{"id":"https://openalex.org/W1998781057","doi":"https://doi.org/10.1155/2012/342602","title":"Time-Course Analysis of Main Markers of Primary Infection in Cats with the Feline Immunodeficiency Virus","display_name":"Time-Course Analysis of Main Markers of Primary Infection in Cats with the Feline Immunodeficiency Virus","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W1998781057","doi":"https://doi.org/10.1155/2012/342602","mag":"1998781057","pmid":"https://pubmed.ncbi.nlm.nih.gov/23049618"},"language":"lv","primary_location":{"id":"doi:10.1155/2012/342602","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/342602","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2012/342602.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/cmmm/2012/342602.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004932556","display_name":"Benjamin Ribba","orcid":null},"institutions":[{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1326498283","display_name":"Institut national de recherche en sciences et technologies du num\u00e9rique","ror":"https://ror.org/02kvxyf05","country_code":"FR","type":"government","lineage":["https://openalex.org/I1326498283"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"B. Ribba","raw_affiliation_strings":["INRIA, Project-team NUMED, Ecole Normale Sup\u00e9rieure de Lyon, 46 all\u00e9e d\u2019Italie, 69007 Lyon Cedex 07, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INRIA, Project-team NUMED, Ecole Normale Sup\u00e9rieure de Lyon, 46 all\u00e9e d\u2019Italie, 69007 Lyon Cedex 07, France","institution_ids":["https://openalex.org/I113428412","https://openalex.org/I1326498283"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023967078","display_name":"H. El Garch","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. El Garch","raw_affiliation_strings":["Discovery Research, Merial SAS, 69007 Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Research, Merial SAS, 69007 Lyon, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109170059","display_name":"S. Brunet","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Brunet","raw_affiliation_strings":["Discovery Research, Merial SAS, 69007 Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Research, Merial SAS, 69007 Lyon, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106427865","display_name":"\u00c9ric Grenier","orcid":"https://orcid.org/0000-0002-2260-1101"},"institutions":[{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1326498283","display_name":"Institut national de recherche en sciences et technologies du num\u00e9rique","ror":"https://ror.org/02kvxyf05","country_code":"FR","type":"government","lineage":["https://openalex.org/I1326498283"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"E. Grenier","raw_affiliation_strings":["INRIA, Project-team NUMED, Ecole Normale Sup\u00e9rieure de Lyon, 46 all\u00e9e d\u2019Italie, 69007 Lyon Cedex 07, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INRIA, Project-team NUMED, Ecole Normale Sup\u00e9rieure de Lyon, 46 all\u00e9e d\u2019Italie, 69007 Lyon Cedex 07, France","institution_ids":["https://openalex.org/I113428412","https://openalex.org/I1326498283"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010454141","display_name":"Filippo Castiglione","orcid":"https://orcid.org/0000-0002-1442-3552"},"institutions":[{"id":"https://openalex.org/I197604219","display_name":"National Academies of Sciences, Engineering, and Medicine","ror":"https://ror.org/02eq2w707","country_code":"US","type":"government","lineage":["https://openalex.org/I197604219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F. Castiglione","raw_affiliation_strings":["Institute for Computing Applications \u201cM. Picone\u201d, National Research Council of Italy (CNR), Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Computing Applications \u201cM. Picone\u201d, National Research Council of Italy (CNR), Rome, Italy","institution_ids":["https://openalex.org/I197604219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055870060","display_name":"Herv\u00e9 Poulet","orcid":"https://orcid.org/0000-0001-7614-9897"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H. Poulet","raw_affiliation_strings":["Discovery Research, Merial SAS, 69007 Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Research, Merial SAS, 69007 Lyon, France","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009327777","display_name":"Philippe Vanhems","orcid":"https://orcid.org/0000-0003-3188-1456"},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Universit\u00e9 Claude Bernard Lyon 1","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210100596","display_name":"Hospices Civils de Lyon","ror":"https://ror.org/01502ca60","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210100596"]},{"id":"https://openalex.org/I4210135640","display_name":"Laboratoire de Biom\u00e9trie et Biologie Evolutive","ror":"https://ror.org/03skt0t88","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I203339264","https://openalex.org/I4210100596","https://openalex.org/I4210104684","https://openalex.org/I4210107625","https://openalex.org/I4210135640"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P. Vanhems","raw_affiliation_strings":["Equipe Epid\u00e9miologie et Sant\u00e9 Publique, Laboratoire de Biom\u00e9trie et Biologie