{"id":"https://openalex.org/W1981482839","doi":"https://doi.org/10.1155/2013/283593","title":"Spatiotemporal Dynamic Simulation of Acute Perfusion/Diffusion Ischemic Stroke Lesions Evolution: A Pilot Study Derived from Longitudinal MR Patient Data","display_name":"Spatiotemporal Dynamic Simulation of Acute Perfusion/Diffusion Ischemic Stroke Lesions Evolution: A Pilot Study Derived from Longitudinal MR Patient Data","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W1981482839","doi":"https://doi.org/10.1155/2013/283593","mag":"1981482839","pmid":"https://pubmed.ncbi.nlm.nih.gov/23853669"},"language":"en","primary_location":{"id":"doi:10.1155/2013/283593","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2013/283593","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2013/283593.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/cmmm/2013/283593.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048784346","display_name":"Islem Rekik","orcid":"https://orcid.org/0000-0001-5595-6673"},"institutions":[{"id":"https://openalex.org/I142476485","display_name":"\u00c9cole Polytechnique","ror":"https://ror.org/05hy3tk52","country_code":"FR","type":"education","lineage":["https://openalex.org/I142476485","https://openalex.org/I4210145102"]},{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]}],"countries":["FR","GB"],"is_corresponding":true,"raw_author_name":"Islem Rekik","raw_affiliation_strings":["CMAP, Ecole Polytechnique, route de Saclay, 91128 Palaiseau, France","Division of Neuroimaging Sciences, Brain Research Imaging Centre (BRIC), Edinburgh University, UK","BRIC - Brain Research Imaging Center (Neuroimaging Sciences Western General Hospital Crewe Road Edinburgh EH4 2XU UK - United Kingdom)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CMAP, Ecole Polytechnique, route de Saclay, 91128 Palaiseau, France","institution_ids":["https://openalex.org/I142476485"]},{"raw_affiliation_string":"Division of Neuroimaging Sciences, Brain Research Imaging Centre (BRIC), Edinburgh University, UK","institution_ids":[]},{"raw_affiliation_string":"BRIC - Brain Research Imaging Center (Neuroimaging Sciences Western General Hospital Crewe Road Edinburgh EH4 2XU UK - United Kingdom)","institution_ids":["https://openalex.org/I2800150677"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031106777","display_name":"St\u00e9phanie Allassonni\u00e8re","orcid":"https://orcid.org/0000-0002-5692-4945"},"institutions":[{"id":"https://openalex.org/I142476485","display_name":"\u00c9cole Polytechnique","ror":"https://ror.org/05hy3tk52","country_code":"FR","type":"education","lineage":["https://openalex.org/I142476485","https://openalex.org/I4210145102"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"St\u00e9phanie Allassonni\u00e8re","raw_affiliation_strings":["CMAP, Ecole Polytechnique, route de Saclay, 91128 Palaiseau, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CMAP, Ecole Polytechnique, route de Saclay, 91128 Palaiseau, France","institution_ids":["https://openalex.org/I142476485"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080254367","display_name":"Stanley Durrleman","orcid":"https://orcid.org/0000-0002-9450-6920"},"institutions":[{"id":"https://openalex.org/I1326498283","display_name":"Institut national de recherche en sciences et technologies du num\u00e9rique","ror":"https://ror.org/02kvxyf05","country_code":"FR","type":"government","lineage":["https://openalex.org/I1326498283"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]},{"id":"https://openalex.org/I4210121705","display_name":"Piti\u00e9-Salp\u00eatri\u00e8re Hospital","ror":"https://ror.org/02mh9a093","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210121705"]},{"id":"https://openalex.org/I4210152724","display_name":"Institut du Cerveau","ror":"https://ror.org/050gn5214","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210152724"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Stanley Durrleman","raw_affiliation_strings":["INRIA, ICM Piti\u00e9-Salp\u00e9tri\u00e8re Hospital, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INRIA, ICM Piti\u00e9-Salp\u00e9tri\u00e8re Hospital, Paris, France","institution_ids":["https://openalex.org/I1326498283","https://openalex.org/I39804081","https://openalex.org/I4210121705","https://openalex.org/I4210152724"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061309461","display_name":"Trevor Carpenter","orcid":"https://orcid.org/0009-0005-5652-3008"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Trevor Carpenter","raw_affiliation_strings":["Division of Neuroimaging Sciences, Brain Research Imaging Centre (BRIC), Edinburgh University, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neuroimaging Sciences, Brain Research Imaging Centre (BRIC), Edinburgh University, UK","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004889443","display_name":"Joanna M. Wardlaw","orcid":"https://orcid.org/0000-0002-9812-6642"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joanna Wardlaw","raw_affiliation_strings":["Division of Neuroimaging Sciences, Brain Research Imaging Centre (BRIC), Edinburgh University, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neuroimaging Sciences, Brain Research Imaging Centre (BRIC), Edinburgh University, UK","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5048784346"],"corresponding_institution_ids":["https://openalex.org/I142476485","https://openalex.org/I2800150677"],"apc_list":{"value":2550,"currency":"USD","value_usd":2550},"apc_paid":{"value":2550,"currency":"USD","value_usd":2550},"fwci":0.9571,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.74662747,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"2013","issue":null,"first_page":"1","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.9797000288963318,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stroke","display_name":"Stroke (engine)","score":0.6421818137168884},{"id":"https://openalex.org/keywords/diffusion-mri","display_name":"Diffusion MRI","score":0.5871756076812744},{"id":"https://openalex.org/keywords/lesion","display_name":"Lesion","score":0.5849126577377319},{"id":"https://openalex.org/keywords/perfusion","display_name":"Perfusion","score":0.5820716619491577},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"Ischemic stroke","score":0.5248926877975464},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5094254612922668},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.45747849345207214},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.4317336976528168},{"id":"https://openalex.org/keywords/perfusion-scanning","display_name":"Perfusion scanning","score":0.42134371399879456},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.3922775089740753},{"id":"https://openalex.org/keywords/ischemia","display_name":"Ischemia","score":0.2715962529182434},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.26805639266967773},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.2032957375049591},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.1051979660987854}],"concepts":[{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.6421818137168884},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.5871756076812744},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.5849126577377319},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.5820716619491577},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.5248926877975464},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5094254612922668},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.45747849345207214},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4317336976528168},{"id":"https://openalex.org/C135691158","wikidata":"https://www.wikidata.org/wiki/Q7168308","display_name":"Perfusion scanning","level":3,"score":0.42134371399879456},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3922775089740753},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.2715962529182434},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.26805639266967773},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.2032957375049591},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.1051979660987854},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D003936","descriptor_name":"Diagnosis, Computer-Assisted","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D021621","descriptor_name":"Imaging, Three-Dimensional","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1155/2013/283593","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2013/283593","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2013/283593.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},{"id":"pmid:23853669","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23853669","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and mathematical methods in medicine","raw_type":null},{"id":"pmh:oai:pure.ed.ac.uk:openaire/f8436913-08e9-423a-9bae-3ddd6f609d8c","is_oa":true,"landing_page_url":"https://www.research.ed.ac.uk/en/publications/f8436913-08e9-423a-9bae-3ddd6f609d8c","pdf_url":null,"source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rekik, I, Allassonni\u00e8re, S, Durrleman, S, Carpenter, T & Wardlaw, J 2013, 'Spatiotemporal Dynamic Simulation of Acute Perfusion/Diffusion Ischemic Stroke Lesions Evolution : A Pilot Study Derived from Longitudinal MR Patient Data', Computational and mathematical methods in medicine, vol. 2013, pp. 283593. https://doi.org/10.1155/2013/283593","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:HAL:hal-00935051v1","is_oa":false,"landing_page_url":"https://inria.hal.science/hal-00935051","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.hindawi.com/journals/cmmm/2013/283593/","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:7451a23298c6455ab175c2e8f511d8cd","is_oa":true,"landing_page_url":"https://doaj.org/article/7451a23298c6455ab175c2e8f511d8cd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computational and Mathematical Methods in Medicine, Vol 2013 (2013)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2704314","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3703431","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3703431","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3703431","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Comput Math Methods Med","raw_type":"Text"},{"id":"pmh:oai:pure.ed.ac.uk:publications/f8436913-08e9-423a-9bae-3ddd6f609d8c","is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11820/f8436913-08e9-423a-9bae-3ddd6f609d8c","pdf_url":null,"source":{"id":"https://openalex.org/S4406922455","display_name":"Edinburgh Research Explorer","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""}],"best_oa_location":{"id":"doi:10.1155/2013/283593","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2013/283593","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2013/283593.