{"id":"https://openalex.org/W2152549251","doi":"https://doi.org/10.1155/2012/323472","title":"Gap Detection for Genome-Scale Constraint-Based Models","display_name":"Gap Detection for Genome-Scale Constraint-Based Models","publication_year":2012,"publication_date":"2012-09-10","ids":{"openalex":"https://openalex.org/W2152549251","doi":"https://doi.org/10.1155/2012/323472","mag":"2152549251","pmid":"https://pubmed.ncbi.nlm.nih.gov/22997515"},"language":"en","primary_location":{"id":"doi:10.1155/2012/323472","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/323472","pdf_url":"https://downloads.hindawi.com/archive/2012/323472.pdf","source":{"id":"https://openalex.org/S146125958","display_name":"Advances in Bioinformatics","issn_l":"1687-8027","issn":["1687-8027","1687-8035"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/archive/2012/323472.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020628068","display_name":"J. Paul Brooks","orcid":"https://orcid.org/0000-0003-0423-8422"},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. Paul Brooks","raw_affiliation_strings":["Center for the Study of Biological Complexity, Virginia Commonwealth University, P.O. Box 843083,  Richmond, VA 23284, USA","Department of Statistical Sciences and Operations Research, Virginia Commonwealth University, P.O. Box 843083,  Richmond, VA 23284, USA","Center for the Study of Biological Complexity, Virginia Commonwealth University, P.O. Box 843083, Richmond, VA 23284, USA","Department of Statistical Sciences and Operations Research, Virginia Commonwealth University, P.O. Box 843083, Richmond, VA 23284, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for the Study of Biological Complexity, Virginia Commonwealth University, P.O. Box 843083,  Richmond, VA 23284, USA","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Department of Statistical Sciences and Operations Research, Virginia Commonwealth University, P.O. Box 843083,  Richmond, VA 23284, USA","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Center for the Study of Biological Complexity, Virginia Commonwealth University, P.O. Box 843083, Richmond, VA 23284, USA","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Department of Statistical Sciences and Operations Research, Virginia Commonwealth University, P.O. Box 843083, Richmond, VA 23284, USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103180067","display_name":"William Burns","orcid":"https://orcid.org/0000-0002-6146-3434"},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William P. Burns","raw_affiliation_strings":["Center for the Study of Biological Complexity, Virginia Commonwealth University, P.O. Box 843083,  Richmond, VA 23284, USA","Center for the Study of Biological Complexity, Virginia Commonwealth University, P.O. Box 843083, Richmond, VA 23284, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for the Study of Biological Complexity, Virginia Commonwealth University, P.O. Box 843083,  Richmond, VA 23284, USA","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Center for the Study of Biological Complexity, Virginia Commonwealth University, P.O. Box 843083, Richmond, VA 23284, USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047715802","display_name":"Stephen S. Fong","orcid":"https://orcid.org/0000-0003-2171-7783"},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen S. Fong","raw_affiliation_strings":["Center for the Study of Biological Complexity, Virginia Commonwealth University, P.O. Box 843083,  Richmond, VA 23284, USA","Department of Chemical and Life Science Engineering, Virginia Commonwealth University, P.O. Box 843083,  Richmond, VA 23284, USA","Department of Chemical and Life Science Engineering, Virginia Commonwealth University, P.O. Box 843083, Richmond, VA 23284, USA","Center for the Study of Biological Complexity, Virginia Commonwealth University, P.O. Box 843083, Richmond, VA 23284, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for the Study of Biological Complexity, Virginia Commonwealth University, P.O. Box 843083,  Richmond, VA 23284, USA","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Department of Chemical and Life Science Engineering, Virginia Commonwealth University, P.O. Box 843083,  Richmond, VA 23284, USA","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Department of Chemical and Life Science Engineering, Virginia Commonwealth University, P.O. Box 843083, Richmond, VA 23284, USA","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Center for the Study of Biological Complexity, Virginia Commonwealth University, P.O. Box 843083, Richmond, VA 23284, USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011062157","display_name":"Chris M. Gowen","orcid":null},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris M. Gowen","raw_affiliation_strings":["Center for the Study of Biological Complexity, Virginia Commonwealth University, P.O. Box 843083,  Richmond, VA 23284, USA","Department of Chemical and Life Science Engineering, Virginia Commonwealth University, P.O. Box 843083,  Richmond, VA 23284, USA","Department of Chemical and Life Science Engineering, Virginia Commonwealth University, P.O. Box 843083, Richmond, VA 23284, USA","Center for the Study of Biological Complexity, Virginia Commonwealth University, P.O. Box 