{"id":"https://openalex.org/W2084419612","doi":"https://doi.org/10.1155/2012/702675","title":"Computational and Mathematical Modeling of Tumor Kinetics and Response to Radiation and Chemotherapy","display_name":"Computational and Mathematical Modeling of Tumor Kinetics and Response to Radiation and Chemotherapy","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2084419612","doi":"https://doi.org/10.1155/2012/702675","mag":"2084419612","pmid":"https://pubmed.ncbi.nlm.nih.gov/23320045"},"language":"en","primary_location":{"id":"doi:10.1155/2012/702675","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/702675","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2012/702675.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"type":"editorial","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/cmmm/2012/702675.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027460327","display_name":"Eva Bezak","orcid":"https://orcid.org/0000-0002-1315-1735"},"institutions":[{"id":"https://openalex.org/I1320133117","display_name":"Royal Adelaide Hospital","ror":"https://ror.org/00carf720","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1320133117","https://openalex.org/I4392738059"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Eva Bezak","raw_affiliation_strings":["Department of Medical Physics Royal Adelaide Hospital, Adelaide, SA 5000, Australia","School of Chemistry and Physics, The University of Adelaide, Adelaide, SA 5005, Australia"],"affiliations":[{"raw_affiliation_string":"Department of Medical Physics Royal Adelaide Hospital, Adelaide, SA 5000, Australia","institution_ids":["https://openalex.org/I1320133117"]},{"raw_affiliation_string":"School of Chemistry and Physics, The University of Adelaide, Adelaide, SA 5005, Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009380500","display_name":"Loredana G. Marcu","orcid":"https://orcid.org/0000-0002-6703-979X"},"institutions":[{"id":"https://openalex.org/I1320133117","display_name":"Royal Adelaide Hospital","ror":"https://ror.org/00carf720","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1320133117","https://openalex.org/I4392738059"]},{"id":"https://openalex.org/I162871001","display_name":"University of Oradea","ror":"https://ror.org/00wzhv093","country_code":"RO","type":"education","lineage":["https://openalex.org/I162871001"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I5681781"]}],"countries":["AU","RO"],"is_corresponding":false,"raw_author_name":"Loredana Marcu","raw_affiliation_strings":["Department of Medical Physics Royal Adelaide Hospital, Adelaide, SA 5000, Australia","Faculty of Science, University of Oradea, Universitatii str., Oradea, Romania","School of Chemistry and Physics, The University of Adelaide, Adelaide, SA 5005, Australia"],"affiliations":[{"raw_affiliation_string":"Department of Medical Physics Royal Adelaide Hospital, Adelaide, SA 5000, Australia","institution_ids":["https://openalex.org/I1320133117"]},{"raw_affiliation_string":"Faculty of Science, University of Oradea, Universitatii str., Oradea, Romania","institution_ids":["https://openalex.org/I162871001"]},{"raw_affiliation_string":"School of Chemistry and Physics, The University of Adelaide, Adelaide, SA 5005, Australia","institution_ids":["https://openalex.org/I5681781"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017206847","display_name":"Scott Penfold","orcid":"https://orcid.org/0000-0002-3422-9108"},"institutions":[{"id":"https://openalex.org/I1320133117","display_name":"Royal Adelaide Hospital","ror":"https://ror.org/00carf720","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1320133117","https://openalex.org/I4392738059"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Scott Penfold","raw_affiliation_strings":["Department of Medical Physics Royal Adelaide Hospital, Adelaide, SA 5000, Australia","School of Chemistry and Physics, The University of Adelaide, Adelaide, SA 5005, Australia"],"affiliations":[{"raw_affiliation_string":"Department of Medical Physics Royal Adelaide Hospital, Adelaide, SA 5000, Australia","institution_ids":["https://openalex.org/I1320133117"]},{"raw_affiliation_string":"School of Chemistry and Physics, The University of Adelaide, Adelaide, SA 5005, Australia","institution_ids":["https://openalex.org/I5681781"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5027460327"],"corresponding_institution_ids":["https://openalex.org/I1320133117","https://openalex.org/I5681781"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.11394044,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2012","issue":null,"first_page":"1","last_page":"2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9797999858856201,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.9797999858856201,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13656","display_name":"Science, Research, and