Evolutive, UMR 5558, CNRS, 8 Avenue Rockefeller, 69310 Lyon cedex, France","Service d'Hygi\u00e8ne, Epid\u00e9miologie et Pr\u00e9vention, Hospices Civils de Lyon, 69008 Lyon, France","Universit\u00e9 de Lyon I, 69000 Villeurbanne, France","Universit\u00e9 de Lyon, 69000 Lyon, Lyon, Universit\u00e9 Lyon I, Villeurbanne, F-69100, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Equipe Epid\u00e9miologie et Sant\u00e9 Publique, Laboratoire de Biom\u00e9trie et Biologie Evolutive, UMR 5558, CNRS, 8 Avenue Rockefeller, 69310 Lyon cedex, France","institution_ids":["https://openalex.org/I4210135640","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Service d'Hygi\u00e8ne, Epid\u00e9miologie et Pr\u00e9vention, Hospices Civils de Lyon, 69008 Lyon, France","institution_ids":["https://openalex.org/I4210100596"]},{"raw_affiliation_string":"Universit\u00e9 de Lyon I, 69000 Villeurbanne, France","institution_ids":["https://openalex.org/I100532134"]},{"raw_affiliation_string":"Universit\u00e9 de Lyon, 69000 Lyon, Lyon, Universit\u00e9 Lyon I, Villeurbanne, F-69100, France","institution_ids":["https://openalex.org/I100532134"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5004932556"],"corresponding_institution_ids":["https://openalex.org/I113428412","https://openalex.org/I1326498283"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":0.2619,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.53530466,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"2012","issue":null,"first_page":"1","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9943000078201294,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/viremia","display_name":"Viremia","score":0.8288064002990723},{"id":"https://openalex.org/keywords/viral-load","display_name":"Viral load","score":0.695724606513977},{"id":"https://openalex.org/keywords/cd8","display_name":"CD8","score":0.6850151419639587},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.622613251209259},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.6099444627761841},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.5850497484207153},{"id":"https://openalex.org/keywords/feline-immunodeficiency-virus","display_name":"Feline immunodeficiency virus","score":0.583360493183136},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.552912712097168},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.5373690724372864},{"id":"https://openalex.org/keywords/cats","display_name":"CATS","score":0.4805612862110138},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.4205440580844879},{"id":"https://openalex.org/keywords/lentivirus","display_name":"Lentivirus","score":0.3364419639110565},{"id":"https://openalex.org/keywords/viral-disease","display_name":"Viral disease","score":0.26148688793182373},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.25292032957077026},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.1313367784023285}],"concepts":[{"id":"https://openalex.org/C2776185481","wikidata":"https://www.wikidata.org/wiki/Q1425304","display_name":"Viremia","level":3,"score":0.8288064002990723},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.695724606513977},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6850151419639587},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.622613251209259},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6099444627761841},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5850497484207153},{"id":"https://openalex.org/C2777841672","wikidata":"https://www.wikidata.org/wiki/Q1129598","display_name":"Feline immunodeficiency virus","level":5,"score":0.583360493183136},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.552912712097168},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5373690724372864},{"id":"https://openalex.org/C2779904517","wikidata":"https://www.wikidata.org/wiki/Q5008900","display_name":"CATS","level":2,"score":0.4805612862110138},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4205440580844879},{"id":"https://openalex.org/C2779690655","wikidata":"https://www.wikidata.org/wiki/Q374232","display_name":"Lentivirus","level":4,"score":0.3364419639110565},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.26148688793182373},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25292032957077026},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1313367784023285},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016089","descriptor_name":"Immunodeficiency Virus, Feline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016089","descriptor_name":"Immunodeficiency Virus, Feline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016089","descriptor_name":"Immunodeficiency Virus, Feline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016181","descriptor_name":"Feline Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016181","descriptor_name":"Feline Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016181","descriptor_name":"Feline Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D019041","descriptor_name":"L-Selectin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019041","descriptor_name":"L-Selectin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019041","descriptor_name":"L-Selectin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1155/2012/342602","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/342602","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2012/342602.