{"id":"https://openalex.org/W4385695835","doi":"https://doi.org/10.1145/3586139.3586145","title":"The Function of Transmembrane Helix and Signal Sequence of Coronavirus in Co-Translational Targeting and Insertion Towards Er","display_name":"The Function of Transmembrane Helix and Signal Sequence of Coronavirus in Co-Translational Targeting and Insertion Towards Er","publication_year":2023,"publication_date":"2023-01-13","ids":{"openalex":"https://openalex.org/W4385695835","doi":"https://doi.org/10.1145/3586139.3586145"},"language":"en","primary_location":{"id":"doi:10.1145/3586139.3586145","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3586139.3586145","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 12th International Conference on Bioscience Biochemistry and Bioinformatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5092617902","display_name":"Duo Bai","orcid":"https://orcid.org/0009-0006-3365-4192"},"institutions":[{"id":"https://openalex.org/I25254941","display_name":"Beijing Normal University","ror":"https://ror.org/022k4wk35","country_code":"CN","type":"education","lineage":["https://openalex.org/I25254941"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Duo Bai","raw_affiliation_strings":["The Experimental High School Attached to Beijing Normal University, China"],"raw_orcid":"https://orcid.org/0009-0006-3365-4192","affiliations":[{"raw_affiliation_string":"The Experimental High School Attached to Beijing Normal University, China","institution_ids":["https://openalex.org/I25254941"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043624070","display_name":"Qi Xie","orcid":"https://orcid.org/0000-0002-3591-8749"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qi Xie","raw_affiliation_strings":["Johns Hopkins University, USA"],"raw_orcid":"https://orcid.org/0000-0002-3591-8749","affiliations":[{"raw_affiliation_string":"Johns Hopkins University, USA","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5092617902"],"corresponding_institution_ids":["https://openalex.org/I25254941"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13939931,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"40","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9923999905586243,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9923999905586243,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9397000074386597,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.9336000084877014,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coronavirus","display_name":"Coronavirus","score":0.7343676090240479},{"id":"https://openalex.org/keywords/transmembrane-protein","display_name":"Transmembrane protein","score":0.6861408948898315},{"id":"https://openalex.org/keywords/transmembrane-domain","display_name":"Transmembrane domain","score":0.6231088042259216},{"id":"https://openalex.org/keywords/membrane-protein","display_name":"Membrane protein","score":0.54549640417099},{"id":"https://openalex.org/keywords/signal-peptide","display_name":"Signal peptide","score":0.5089325904846191},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4848562479019165},{"id":"https://openalex.org/keywords/protein-targeting","display_name":"Protein targeting","score":0.4723720848560333},{"id":"https://openalex.org/keywords/protein-secondary-structure","display_name":"Protein secondary structure","score":0.46442925930023193},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.45391610264778137},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.4232792258262634},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.24211043119430542},{"id":"https://openalex.org/keywords/coronavirus-disease-2019","display_name":"Coronavirus disease 2019 (COVID-19)","score":0.19472843408584595},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.19025930762290955},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.07140284776687622},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.06711703538894653}],"concepts":[{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.7343676090240479},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.6861408948898315},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.6231088042259216},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.54549640417099},{"id":"https://openalex.org/C10858879","wikidata":"https://www.wikidata.org/wiki/Q899790","display_name":"Signal peptide","level":4,"score":0.5089325904846191},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4848562479019165},{"id":"https://openalex.org/C559089031","wikidata":"https://www.wikidata.org/wiki/Q658882","display_name":"Protein