{"id":"https://openalex.org/W1984020122","doi":"https://doi.org/10.1155/2012/790281","title":"Membrane Protein Stability Analyses by Means of Protein Energy Profiles in Case of Nephrogenic Diabetes Insipidus","display_name":"Membrane Protein Stability Analyses by Means of Protein Energy Profiles in Case of Nephrogenic Diabetes Insipidus","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W1984020122","doi":"https://doi.org/10.1155/2012/790281","mag":"1984020122","pmid":"https://pubmed.ncbi.nlm.nih.gov/22474537"},"language":"en","primary_location":{"id":"doi:10.1155/2012/790281","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/790281","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2012/790281.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/cmmm/2012/790281.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000213880","display_name":"Florian Heinke","orcid":null},"institutions":[{"id":"https://openalex.org/I116397343","display_name":"Hochschule Mittweida","ror":"https://ror.org/024ga3r86","country_code":"DE","type":"education","lineage":["https://openalex.org/I116397343"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Florian Heinke","raw_affiliation_strings":["Department of Mathematics, Natural and Computer Sciences, Hochschule Mittweida, University of Applied Sciences, Technikumplatz 17, 09648 Mittweida, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Natural and Computer Sciences, Hochschule Mittweida, University of Applied Sciences, Technikumplatz 17, 09648 Mittweida, Germany","institution_ids":["https://openalex.org/I116397343"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023295736","display_name":"Dirk Labudde","orcid":"https://orcid.org/0000-0003-0466-0017"},"institutions":[{"id":"https://openalex.org/I116397343","display_name":"Hochschule Mittweida","ror":"https://ror.org/024ga3r86","country_code":"DE","type":"education","lineage":["https://openalex.org/I116397343"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Dirk Labudde","raw_affiliation_strings":["Department of Mathematics, Natural and Computer Sciences, Hochschule Mittweida, University of Applied Sciences, Technikumplatz 17, 09648 Mittweida, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Natural and Computer Sciences, Hochschule Mittweida, University of Applied Sciences, Technikumplatz 17, 09648 Mittweida, Germany","institution_ids":["https://openalex.org/I116397343"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5023295736"],"corresponding_institution_ids":["https://openalex.org/I116397343"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":0.6717,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.67547375,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"2012","issue":null,"first_page":"1","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.994700014591217,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11967","display_name":"Electrolyte and hormonal disorders","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nephrogenic-diabetes-insipidus","display_name":"Nephrogenic diabetes insipidus","score":0.8185954093933105},{"id":"https://openalex.org/keywords/diabetes-insipidus","display_name":"Diabetes insipidus","score":0.6088552474975586},{"id":"https://openalex.org/keywords/protein-stability","display_name":"Protein stability","score":0.4660661518573761},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3698161244392395},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.32003656029701233},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.30838772654533386},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.09439218044281006}],"concepts":[{"id":"https://openalex.org/C2777464133","wikidata":"https://www.wikidata.org/wiki/Q2892779","display_name":"Nephrogenic diabetes insipidus","level":3,"score":0.8185954093933105},{"id":"https://openalex.org/C2776958162","wikidata":"https://www.wikidata.org/wiki/Q220551","display_name":"Diabetes insipidus","level":2,"score":0.6088552474975586},{"id":"https://openalex.org/C2988375501","wikidata":"https://www.wikidata.org/wiki/Q847556","display_name":"Protein stability","level":2,"score":0.4660661518573761},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3698161244392395},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32003656029701233},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30838772654533386},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09439218044281006}],"mesh":[{"descriptor_ui":"D001127","descriptor_name":"Arginine Vasopressin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001127","descriptor_name":"Arginine Vasopressin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001127","descriptor_name":"Arginine Vasopressin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017483","descriptor_name":"Receptors, Vasopressin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017483","descriptor_name":"Receptors, Vasopressin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017483","descriptor_name":"Receptors, Vasopressin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017483","descriptor_name":"Receptors, Vasopressin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017483","descriptor_name":"Receptors, Vasopressin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017483","descriptor_name":"Receptors, Vasopressin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018500","descriptor_name":"Diabetes Insipidus, Nephrogenic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018500","descriptor_name":"Diabetes Insipidus, Nephrogenic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018500","descriptor_name":"Diabetes Insipidus, Nephrogenic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051399","descriptor_name":"Aquaporin 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051399","descriptor_name":"Aquaporin 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051399","descriptor_name":"Aquaporin 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051399","descriptor_name":"Aquaporin 2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051399","descriptor_name":"Aquaporin 2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051399","descriptor_name":"Aquaporin 2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1155/2012/790281","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/790281","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2012/790281.