{"id":"https://openalex.org/W2613002003","doi":"https://doi.org/10.1147/jrd.2017.2679558","title":"Dendritic spines modify action potential back-propagation in a multicompartment neuronal model","display_name":"Dendritic spines modify action potential back-propagation in a multicompartment neuronal model","publication_year":2017,"publication_date":"2017-03-01","ids":{"openalex":"https://openalex.org/W2613002003","doi":"https://doi.org/10.1147/jrd.2017.2679558","mag":"2613002003"},"language":"en","primary_location":{"id":"doi:10.1147/jrd.2017.2679558","is_oa":false,"landing_page_url":"https://doi.org/10.1147/jrd.2017.2679558","pdf_url":null,"source":{"id":"https://openalex.org/S4210219925","display_name":"IBM Journal of Research and Development","issn_l":"0018-8646","issn":["0018-8646","2151-8556"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320652","host_organization_name":"IBM","host_organization_lineage":["https://openalex.org/P4310320652"],"host_organization_lineage_names":["IBM"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IBM Journal of Research and Development","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010943873","display_name":"T. M. Hoang Trong","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. M. Hoang Trong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071028748","display_name":"Sarah E. Motley","orcid":"https://orcid.org/0000-0003-0980-7225"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. E. Motley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109184237","display_name":"J. Wagner","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Wagner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028892052","display_name":"Robert R. Kerr","orcid":"https://orcid.org/0000-0001-8718-7469"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. R. Kerr","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5091293385","display_name":"James Kozloski","orcid":"https://orcid.org/0000-0003-3420-4688"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Kozloski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1171,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.41493453,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"61","issue":"2/3","first_page":"11:1","last_page":"11:13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12236","display_name":"Photoreceptor and optogenetics research","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dendritic-spine","display_name":"Dendritic spine","score":0.7438278198242188},{"id":"https://openalex.org/keywords/neocortex","display_name":"Neocortex","score":0.6685967445373535},{"id":"https://openalex.org/keywords/neuron","display_name":"Neuron","score":0.6579021215438843},{"id":"https://openalex.org/keywords/spine","display_name":"SPINE (molecular biology)","score":0.6245379447937012},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.5591872930526733},{"id":"https://openalex.org/keywords/dendrite","display_name":"Dendrite (mathematics)","score":0.5498988628387451},{"id":"https://openalex.org/keywords/synapse","display_name":"Synapse","score":0.49061694741249084},{"id":"https://openalex.org/keywords/dendritic-filopodia","display_name":"Dendritic filopodia","score":0.46560102701187134},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.42381617426872253},{"id":"https://openalex.org/keywords/dendritic-spike","display_name":"Dendritic spike","score":0.4100024104118347},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.38519105315208435},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.32221996784210205},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.27283281087875366},{"id":"https://openalex.org/keywords/geometry","display_name":"Geometry","score":0.15405842661857605},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.088174968957901}],"concepts":[{"id":"https://openalex.org/C174884520","wikidata":"https://www.wikidata.org/wiki/Q902079","display_name":"Dendritic spine","level":3,"score":0.7438278198242188},{"id":"https://openalex.org/C2777222312","wikidata":"https://www.wikidata.org/wiki/Q726562","display_name":"Neocortex","level":2,"score":0.6685967445373535},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.6579021215438843},{"id":"https://openalex.org/C205383261","wikidata":"https://www.wikidata.org/wiki/Q7392570","display_name":"SPINE (molecular biology)","level":2,"score":0.6245379447937012},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5591872930526733},{"id":"https://openalex.org/C84248122","wikidata":"https://www.wikidata.org/wiki/Q5256671","display_name":"Dendrite (mathematics)","level":2,"score":0.5498988628387451},{"id":"https://openalex.org/C127445978","wikidata":"https://www.wikidata.org/wiki/Q187181","display_name":"Synapse","level":2,"score":0.49061694741249084},{"id":"https://openalex.org/C53250682","wikidata":"https://www.wikidata.org/wiki/Q5256674","display_name":"Dendritic filopodia","level":4,"score":0.46560102701187134},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.42381617426872253},{"id":"https://openalex.org/C50820595","wikidata":"https://www.wikidata.org/wiki/Q5256675","display_name":"Dendritic