{"id":"https://openalex.org/W4393969985","doi":"https://doi.org/10.1145/3644116.3644313","title":"Exploring the role and mechanism of herbal pair fanbaicao-daxueteng in the treatment of UC based on GEO chip and bioinformatics","display_name":"Exploring the role and mechanism of herbal pair fanbaicao-daxueteng in the treatment of UC based on GEO chip and bioinformatics","publication_year":2023,"publication_date":"2023-10-20","ids":{"openalex":"https://openalex.org/W4393969985","doi":"https://doi.org/10.1145/3644116.3644313"},"language":"en","primary_location":{"id":"doi:10.1145/3644116.3644313","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3644116.3644313","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3644116.3644313","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2023 4th International Symposium on Artificial Intelligence for Medicine Science","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://dl.acm.org/doi/pdf/10.1145/3644116.3644313","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018896568","display_name":"Feng Xu","orcid":"https://orcid.org/0000-0002-9168-561X"},"institutions":[{"id":"https://openalex.org/I178232147","display_name":"Guizhou University","ror":"https://ror.org/02wmsc916","country_code":"CN","type":"education","lineage":["https://openalex.org/I178232147"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Xu","raw_affiliation_strings":["Department of Pharmacy, Guizhou University of Traditional Chinese Medicine, China"],"raw_orcid":"https://orcid.org/0000-0002-9168-561X","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Guizhou University of Traditional Chinese Medicine, China","institution_ids":["https://openalex.org/I178232147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034938775","display_name":"Hongmei Wu","orcid":"https://orcid.org/0000-0002-4974-0785"},"institutions":[{"id":"https://openalex.org/I178232147","display_name":"Guizhou University","ror":"https://ror.org/02wmsc916","country_code":"CN","type":"education","lineage":["https://openalex.org/I178232147"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongmei Wu","raw_affiliation_strings":["Department of Pharmacy, Guizhou University of Traditional Chinese Medicine, China"],"raw_orcid":"https://orcid.org/0000-0002-4974-0785","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Guizhou University of Traditional Chinese Medicine, China","institution_ids":["https://openalex.org/I178232147"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089366650","display_name":"Xiangpei Wang","orcid":"https://orcid.org/0000-0001-9571-4003"},"institutions":[{"id":"https://openalex.org/I4210095439","display_name":"Guizhou Minzu University","ror":"https://ror.org/00qm4t918","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210095439"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangpei Wang","raw_affiliation_strings":["School of Ethnic-Minority Medicine, Guizhou Minzu University, China"],"raw_orcid":"https://orcid.org/0000-0001-9571-4003","affiliations":[{"raw_affiliation_string":"School of Ethnic-Minority Medicine, Guizhou Minzu University, China","institution_ids":["https://openalex.org/I4210095439"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.44938017,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1157","last_page":"1164"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11889","display_name":"Ginseng Biological Effects and Applications","score":0.993399977684021,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12817","display_name":"Pharmacological Effects of Natural Compounds","score":0.9861000180244446,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.8017883896827698},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5537675619125366},{"id":"https://openalex.org/keywords/chip","display_name":"Chip","score":0.4886091351509094},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3878692090511322},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3733495771884918},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2010442018508911},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.14391779899597168},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.09451383352279663}],"concepts":[{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.8017883896827698},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5537675619125366},{"id":"https://openalex.org/C165005293","wikidata":"https://www.wikidata.org/wiki/Q1074500","display_name":"Chip","level":2,"score":0.4886091351509094},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3878692090511322},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3733495771884918},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2010442018508911},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.14391779899597168},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.09451383352279663},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3644116.3644313","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3644116.3644313","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3644116.3644313","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2023 