{"id":"https://openalex.org/W4385695841","doi":"https://doi.org/10.1145/3586139.3586154","title":"Investigating Conventional and Novel Methods for Treatment of Cancer","display_name":"Investigating Conventional and Novel Methods for Treatment of Cancer","publication_year":2023,"publication_date":"2023-01-13","ids":{"openalex":"https://openalex.org/W4385695841","doi":"https://doi.org/10.1145/3586139.3586154"},"language":"en","primary_location":{"id":"doi:10.1145/3586139.3586154","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3586139.3586154","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3586139.3586154","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 12th International Conference on Bioscience Biochemistry and Bioinformatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://dl.acm.org/doi/pdf/10.1145/3586139.3586154","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085022639","display_name":"Z. Qu","orcid":"https://orcid.org/0009-0005-1735-3552"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Zhixuan Qu","raw_affiliation_strings":["life science, Imperial College London, UK"],"raw_orcid":"https://orcid.org/0009-0005-1735-3552","affiliations":[{"raw_affiliation_string":"life science, Imperial College London, UK","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085022639"],"corresponding_institution_ids":["https://openalex.org/I47508984"],"apc_list":null,"apc_paid":null,"fwci":1.345,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.83799138,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"103","last_page":"111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.647791862487793},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.5944284796714783},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5609472990036011},{"id":"https://openalex.org/keywords/radiation-therapy","display_name":"Radiation therapy","score":0.5562390089035034},{"id":"https://openalex.org/keywords/chimeric-antigen-receptor","display_name":"Chimeric antigen receptor","score":0.49754980206489563},{"id":"https://openalex.org/keywords/cancer-treatment","display_name":"Cancer treatment","score":0.48884958028793335},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.4544326663017273},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"Immunotherapy","score":0.43584877252578735},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"Chemotherapy","score":0.4332849085330963},{"id":"https://openalex.org/keywords/metastasis","display_name":"Metastasis","score":0.4195629358291626},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.4187122583389282},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3725210428237915},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.33296287059783936},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.3186696171760559},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.29651179909706116},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.21038615703582764}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.647791862487793},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5944284796714783},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5609472990036011},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5562390089035034},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.49754980206489563},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.48884958028793335},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4544326663017273},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.43584877252578735},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4332849085330963},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4195629358291626},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4187122583389282},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3725210428237915},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33296287059783936},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3186696171760559},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29651179909706116},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21038615703582764}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3586139.3586154","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3586139.3586154","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3586139.3586154","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 12th International Conference on Bioscience Biochemistry and Bioinformatics","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1145/3586139.3586154","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3586139.3586154","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3586139.3586154","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 12th International Conference on Bioscience Biochemistry and