{"id":"https://openalex.org/W2045925231","doi":"https://doi.org/10.1155/2012/469769","title":"Predictive Models for Maximum Recommended Therapeutic Dose of Antiretroviral Drugs","display_name":"Predictive Models for Maximum Recommended Therapeutic Dose of Antiretroviral Drugs","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2045925231","doi":"https://doi.org/10.1155/2012/469769","mag":"2045925231","pmid":"https://pubmed.ncbi.nlm.nih.gov/22481974"},"language":"en","primary_location":{"id":"doi:10.1155/2012/469769","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/469769","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2012/469769.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/cmmm/2012/469769.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052285925","display_name":"Michael L. Branham","orcid":null},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"Michael Lee Branham","raw_affiliation_strings":["School of Pharmacy and Pharmacology, University of KwaZulu-Natal, Durban 4001, South Africa","School of Pharmacy and Pharmacology, University of KwaZulu Natal, Durban 4001, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy and Pharmacology, University of KwaZulu-Natal, Durban 4001, South Africa","institution_ids":["https://openalex.org/I95023434"]},{"raw_affiliation_string":"School of Pharmacy and Pharmacology, University of KwaZulu Natal, Durban 4001, South Africa","institution_ids":["https://openalex.org/I95023434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048393571","display_name":"Edward A. Ross","orcid":"https://orcid.org/0000-0002-0807-3090"},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward A. Ross","raw_affiliation_strings":["School of Medicine, University of Florida, Gainesville, FL 32601, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, University of Florida, Gainesville, FL 32601, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040688854","display_name":"Thirumala Govender","orcid":"https://orcid.org/0000-0002-4968-4779"},"institutions":[{"id":"https://openalex.org/I95023434","display_name":"University of KwaZulu-Natal","ror":"https://ror.org/04qzfn040","country_code":"ZA","type":"education","lineage":["https://openalex.org/I95023434"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Thirumala Govender","raw_affiliation_strings":["School of Pharmacy and Pharmacology, University of KwaZulu-Natal, Durban 4001, South Africa","School of Pharmacy and Pharmacology, University of KwaZulu Natal, Durban 4001, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy and Pharmacology, University of KwaZulu-Natal, Durban 4001, South Africa","institution_ids":["https://openalex.org/I95023434"]},{"raw_affiliation_string":"School of Pharmacy and Pharmacology, University of KwaZulu Natal, Durban 4001, South Africa","institution_ids":["https://openalex.org/I95023434"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5052285925"],"corresponding_institution_ids":["https://openalex.org/I95023434"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":0.4885,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.63883097,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"2012","issue":null,"first_page":"1","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10908","display_name":"Analytical Chemistry and Chromatography","score":0.9930999875068665,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipophilicity","display_name":"Lipophilicity","score":0.5304103493690491},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.470800518989563},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.46557730436325073},{"id":"https://openalex.org/keywords/linear-regression","display_name":"Linear regression","score":0.42554205656051636},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3975450396537781},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3460124135017395},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.33848661184310913},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.33192625641822815},{"id":"https://openalex.org/keywords/analytical-chemistry","display_name":"Analytical Chemistry (journal)","score":0.3263075053691864},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3102135956287384},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.261752724647522},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.21602705121040344}],"concepts":[{"id":"https://openalex.org/C201399114","wikidata":"https://www.wikidata.org/wiki/Q898401","display_name":"Lipophilicity","level":2,"score":0.5304103493690491},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.470800518989563},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.46557730436325073},{"id":"https://openalex.org/C48921125","wikidata":"https://www.wikidata.org/wiki/Q10861030","display_name":"Linear regression","level":2,"score":0.42554205656051636},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3975450396537781},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3460124135017395},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.33848661184310913},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.33192625641822815},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.3263075053691864},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3102135956287384},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.261752724647522},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.21602705121040344},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019055","descriptor_name":"No-Observed-Adverse-Effect Level","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019055","descriptor_name":"No-Observed-Adverse-Effect Level","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019055","descriptor_name":"No-Observed-Adverse-Effect Level","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044966","descriptor_name":"Anti-Retroviral Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D044966","descriptor_name":"Anti-Retroviral Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D044966","descriptor_name":"Anti-Retroviral Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D044966","descriptor_name":"Anti-Retroviral Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D044966","descriptor_name":"Anti-Retroviral Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D044966","descriptor_name":"Anti-Retroviral Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D044966","descriptor_name":"Anti-Retroviral Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D044966","descriptor_name":"Anti-Retroviral Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D044966","descriptor_name":"Anti-Retroviral Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1155/2012/469769","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/469769","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2012/469769.