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5699999928474426,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1112932569","display_name":null,"funder_award_id":"MC_G1002455","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320313269","display_name":"Scottish Government","ror":"https://ror.org/04v2xmd71"},{"id":"https://openalex.org/F4320320064","display_name":"Scottish Funding Council","ror":"https://ror.org/056bwcz71"},{"id":"https://openalex.org/F4320320332","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334783","display_name":"Efficacy and Mechanism Evaluation Programme","ror":"https://ror.org/0187kwz08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1981482839.pdf","grobid_xml":"https://content.openalex.org/works/W1981482839.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W74690246","https://openalex.org/W1543220894","https://openalex.org/W1573041381","https://openalex.org/W1698856871","https://openalex.org/W1886447711","https://openalex.org/W1968324224","https://openalex.org/W1977877018","https://openalex.org/W1986442311","https://openalex.org/W1989754340","https://openalex.org/W1995253919","https://openalex.org/W1997064745","https://openalex.org/W2000322457","https://openalex.org/W2003058719","https://openalex.org/W2006440647","https://openalex.org/W2009049939","https://openalex.org/W2012044907","https://openalex.org/W2018636616","https://openalex.org/W2041645861","https://openalex.org/W2044917658","https://openalex.org/W2047791068","https://openalex.org/W2057787986","https://openalex.org/W2073494433","https://openalex.org/W2079239744","https://openalex.org/W2082857092","https://openalex.org/W2092854526","https://openalex.org/W2095877654","https://openalex.org/W2097805840","https://openalex.org/W2098973055","https://openalex.org/W2112571673","https://openalex.org/W2119214090","https://openalex.org/W2126266657","https://openalex.org/W2139193549","https://openalex.org/W2151430135","https://openalex.org/W2157338473","https://openalex.org/W2167581865","https://openalex.org/W2170597858","https://openalex.org/W2928618355","https://openalex.org/W2973696211","https://openalex.org/W4256457228"],"related_works":["https://openalex.org/W2467919609","https://openalex.org/W3032083687","https://openalex.org/W2373954417","https://openalex.org/W2383101986","https://openalex.org/W2471267301","https://openalex.org/W2467341106","https://openalex.org/W2385340480","https://openalex.org/W2133730772","https://openalex.org/W2015301357","https://openalex.org/W2361304792"],"abstract_inverted_index":{"The":[0],"spatiotemporal":[1],"evolution":[2,75,109,138],"of":[3,45,76,94,101,136],"stroke":[4,78,180],"lesions,":[5,155],"from":[6,79],"acute":[7],"injury":[8],"to":[9,24,31],"final":[10,174],"tissue":[11,175],"damage,":[12],"is":[13,21,65],"complex.":[14],"Diffusion-weighted":[15],"(DWI)":[16],"and":[17,29,36,42,119,163,183],"perfusion-weighted":[18],"(PWI)":[19],"imaging":[20],"commonly":[22],"used":[23,54],"detect":[25],"early":[26],"ischemic":[27,77],"changes":[28,147],"attempts":[30],"distinguish":[32],"between":[33],"permanently":[34],"damaged":[35],"salvageable":[37],"tissues.":[38],"To":[39],"date,":[40],"2D":[41],"3D":[43],"measures":[44],"diffusion/perfusion":[46],"regions":[47],"at":[48],"individual":[49],"timepoints":[50],"have":[51],"been":[52],"widely":[53],"but":[55,156],"may":[56],"underestimate":[57],"the":[58,73,92,99,127,130,170,173],"true":[59],"lesion":[60,137,151],"spatio-temporal":[61,67,107],"dynamics.":[62],"Currently":[63],"there":[64],"no":[66],"4D":[68,86],"dynamic":[69,134,146],"model":[70,128],"that":[71],"simulates":[72],"continuous":[74,108],"MR":[80,111],"images.":[81],"We":[82],"determined":[83],"whether":[84],"a":[85],"current-based":[87],"diffeomorphic":[88],"model,":[89],"developed":[90],"in":[91,169],"field":[93],"statistical":[95],"modeling":[96],"for":[97,110,142,181],"measuring":[98],"variability":[100],"anatomical":[102],"surfaces,":[103],"could":[104],"estimate":[105],"patient-specific":[106],"PWI":[112,154],"(measured":[113],"as":[114],"mean":[115],"transit":[116],"time,":[117],"(MTT))":[118],"DWI":[120,150,182],"lesions.":[121],"In":[122],"our":[123],"representative":[124],"pilot":[125],"sample,":[126],"fitted":[129],"data":[131],"well.":[132],"Our":[133],"analysis":[135],"showed":[139],"different":[140],"patterns;":[141],"example,":[143],"some":[144],"DWI/PWI":[145],"corresponded":[148],"with":[149],"expansion":[152],"into":[153],"other":[157],"patterns":[158],"were":[159],"much":[160],"more":[161],"complex":[162],"diverse.":[164],"There":[165],"was":[166,177],"wide":[167],"variation":[168],"time":[171],"when":[172],"damage":[176],"reached":[178],"after":[179],"MTT.":[184]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-07-31T08:31:51.225901","created_date":"2025-10-10T00:00:00"}