Bioinformatics","raw_type":"proceedings-article"},"sustainable_development_goals":[{"score":0.8500000238418579,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4385695841.pdf"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W616296877","https://openalex.org/W1529490909","https://openalex.org/W1576083219","https://openalex.org/W1692777765","https://openalex.org/W1758612015","https://openalex.org/W1964173702","https://openalex.org/W1977658535","https://openalex.org/W1978594463","https://openalex.org/W1979183808","https://openalex.org/W1994257030","https://openalex.org/W2068834940","https://openalex.org/W2069585604","https://openalex.org/W2081241438","https://openalex.org/W2099560139","https://openalex.org/W2105400883","https://openalex.org/W2138784722","https://openalex.org/W2141967996","https://openalex.org/W2144591044","https://openalex.org/W2397917110","https://openalex.org/W2554763217","https://openalex.org/W2597618526","https://openalex.org/W2606915822","https://openalex.org/W2623802897","https://openalex.org/W2740938625","https://openalex.org/W2763751953","https://openalex.org/W2769426045","https://openalex.org/W2789026035","https://openalex.org/W2789514868","https://openalex.org/W2800864435","https://openalex.org/W2802153299","https://openalex.org/W2806820493","https://openalex.org/W2904029973","https://openalex.org/W2919051790","https://openalex.org/W2942052760","https://openalex.org/W3006138994","https://openalex.org/W3028523516","https://openalex.org/W3042291772","https://openalex.org/W3047882216","https://openalex.org/W3091829431","https://openalex.org/W3106735065","https://openalex.org/W3123999894","https://openalex.org/W3134655285","https://openalex.org/W3204655553","https://openalex.org/W4200252549","https://openalex.org/W4234139091","https://openalex.org/W4286851963","https://openalex.org/W6636305823","https://openalex.org/W6679182624","https://openalex.org/W6757459189","https://openalex.org/W6820668957"],"related_works":["https://openalex.org/W2922707684","https://openalex.org/W4360983034","https://openalex.org/W4283731173","https://openalex.org/W1996150995","https://openalex.org/W4220655021","https://openalex.org/W4291367166","https://openalex.org/W4213439341","https://openalex.org/W4380354235","https://openalex.org/W2568845480","https://openalex.org/W4308359949"],"abstract_inverted_index":{"Cancer":[0,149],"is":[1,115,150],"one":[2,84],"of":[3,71,85,102,186],"the":[4,27,65,86,100,165,187],"most":[5],"challenging":[6],"health":[7],"problems":[8],"facing":[9],"humankind.":[10],"Conventional":[11],"treatments":[12,90,214],"such":[13,135,157,173,213],"as":[14,136,158,174],"surgery,":[15],"chemotherapy":[16],"and":[17,42,62,69,95,128,146,154,177,199,204],"radiotherapy":[18],"can":[19,35,180,190],"usually":[20],"have":[21,36],"a":[22,75,106,151],"positive":[23],"patient":[24],"outcome":[25],"in":[26,141,168,218],"early-stage":[28],"tumours":[29],"without":[30],"metastasis.":[31],"However,":[32,132],"late-stage":[33],"cancers":[34,104],"high":[37,92,96,125,129],"mortality;":[38],"therefore,":[39],"urging":[40],"scientists":[41],"clinicians":[43],"to":[44,163,209],"investigate":[45],"novel":[46,89,117,200],"treatment":[47,51,55,101,118,202],"approaches.":[48],"Novel":[49],"cancer":[50,60,193,201,219],"methods":[52,203],"provide":[53,191],"specific":[54],"for":[56,124],"patients":[57],"with":[58,74,91,105],"different":[59],"types":[61],"substantially":[63],"elevate":[64],"survival":[66],"rate,":[67],"prognosis,":[68],"quality":[70],"life,":[72],"commonly":[73],"much":[76],"lower":[77],"immune-related":[78],"side":[79],"effect.":[80],"Monoclonal":[81],"antibodies":[82],"are":[83,215],"fastest":[87],"growing":[88],"target":[93,121,126],"specificity":[94,127],"therapeutic":[97,130],"selectivity,":[98],"enabling":[99],"advanced":[103],"low":[107],"autoimmune":[108],"inflammatory":[109],"reaction.":[110],"Chimeric":[111],"antigen":[112],"receptor":[113],"(CAR)-T":[114],"another":[116],"which":[119,207],"edits":[120],"T":[122],"lymphocytes":[123],"selectivity.":[131],"challenges":[133,206],"exist,":[134],"cytokine":[137],"release":[138],"syndrome":[139],"resulting":[140],"immunotoxicity":[142,182],"problems,":[143,183],"including":[144],"neurotoxicity":[145],"brain":[147],"oedema.":[148],"genetic":[152],"disease,":[153],"gene-editing":[155],"technologies,":[156],"CRISPR/Cas9,":[159],"enable":[160],"gene":[161,169],"modification":[162],"cure":[164],"disease":[166],"completely":[167],"therapy.":[170],"Although":[171],"limitations,":[172],"off-target":[175],"effect":[176],"DNA-damaged":[178],"toxicity":[179],"cause":[181],"multiple":[184],"derivatives":[185],"CRISPR":[188],"system":[189],"long-term":[192],"treatment.":[194,220],"This":[195],"review":[196],"discusses":[197],"conventional":[198],"explains":[205],"need":[208],"be":[210],"addressed":[211],"before":[212],"widely":[216],"available":[217]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2}],"updated_date":"2026-01-21T23:30:37.877113","created_date":"2025-10-10T00:00:00"}