw_affiliation_strings":["Department of Pediatric Cardiology, Children's Hospital of Soochow University, Suzhou 215003, China"],"affiliations":[{"raw_affiliation_string":"Department of Pediatric Cardiology, Children's Hospital of Soochow University, Suzhou 215003, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101410591","display_name":"Lei Cao","orcid":"https://orcid.org/0009-0001-7548-3866"},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Cao","raw_affiliation_strings":["Department of Pediatric Cardiology, Children's Hospital of Soochow University, Suzhou 215003, China"],"affiliations":[{"raw_affiliation_string":"Department of Pediatric Cardiology, Children's Hospital of Soochow University, Suzhou 215003, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090606230","display_name":"Yueyue Ding","orcid":null},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue-yue Ding","raw_affiliation_strings":["Department of Pediatric Cardiology, Children's Hospital of Soochow University, Suzhou 215003, China"],"affiliations":[{"raw_affiliation_string":"Department of Pediatric Cardiology, Children's Hospital of Soochow University, Suzhou 215003, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100359113","display_name":"Ye Chen","orcid":"https://orcid.org/0000-0002-7964-7899"},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ye Chen","raw_affiliation_strings":["Department of Pediatric Cardiology, Children's Hospital of Soochow University, Suzhou 215003, China"],"affiliations":[{"raw_affiliation_string":"Department of Pediatric Cardiology, Children's Hospital of Soochow University, Suzhou 215003, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042226970","display_name":"Ji-juan Dou","orcid":null},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ji-juan Dou","raw_affiliation_strings":["Department of Pediatric Cardiology, Children's Hospital of Soochow University, Suzhou 215003, China"],"affiliations":[{"raw_affiliation_string":"Department of Pediatric Cardiology, Children's Hospital of Soochow University, Suzhou 215003, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062322572","display_name":"Jie Huang","orcid":"https://orcid.org/0000-0002-3917-912X"},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Huang","raw_affiliation_strings":["Department of Pediatric Cardiology, Children's Hospital of Soochow University, Suzhou 215003, China"],"affiliations":[{"raw_affiliation_string":"Department of Pediatric Cardiology, Children's Hospital of Soochow University, Suzhou 215003, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030434545","display_name":"Yifei Tang","orcid":"https://orcid.org/0000-0003-1979-9070"},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi-fei Tang","raw_affiliation_strings":["Center for Systems Biology, Soochow University, Suzhou 215006, China"],"affiliations":[{"raw_affiliation_string":"Center for Systems Biology, Soochow University, Suzhou 215006, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076695260","display_name":"Wentao Wu","orcid":"https://orcid.org/0000-0001-7621-2198"},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen-tao Wu","raw_affiliation_strings":["Center for Systems Biology, Soochow University, Suzhou 215006, China"],"affiliations":[{"raw_affiliation_string":"Center for Systems Biology, Soochow University, Suzhou 215006, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059694528","display_name":"Weirong Cui","orcid":null},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei-rong Cui","raw_affiliation_strings":["Center for Systems Biology, Soochow University, Suzhou 215006, China"],"affiliations":[{"raw_affiliation_string":"Center for Systems Biology, Soochow University, Suzhou 215006, China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112776930","display_name":"Haitao Lv","orcid":null},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hai-tao Lv","raw_affiliation_strings":["Department of Pediatric Cardiology, Children's Hospital of Soochow University, Suzhou 215003, China"],"affiliations":[{"raw_affiliation_string":"Department of Pediatric Cardiology, Children's Hospital of Soochow University, Suzhou 215003, China","institution_ids":["https://openalex.org/I3923682"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5112776930"],"corresponding_institution_ids":["https://openalex.org/I3923682"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":3.2016,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.91477906,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"2013","issue":null,"first_page":"1","last_page":"17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11892","display_name":"Kawasaki Disease and Coronary Complications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11892","display_name":"Kawasaki