{"id":"https://openalex.org/W2038707074","doi":"https://doi.org/10.1155/2012/839837","title":"MicroRNA Response Elements-Mediated miRNA-miRNA Interactions in Prostate Cancer","display_name":"MicroRNA Response Elements-Mediated miRNA-miRNA Interactions in Prostate Cancer","publication_year":2012,"publication_date":"2012-11-04","ids":{"openalex":"https://openalex.org/W2038707074","doi":"https://doi.org/10.1155/2012/839837","mag":"2038707074","pmid":"https://pubmed.ncbi.nlm.nih.gov/23193399"},"language":"en","primary_location":{"id":"doi:10.1155/2012/839837","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/839837","pdf_url":"https://downloads.hindawi.com/journals/abi/2012/839837.pdf","source":{"id":"https://openalex.org/S146125958","display_name":"Advances in Bioinformatics","issn_l":"1687-8027","issn":["1687-8027","1687-8035"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/abi/2012/839837.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032201078","display_name":"Mohammed Alshalalfa","orcid":"https://orcid.org/0000-0001-8405-3035"},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]},{"id":"https://openalex.org/I37417134","display_name":"Palestine Polytechnic University","ror":"https://ror.org/03wwspn40","country_code":"PS","type":"education","lineage":["https://openalex.org/I37417134"]}],"countries":["CA","PS"],"is_corresponding":true,"raw_author_name":"Mohammed Alshalalfa","raw_affiliation_strings":["Biotechnology Research Center, Palestine Polytechnic University, Hebron, Palestine","Department of Computer Science, University of Calgary, 2500 University Dr. NW, Calgary, AB, Canada T2N 1N4"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotechnology Research Center, Palestine Polytechnic University, Hebron, Palestine","institution_ids":["https://openalex.org/I37417134"]},{"raw_affiliation_string":"Department of Computer Science, University of Calgary, 2500 University Dr. NW, Calgary, AB, Canada T2N 1N4","institution_ids":["https://openalex.org/I168635309"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5032201078"],"corresponding_institution_ids":["https://openalex.org/I168635309","https://openalex.org/I37417134"],"apc_list":null,"apc_paid":{"value":773,"currency":"EUR","value_usd":833},"fwci":0.911,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.75625,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"2012","issue":null,"first_page":"1","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.9301140308380127},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6356013417243958},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"Prostate cancer","score":0.6028856635093689},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5093296766281128},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.5068333745002747},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.4992794990539551},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"Gene silencing","score":0.48255985975265503},{"id":"https://openalex.org/keywords/suppressor","display_name":"Suppressor","score":0.4726787209510803},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.4662555456161499},{"id":"https://openalex.org/keywords/metastasis","display_name":"Metastasis","score":0.4601723551750183},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.44724714756011963},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.4467141628265381},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.4342947006225586},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.3453676700592041},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1978171169757843}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.9301140308380127},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6356013417243958},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6028856635093689},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5093296766281128},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5068333745002747},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4992794990539551},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.48255985975265503},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.4726787209510803},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4662555456161499},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4601723551750183},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44724714756011963},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4467141628265381},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4342947006225586},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3453676700592041},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1978171169757843}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1155/2012/839837","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/839837","pdf_url":"https://downloads.hindawi.com/journals/abi/2012/839837.pdf","source":{"id":"https://openalex.org/S146125958","display_name":"Advances in Bioinformatics","issn_l":"1687-8027","issn":["1687-8027","1687-8035"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:23193399","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23193399","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in