{"id":"https://openalex.org/W2071277303","doi":"https://doi.org/10.1155/2012/348471","title":"Risk-Adaptive Volumetric Modulated Arc Therapy Using Biological Objective Functions for Subvolume Boosting in Radiotherapy","display_name":"Risk-Adaptive Volumetric Modulated Arc Therapy Using Biological Objective Functions for Subvolume Boosting in Radiotherapy","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2071277303","doi":"https://doi.org/10.1155/2012/348471","mag":"2071277303","pmid":"https://pubmed.ncbi.nlm.nih.gov/22792127"},"language":"en","primary_location":{"id":"doi:10.1155/2012/348471","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/348471","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2012/348471.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/cmmm/2012/348471.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026836599","display_name":"Nicholas Hardcastle","orcid":"https://orcid.org/0000-0001-7796-8472"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]},{"id":"https://openalex.org/I2800555584","display_name":"Peter MacCallum Cancer Centre","ror":"https://ror.org/02a8bt934","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800555584"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"Nicholas Hardcastle","raw_affiliation_strings":["Centre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW 2522, Australia","Department of Physical Sciences, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia","Departments of Human Oncology and Medical Physics, University of Wisconsin-Madison, Madison, WI 53792, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540"]},{"raw_affiliation_string":"Department of Physical Sciences, Peter MacCallum Cancer Centre, East Melbourne, VIC 3002, Australia","institution_ids":["https://openalex.org/I2800555584"]},{"raw_affiliation_string":"Departments of Human Oncology and Medical Physics, University of Wisconsin-Madison, Madison, WI 53792, USA","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023209696","display_name":"Wolfgang A. Tom\u00e9","orcid":"https://orcid.org/0000-0003-1586-8091"},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I19772626","display_name":"Yeshiva University","ror":"https://ror.org/045x93337","country_code":"US","type":"education","lineage":["https://openalex.org/I19772626"]},{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]}],"countries":["AU","US"],"is_corresponding":true,"raw_author_name":"Wolfgang A. Tome","raw_affiliation_strings":["Centre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW 2522, Australia","Departments of Human Oncology and Medical Physics, University of Wisconsin-Madison, Madison, WI 53792, USA","Oncophysics Institute, Albert Einstein College of Medicine of Yeshiva University, Jack and Pearl Resnick Campus, 1300 Morris Park Avenue, Bronx, NY 10461, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Medical Radiation Physics, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540"]},{"raw_affiliation_string":"Departments of Human Oncology and Medical Physics, University of Wisconsin-Madison, Madison, WI 53792, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Oncophysics Institute, Albert Einstein College of Medicine of Yeshiva University, Jack and Pearl Resnick Campus, 1300 Morris Park Avenue, Bronx, NY 10461, USA","institution_ids":["https://openalex.org/I129975664","https://openalex.org/I19772626"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5023209696"],"corresponding_institution_ids":["https://openalex.org/I129975664","https://openalex.org/I135310074","https://openalex.org/I19772626","https://openalex.org/I204824540"],"apc_list":{"value":2550,"currency":"USD","value_usd":2550},"apc_paid":{"value":2550,"currency":"USD","value_usd":2550},"fwci":0.6753,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.74185341,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"2012","issue":null,"first_page":"1","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/boosting","display_name":"Boosting (machine learning)","score":0.7152746319770813},{"id":"https://openalex.org/keywords/radiation-therapy","display_name":"Radiation therapy","score":0.6788114309310913},{"id":"https://openalex.org/keywords/arc","display_name":"Arc (geometry)","score":0.49976205825805664},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4721893072128296},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3601246476173401},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.325333833694458},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3172774910926819},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2958601713180542},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.18298375606536865},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.13509339094161987}],"concepts":[{"id":"https://openalex.org/C46686674","wikidata":"https://www.wikidata.org/wiki/Q466303","display_name":"Boosting (machine learning)","level":2,"score":0.7152746319770813},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.6788114309310913},{"id":"https://openalex.org/C83415579","wikidata":"https://www.wikidata.org/wiki/Q161973","display_name":"Arc (geometry)","level":2,"score":0.49976205825805664},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4721893072128296},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3601246476173401},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.325333833694458},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3172774910926819},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2958601713180542},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18298375606536865},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.13509339094161987},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001743","descriptor_name":"Urinary Bladder","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D001743","descriptor_name":"Urinary Bladder","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D001743","descriptor_name":"Urinary Bladder","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":false},{"descriptor_ui":"D011874","descriptor_name":"Radiometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011874","descriptor_name":"Radiometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011874","descriptor_name":"Radiometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011879","descriptor_name":"Radiotherapy Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011879","descriptor_name":"Radiotherapy Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011879","descriptor_name":"Radiotherapy Dosage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011880","descriptor_name":"Radiotherapy Planning, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011880","descriptor_name":"Radiotherapy Planning, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D011880","descriptor_name":"Radiotherapy