843083, Richmond, VA 23284, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for the Study of Biological Complexity, Virginia Commonwealth University, P.O. Box 843083,  Richmond, VA 23284, USA","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Department of Chemical and Life Science Engineering, Virginia Commonwealth University, P.O. Box 843083,  Richmond, VA 23284, USA","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Department of Chemical and Life Science Engineering, Virginia Commonwealth University, P.O. Box 843083, Richmond, VA 23284, USA","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Center for the Study of Biological Complexity, Virginia Commonwealth University, P.O. Box 843083, Richmond, VA 23284, USA","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032126274","display_name":"Seth B. Roberts","orcid":null},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seth B. Roberts","raw_affiliation_strings":["Center for the Study of Biological Complexity, Virginia Commonwealth University, P.O. Box 843083,  Richmond, VA 23284, USA","Department of Chemical and Life Science Engineering, Virginia Commonwealth University, P.O. Box 843083,  Richmond, VA 23284, USA","Department of Chemical and Life Science Engineering, Virginia Commonwealth University, P.O. Box 843083, Richmond, VA 23284, USA","Center for the Study of Biological Complexity, Virginia Commonwealth University, P.O. Box 843083, Richmond, VA 23284, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for the Study of Biological Complexity, Virginia Commonwealth University, P.O. Box 843083,  Richmond, VA 23284, USA","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Department of Chemical and Life Science Engineering, Virginia Commonwealth University, P.O. Box 843083,  Richmond, VA 23284, USA","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Department of Chemical and Life Science Engineering, Virginia Commonwealth University, P.O. Box 843083, Richmond, VA 23284, USA","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Center for the Study of Biological Complexity, Virginia Commonwealth University, P.O. Box 843083, Richmond, VA 23284, USA","institution_ids":["https://openalex.org/I184840846"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5020628068"],"corresponding_institution_ids":["https://openalex.org/I184840846"],"apc_list":null,"apc_paid":null,"fwci":1.3434,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.80273978,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"2012","issue":null,"first_page":"1","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9919999837875366,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flux-balance-analysis","display_name":"Flux balance analysis","score":0.8081235885620117},{"id":"https://openalex.org/keywords/constraint","display_name":"Constraint (computer-aided design)","score":0.7876765727996826},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7567448616027832},{"id":"https://openalex.org/keywords/organism","display_name":"Organism","score":0.7240737676620483},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.6946189403533936},{"id":"https://openalex.org/keywords/scale","display_name":"Scale (ratio)","score":0.4516826570034027},{"id":"https://openalex.org/keywords/cellular-metabolism","display_name":"Cellular metabolism","score":0.4500546455383301},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3827563524246216},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.35784339904785156},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.1915944218635559},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.12044516205787659},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.11139649152755737},{"id":"https://openalex.org/keywords/metabolism","display_name":"Metabolism","score":0.07488515973091125}],"concepts":[{"id":"https://openalex.org/C167091322","wikidata":"https://www.wikidata.org/wiki/Q5463029","display_name":"Flux balance analysis","level":2,"score":0.8081235885620117},{"id":"https://openalex.org/C2776036281","wikidata":"https://www.wikidata.org/wiki/Q48769818","display_name":"Constraint (computer-aided design)","level":2,"score":0.7876765727996826},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7567448616027832},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.7240737676620483},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6946189403533936},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.4516826570034027},{"id":"https://openalex.org/C2994212657","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Cellular metabolism","level":3,"score":0.4500546455383301},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3827563524246216},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.35784339904785156},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.1915944218635559},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12044516205787659},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.11139649152755737},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.07488515973091125},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1155/2012/323472","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/323472","pdf_url":"https://downloads.hindawi.com/archive/2012/323472.pdf","source":{"id":"https://openalex.org/S146125958","display_name":"Advances