Medicine","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6813622713088989},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.6331770420074463},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"Pancreatic cancer","score":0.5792328119277954},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5615214705467224},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"Ovarian cancer","score":0.5318519473075867},{"id":"https://openalex.org/keywords/cause-of-death","display_name":"Cause of death","score":0.5058817267417908},{"id":"https://openalex.org/keywords/radiation-therapy","display_name":"Radiation therapy","score":0.4744066894054413},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.4738222360610962},{"id":"https://openalex.org/keywords/death-toll","display_name":"Death toll","score":0.45410358905792236},{"id":"https://openalex.org/keywords/mortality-rate","display_name":"Mortality rate","score":0.4284393787384033},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.4029979407787323},{"id":"https://openalex.org/keywords/environmental-health","display_name":"Environmental health","score":0.11996114253997803}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6813622713088989},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6331770420074463},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5792328119277954},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5615214705467224},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5318519473075867},{"id":"https://openalex.org/C29374701","wikidata":"https://www.wikidata.org/wiki/Q1931388","display_name":"Cause of death","level":3,"score":0.5058817267417908},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4744066894054413},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4738222360610962},{"id":"https://openalex.org/C2991839399","wikidata":"https://www.wikidata.org/wiki/Q96476851","display_name":"Death toll","level":2,"score":0.45410358905792236},{"id":"https://openalex.org/C179755657","wikidata":"https://www.wikidata.org/wiki/Q58702","display_name":"Mortality rate","level":2,"score":0.4284393787384033},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4029979407787323},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.11996114253997803}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004358","descriptor_name":"Drug Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004358","descriptor_name":"Drug Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004358","descriptor_name":"Drug Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011878","descriptor_name":"Radiotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011878","descriptor_name":"Radiotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011878","descriptor_name":"Radiotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1155/2012/702675","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/702675","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2012/702675.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},{"id":"pmid:23320045","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23320045","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and mathematical methods in medicine","raw_type":null},{"id":"pmh:oai:digital.library.adelaide.edu.au:2440/87471","is_oa":true,"landing_page_url":"http://hdl.handle.net/2440/87471","pdf_url":null,"source":{"id":"https://openalex.org/S4306401835","display_name":"Adelaide Research & Scholarship (AR&S) (University of Adelaide)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I5681781","host_organization_name":"The University of Adelaide","host_organization_lineage":["https://openalex.org/I5681781"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dx.doi.org/10.1155/2012/702675","raw_type":"Journal article"},{"id":"pmh:oai:doaj.org/article:b35c413a20fb4d16b4f16771fcdcdc2e","is_oa":true,"landing_page_url":"https://doaj.org/article/b35c413a20fb4d16b4f16771fcdcdc2e","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computational and Mathematical Methods in Medicine, Vol 2012 (2012)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3539459","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3539459","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Comput Math Methods Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1155/2012/702675","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/702675","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2012/702675.