{"id":"https://openalex.org/W4387346510","doi":"https://doi.org/10.1145/3584371.3613043","title":"Identification of therapeutic targets for muscle atrophy via analyzing transcriptomic profiles with systems biology approaches","display_name":"Identification of therapeutic targets for muscle atrophy via analyzing transcriptomic profiles with systems biology approaches","publication_year":2023,"publication_date":"2023-09-03","ids":{"openalex":"https://openalex.org/W4387346510","doi":"https://doi.org/10.1145/3584371.3613043"},"language":"en","primary_location":{"id":"doi:10.1145/3584371.3613043","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3584371.3613043","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3584371.3613043","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 14th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://dl.acm.org/doi/pdf/10.1145/3584371.3613043","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036767684","display_name":"Ahyoung Choi","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ahyoung Choi","raw_affiliation_strings":["MOGAM Institute for Biomedical Research, Seoul, -Select-, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-2522-4364","affiliations":[{"raw_affiliation_string":"MOGAM Institute for Biomedical Research, Seoul, -Select-, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085016586","display_name":"No Soo Kim","orcid":"https://orcid.org/0000-0003-1437-708X"},"institutions":[{"id":"https://openalex.org/I4210087584","display_name":"Korea Institute of Oriental Medicine","ror":"https://ror.org/005rpmt10","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210087584","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"No Soo Kim","raw_affiliation_strings":["Korea Institute of Oriental Medicine, Daejeon, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0003-1437-708X","affiliations":[{"raw_affiliation_string":"Korea Institute of Oriental Medicine, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I4210087584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008031606","display_name":"Aeyung Kim","orcid":"https://orcid.org/0000-0002-3176-3671"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aeyung Kim","raw_affiliation_strings":["Korean Medicine (KM) Application Center, Daegu, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-3176-3671","affiliations":[{"raw_affiliation_string":"Korean Medicine (KM) Application Center, Daegu, Republic of Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043242171","display_name":"Haeseung Lee","orcid":"https://orcid.org/0000-0002-9947-4032"},"institutions":[{"id":"https://openalex.org/I4921948","display_name":"Pusan National University","ror":"https://ror.org/01an57a31","country_code":"KR","type":"education","lineage":["https://openalex.org/I4921948"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Haeseung Lee","raw_affiliation_strings":["Pusan National University, Busan, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0002-9947-4032","affiliations":[{"raw_affiliation_string":"Pusan National University, Busan, Republic of Korea","institution_ids":["https://openalex.org/I4921948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086722086","display_name":"Hyunjin Shin","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hyunjin Shin","raw_affiliation_strings":["MOGAM Institute for Biomedical Research, Seoul, Republic of Korea"],"raw_orcid":"https://orcid.org/0009-0007-6819-4592","affiliations":[{"raw_affiliation_string":"MOGAM Institute for Biomedical Research, Seoul, Republic of Korea","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5036767684"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.29475855,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"Muscle atrophy","score":0.8270953893661499},{"id":"https://openalex.org/keywords/atrophy","display_name":"Atrophy","score":0.7556155323982239},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.678837776184082},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5384893417358398},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"Skeletal muscle","score":0.49316877126693726},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.37236902117729187},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3637843728065491},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.3379459083080292},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3248801827430725},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.32092398405075073},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.22052717208862305},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.21332839131355286},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.19368404150009155}],"concepts":[{"id":"https://openalex.org/C2776263037","wikidata":"https://www.wikidata.org/wiki/Q1557686","display_name":"Muscle