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},{"id":"pmid:22474537","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22474537","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and mathematical methods in medicine","raw_type":null},{"id":"pmh:oai:europepmc.org:2326404","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3312259","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1155/2012/790281","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/790281","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2012/790281.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation","score":0.46000000834465027}],"awards":[],"funders":[{"id":"https://openalex.org/F4320328735","display_name":"Freistaat Sachsen","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1984020122.pdf","grobid_xml":"https://content.openalex.org/works/W1984020122.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W67655226","https://openalex.org/W1211137896","https://openalex.org/W1525759724","https://openalex.org/W1570448133","https://openalex.org/W1606294538","https://openalex.org/W1965151258","https://openalex.org/W1973128208","https://openalex.org/W2001956250","https://openalex.org/W2009703891","https://openalex.org/W2010971003","https://openalex.org/W2011495938","https://openalex.org/W2014095962","https://openalex.org/W2023254642","https://openalex.org/W2027408247","https://openalex.org/W2034367303","https://openalex.org/W2037312364","https://openalex.org/W2043628797","https://openalex.org/W2045777307","https://openalex.org/W2045782920","https://openalex.org/W2049917308","https://openalex.org/W2056402029","https://openalex.org/W2060920066","https://openalex.org/W2068390752","https://openalex.org/W2074231493","https://openalex.org/W2079126167","https://openalex.org/W2083977903","https://openalex.org/W2087064593","https://openalex.org/W2091778154","https://openalex.org/W2095536604","https://openalex.org/W2096250412","https://openalex.org/W2101250526","https://openalex.org/W2103815459","https://openalex.org/W2105612671","https://openalex.org/W2107452580","https://openalex.org/W2110834905","https://openalex.org/W2118200955","https://openalex.org/W2119254621","https://openalex.org/W2124782304","https://openalex.org/W2128984164","https://openalex.org/W2129556489","https://openalex.org/W2129838159","https://openalex.org/W2131736388","https://openalex.org/W2140767931","https://openalex.org/W2142072041","https://openalex.org/W2144998676","https://openalex.org/W2147993766","https://openalex.org/W2152301430","https://openalex.org/W2153517511","https://openalex.org/W2166495492","https://openalex.org/W2167257955","https://openalex.org/W2170441710","https://openalex.org/W2171885962","https://openalex.org/W2282054059","https://openalex.org/W2768565525","https://openalex.org/W4235736168","https://openalex.org/W4236547687","https://openalex.org/W4240401512","https://openalex.org/W4246356731","https://openalex.org/W4249572021","https://openalex.org/W4297963216"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W4240531516","https://openalex.org/W2079461876","https://openalex.org/W1521665888","https://openalex.org/W323327258","https://openalex.org/W4223591108","https://openalex.org/W2594493285","https://openalex.org/W1560276986","https://openalex.org/W2097317513","https://openalex.org/W2026552878"],"abstract_inverted_index":{"Diabetes":[0],"insipidus":[1],"(DI)":[2],"is":[3,22,46,65,95],"a":[4,54,66,111,141,156],"rare":[5],"endocrine,":[6],"inheritable":[7],"disorder":[8,67],"with":[9],"low":[10],"incidences":[11],"in":[12,39,58,68,97,107,128,146],"an":[13],"estimated":[14],"one":[15],"per":[16],"25,000-30,000":[17],"live":[18],"births.":[19],"This":[20,82],"disease":[21],"characterized":[23],"by":[24],"polyuria":[25],"and":[26,133,149,170],"compensatory":[27],"polydypsia.":[28],"The":[29],"diverse":[30],"underlying":[31],"causes":[32],"of":[33,56,80,88,119,131,144,173,191],"DI":[34],"can":[35,52],"be":[36,53],"central":[37],"defects,":[38],"which":[40,69,114,187],"no":[41],"functional":[42],"arginine":[43],"vasopressin":[44],"(AVP)":[45],"released":[47],"from":[48,91],"the":[49,59,78,86,92,98,108,117,124,129,168,189],"pituitary":[50],"or":[51],"result":[55],"defects":[57],"kidney":[60,109],"(nephrogenic":[61],"DI,":[62],"NDI).":[63],"NDI":[64],"patients":[70],"are":[71],"unable":[72],"to":[73,102,116,137,167,182,195],"concentrate":[74],"their":[75],"urine":[76],"despite":[77],"presence":[79],"AVP.":[81],"antidiuretic":[83],"hormone":[84],"regulates":[85],"process":[87],"water":[89,121,184],"reabsorption":[90],"prourine":[93],"that":[94,177],"formed":[96],"kidney.":[99],"It":[100],"binds":[101],"its":[103,147],"type-2":[104],"receptor":[105],"(V2R)":[106],"induces":[110],"cAMP-driven":[112],"cascade,":[113],"leads":[115],"insertion":[118],"aquaporin-2":[120,134],"channels":[122],"into":[123],"apical":[125],"membrane.":[126],"Mutations":[127],"genes":[130],"V2R":[132,145],"often":[135],"lead":[136],"NDI.":[138],"We":[139,175],"investigated":[140],"structure":[142],"model":[143],"bound":[148],"unbound":[150],"state":[151],"regarding":[152],"protein":[153,158],"stability":[154],"using":[155],"novel":[157],"energy":[159],"profile":[160],"approach.":[161],"Furthermore,":[162],"these":[163],"techniques":[164],"were":[165],"applied":[166],"wild-type":[169],"selected":[171],"mutations":[172],"aquaporin-2.":[174],"show":[176],"our":[178,192],"results":[179],"correspond":[180],"well":[181],"experimental":[183],"ux":[185],"analysis,":[186],"confirms":[188],"applicability":[190],"theoretical":[193],"approach":[194],"equivalent":[196],"problems.":[197]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}