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},{"id":"pmid:23049618","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23049618","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and mathematical methods in medicine","raw_type":null},{"id":"pmh:oai:HAL:hal-00756348v1","is_oa":false,"landing_page_url":"https://inria.hal.science/hal-00756348","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computational and Mathematical Methods in Medicine, 2012, 2012, pp.1-9. ⟨10.1155/2012/342602⟩","raw_type":"Journal articles"},{"id":"pmh:oai:doaj.org/article:b223d234f1824b999dfbdc76db1de194","is_oa":false,"landing_page_url":"https://doaj.org/article/b223d234f1824b999dfbdc76db1de194","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computational and Mathematical Methods in Medicine, Vol 2012 (2012)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3463190","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3463190","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Comput Math Methods Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1155/2012/342602","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/342602","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2012/342602.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1998781057.pdf","grobid_xml":"https://content.openalex.org/works/W1998781057.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1530152146","https://openalex.org/W1574899644","https://openalex.org/W1943757146","https://openalex.org/W1980587508","https://openalex.org/W1989148484","https://openalex.org/W1993147091","https://openalex.org/W1999410105","https://openalex.org/W2022098233","https://openalex.org/W2032008131","https://openalex.org/W2034665292","https://openalex.org/W2042784056","https://openalex.org/W2051269276","https://openalex.org/W2055170530","https://openalex.org/W2061657962","https://openalex.org/W2061790725","https://openalex.org/W2083668821","https://openalex.org/W2094144630","https://openalex.org/W2108807617","https://openalex.org/W2127510350","https://openalex.org/W2136497694","https://openalex.org/W2143148297","https://openalex.org/W2146207113","https://openalex.org/W2155525214","https://openalex.org/W2171141994","https://openalex.org/W2293739207"],"related_works":["https://openalex.org/W2020914954","https://openalex.org/W2157490601","https://openalex.org/W2063315503","https://openalex.org/W2024461587","https://openalex.org/W2116740051","https://openalex.org/W2117222615","https://openalex.org/W2014846716","https://openalex.org/W23989810","https://openalex.org/W2152136407","https://openalex.org/W2008446410"],"abstract_inverted_index":{"Studies":[0],"of":[1,4,21,31,45,54,63,68,87,91,112,121,159,165,172,174,178,187,200,215,240],"the":[2,5,32,46,80,85,89,92,96,117,122,157,170,185,197,212,234,238],"response":[3],"immune":[6,69],"system":[7,70],"to":[8,40,43,59,78,245],"feline":[9],"immunodeficiency":[10],"virus":[11],"(FIV)":[12],"during":[13],"primary":[14],"infection":[15,160],"have":[16],"shown":[17],"that":[18,169,190],"a":[19,61,74,110,129,137,145,162],"subpopulation":[20,56],"CD8(+)":[22,48,124],"T-cells":[23],"with":[24,103,144,184],"an":[25,66,133],"activated":[26],"phenotype":[27],"and":[28,65,95,136,177,218,225,236],"reduced":[29],"expression":[30],"CD8\u03b2":[33],"chain":[34],"(denoted":[35],"CD8\u03b2(low)":[36,93,118,179,201,216],"T":[37,49],"cells)":[38],"expands":[39],"reach":[41],"up":[42],"80%":[44],"total":[47,123],"cell":[50],"count.":[51],"The":[52,203],"expansion":[53,134],"this":[55],"is":[57,126],"considered":[58],"be":[60,227],"signature":[62],"FIV":[64],"indicator":[67],"alteration.":[71],"We":[72,155,167],"use":[73],"simple":[75,205],"mathematical":[76],"formalism":[77],"study":[79],"relationships":[81],"over":[82],"time":[83,213],"between":[84],"dose":[86,158,186],"infection,":[88],"size":[90],"population,":[94],"circulating":[97,219],"viral":[98,175,220],"load":[99,176,221],"in":[100,222],"cats":[101,224],"infected":[102,153],"FIV.":[104],"Viremia":[105],"profiles":[106],"are":[107,142,181,207],"described":[108],"using":[109,148],"combination":[111],"two":[113,204],"exponential":[114],"laws,":[115],"whereas":[116],"percentage":[119,180,217],"(out":[120],"population)":[125],"represented":[127],"by":[128],"Gompertz":[130],"law":[131],"including":[132],"phase":[135],"saturation":[138],"phase.":[139],"Model":[140],"parameters":[141],"estimated":[143],"population":[146],"approach":[147],"data":[149],"from":[150],"102":[151],"experimentally":[152],"cats.":[154],"examine":[156],"as":[161],"potential":[163],"covariate":[164],"parameters.":[166],"find":[168],"rates":[171],"increase":[173],"both":[182],"correlated":[183],"infection.":[188,247],"Cats":[189],"develop":[191],"strong":[192],"acute":[193],"viremia":[194],"also":[195],"show":[196],"largest":[198],"degree":[199],"expansion.":[202],"models":[206],"robust":[208],"tools":[209],"for":[210,229],"analysing":[211],"course":[214],"FIV-infected":[223],"may":[226],"useful":[228],"generating":[230],"new":[231],"insights":[232],"on":[233,237],"disease":[235],"design":[239],"therapeutic":[241],"strategies,":[242],"potentially":[243],"applicable":[244],"HIV":[246]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}