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/17","score":0.4099999964237213,"display_name":"Partnerships for the goals"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2084419612.pdf","grobid_xml":"https://content.openalex.org/works/W2084419612.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3119322961","https://openalex.org/W3201249131","https://openalex.org/W3033355452","https://openalex.org/W4224024452","https://openalex.org/W874523103","https://openalex.org/W2393219284","https://openalex.org/W2349884658","https://openalex.org/W2357814911","https://openalex.org/W2374126877","https://openalex.org/W2000957115"],"abstract_inverted_index":{"The":[0,175,746],"AACR":[1],"Cancer":[2,159],"Progress":[3],"Report":[4],"(2011)":[5],"shows":[6],"that":[7,181,346,481,547,653,696,718,795],"in":[8,23,27,44,59,112,124,209,257,260,392,451,494,511,520,532,614,655,663,682,697,748,760,784],"the":[9,50,62,97,109,117,127,140,150,155,161,168,182,194,226,238,270,295,303,306,333,352,360,421,437,465,502,517,521,527,539,543,555,562,578,604,632,641,646,650,656,672,675,730,761,796],"USA":[10],"from":[11,17,42,66,96,185,439,590],"1990":[12],"to":[13,21,79,99,119,129,223,236,287,341,358,369,394,412,433,510,572,577,581,602,742],"2007,":[14],"death":[15,88,94,173],"rates":[16,65,89],"all":[18,47,166,311],"cancers":[19],"dropped":[20],"22%":[22],"men":[24],"and":[25,72,84,114,203,215,240,253,274,283,291,300,328,354,366,382,430,445,470,477,583,734,740,744,757,770,804,815],"14%":[26],"women.":[28],"More":[29],"than":[30,191,713],"68%":[31],"of":[32,143,147,154,157,165,167,172,198,229,242,272,279,285,297,305,336,351,362,397,403,436,442,468,473,489,542,558,561,606,623,640,649,661,674,690,732,737,763,778,781,812],"adults":[33],"live":[34],"five":[35],"years":[36],"or":[37,126,259],"more":[38],"after":[39,671],"diagnosis,":[40],"up":[41],"50%":[43],"1975.":[45,60],"For":[46],"paediatric":[48],"cancers,":[49,69,116],"five-year":[51],"survival":[52,64],"rate":[53],"is":[54,139,149,187,409,596,610,693,719],"80%,":[55],"compared":[56,509],"with":[57,406,479,569,574],"52%":[58],"However,":[61],"poor":[63],"most":[67],"deadly":[68],"pancreatic,":[70],"ovarian":[71,115],"glioblastoma":[73,789],"multiforme":[74,790],"(GBM),":[75],"have":[76,293,550,751],"not":[77,600],"changed":[78],"this":[80,148,724,749,800],"date.\r\n\r\nDespite":[81],"many":[82,329,771],"technological":[83],"clinical":[85,534,591],"advances,":[86],"cancer":[87,144,186,243,280,313,315,495,764,782],"are":[90,212,244,387,456,497,536,593],"still":[91],"high.":[92],"Patient":[93],"arises":[95],"failure":[98],"detect":[100],"primary":[101,121,141],"tumors":[102,286],"before":[103,132],"they":[104,133,460],"spread":[105],"their":[106,708],"micrometastases":[107,131],"around":[108],"body,":[110],"as":[111,123,450,459,498,508,594,618,806,808],"pancreatic":[113],"inability":[118,128],"control":[120],"tumors,":[122],"GBM,":[125],"eliminate":[130],"form":[134],"new":[135],"lesions.":[136],"Disseminated":[137],"disease":[138,353],"cause":[142,197],"death.\r\n\r\nOn":[145],"top":[146,639],"rapidly":[151],"developing":[152],"cost":[153,228],"management":[156],"cancer.":[158],"causes":[160,171,239],"highest":[162],"economic":[163,183,199],"loss":[164,200],"15":[169],"leading":[170,196],"worldwide.":[174],"World":[176],"Health":[177,207],"Organisation":[178],"(WHO)":[179],"notes":[180],"toll":[184],"nearly":[188],"20%":[189],"higher":[190],"heart":[192],"disease,":[193],"second":[195],"($895":[201],"billion":[202],"$753":[204],"billion,":[205],"resp.).":[206],"budgets":[208],"developed":[210],"countries":[211],"continually":[213],"expanding":[214],"constrained":[216],"by":[217,486,645,680,754],"limited":[218],"resources.":[219],"But":[220],"cost/benefit":[221],"analyses":[222],"determine":[224],"whether":[225],"increased":[227],"treatment":[230,241,705,716],"achieves":[231],"improved":[232],"outcomes":[233],"remain":[234],"unknown.\r\n\r\nApproaches":[235],"understanding":[237],"numerous,":[245],"involving":[246,321],"chemistry,":[247],"physics,":[248],"biology,":[249],"genetics,":[250],"medicine,":[251],"pharmacology,":[252],"experiments":[254],"based":[255,388,706,720],"on":[256,389,638,707,721],"vivo":[258,512,683],"vitro":[261],"setups,":[262],"using":[263],"animal":[264],"models":[265,278,345,549],"and/or":[266],"human":[267],"trials.":[268],"Among":[269],"plethora":[271],"experimental":[273,585],"research":[275,299,496,522,758],"activities,":[276],"mathematical":[277,344,735],"growth,":[281],"behaviour,":[282],"response":[284,368,741],"agents":[288],"like":[289,310],"chemotherapy":[290],"radiotherapy":[292],"been":[294,678,752],"subject":[296],"intensive":[298],"development":[301],"since":[302],"middle":[304],"last":[307],"century.":[308],"Just":[309],"other":[312,422],"research,":[314],"modeling":[316,374,493,566,616,736,783],"requires":[317],"a":[318,398,440,487,533,607,612,615,620,700,715,809,816],"multidisciplinary":[319],"approach,":[320],"physicists,":[322],"mathematicians,":[323],"molecular":[324],"biologists,":[325],"medical":[326],"specialists,":[327],"others.":[330,772],"At":[331],"present,":[332],"rapid":[334],"growth":[335],"computational":[337,733],"power":[338],"allows":[339,538,553,567],"us":[340],"build":[342],"complex":[343,363,414],"can":[347,355,376,461,627,685,702],"investigate":[348,359],"different":[349],"aspects":[350],"be":[356,377,483,628,667],"used":[357,411],"role":[361],"tumor":[364,415,738],"behaviour":[365],"its":[367],"various":[370,418],"therapeutic":[371],"protocols.\r\n\r\nIn":[372],"general,":[373],"methods":[375,381,386,425,455],"divided":[378],"into":[379,463],"analytical":[380],"stochastic":[383,424],"methods.":[384],"Analytical":[385],"deterministic":[390],"equations":[391,405],"order":[393],"model":[395,413,603,665,676],"evolution":[396,435],"biological":[399,608,625,658],"system.":[400],"A":[401],"set":[402,441,488],"differential":[404],"multiple":[407],"parameters":[408,711],"often":[410],"kinetics":[416,739],"under":[417],"conditions.":[419],"On":[420],"hand,":[423],"use":[426],"random":[427],"number":[428,622],"generators":[429],"probability":[431],"distributions":[432],"simulate":[434],"system":[438],"initial":[443],"conditions":[444],"parameter":[446],"values":[447],"(also":[448],"known":[449,624,635],"silico":[452,664],"models).":[453],"These":[454],"particularly":[457],"useful":[458,803],"take":[462],"account":[464],"high":[466],"degree":[467],"complexity":[469],"multifaceted":[471],"nature":[472],"cellular":[474],"proliferation,":[475],"communication,":[476],"interactions":[478],"reagents":[480],"cannot":[482],"easily":[484],"described":[485],"equations.":[490],"\r\n\r\n\r\nPros":[491],"for":[492,505,530,554,630,688],"follows.\r\n\r\n\r\nModeling":[499],"significantly":[500],"reduces":[501,516,526],"time":[503],"needed":[504],"an":[506,662],"outcome":[507],"techniques;":[513],"it":[514],"also":[515,686],"costs":[518,564],"involved":[519],"and,":[523],"very":[524,597],"importantly,":[525],"risks,":[528],"which,":[529],"example,":[531],"trial":[535],"unavoidable.\r\n\r\n\r\nModeling":[537],"easy":[540],"investigation":[541],"\u201cwhat":[544],"if?\u201d":[545],"scenarios;":[546],"is,":[548],"predictive":[551],"power.\r\n\r\n\r\nModeling":[552],"quantitative":[556],"assessment":[557],"qualitative":[559],"processes.\r\n\r\n\r\nBecause":[560],"low":[563],"involved,":[565],"researchers":[568,756],"modest":[570],"infrastructure":[571],"contribute":[573],"valuable":[575],"ideas":[576],"field.\r\n\r\n\r\nModeling":[579],"enables":[580],"quantify":[582],"interpret":[584],"results,":[586],"including":[587],"data":[588],"obtained":[589],"trials.\r\n\r\n\r\n\r\n\r\n\r\nCons":[592],"follows.\r\n\r\n\r\nIt":[595],"difficult,":[598],"if":[599],"impossible,":[601],"entirety":[605],"process.\r\n\r\n\r\nThere":[609],"always":[611],"compromise":[613,636,643],"process":[617],"only":[619,670],"certain":[621],"processes/parameters":[626],"accounted":[629],"within":[631],"model.":[633],"This":[634],"exists":[637],"unknown":[642,651],"represented":[644],"obvious":[647],"omission":[648],"processes":[652],"happen":[654],"modeled":[657],"system.\r\n\r\n\r\nThe":[659],"results":[660],"should":[666],"considered":[668],"clinically":[669],"credibility":[673],"has":[677],"validated":[679],"several":[681],"results.\r\n\r\n\r\n\r\n\r\nModels":[684],"allow":[687],"individualization":[689],"treatments.":[691],"It":[692],"therefore":[694],"possible":[695],"near":[698],"future":[699],"patient":[701],"receive":[703],"individualized":[704],"specific":[709,785],"biological/genetic":[710],"rather":[712],"undergoing":[714],"protocol":[717],"population":[722],"averages.\r\n\r\nIn":[723],"special":[725],"issue":[726,750,801],"we":[727],"will":[728,798],"explore":[729],"topic":[731],"radiation":[743,766],"chemotherapy.":[745],"papers":[747,774],"contributed":[753],"eminent":[755],"groups":[759],"area":[762],"modeling,":[765,768],"biology":[767],"microdosimetry,":[769],"Several":[773],"offer":[775],"comprehensive":[776],"reviews":[777],"current":[779],"status":[780],"areas":[786],"(e.g.,":[787],"hypoxia,":[788],"models,":[791],"etc.).":[792],"We":[793],"trust":[794],"readers":[797],"find":[799],"both":[802],"practical":[805],"well":[807],"good":[810],"source":[811],"reference":[813],"material":[814],"stimulating":[817],"read.\r\n\r\n\r\nEva":[818],"Bezak":[819],"\r\n\r\nLoredana":[820],"Marcu":[821],"\r\n\r\nScott":[822],"Penfold":[823]},"counts_by_year":[],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}