{"id":"https://openalex.org/W4313136189","doi":"https://doi.org/10.1145/3570773.3570784","title":"Research status and prospect of immune checkpoint inhibitors for melanoma","display_name":"Research status and prospect of immune checkpoint inhibitors for melanoma","publication_year":2022,"publication_date":"2022-10-13","ids":{"openalex":"https://openalex.org/W4313136189","doi":"https://doi.org/10.1145/3570773.3570784"},"language":"en","primary_location":{"id":"doi:10.1145/3570773.3570784","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3570773.3570784","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 3rd International Symposium on Artificial Intelligence for Medicine Sciences","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060430167","display_name":"Yuyi Liang","orcid":"https://orcid.org/0000-0002-4306-3699"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yuyi Liang","raw_affiliation_strings":["155 Consumers Rd Unit 108, Canada"],"affiliations":[{"raw_affiliation_string":"155 Consumers Rd Unit 108, Canada","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083361374","display_name":"Tianshi Liu","orcid":"https://orcid.org/0000-0001-8539-7286"},"institutions":[{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianshi Liu","raw_affiliation_strings":["Department of Otolaryngology, Zhongshan Hospital, Fudan University, China"],"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Zhongshan Hospital, Fudan University, China","institution_ids":["https://openalex.org/I4210127074","https://openalex.org/I24943067"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060270262","display_name":"Yifan Wu","orcid":"https://orcid.org/0000-0002-0274-3305"},"institutions":[{"id":"https://openalex.org/I12411659","display_name":"Tianjin University of Traditional Chinese Medicine","ror":"https://ror.org/05dfcz246","country_code":"CN","type":"education","lineage":["https://openalex.org/I12411659"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yifan Wu","raw_affiliation_strings":["Department of clinical medicine in Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, China"],"affiliations":[{"raw_affiliation_string":"Department of clinical medicine in Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, China","institution_ids":["https://openalex.org/I12411659"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5060430167"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.27377522,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"30","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"Melanoma","score":0.8930790424346924},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.7266870737075806},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"Drug resistance","score":0.5616050958633423},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.5235856771469116},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5079053044319153},{"id":"https://openalex.org/keywords/incidence","display_name":"Incidence (geometry)","score":0.4731389582157135},{"id":"https://openalex.org/keywords/metastasis","display_name":"Metastasis","score":0.46720001101493835},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.4461973011493683},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"Combination therapy","score":0.4418472945690155},{"id":"https://openalex.org/keywords/metastatic-melanoma","display_name":"Metastatic melanoma","score":0.41740483045578003},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.3525939881801605},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.336896687746048},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.22703710198402405},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.08780035376548767}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.8930790424346924},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7266870737075806},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5616050958633423},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5235856771469116},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5079053044319153},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.4731389582157135},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.46720001101493835},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4461973011493683},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.4418472945690155},{"id":"https://openalex.org/C2994587330","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Metastatic melanoma","level":3,"score":0.41740483045578003},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3525939881801605},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.336896687746048},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.22703710198402405},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08780035376548767},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3570773.3570784","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3570773.3570784","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the 3rd International Symposium on Artificial Intelligence for Medicine Sciences","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.4399999976158142}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1809627231","https://openalex.org/W1967828043","https://openalex.org/W1975502721","https://openalex.org/W1977012657","https://openalex.org/W2004630197","https://openalex.org/W2062948694","https://openalex.org/W2089210293","https://openalex.org/W2111381709","https://openalex.org/W2115424172","https://openalex.org/W2128035403","https://openalex.org/W2143772132","https://openalex.org/W2164281389","https://openalex.org/W2185075416","https://openalex.org/W2558219863","https://openalex.org/W2782333299","https://openalex.org/W2804681185","https://openalex.org/W2963476376","https://openalex.org/W4233298134","https://openalex.org/W4233897861","https://openalex.org/W6667031232","https://openalex.org/W6675009111","https://openalex.org/W6736830243","https://openalex.org/W6748460179","https://openalex.org/W6808171529","https://openalex.org/W7073599445"],"related_works":["https://openalex.org/W1991879524","https://openalex.org/W2171435634","https://openalex.org/W4292582583","https://openalex.org/W2159897971","https://openalex.org/W2964433561","https://openalex.org/W95056088","https://openalex.org/W2011769377","https://openalex.org/W2337657580","https://openalex.org/W2014887256","https://openalex.org/W2782900440"],"abstract_inverted_index":{"Melanoma":[0],"is":[1,13,105],"a":[2,34,39,113],"common":[3],"cutaneous":[4],"malignant":[5],"tumor":[6],"in":[7,59,129],"clinic.":[8],"The":[9],"incidence":[10],"of":[11,43,57,80,102,119,127,132,137],"melanoma":[12,32,63,133],"on":[14,99],"the":[15,77,100,117,124,130,135],"rise,":[16],"with":[17,30,38,61,65],"serious":[18],"phenotype":[19],"and":[20,27,51,54,70,134],"easy":[21],"metastasis.":[22],"Prior":[23],"to":[24,76,94,115],"targeted":[25],"therapy":[26],"ICI,":[28,81,95],"patients":[29,60,89],"advanced":[31,62],"had":[33],"very":[35],"poor":[36],"prognosis,":[37],"5-year":[40],"survival":[41,50,53],"rate":[42],"less":[44],"than":[45],"10%.":[46],"ICI":[47,128],"extended":[48],"progression-free":[49],"overall":[52],"improved":[55],"quality":[56],"life":[58],"compared":[64],"conventional":[66],"treatment.":[67],"As":[68],"more":[69,71],"attention":[72],"has":[73],"been":[74,85],"paid":[75],"clinical":[78,125],"application":[79],"its":[82],"limitations":[83],"have":[84],"further":[86,97],"discovered.":[87],"Some":[88],"develop":[90],"resistance":[91,104],"or":[92],"insensitivity":[93],"so":[96],"research":[98],"mechanism":[101,136],"drug":[103,109,138],"needed.":[106],"In":[107],"addition,":[108],"combination":[110],"may":[111],"be":[112],"way":[114],"improve":[116],"effect":[118],"ICI.":[120],"This":[121],"article":[122],"reviews":[123],"efficacy":[126],"treatment":[131],"resistance.":[139]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