atrophy","level":3,"score":0.8270953893661499},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.7556155323982239},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.678837776184082},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5384893417358398},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.49316877126693726},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37236902117729187},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3637843728065491},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3379459083080292},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3248801827430725},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32092398405075073},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.22052717208862305},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21332839131355286},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19368404150009155}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3584371.3613043","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3584371.3613043","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3584371.3613043","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 14th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1145/3584371.3613043","is_oa":true,"landing_page_url":"https://doi.org/10.1145/3584371.3613043","pdf_url":"https://dl.acm.org/doi/pdf/10.1145/3584371.3613043","source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 14th ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics","raw_type":"proceedings-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6899999976158142}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387346510.pdf","grobid_xml":"https://content.openalex.org/works/W4387346510.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1984832913","https://openalex.org/W3137012746","https://openalex.org/W2508547619","https://openalex.org/W4386425299","https://openalex.org/W3017811988","https://openalex.org/W2052379600","https://openalex.org/W2900206747","https://openalex.org/W2766376400","https://openalex.org/W4389727574","https://openalex.org/W2028641245"],"abstract_inverted_index":{"Skeletal":[0],"muscle":[1,10,44,60,84,207],"atrophy":[2,13,45,61,111],"is":[3,14,35],"defined":[4],"as":[5],"an":[6,198],"unwanted":[7],"loss":[8],"of":[9,16,21,27,59,66,81,89,165],"mass.":[11],"Muscle":[12],"one":[15],"the":[17,53,64,78,150,155,163,180],"major":[18],"side":[19],"effects":[20],"high":[22],"dose":[23],"or":[24],"long-term":[25],"usage":[26],"glucocorticoids":[28],"(e.g.,":[29],"dexamethasone);":[30],"therefore,":[31],"such":[32],"a":[33,40,87,98,174,203],"drug":[34],"often":[36],"used":[37],"to":[38,51,154],"induce":[39],"model":[41],"system":[42],"for":[43,206],"research.":[46],"This":[47],"study":[48,194],"was":[49],"designed":[50],"explore":[52],"key":[54,151],"factors":[55],"and":[56,76,113,132,136,139,183],"molecular":[57],"mechanisms":[58],"based":[62],"on":[63,179],"analysis":[65,146],"transcriptomic":[67],"profiles":[68],"using":[69],"systems":[70],"biology":[71],"approaches.":[72],"Here,":[73],"we":[74,100,122,190],"generated":[75],"analyzed":[77],"RNA-seq":[79],"data":[80],"gastrocnemius":[82],"(GA)":[83],"specimens":[85],"from":[86],"group":[88],"C57BL/6":[90],"male":[91],"mice":[92],"treated":[93],"with":[94,110,159],"dexamethasone":[95],"(DEX).":[96],"As":[97],"result,":[99],"successfully":[101],"identified":[102],"659":[103],"differentially":[104],"expressed":[105],"genes":[106,172],"between":[107],"GA":[108],"muscles":[109],"(n=4)":[112],"healthy":[114],"controls":[115],"(n=5).":[116],"By":[117],"running":[118],"pathway":[119,171],"enrichment":[120],"analysis,":[121],"found":[123],"interesting":[124],"gene":[125],"sets":[126],"including":[127],"circadian":[128],"rhythm,":[129],"protein":[130],"digestion":[131],"absorption,":[133],"AMPK":[134],"signaling,":[135],"antigen":[137],"processing":[138],"presentation":[140],"pathways.":[141],"Furthermore,":[142],"our":[143,193],"active":[144],"subnetwork":[145],"also":[147],"showed":[148],"that":[149,169,192],"molecules":[152],"belonging":[153],"pathways":[156],"tightly":[157],"interact":[158],"each":[160],"other":[161],"at":[162],"level":[164],"protein-protein":[166],"interaction,":[167],"assuring":[168],"these":[170],"provide":[173],"critical":[175],"clue":[176],"in":[177],"understanding":[178],"disease":[181],"mechanism":[182],"subsequent":[184],"therapeutic":[185],"target":[186],"identification.":[187],"In":[188],"conclusion,":[189],"believe":[191],"results":[195],"will":[196],"be":[197],"important":[199],"step":[200],"towards":[201],"finding":[202],"treatment":[204],"solution":[205],"atrophy.":[208]},"counts_by_year":[],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