Disease and Coronary Complications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12018","display_name":"Coronary Artery Anomalies","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12598","display_name":"Cardiac Structural Anomalies and Repair","score":0.9914000034332275,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pathogenesis","display_name":"Pathogenesis","score":0.8048762083053589},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6975119113922119},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.6555681824684143},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6208685636520386},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.554275631904602},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.5199169516563416},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.5145951509475708},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.48673203587532043},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.46168532967567444},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.43039190769195557},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3426181674003601},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2150259017944336},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.13089588284492493},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.10457733273506165}],"concepts":[{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.8048762083053589},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6975119113922119},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6555681824684143},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6208685636520386},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.554275631904602},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5199169516563416},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5145951509475708},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.48673203587532043},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.46168532967567444},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.43039190769195557},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3426181674003601},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2150259017944336},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.13089588284492493},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10457733273506165},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009080","descriptor_name":"Mucocutaneous Lymph Node Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009080","descriptor_name":"Mucocutaneous Lymph Node Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009080","descriptor_name":"Mucocutaneous Lymph Node Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015810","descriptor_name":"Linkage Disequilibrium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050778","descriptor_name":"NFATC Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050778","descriptor_name":"NFATC Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050778","descriptor_name":"NFATC Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1155/2013/989307","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2013/989307","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2013/989307.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},{"id":"pmid:23533546","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23533546","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and mathematical methods in medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:fbe38970f88e463f8d35cfc83800c801","is_oa":true,"landing_page_url":"https://doaj.org/article/fbe38970f88e463f8d35cfc83800c801","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computational and Mathematical Methods in Medicine, Vol 2013 (2013)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2604537","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3606754","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1155/2013/989307","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2013/989307","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2013/989307.