in Bioinformatics","issn_l":"1687-8027","issn":["1687-8027","1687-8035"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:22997515","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22997515","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in bioinformatics","raw_type":null},{"id":"pmh:oai:scholarscompass.vcu.edu:ssor_pubs-1003","is_oa":true,"landing_page_url":"https://scholarscompass.vcu.edu/ssor_pubs/3","pdf_url":null,"source":{"id":"https://openalex.org/S4377196340","display_name":"VCU Scholars Compass (Virginia Commonwealth University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I184840846","host_organization_name":"Virginia Commonwealth University","host_organization_lineage":["https://openalex.org/I184840846"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Statistical Sciences and Operations Research Publications","raw_type":"text"},{"id":"pmh:oai:europepmc.org:2448495","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3444828","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1155/2012/323472","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/323472","pdf_url":"https://downloads.hindawi.com/archive/2012/323472.pdf","source":{"id":"https://openalex.org/S146125958","display_name":"Advances in Bioinformatics","issn_l":"1687-8027","issn":["1687-8027","1687-8035"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3395046081","display_name":null,"funder_award_id":"NNX09AR44A","funder_id":"https://openalex.org/F4320306101","funder_display_name":"National Aeronautics and Space Administration"}],"funders":[{"id":"https://openalex.org/F4320306101","display_name":"National Aeronautics and Space Administration","ror":"https://ror.org/027ka1x80"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2152549251.pdf","grobid_xml":"https://content.openalex.org/works/W2152549251.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1597762351","https://openalex.org/W1668755435","https://openalex.org/W1814099126","https://openalex.org/W1976672440","https://openalex.org/W1996529795","https://openalex.org/W2013171416","https://openalex.org/W2014348203","https://openalex.org/W2017065632","https://openalex.org/W2045780029","https://openalex.org/W2073837631","https://openalex.org/W2079733254","https://openalex.org/W2083011190","https://openalex.org/W2085236271","https://openalex.org/W2091317547","https://openalex.org/W2096245011","https://openalex.org/W2097588479","https://openalex.org/W2100084634","https://openalex.org/W2101501829","https://openalex.org/W2107459209","https://openalex.org/W2118053673","https://openalex.org/W2128746754","https://openalex.org/W2132992030","https://openalex.org/W2135206190","https://openalex.org/W2138688367","https://openalex.org/W2144885342","https://openalex.org/W2159482845","https://openalex.org/W2161575197","https://openalex.org/W2169528473","https://openalex.org/W2494779131","https://openalex.org/W3103786587","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W2073612090","https://openalex.org/W1995733425","https://openalex.org/W2148190806","https://openalex.org/W1576707484","https://openalex.org/W112689186","https://openalex.org/W2146696410","https://openalex.org/W1544925715","https://openalex.org/W2025172803","https://openalex.org/W2573984017","https://openalex.org/W2989744272"],"abstract_inverted_index":{"Constraint-based":[0],"metabolic":[1,126],"models":[2,9,115],"are":[3,67,152,177],"currently":[4],"the":[5,50,72,80,91,98,136,156],"most":[6],"comprehensive":[7],"system-wide":[8],"of":[10,23,52,64,97],"cellular":[11],"metabolism.":[12],"Several":[13],"challenges":[14],"arise":[15],"when":[16],"building":[17],"an":[18,24],"in":[19,71,93,102,147,168],"silico":[20],"constraint-based":[21],"model":[22,55,106],"organism":[25,107],"that":[26,48,66,129,148,169],"need":[27],"to":[28,60,69,76,111,154],"be":[29,37,132],"addressed":[30],"before":[31],"flux":[32],"balance":[33],"analysis":[34],"(FBA)":[35],"can":[36],"applied":[38,75,110],"for":[39,89,116],"simulations.":[40],"An":[41],"algorithm":[42,81,99],"called":[43],"FBA-Gap":[44],"is":[45,100,109,139,161],"presented":[46],"here":[47],"aids":[49],"construction":[51],"a":[53,61,77,83,86,104,124,143],"working":[54,78,114],"based":[56],"on":[57],"plausible":[58,172],"modifications":[59],"given":[62],"list":[63],"reactions":[65,151,173,176],"known":[68],"occur":[70],"organism.":[73],"When":[74],"model,":[79],"gives":[82],"hypothesis":[84],"concerning":[85],"minimal":[87],"medium":[88],"sustaining":[90],"cell":[92],"culture.":[94],"The":[95,158],"utility":[96],"demonstrated":[101],"creating":[103],"new":[105,150],"and":[108,174],"four":[112],"existing":[113],"generating":[117],"hypotheses":[118],"about":[119],"culture":[120],"media.":[121],"In":[122],"modifying":[123],"partial":[125],"reconstruction":[127],"so":[128],"biomass":[130],"may":[131],"produced":[133],"using":[134],"FBA,":[135],"proposed":[137,145,159],"method":[138,146,160],"more":[140,163],"efficient":[141],"than":[142,165],"previously":[144],"fewer":[149],"added":[153],"complete":[155],"model.":[157],"also":[162],"accurate":[164],"other":[166],"approaches":[167],"only":[170],"biologically":[171],"exchange":[175],"used.":[178]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}