targeting","level":4,"score":0.4723720848560333},{"id":"https://openalex.org/C62614982","wikidata":"https://www.wikidata.org/wiki/Q904984","display_name":"Protein secondary structure","level":2,"score":0.46442925930023193},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.45391610264778137},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4232792258262634},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24211043119430542},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.19472843408584595},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.19025930762290955},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07140284776687622},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06711703538894653},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3586139.3586145","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3586139.3586145","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 12th International Conference on Bioscience Biochemistry and Bioinformatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Responsible consumption and production","id":"https://metadata.un.org/sdg/12","score":0.44999998807907104}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1975304761","https://openalex.org/W1976215395","https://openalex.org/W1996478334","https://openalex.org/W2025859600","https://openalex.org/W2069516894","https://openalex.org/W2112504441","https://openalex.org/W2151390847","https://openalex.org/W2489503660","https://openalex.org/W2789857505","https://openalex.org/W2799876761","https://openalex.org/W2947642275","https://openalex.org/W3013855790","https://openalex.org/W3087529209","https://openalex.org/W3093061534","https://openalex.org/W3096967708","https://openalex.org/W3106737244","https://openalex.org/W3123421077","https://openalex.org/W3198983266","https://openalex.org/W3203433659","https://openalex.org/W4281790889"],"related_works":["https://openalex.org/W2051293392","https://openalex.org/W2734424435","https://openalex.org/W2069790849","https://openalex.org/W1605284188","https://openalex.org/W4318612088","https://openalex.org/W1522173523","https://openalex.org/W1994599344","https://openalex.org/W1974240269","https://openalex.org/W2052797135","https://openalex.org/W2761639599"],"abstract_inverted_index":{"SARS-Cov-2,":[0],"a":[1,18,76,161,171,190,215],"type":[2],"of":[3,53,62,94,105,106,133,148,157,204,222],"coronavirus,":[4],"caused":[5],"the":[6,10,26,31,48,59,63,81,91,95,101,111,119,124,130,154,165,181,185,195,202,208,220,226],"global":[7],"pandemic,":[8],"and":[9,51,84,109,136,143,188],"era":[11],"has":[12,17],"yet":[13],"ended.":[14],"The":[15],"coronavirus":[16,32,54,64,205,223],"complicated":[19],"life":[20],"cycle.":[21],"Many":[22],"researchers":[23],"have":[24],"investigated":[25,110],"targeting":[27,50,217],"steps":[28],"to":[29,39,79,193],"prevent":[30],"from":[33,67],"replicating":[34],"in":[35,225],"human":[36],"cells,":[37],"aiming":[38],"find":[40],"an":[41],"efficient":[42],"treatment.":[43],"Here,":[44],"I":[45,57,74,98,127,150,179,211],"focus":[46],"on":[47,72,123,207],"co-translational":[49,92],"insertion":[52,108],"structure":[55,65],"proteins.":[56,97],"calculated":[58,100],"Kyte-Doolittle":[60],"hydrophobicity":[61,142],"proteins":[66,138],"over":[68],"61":[69],"species.":[70],"Based":[71,122],"this,":[73],"developed":[75],"simple":[77],"algorism":[78],"search":[80],"signal":[82,155,172],"sequence":[83,116,156,173],"transmembrane":[85,131],"helix":[86],"which":[87,167],"is":[88,168,199],"responsible":[89],"for":[90,174,201,219],"synthesis":[93],"viral":[96],"further":[99],"apparent":[102,145],"free":[103,146],"energy":[104,147],"membrane":[107,175],"consensus":[112],"sequences":[113],"by":[114],"multiple":[115],"alignment":[117],"using":[118],"ClustalOmega":[120],"algorism.":[121],"computational":[125],"calculations,":[126],"found":[128,152,189],"that":[129,153],"helixes":[132],"S":[134,158],"protein":[135,159,192],"E":[137],"show":[139],"extremely":[140],"high":[141],"low":[144],".":[149],"also":[151],"shows":[160],"non-charged":[162],"characteristic":[163],"at":[164],"N-terminus,":[166],"typical":[169],"as":[170],"targeting.":[176],"After":[177],"that,":[178],"predicted":[180],"second":[182],"structure,":[183],"did":[184],"molecular":[186],"docking":[187],"possible":[191],"inhibit":[194],"protein.":[196],"This":[197],"research":[198],"important":[200],"understanding":[203],"assembly":[206],"membrane.":[209],"Therefore,":[210],"hope":[212],"it":[213],"provides":[214],"new":[216],"site":[218],"inhibition":[221],"replication":[224],"host":[227],"cells.":[228]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