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6899999976158142,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1303739252","display_name":null,"funder_award_id":"H201127","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"},{"id":"https://openalex.org/G3066978762","display_name":null,"funder_award_id":"SYS201144","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"},{"id":"https://openalex.org/G3910829908","display_name":null,"funder_award_id":"China","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"},{"id":"https://openalex.org/G8042217302","display_name":null,"funder_award_id":"BK2010032","funder_id":"https://openalex.org/F4320322769","funder_display_name":"Natural Science Foundation of Jiangsu Province"}],"funders":[{"id":"https://openalex.org/F4320321605","display_name":"Government of Jiangsu Province","ror":"https://ror.org/004svx814"},{"id":"https://openalex.org/F4320322769","display_name":"Natural Science Foundation of Jiangsu Province","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324720","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2078539405.pdf","grobid_xml":"https://content.openalex.org/works/W2078539405.grobid-xml"},"referenced_works_count":183,"referenced_works":["https://openalex.org/W120838493","https://openalex.org/W141433120","https://openalex.org/W254931895","https://openalex.org/W303733750","https://openalex.org/W1483584036","https://openalex.org/W1493513500","https://openalex.org/W1500811357","https://openalex.org/W1509578353","https://openalex.org/W1522927870","https://openalex.org/W1549582151","https://openalex.org/W1552490245","https://openalex.org/W1569503463","https://openalex.org/W1603077759","https://openalex.org/W1604523777","https://openalex.org/W1604641216","https://openalex.org/W1606727311","https://openalex.org/W1614729903","https://openalex.org/W1632342369","https://openalex.org/W1911192306","https://openalex.org/W1913594446","https://openalex.org/W1926837691","https://openalex.org/W1949341618","https://openalex.org/W1956596980","https://openalex.org/W1964952023","https://openalex.org/W1965107349","https://openalex.org/W1965178222","https://openalex.org/W1966132002","https://openalex.org/W1968126596","https://openalex.org/W1968835396","https://openalex.org/W1971141217","https://openalex.org/W1971273110","https://openalex.org/W1973004130","https://openalex.org/W1974531338","https://openalex.org/W1974869556","https://openalex.org/W1975430314","https://openalex.org/W1979431485","https://openalex.org/W1980762493","https://openalex.org/W1984317734","https://openalex.org/W1986542865","https://openalex.org/W1987935050","https://openalex.org/W1988569065","https://openalex.org/W1990350564","https://openalex.org/W1991353039","https://openalex.org/W1991401817","https://openalex.org/W1993774985","https://openalex.org/W1993846409","https://openalex.org/W1994447752","https://openalex.org/W1996172186","https://openalex.org/W1996682314","https://openalex.org/W1996822812","https://openalex.org/W1997886864","https://openalex.org/W2000746330","https://openalex.org/W2001625025","https://openalex.org/W2002678013","https://openalex.org/W2003905084","https://openalex.org/W2004679906","https://openalex.org/W2005374549","https://openalex.org/W2005729912","https://openalex.org/W2006323243","https://openalex.org/W2006540387","https://openalex.org/W2007727533","https://openalex.org/W2010068120","https://openalex.org/W2010216247","https://openalex.org/W2011338686","https://openalex.org/W2013841086","https://openalex.org/W2015418566","https://openalex.org/W2015949567","https://openalex.org/W2016046131","https://openalex.org/W2016129084","https://openalex.org/W2018040903","https://openalex.org/W2019014574","https://openalex.org/W2021839928","https://openalex.org/W2024092514","https://openalex.org/W2027622905","https://openalex.org/W2028373180","https://openalex.org/W2028799436","https://openalex.org/W2029293239","https://openalex.org/W2029325494","https://openalex.org/W2031905931","https://openalex.org/W2032126500","https://openalex.org/W2032381702","https://openalex.org/W2037292475","https://openalex.org/W2037956005","https://openalex.org/W2039196787","https://openalex.org/W2041962299","https://openalex.org/W2042462012","https://openalex.org/W2045055598","https://openalex.org/W2050052489","https://openalex.org/W2050593306","https://openalex.org/W2050872433","https://openalex.org/W2050966310","https://openalex.org/W2051120393","https://openalex.org/W2051726240","https://openalex.org/W2052157425","https://openalex.org/W2052334822","https://openalex.org/W2052814999","https://openalex.org/W2053452881","https://openalex.org/W2054256769","https://openalex.org/W2057388623","https://openalex.org/W2059029747","https://openalex.org/W2059912147","https://openalex.org/W2060310993","https://openalex.org/W2062469526","https://openalex.org/W2062470234","https://openalex.org/W2065556248","https://openalex.org/W2065819518","https://openalex.org/W2066442186","https://openalex.org/W2066762300","https://openalex.org/W2068425507","https://openalex.org/W2069265397","https://openalex.org/W2071719184","https://openalex.org/W2073580835","https://openalex.org/W2073730386","https://openalex.org/W2075487270","https://openalex.org/W2076201002","https://openalex.org/W2077397494","https://openalex.org/W2078515648","https://openalex.org/W2080077971","https://openalex.org/W2080254149","https://openalex.org/W2082222905","https://openalex.org/W2082247152