{"id":"https://openalex.org/W2107752871","doi":"https://doi.org/10.1155/2010/471408","title":"Timing of Imaging after <scp>D</scp>\u2010Luciferin Injection Affects the Longitudinal Assessment of Tumor Growth Using In Vivo Bioluminescence Imaging","display_name":"Timing of Imaging after <scp>D</scp>\u2010Luciferin Injection Affects the Longitudinal Assessment of Tumor Growth Using In Vivo Bioluminescence Imaging","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W2107752871","doi":"https://doi.org/10.1155/2010/471408","mag":"2107752871","pmid":"https://pubmed.ncbi.nlm.nih.gov/20671955"},"language":"en","primary_location":{"id":"doi:10.1155/2010/471408","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2010/471408","pdf_url":"https://downloads.hindawi.com/journals/ijbi/2010/471408.pdf","source":{"id":"https://openalex.org/S108408918","display_name":"International Journal of Biomedical Imaging","issn_l":"1687-4188","issn":["1687-4188","1687-4196"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biomedical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://downloads.hindawi.com/journals/ijbi/2010/471408.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025994244","display_name":"Yusuke Inoue","orcid":"https://orcid.org/0000-0001-7250-8303"},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yusuke Inoue","raw_affiliation_strings":["Department of Radiology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan","Department of Radiology, Institute of Medical Science, University of Tokyo, Tokyo, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan","institution_ids":["https://openalex.org/I74801974","https://openalex.org/I161296585"]},{"raw_affiliation_string":"Department of Radiology, Institute of Medical Science, University of Tokyo, Tokyo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085176718","display_name":"Shigeru Kiryu","orcid":"https://orcid.org/0000-0003-1440-9483"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeru Kiryu","raw_affiliation_strings":["Department of Radiology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639","Department of Radiology, Institute of Medical Science, University of Tokyo, Tokyo, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Radiology, Institute of Medical Science, University of Tokyo, Tokyo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031549671","display_name":"Makoto Watanabe","orcid":"https://orcid.org/0000-0002-5064-9583"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Watanabe","raw_affiliation_strings":["Department of Radiology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639","Department of Radiology, Institute of Medical Science, University of Tokyo, Tokyo, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Radiology, Institute of Medical Science, University of Tokyo, Tokyo, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018044109","display_name":"Arinobu Tojo","orcid":"https://orcid.org/0000-0001-9016-1948"},"institutions":[{"id":"https://openalex.org/I158929114","display_name":"Tokyo Medical University","ror":"https://ror.org/00k5j5c86","country_code":"JP","type":"education","lineage":["https://openalex.org/I158929114"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I4210117918","display_name":"Institute for Advanced Medical Research","ror":"https://ror.org/02ek94012","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117918"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Arinobu Tojo","raw_affiliation_strings":["Division of Molecular Therapy, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639","Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan#TAB#"],"affiliations":[{"raw_affiliation_string":"Division of Molecular Therapy, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639","institution_ids":["https://openalex.org/I4210117918","https://openalex.org/I158929114"]},{"raw_affiliation_string":"Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan#TAB#","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067868993","display_name":"Kuni Ohtomo","orcid":null},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]},{"id":"https://openalex.org/I4210109338","display_name":"University of Tokyo Hospital","ror":"https://ror.org/022cvpj02","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210109338"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kuni Ohtomo","raw_affiliation_strings":["Department of Radiology, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033","Department of Radiology; Graduate School of Medicine; University of Tokyo; Tokyo Japan"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033","institution_ids":["https://openalex.org/I74801974","https://openalex.org/I4210109338"]},{"raw_affiliation_string":"Department of Radiology; Graduate School of Medicine; University of Tokyo; Tokyo Japan","institution_ids":["https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5025994244"],"corresponding_institution_ids":["https://openalex.org/I161296585","https://openalex.org/I74801974"],"apc_list":{"value":900,"currency":"USD","value_usd":900},"apc_paid":{"value":900,"currency":"USD","value_usd":900},"fwci":0.5407,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.66747116,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"2010","issue":"1","first_page":"471408","last_page":"471408"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12561","display_name":"bioluminescence and chemiluminescence research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12561","display_name":"bioluminescence and chemiluminescence research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.994700014591217,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bioluminescence","display_name":"Bioluminescence","score":0.8065432906150818},{"id":"https://openalex.org/keywords/bioluminescence-imaging","display_name":"Bioluminescence