4th International Symposium on Artificial Intelligence for Medicine Science","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1145/3644116.3644313","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3644116.3644313","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3644116.3644313","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 2023 4th International Symposium on Artificial Intelligence for Medicine Science","raw_type":"proceedings-article"},"sustainable_development_goals":[{"score":0.75,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321927","display_name":"Guizhou University","ror":"https://ror.org/02wmsc916"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4393969985.pdf","grobid_xml":"https://content.openalex.org/works/W4393969985.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1942019828","https://openalex.org/W1971117375","https://openalex.org/W1974897843","https://openalex.org/W1999091695","https://openalex.org/W2000612943","https://openalex.org/W2026450012","https://openalex.org/W2033814857","https://openalex.org/W2072738451","https://openalex.org/W2114278193","https://openalex.org/W2143953127","https://openalex.org/W2173658293","https://openalex.org/W2565571909","https://openalex.org/W2783896690","https://openalex.org/W2947257267","https://openalex.org/W2948848588","https://openalex.org/W2991801549","https://openalex.org/W3013640160","https://openalex.org/W3118272007","https://openalex.org/W3119299567","https://openalex.org/W3124404381","https://openalex.org/W3158761183","https://openalex.org/W3174191614","https://openalex.org/W3177027696","https://openalex.org/W3184283177","https://openalex.org/W4207049070","https://openalex.org/W4210500577","https://openalex.org/W4226094589","https://openalex.org/W4297494173","https://openalex.org/W4307338429","https://openalex.org/W4310465775","https://openalex.org/W4313593639","https://openalex.org/W4384023470","https://openalex.org/W4385060814","https://openalex.org/W4385728359","https://openalex.org/W4385766868","https://openalex.org/W6629818091"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W2382997850","https://openalex.org/W2382290278","https://openalex.org/W2478288626","https://openalex.org/W4391913857","https://openalex.org/W2350741829"],"abstract_inverted_index":{"Potentilla":[0],"discolor":[1],"(fanbaicao)":[2],"and":[3,36,47,55,62,83,91,112,133,135,145,158,162,166,174,192],"Sargentodoxae":[4],"caulis":[5],"(daxueteng)":[6],"are":[7,186],"commonly":[8],"used":[9,39],"in":[10,147,170],"the":[11,17,42,49,92,118,148,179,189],"treatment":[12],"of":[13,19,45,58,74,87,96,117,125,181,194],"gastrointestinal":[14],"disorders,":[15],"but":[16],"effect":[18],"herbal":[20],"pair":[21],"fanbaicao-daxueteng":[22],"(HPFD)":[23],"on":[24],"ulcerative":[25],"colitis":[26],"(UC)":[27],"is":[28],"not":[29],"known.":[30],"In":[31],"this":[32],"study,":[33],"GEO":[34,80],"chip":[35],"bioinformatics":[37,182],"were":[38,66,76,89,104,127],"to":[40,129],"construct":[41],"\"component-target-disease\"":[43,93],"network":[44,95,116],"HPFD,":[46],"analyze":[48],"core":[50],"targets,":[51],"main":[52],"active":[53],"ingredients":[54],"signaling":[56,153,164],"pathways":[57],"HPFD.":[59,195],"Further,":[60],"literature":[61],"molecular":[63,175],"docking":[64,176],"validation":[65],"performed.":[67],"As":[68],"a":[69,168],"result,":[70],"348":[71],"differential":[72],"genes":[73],"UC":[75],"obtained":[77],"from":[78],"five":[79],"gene":[81],"chips,":[82],"132":[84],"chemical":[85],"constituents":[86],"HPFD":[88,97,126,140],"included,":[90],"interaction":[94,115],"was":[98,121],"successfully":[99],"constructed.":[100,122],"10":[101],"key":[102],"targets":[103,120],"identified,":[105],"like":[106],"PTGS2,":[107],"CA2,":[108],"MMP9,":[109],"MMP1,":[110],"MMP12":[111],"MMP3.":[113],"Protein-protein":[114],"intersecting":[119],"115":[123],"components":[124],"related":[128],"its":[130],"anti-UC":[131],"effect,":[132],"GO":[134],"KEGG":[136],"analyses":[137],"revealed":[138],"that":[139],"may":[141],"regulate":[142],"bile":[143],"acids":[144],"immunoinflammation":[146],"intestinal":[149],"tract":[150],"through":[151],"multitude":[152],"pathways,":[154],"such":[155],"as":[156],"lipid":[157],"atherosclerosis,":[159],"Bile":[160],"secretion,":[161],"IL-17":[163],"pathway,":[165],"play":[167],"role":[169],"treating":[171],"UC.":[172],"Literature":[173],"also":[177],"validated":[178],"results":[180,185],"analysis.":[183],"These":[184],"valuable":[187],"for":[188],"further":[190],"development":[191],"utilization":[193]},"counts_by_year":[],"updated_date":"2026-07-31T08:31:51.225901","created_date":"2025-10-10T00:00:00"}