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},{"id":"pmid:22481974","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22481974","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and mathematical methods in medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:45d9dfd025b24caf9b8d539f57bf8d76","is_oa":true,"landing_page_url":"https://doaj.org/article/45d9dfd025b24caf9b8d539f57bf8d76","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computational and Mathematical Methods in Medicine, Vol 2012 (2012)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3299291","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3299291","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Comput Math Methods Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1155/2012/469769","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/469769","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2012/469769.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2045925231.pdf","grobid_xml":"https://content.openalex.org/works/W2045925231.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1510224559","https://openalex.org/W1520727604","https://openalex.org/W1751671986","https://openalex.org/W1974499807","https://openalex.org/W1976557020","https://openalex.org/W1983358634","https://openalex.org/W1988902981","https://openalex.org/W1990878163","https://openalex.org/W1994045278","https://openalex.org/W1995155741","https://openalex.org/W1999703363","https://openalex.org/W2012222545","https://openalex.org/W2021133788","https://openalex.org/W2021505761","https://openalex.org/W2037294386","https://openalex.org/W2038342867","https://openalex.org/W2055532901","https://openalex.org/W2060992818","https://openalex.org/W2062286166","https://openalex.org/W2065324366","https://openalex.org/W2065466552","https://openalex.org/W2068950612","https://openalex.org/W2072462334","https://openalex.org/W2074333823","https://openalex.org/W2080364776","https://openalex.org/W2089104366","https://openalex.org/W2090996511","https://openalex.org/W2095935525","https://openalex.org/W2101080301","https://openalex.org/W2113018849","https://openalex.org/W2116844530","https://openalex.org/W2116893683","https://openalex.org/W2117211286","https://openalex.org/W2126595621","https://openalex.org/W2127199675","https://openalex.org/W2127706932","https://openalex.org/W2131626361","https://openalex.org/W2135732933","https://openalex.org/W2137313254","https://openalex.org/W2140534639","https://openalex.org/W2140666517","https://openalex.org/W2152616967","https://openalex.org/W2163565350","https://openalex.org/W2295271006","https://openalex.org/W2321536904","https://openalex.org/W3143890092","https://openalex.org/W4232479951","https://openalex.org/W4248107770","https://openalex.org/W4255651593"],"related_works":["https://openalex.org/W785759412","https://openalex.org/W2911418701","https://openalex.org/W2052883464","https://openalex.org/W4301110780","https://openalex.org/W2169505840","https://openalex.org/W2159789341","https://openalex.org/W1524165232","https://openalex.org/W2151356126","https://openalex.org/W2084732496","https://openalex.org/W2135760566"],"abstract_inverted_index":{"A":[0,69],"novel":[1],"method":[2,131],"for":[3,130,197],"predicting":[4],"maximum":[5,182],"recommended":[6],"therapeutic":[7,183],"dose":[8],"(MRTD)":[9],"is":[10],"presented":[11],"using":[12,92],"quantitative":[13],"structure":[14],"property":[15,42],"relationships":[16],"(QSPRs)":[17],"and":[18,60,82,126,181],"artificial":[19],"neural":[20,85,139],"networks":[21],"(ANNs).":[22],"MRTD":[23,36,103,133,185],"data":[24],"of":[25,44,178,192],"31":[26],"structurally":[27],"diverse":[28],"Antiretroviral":[29],"drugs":[30,180],"(ARVs)":[31],"were":[32,63,90],"collected":[33],"from":[34,65],"FDA":[35],"Database":[37],"or":[38],"package":[39],"inserts.":[40],"Molecular":[41],"descriptors":[43],"each":[45],"compound,":[46],"that":[47,102],"is,":[48],"molecular":[49],"mass,":[50],"aqueous":[51,176],"solubility,":[52],"lipophilicity,":[53],"biotransformation":[54],"half":[55,58],"life,":[56,59],"oxidation":[57],"biodegradation":[61],"probability":[62],"calculated":[64],"their":[66],"SMILES":[67],"codes.":[68],"training":[70],"set":[71,96],"(n":[72,97],"=":[73,98,143,146,149,160,163,166],"23)":[74],"was":[75,113,134],"used":[76],"to":[77],"construct":[78],"multiple":[79,156],"linear":[80,157],"regression":[81,158],"back":[83],"propagation":[84],"network":[86,140],"models.":[87],"The":[88],"models":[89,170],"validated":[91],"an":[93],"external":[94],"test":[95],"8)":[99],"which":[100],"demonstrated":[101],"values":[104],"may":[105,187],"be":[106],"predicted":[107,135],"with":[108],"reasonable":[109],"accuracy.":[110],"Model":[111],"predictability":[112],"described":[114],"by":[115,136,154],"root":[116],"mean":[117],"squared":[118],"errors":[119],"(RMSEs),":[120],"Kendall's":[121],"correlation":[122,174],"coefficients":[123],"(tau),":[124],"P-values,":[125],"Bland":[127],"Altman":[128],"plots":[129],"comparisons.":[132],"a":[137,172],"6-3-1":[138],"model":[141],"(RMSE":[142,159],"13.67,":[144],"tau":[145,162],"0.643,":[147],"P":[148,165],"0.035)":[150],"more":[151,194],"accurately":[152],"than":[153],"the":[155,190],"27.27,":[161],"0.714,":[164],"0.019)":[167],"model.":[168],"Both":[169],"illustrated":[171],"moderate":[173],"between":[175],"solubility":[177],"antiretroviral":[179],"dose.":[184],"prediction":[186],"assist":[188],"in":[189],"design":[191],"safer,":[193],"effective":[195],"treatments":[196],"HIV":[198],"infection.":[199]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}