imaging","score":0.7692745923995972},{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.7390806674957275},{"id":"https://openalex.org/keywords/luciferin","display_name":"Luciferin","score":0.599061906337738},{"id":"https://openalex.org/keywords/luciferase","display_name":"Luciferase","score":0.5079465508460999},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.39909374713897705},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3360726833343506},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22943368554115295},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.21792680025100708},{"id":"https://openalex.org/keywords/biotechnology","display_name":"Biotechnology","score":0.11861225962638855}],"concepts":[{"id":"https://openalex.org/C5176359","wikidata":"https://www.wikidata.org/wiki/Q179924","display_name":"Bioluminescence","level":2,"score":0.8065432906150818},{"id":"https://openalex.org/C161997846","wikidata":"https://www.wikidata.org/wiki/Q4915066","display_name":"Bioluminescence imaging","level":5,"score":0.7692745923995972},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7390806674957275},{"id":"https://openalex.org/C2781309008","wikidata":"https://www.wikidata.org/wiki/Q369745","display_name":"Luciferin","level":5,"score":0.599061906337738},{"id":"https://openalex.org/C111335760","wikidata":"https://www.wikidata.org/wiki/Q95385166","display_name":"Luciferase","level":4,"score":0.5079465508460999},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39909374713897705},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3360726833343506},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22943368554115295},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21792680025100708},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.11861225962638855},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1155/2010/471408","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2010/471408","pdf_url":"https://downloads.hindawi.com/journals/ijbi/2010/471408.pdf","source":{"id":"https://openalex.org/S108408918","display_name":"International Journal of Biomedical Imaging","issn_l":"1687-4188","issn":["1687-4188","1687-4196"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biomedical Imaging","raw_type":"journal-article"},{"id":"pmid:20671955","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20671955","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of biomedical imaging","raw_type":null},{"id":"pmh:oai:doaj.org/article:a26e3ecba01e40f99efa6a347b08883b","is_oa":true,"landing_page_url":"https://doaj.org/article/a26e3ecba01e40f99efa6a347b08883b","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Biomedical Imaging, Vol 2010 (2010)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2910476","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2910476","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Int J Biomed Imaging","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1155/2010/471408","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2010/471408","pdf_url":"https://downloads.hindawi.com/journals/ijbi/2010/471408.pdf","source":{"id":"https://openalex.org/S108408918","display_name":"International Journal of Biomedical Imaging","issn_l":"1687-4188","issn":["1687-4188","1687-4196"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Biomedical Imaging","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2107752871.pdf","grobid_xml":"https://content.openalex.org/works/W2107752871.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W21498029","https://openalex.org/W1575196595","https://openalex.org/W1969697461","https://openalex.org/W1976633158","https://openalex.org/W1983034750","https://openalex.org/W2014805256","https://openalex.org/W2032771101","https://openalex.org/W2045483822","https://openalex.org/W2060578335","https://openalex.org/W2063560639","https://openalex.org/W2114352009","https://openalex.org/W2134951683","https://openalex.org/W2136018508","https://openalex.org/W2136246451","https://openalex.org/W2156363348"],"related_works":["https://openalex.org/W4252337116","https://openalex.org/W2179438169","https://openalex.org/W2317157107","https://openalex.org/W2037413647","https://openalex.org/W1964907928","https://openalex.org/W4253858024","https://openalex.org/W2604832456","https://openalex.org/W3030290269","https://openalex.org/W2072452384","https://openalex.org/W2323786808"],"abstract_inverted_index":{"The":[0,43,114],"peak":[1,44,87,101],"signal":[2,5,79,88,92,102],"or":[3,95],"the":[4,19,75,78,86,91,100,118,138],"at":[6,80,93],"a":[7,65,81],"predetermined,":[8],"fixed":[9,82],"time":[10,45,83,115,126],"point":[11,84],"after":[12,33,52,120,127],"D-luciferin":[13,37,121],"injection":[14,35,122],"may":[15,123],"be":[16,134],"used":[17],"for":[18,99,105,141],"quantitative":[20,142],"analysis":[21],"of":[22,36,60,67,111,117],"in":[23,38,46],"vivo":[24],"bioluminescence":[25,31,143],"imaging.":[26],"We":[27],"repeatedly":[28],"performed":[29],"sequential":[30],"imaging":[32,139],"subcutaneous":[34,41],"mice":[39],"bearing":[40],"tumors.":[42],"each":[47],"measurement":[48],"became":[49],"shorter":[50],"early":[51],"cell":[53,128],"inoculation,":[54,129],"presumably":[55],"due":[56],"to":[57],"gradual":[58],"establishment":[59],"intratumoral":[61],"vasculature,":[62],"and":[63,85,130],"reached":[64],"plateau":[66],"about":[68],"10":[69,96],"min":[70,97],"on":[71],"day":[72],"10.":[73],"Although":[74],"correlation":[76],"between":[77],"was":[89,103],"high,":[90],"5":[94],"normalized":[98],"lower":[104],"earlier":[106],"days,":[107],"which":[108],"caused":[109],"overestimation":[110],"tumor":[112,144],"growth.":[113],"course":[116],"signals":[119],"vary":[124],"with":[125],"this":[131],"variation":[132],"should":[133],"considered":[135],"when":[136],"determining":[137],"protocol":[140],"monitoring.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2016-06-24T00:00:00"}