Planning, Computer-Assisted","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012007","descriptor_name":"Rectum","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D012007","descriptor_name":"Rectum","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D012007","descriptor_name":"Rectum","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018787","descriptor_name":"Radiation Oncology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018787","descriptor_name":"Radiation Oncology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018787","descriptor_name":"Radiation Oncology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020266","descriptor_name":"Radiotherapy, Conformal","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020266","descriptor_name":"Radiotherapy, Conformal","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020266","descriptor_name":"Radiotherapy, Conformal","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D050397","descriptor_name":"Radiotherapy, Intensity-Modulated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D050397","descriptor_name":"Radiotherapy, Intensity-Modulated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D050397","descriptor_name":"Radiotherapy, Intensity-Modulated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1155/2012/348471","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/348471","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2012/348471.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},{"id":"pmid:22792127","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22792127","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and mathematical methods in medicine","raw_type":null},{"id":"pmh:oai:europepmc.org:2399850","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3390113","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:ro.uow.edu.au:eispapers-3069","is_oa":false,"landing_page_url":"https://ro.uow.edu.au/eispapers/2060","pdf_url":null,"source":{"id":"https://openalex.org/S4306400510","display_name":"Research Online (University of Wollongong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I204824540","host_organization_name":"University of Wollongong","host_organization_lineage":["https://openalex.org/I204824540"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty of Engineering and Information Sciences - Papers: Part A","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:f75553e46f5b4ceebc21edd1bcbf0693","is_oa":false,"landing_page_url":"https://doaj.org/article/f75553e46f5b4ceebc21edd1bcbf0693","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computational and Mathematical Methods in Medicine, Vol 2012 (2012)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/27762396","is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Risk-adaptive_volumetric_modulated_arc_therapy_using_biological_objective_functions_for_subvolume_boosting_in_radiotherapy/27762396","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1155/2012/348471","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/348471","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2012/348471.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.800000011920929}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2071277303.pdf","grobid_xml":"https://content.openalex.org/works/W2071277303.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W1907973709","https://openalex.org/W1973123510","https://openalex.org/W1976996553","https://openalex.org/W1992824185","https://openalex.org/W1995937547","https://openalex.org/W1997208081","https://openalex.org/W2003218091","https://openalex.org/W2012514380","https://openalex.org/W2026900109","https://openalex.org/W2037604445","https://openalex.org/W2039617073","https://openalex.org/W2054060538","https://openalex.org/W2054407863","https://openalex.org/W2091262134","https://openalex.org/W2092499410","https://openalex.org/W2104133157","https://openalex.org/W2140044955","https://openalex.org/W2166010438"],"related_works":["https://openalex.org/W2125652721","https://openalex.org/W1540371141","https://openalex.org/W1549363203","https://openalex.org/W4231274751","https://openalex.org/W2154063878","https://openalex.org/W2556012038","https://openalex.org/W1489772951","https://openalex.org/W1518215897","https://openalex.org/W1538046993","https://openalex.org/W1566995892"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Simultaneous":[1],"integrated":[2,204],"boost":[3,121,205],"(SIB)":[4],"for":[5,50,65,184,201],"prostate":[6,35,52,56,118],"cancer":[7,57],"allows":[8],"increases":[9],"in":[10,113,176],"tumor":[11],"control":[12],"probability":[13],"while":[14],"respecting":[15],"normal":[16,142],"tissue":[17,143],"dose":[18,191],"constraints.":[19,192],"Biological":[20],"optimization":[21,70,79,173],"functions":[22],"that":[23,180],"optimize":[24],"based":[25],"on":[26,104],"treatment":[27,162],"outcome":[28,210],"can":[29],"be":[30],"used":[31],"to":[32,93,138,158],"create":[33],"SIB":[34,51,185],"plans.":[36,107],"This":[37,196],"study":[38,197],"investigates":[39],"the":[40,90,105,117,120],"feasibility":[41],"of":[42,75,80,89,123],"biologically":[43],"optimized":[44],"volumetric":[45],"modulated":[46],"arc":[47,96],"therapy":[48],"(VMAT)":[49],"radiotherapy.":[53],"METHODS:":[54],"Five":[55],"patients":[58],"with":[59],"diffusion-weighted":[60],"MR":[61],"images":[62],"were":[63,146],"selected":[64],"analysis.":[66],"A":[67,99],"two-step":[68],"VMAT":[69,97,110,178,206],"was":[71,102,164],"performed,":[72],"which":[73],"consisted":[74],"an":[76],"initial":[77],"biological":[78,172,209],"a":[81,94,114,199],"static":[82,91],"gantry":[83],"angle":[84],"delivery":[85,92],"followed":[86],"by":[87],"conversion":[88],"single":[95],"plan.":[98],"dosimetric":[100],"analysis":[101],"performed":[103],"resulting":[106],"RESULTS:":[108],"The":[109,170],"plans":[111,179],"resulted":[112,175],"\u0394EUD":[115],"between":[116,124,147],"and":[119,127,149,189],"volume":[122],"15.1":[125],"Gy":[126,134,157],"20.3":[128],"Gy.":[129,160],"Rectal":[130],"volumes":[131],"receiving":[132],"75.6":[133],"ranged":[135,154],"from":[136,155],"4.5":[137],"9.9%.":[139],"Expected":[140],"rectal":[141,188],"complication":[144],"probabilities":[145],"8.6%":[148],"21.4%.":[150],"Maximum":[151],"bladder":[152,190],"doses":[153],"73.6":[156],"75.8":[159],"Estimated":[161],"time":[163],"120":[165],"s":[166],"or":[167],"less.":[168],"CONCLUSIONS:":[169],"presented":[171],"method":[174,200],"deliverable":[177],"achieved":[181],"sufficient":[182],"modulation":[183],"without":[186],"violating":[187],"ADVANCES":[193],"IN":[194],"KNOWLEDGE:":[195],"presents":[198],"creating":[202],"simultaneous":[203],"treatments":[207],"using":[208],"objective":[211],"functions.":[212]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-08-15T07:11:24.734988","created_date":"2025-10-10T00:00:00"}