{"id":"https://openalex.org/W2165255548","doi":"https://doi.org/10.1155/2009/247646","title":"Merging Mixture Components for Cell Population Identification in Flow Cytometry","display_name":"Merging Mixture Components for Cell Population Identification in Flow Cytometry","publication_year":2009,"publication_date":"2009-11-12","ids":{"openalex":"https://openalex.org/W2165255548","doi":"https://doi.org/10.1155/2009/247646","mag":"2165255548","pmid":"https://pubmed.ncbi.nlm.nih.gov/20049161"},"language":"en","primary_location":{"id":"doi:10.1155/2009/247646","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2009/247646","pdf_url":"https://downloads.hindawi.com/archive/2009/247646.pdf","source":{"id":"https://openalex.org/S146125958","display_name":"Advances in Bioinformatics","issn_l":"1687-8027","issn":["1687-8027","1687-8035"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/archive/2009/247646.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069196767","display_name":"Greg Finak","orcid":"https://orcid.org/0000-0003-4341-9090"},"institutions":[{"id":"https://openalex.org/I4210158752","display_name":"Montreal Clinical Research Institute","ror":"https://ror.org/05m8pzq90","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210158752","https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Greg Finak","raw_affiliation_strings":["Computational Biology Unit, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, QC, H2W1R7, Canada"],"affiliations":[{"raw_affiliation_string":"Computational Biology Unit, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, QC, H2W1R7, Canada","institution_ids":["https://openalex.org/I4210158752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081990226","display_name":"Ali Bashashati","orcid":"https://orcid.org/0000-0002-4212-7224"},"institutions":[{"id":"https://openalex.org/I4210094500","display_name":"Terry Fox Research Institute","ror":"https://ror.org/00mtf6c40","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210094500"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ali Bashashati","raw_affiliation_strings":["Terry Fox Laboratory, BC Cancer Research Center, Vancouver, BC, Canada V5Z 1L3"],"affiliations":[{"raw_affiliation_string":"Terry Fox Laboratory, BC Cancer Research Center, Vancouver, BC, Canada V5Z 1L3","institution_ids":["https://openalex.org/I4210094500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035285628","display_name":"Ryan R. Brinkman","orcid":"https://orcid.org/0000-0002-9765-2990"},"institutions":[{"id":"https://openalex.org/I4210094500","display_name":"Terry Fox Research Institute","ror":"https://ror.org/00mtf6c40","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210094500"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ryan Brinkman","raw_affiliation_strings":["Terry Fox Laboratory, BC Cancer Research Center, Vancouver, BC, Canada V5Z 1L3"],"affiliations":[{"raw_affiliation_string":"Terry Fox Laboratory, BC Cancer Research Center, Vancouver, BC, Canada V5Z 1L3","institution_ids":["https://openalex.org/I4210094500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005741024","display_name":"Rapha\u00ebl Gottardo","orcid":"https://orcid.org/0000-0002-3867-0232"},"institutions":[{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]},{"id":"https://openalex.org/I4210158752","display_name":"Montreal Clinical Research Institute","ror":"https://ror.org/05m8pzq90","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210158752","https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Rapha\u00ebl Gottardo","raw_affiliation_strings":["Computational Biology Unit, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, QC, H2W1R7, Canada","D\u00e9partement de Biochimie, Universit\u00e9 de Montreal, Montreal, QC, Canada"],"affiliations":[{"raw_affiliation_string":"Computational Biology Unit, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, QC, H2W1R7, Canada","institution_ids":["https://openalex.org/I4210158752"]},{"raw_affiliation_string":"D\u00e9partement de Biochimie, Universit\u00e9 de Montreal, Montreal, QC, Canada","institution_ids":["https://openalex.org/I70931966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5005741024"],"corresponding_institution_ids":["https://openalex.org/I4210158752","https://openalex.org/I70931966"],"apc_list":null,"apc_paid":null,"fwci":7.6799,"has_fulltext":true,"cited_by_count":104,"citation_normalized_percentile":{"value":0.97340576,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"2009","issue":null,"first_page":"1","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11901","display_name":"Bayesian Methods and Mixture Models","score":0.9934999942779541,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11901","display_name":"Bayesian Methods and Mixture Models","score":0.9934999942779541,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9890000224113464,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9757999777793884,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bioconductor","display_name":"Bioconductor","score":0.8887631893157959},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.8033553957939148},{"id":"https://openalex.org/keywords/mixture-model","display_name":"Mixture model","score":0.6243512034416199},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.6098818182945251},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.6064146757125854},{"id":"https://openalex.org/keywords/pipeline","display_name":"Pipeline (software)","score":0.5598242878913879},{"id":"https://openalex.org/keywords/software","display_name":"Software","score":0.5419595241546631},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.4992697238922119},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.4372398257255554},{"id":"https://openalex.org/keywords/throughput","display_name":"Throughput","score":0.41882967948913574},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2214774787425995},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.08426272869110107}],"concepts":[{"id":"https://openalex.org/C2779694297","wikidata":"https://www.wikidata.org/wiki/Q2888953","display_name":"Bioconductor","level":3,"score":0.8887631893157959},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.8033553957939148},{"id":"https://openalex.org/C61224824","wikidata":"https://www.wikidata.org/wiki/Q2260434","display_name":"Mixture model","level":2,"score":0.6243512034416199},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6098818182945251},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.6064146757125854},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.5598242878913879},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.5419595241546631},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4992697238922119},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.4372398257255554},{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.41882967948913574},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2214774787425995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08426272869110107},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1155/2009/247646","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2009/247646","pdf_url":"https://downloads.hindawi.com/archive/2009/247646.pdf","source":{"id":"https://openalex.org/S146125958","display_name":"Advances in Bioinformatics","issn_l":"1687-8027","issn":["1687-8027","1687-8035"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:20049161","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20049161","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:2798116","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2798116","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Adv Bioinformatics","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1155/2009/247646","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2009/247646","pdf_url":"https://downloads.hindawi.com/archive/2009/247646.pdf","source":{"id":"https://openalex.org/S146125958","display_name":"Advances in Bioinformatics","issn_l":"1687-8027","issn":["1687-8027","1687-8035"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3596225420","display_name":null,"funder_award_id":"EB008400","funder_id":"https://openalex.org/F4320319965","funder_display_name":"Michael Smith Health Research BC"},{"id":"https://openalex.org/G551603443","display_name":null,"funder_award_id":"EB008400","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G5613641438","display_name":null,"funder_award_id":"EB008400","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320319965","display_name":"Michael Smith Health Research BC","ror":"https://ror.org/020x39229"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2165255548.pdf","grobid_xml":"https://content.openalex.org/works/W2165255548.grobid-xml"},"referenced_works_count":19,"referenced_works":["https://openalex.org/W1482639564","https://openalex.org/W1969039219","https://openalex.org/W1973041621","https://openalex.org/W1975826061","https://openalex.org/W2000866074","https://openalex.org/W2003144493","https://openalex.org/W2031471496","https://openalex.org/W2038885294","https://openalex.org/W2042829929","https://openalex.org/W2061507083","https://openalex.org/W2089410874","https://openalex.org/W2094112244","https://openalex.org/W2096878708","https://openalex.org/W2097446839","https://openalex.org/W2109820980","https://openalex.org/W2160697532","https://openalex.org/W2168175751","https://openalex.org/W4248463836","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2135678793","https://openalex.org/W2011682793","https://openalex.org/W2109288169","https://openalex.org/W2157684052","https://openalex.org/W2978247079","https://openalex.org/W2140163842","https://openalex.org/W2148708580","https://openalex.org/W2166887457","https://openalex.org/W2375218795","https://openalex.org/W2393010557"],"abstract_inverted_index":{"We":[0,23,126],"present":[1],"a":[2,38,93,102,111],"framework":[3,32,63,120,132],"for":[4,56,90,104],"the":[5,20,26,42,65,69,83,117,128,144,148],"identification":[6],"of":[7,41,44,68,71,130],"cell":[8,46,73,108],"subpopulations":[9,47,74,109],"in":[10,92,110,143],"flow":[11,58],"cytometry":[12,59],"data":[13,60,124],"based":[14],"on":[15,133],"merging":[16,28],"mixture":[17,51],"components":[18],"using":[19],"flowClust":[21,119],"methodology.":[22],"show":[24],"that":[25,114],"cluster":[27],"algorithm":[29,84],"under":[30],"our":[31,131],"improves":[33],"model":[34],"fit":[35],"and":[36,75,121,135],"provides":[37],"better":[39],"estimate":[40],"number":[43,70],"distinct":[45,72],"than":[48],"either":[49],"Gaussian":[50],"models":[52],"or":[53],"flowClust,":[54],"especially":[55],"complicated":[57],"distributions.":[61],"Our":[62],"allows":[64],"automated":[66],"selection":[67],"we":[76,100],"are":[77],"able":[78],"to":[79],"identify":[80],"cases":[81],"where":[82],"fails,":[85],"thus":[86],"making":[87],"it":[88],"suitable":[89],"application":[91],"high":[94],"throughput":[95],"FCM":[96,137],"analysis":[97],"pipeline.":[98],"Furthermore,":[99],"demonstrate":[101,127],"method":[103],"summarizing":[105],"complex":[106],"merged":[107],"simple":[112],"manner":[113],"integrates":[115],"with":[116],"existing":[118],"enables":[122],"downstream":[123],"analysis.":[125],"performance":[129],"simulated":[134],"real":[136],"data.":[138],"The":[139],"software":[140],"is":[141],"available":[142],"flowMerge":[145],"package":[146],"through":[147],"Bioconductor":[149],"project.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":9}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