spike","level":4,"score":0.4100024104118347},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.38519105315208435},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.32221996784210205},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27283281087875366},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.15405842661857605},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.088174968957901},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.0},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.0},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.0},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1147/jrd.2017.2679558","is_oa":false,"landing_page_url":"https://doi.org/10.1147/jrd.2017.2679558","pdf_url":null,"source":{"id":"https://openalex.org/S4210219925","display_name":"IBM Journal of Research and Development","issn_l":"0018-8646","issn":["0018-8646","2151-8556"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320652","host_organization_name":"IBM","host_organization_lineage":["https://openalex.org/P4310320652"],"host_organization_lineage_names":["IBM"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IBM Journal of Research and Development","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Industry, innovation and infrastructure","score":0.6299999952316284,"id":"https://metadata.un.org/sdg/9"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1510930287","https://openalex.org/W1521767116","https://openalex.org/W1528942588","https://openalex.org/W1634968545","https://openalex.org/W1661173264","https://openalex.org/W1740418581","https://openalex.org/W1798313689","https://openalex.org/W1971095698","https://openalex.org/W1971689790","https://openalex.org/W1980574091","https://openalex.org/W1983284219","https://openalex.org/W1987510656","https://openalex.org/W1994348876","https://openalex.org/W1995831678","https://openalex.org/W2007944782","https://openalex.org/W2019249853","https://openalex.org/W2021285984","https://openalex.org/W2021951036","https://openalex.org/W2035721488","https://openalex.org/W2042670053","https://openalex.org/W2045721385","https://openalex.org/W2049511526","https://openalex.org/W2055875880","https://openalex.org/W2068904459","https://openalex.org/W2070524933","https://openalex.org/W2073818625","https://openalex.org/W2078262440","https://openalex.org/W2088446997","https://openalex.org/W2092581899","https://openalex.org/W2099683418","https://openalex.org/W2101417788","https://openalex.org/W2102193338","https://openalex.org/W2111155182","https://openalex.org/W2128519053","https://openalex.org/W2137979527","https://openalex.org/W2154323800","https://openalex.org/W2157990975","https://openalex.org/W2160880533","https://openalex.org/W2168025484","https://openalex.org/W2171612971","https://openalex.org/W2238721744","https://openalex.org/W2271367358","https://openalex.org/W2411878395","https://openalex.org/W4232521433","https://openalex.org/W4239731216","https://openalex.org/W6675248244"],"related_works":["https://openalex.org/W4211041102","https://openalex.org/W2056677165","https://openalex.org/W2739648918","https://openalex.org/W2149246533","https://openalex.org/W2062820369","https://openalex.org/W2015312171","https://openalex.org/W4317651578","https://openalex.org/W3131514060","https://openalex.org/W2109399781","https://openalex.org/W1992616517"],"abstract_inverted_index":{"Pyramidal":[0],"neurons":[1],"in":[2,96,151],"the":[3,32,39,51,62,67,71,116,136,157,162,182],"brain's":[4],"neocortex":[5],"receive,":[6],"on":[7,195,201],"average,":[8],"approximately":[9],"10,000":[10],"synaptic":[11],"inputs.":[12],"The":[13],"majority":[14],"of":[15,31,47,53,74,93,101,119,138,144,170,197],"these":[16],"are":[17,23,104,132],"made":[18],"onto":[19],"dendritic":[20],"spines,":[21],"which":[22,97],"chemically":[24],"and":[25,50,59,76,85,147,167,173,177,185,204],"electrically":[26],"isolated":[27],"from":[28,115],"other":[29],"parts":[30],"neuron.":[33],"We":[34,88,159],"present":[35],"an":[36],"extension":[37],"to":[38,69,134,148],"IBM":[40],"Neural":[41],"Tissue":[42],"Simulator":[43],"that":[44,190],"models":[45],"details":[46],"neuron":[48,84,95,122],"morphology":[49,203],"dynamics":[52,79,179],"intracellular":[54],"diffusible":[55],"ions":[56],"or":[57],"molecules,":[58],"here,":[60],"for":[61],"first":[63],"time,":[64],"we":[65],"demonstrate":[66],"ability":[68],"simulate":[70],"functional":[72],"role":[73],"spines":[75,102,150,169,191],"their":[77,202],"calcium":[78,178],"at":[80],"a":[81,90,94,98,126,142,152,193],"detailed":[82],"whole":[83],"tissue":[86],"level.":[87],"create":[89],"multicompartment":[91],"model":[92,121,163],"realistic":[99,154],"number":[100],"(\u223c10,000)":[103],"explicitly":[105],"simulated":[106],"as":[107,141],"individual":[108],"compartments":[109,111],"(two":[110],"per":[112],"spine)":[113],"branching":[114],"dendrites.":[117],"Simulations":[118],"this":[120],"run":[123],"efficiently":[124],"using":[125],"parallel":[127],"computing":[128],"infrastructure.":[129],"Experimental":[130],"data":[131],"used":[133],"constrain":[135],"geometry":[137],"each":[139],"spine":[140,183],"function":[143],"morphological":[145],"class":[146],"distribute":[149],"statistically":[153],"manner":[155],"along":[156],"dendrite.":[158],"show":[160],"how":[161,174],"behaves":[164],"differently":[165],"with":[166],"without":[168],"different":[171],"classes":[172],"transmembrane":[175],"potential":[176],"differ":[180],"between":[181],"neck":[184,205],"shaft.":[186],"These":[187],"results":[188],"suggest":[189],"impose":[192],"constraint":[194],"back-propagation":[196],"action":[198],"potentials":[199],"dependent":[200],"resistance.":[206]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