","https://openalex.org/W2082449513","https://openalex.org/W2085067807","https://openalex.org/W2087987586","https://openalex.org/W2092319768","https://openalex.org/W2093753608","https://openalex.org/W2094298095","https://openalex.org/W2095445691","https://openalex.org/W2096263237","https://openalex.org/W2096819701","https://openalex.org/W2098627447","https://openalex.org/W2103553546","https://openalex.org/W2104639932","https://openalex.org/W2107119569","https://openalex.org/W2108133866","https://openalex.org/W2111650534","https://openalex.org/W2111662704","https://openalex.org/W2111866535","https://openalex.org/W2112278496","https://openalex.org/W2114463608","https://openalex.org/W2116014852","https://openalex.org/W2117946325","https://openalex.org/W2118423226","https://openalex.org/W2122702950","https://openalex.org/W2123744383","https://openalex.org/W2125488784","https://openalex.org/W2127177109","https://openalex.org/W2128025794","https://openalex.org/W2130667293","https://openalex.org/W2132325104","https://openalex.org/W2135378275","https://openalex.org/W2136341846","https://openalex.org/W2136895807","https://openalex.org/W2140283734","https://openalex.org/W2142378380","https://openalex.org/W2142487084","https://openalex.org/W2146288480","https://openalex.org/W2146713119","https://openalex.org/W2146750540","https://openalex.org/W2150264698","https://openalex.org/W2159461863","https://openalex.org/W2161457594","https://openalex.org/W2166098285","https://openalex.org/W2166138550","https://openalex.org/W2168089016","https://openalex.org/W2169559786","https://openalex.org/W2169839342","https://openalex.org/W2170556286","https://openalex.org/W2172196619","https://openalex.org/W2297211735","https://openalex.org/W2327006078","https://openalex.org/W2327814395","https://openalex.org/W2350840859","https://openalex.org/W2375943177","https://openalex.org/W2379595419","https://openalex.org/W2396123375","https://openalex.org/W2407476627","https://openalex.org/W2417012635","https://openalex.org/W2885103097","https://openalex.org/W2955305611","https://openalex.org/W4211164083","https://openalex.org/W4232309938","https://openalex.org/W4239255223"],"related_works":["https://openalex.org/W2365906682","https://openalex.org/W2356836538","https://openalex.org/W2388744202","https://openalex.org/W1539935214","https://openalex.org/W4390666975","https://openalex.org/W4394738710","https://openalex.org/W4306929873","https://openalex.org/W1864400744","https://openalex.org/W1205682447","https://openalex.org/W2124343538"],"abstract_inverted_index":{"Kawasaki":[0],"disease":[1,19],"(KD)":[2],"is":[3,20],"a":[4,100,153],"complex":[5],"disease,":[6],"leading":[7],"to":[8,64,66,72,177],"the":[9,35,120,128,147,168],"damage":[10],"of":[11,37,102,122,132,149,170,180],"multisystems.":[12],"The":[13],"pathogen":[14],"that":[15],"triggers":[16],"this":[17,50,171],"sophisticated":[18],"still":[21],"unknown":[22],"since":[23],"it":[24],"was":[25],"first":[26],"reported":[27],"in":[28,39,99,119,146],"1967.":[29],"To":[30],"increase":[31],"our":[32],"knowledge":[33],"on":[34,157],"effects":[36],"genes":[38,45,62,96,165],"KD,":[40,67,77],"we":[41],"extracted":[42],"statistically":[43,92],"significant":[44,93],"so":[46,79],"far":[47],"associated":[48],"with":[49,139],"mysterious":[51],"illness":[52],"from":[53],"candidate":[54],"gene":[55],"studies":[56],"and":[57,78,84,110,135,166],"genome-wide":[58],"association":[59],"studies.":[60],"These":[61,95],"contributed":[63],"susceptibility":[65],"coronary":[68],"artery":[69],"lesions,":[70],"resistance":[71],"initial":[73],"IVIG":[74],"treatment,":[75],"incomplete":[76],"on.":[80],"Gene":[81],"ontology":[82],"category":[83],"pathways":[85],"were":[86,97,116],"analyzed":[87],"for":[88],"relationships":[89],"among":[90],"these":[91,164],"genes.":[94],"represented":[98],"variety":[101],"functional":[103],"categories,":[104],"including":[105],"immune":[106,123,130],"response,":[107,109],"inflammatory":[108],"cellular":[111],"calcium":[112],"ion":[113],"homeostasis.":[114],"They":[115],"mainly":[117],"enriched":[118],"pathway":[121,131],"response.":[124],"We":[125],"further":[126],"highlighted":[127],"compelling":[129],"NF-AT":[133],"signal":[134],"leukocyte":[136],"interactions":[137],"combined":[138],"another":[140],"transcription":[141],"factor":[142],"NF-":[143],"\u03ba":[144],"B":[145],"pathogenesis":[148,179],"KD.":[150,181],"STRING":[151],"analysis,":[152],"network":[154],"analysis":[155],"focusing":[156],"protein":[158],"interactions,":[159],"validated":[160],"close":[161],"contact":[162],"between":[163],"implied":[167],"importance":[169],"pathway.":[172],"This":[173],"data":[174],"will":[175],"contribute":[176],"understanding":[178]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}