bioinformatics","raw_type":null},{"id":"pmh:oai:prism.ucalgary.ca:1880/108369","is_oa":true,"landing_page_url":"http://hdl.handle.net/1880/108369","pdf_url":null,"source":{"id":"https://openalex.org/S4306402212","display_name":"PRISM (University of Calgary)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I168635309","host_organization_name":"University of Calgary","host_organization_lineage":["https://openalex.org/I168635309"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:prism.ucalgary.ca:1880/49595","is_oa":true,"landing_page_url":"http://hdl.handle.net/1880/49595","pdf_url":"http://hdl.handle.net/1880/49595","source":{"id":"https://openalex.org/S4306402212","display_name":"PRISM (University of Calgary)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I168635309","host_organization_name":"University of Calgary","host_organization_lineage":["https://openalex.org/I168635309"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3502784","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3502784","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Adv Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1155/2012/839837","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/839837","pdf_url":"https://downloads.hindawi.com/journals/abi/2012/839837.pdf","source":{"id":"https://openalex.org/S146125958","display_name":"Advances in Bioinformatics","issn_l":"1687-8027","issn":["1687-8027","1687-8035"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7599999904632568}],"awards":[],"funders":[{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2038707074.pdf","grobid_xml":"https://content.openalex.org/works/W2038707074.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1604827622","https://openalex.org/W1648301895","https://openalex.org/W1966498224","https://openalex.org/W1971623350","https://openalex.org/W1986214281","https://openalex.org/W2002995168","https://openalex.org/W2029127250","https://openalex.org/W2048603557","https://openalex.org/W2050869737","https://openalex.org/W2053835153","https://openalex.org/W2059073003","https://openalex.org/W2067419055","https://openalex.org/W2073764144","https://openalex.org/W2076954411","https://openalex.org/W2093624975","https://openalex.org/W2097948046","https://openalex.org/W2107633226","https://openalex.org/W2107940486","https://openalex.org/W2113390076","https://openalex.org/W2116100742","https://openalex.org/W2117391818","https://openalex.org/W2131880008","https://openalex.org/W2134118500","https://openalex.org/W2155142785","https://openalex.org/W2157795344","https://openalex.org/W2164194749","https://openalex.org/W2597632520","https://openalex.org/W4294107304"],"related_works":["https://openalex.org/W2026936876","https://openalex.org/W2997612862","https://openalex.org/W2128583238","https://openalex.org/W2010571965","https://openalex.org/W2034377088","https://openalex.org/W2002709996","https://openalex.org/W4387092964","https://openalex.org/W2103471012","https://openalex.org/W2966064480","https://openalex.org/W2115810854"],"abstract_inverted_index":{"The":[0,106,115],"cell":[1,17],"is":[2,36,117,141],"a":[3,19,42,142,171],"highly":[4],"organized":[5],"system":[6],"of":[7,26,32,49,64,124,170],"interacting":[8],"molecules":[9],"including":[10],"proteins,":[11],"mRNAs,":[12],"and":[13,55,67,79,98,156],"miRNAs.":[14,164],"Analyzing":[15],"the":[16,30,47,62,121,135,168],"from":[18],"systems":[20],"perspective":[21],"by":[22],"integrating":[23],"different":[24],"types":[25],"data":[27,71],"helps":[28],"revealing":[29],"complexity":[31],"diseases.":[33],"Although":[34],"there":[35],"emerging":[37],"evidence":[38],"that":[39,139,159,183],"microRNAs":[40,50],"have":[41],"functional":[43,93,122],"role":[44,48,123],"in":[45,51,145],"cancer,":[46],"mediating":[52],"cancer":[53,148],"progression":[54],"metastasis":[56],"remains":[57],"not":[58],"fully":[59],"explored.":[60],"As":[61],"amount":[63],"available":[65],"miRNA":[66,86,99,110],"mRNA":[68,97],"gene":[69,77],"expression":[70,78,100,178],"grows,":[72],"more":[73],"systematic":[74],"methods":[75],"combining":[76],"biological":[80],"networks":[81],"become":[82],"necessary":[83],"to":[84,101,119,129,176,179],"explore":[85],"function.":[87],"In":[88],"this":[89],"work":[90,166],"I":[91],"integrated":[92],"miRNA-target":[94],"interactions":[95,131],"with":[96],"infer":[102],"mRNA-mediated":[103],"miRNA-miRNA":[104],"interactions.":[105],"inferred":[107],"network":[108,116,172],"represents":[109],"modulation":[111],"through":[112],"common":[113],"targets.":[114],"used":[118],"characterize":[120],"microRNA":[125],"response":[126],"element":[127],"(MRE)":[128],"mediate":[130],"between":[132],"miRNAs":[133,151,182],"targeting":[134],"MRE.":[136],"Results":[137],"revealed":[138],"miRNA-1":[140],"key":[143],"player":[144],"regulating":[146],"prostate":[147,185],"progression.":[149],"11":[150],"were":[152],"identified":[153],"as":[154,161,174],"diagnostic":[155],"prognostic":[157],"biomarkers":[158],"act":[160],"tumor":[162],"suppressor":[163],"This":[165],"demonstrates":[167],"utility":[169],"analysis":[173],"opposed":[175],"differential":[177],"find":[180],"important":[181],"regulate":[184],"cancer.":[186]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-07-02T09:51:11.867554","created_date":"2025-10-10T00:00:00"}
