{"id":"https://openalex.org/W4214920733","doi":"https://doi.org/10.1145/3510427.3510445","title":"Investigating the Mechanism of Chemical Drugs on Neurodegenerative Diseases","display_name":"Investigating the Mechanism of Chemical Drugs on Neurodegenerative Diseases","publication_year":2022,"publication_date":"2022-01-07","ids":{"openalex":"https://openalex.org/W4214920733","doi":"https://doi.org/10.1145/3510427.3510445"},"language":"en","primary_location":{"id":"doi:10.1145/3510427.3510445","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3510427.3510445","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 12th International Conference on Bioscience, Biochemistry and Bioinformatics","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002324851","display_name":"Yunbin SHEN","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"YiYang Shen","raw_affiliation_strings":["Eastbourne College, UK"],"affiliations":[{"raw_affiliation_string":"Eastbourne College, UK","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5002324851"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1742,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.53113485,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"120","last_page":"124"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12891","display_name":"Medicinal Plants and Neuroprotection","score":0.9925000071525574,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"Substantia nigra","score":0.6506428718566895},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6331529021263123},{"id":"https://openalex.org/keywords/dopamine","display_name":"Dopamine","score":0.5359341502189636},{"id":"https://openalex.org/keywords/levodopa","display_name":"Levodopa","score":0.47320932149887085},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.4340885281562805},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"Neurodegeneration","score":0.43033531308174133},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.42597177624702454},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"Cognitive decline","score":0.41772329807281494},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.40430232882499695},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.37768861651420593},{"id":"https://openalex.org/keywords/parkinsons-disease","display_name":"Parkinson's disease","score":0.3285934031009674},{"id":"https://openalex.org/keywords/dementia","display_name":"Dementia","score":0.30860134959220886},{"id":"https://openalex.org/keywords/dopaminergic","display_name":"Dopaminergic","score":0.24568966031074524},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.24500277638435364},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.1974232792854309}],"concepts":[{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.6506428718566895},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6331529021263123},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5359341502189636},{"id":"https://openalex.org/C2780304432","wikidata":"https://www.wikidata.org/wiki/Q300989","display_name":"Levodopa","level":4,"score":0.47320932149887085},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4340885281562805},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.43033531308174133},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.42597177624702454},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.41772329807281494},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40430232882499695},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.37768861651420593},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.3285934031009674},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.30860134959220886},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.24568966031074524},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24500277638435364},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.1974232792854309},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3510427.3510445","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3510427.3510445","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2022 12th International Conference on Bioscience, Biochemistry and Bioinformatics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6499999761581421}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W152815861","https://openalex.org/W1529185793","https://openalex.org/W1605886981","https://openalex.org/W1804923980","https://openalex.org/W1897859562","https://openalex.org/W1984652813","https://openalex.org/W2042808393","https://openalex.org/W2053972194","https://openalex.org/W2073566962","https://openalex.org/W2085907924","https://openalex.org/W2102711224","https://openalex.org/W2113463442","https://openalex.org/W2126149232","https://openalex.org/W2129085204","https://openalex.org/W2164898103","https://openalex.org/W2226005455","https://openalex.org/W2884196012","https://openalex.org/W2905504149","https://openalex.org/W2909265047","https://openalex.org/W2965717703","https://openalex.org/W3042050487","https://openalex.org/W3159661950","https://openalex.org/W4213459747"],"related_works":["https://openalex.org/W1975640329","https://openalex.org/W1572566098","https://openalex.org/W2374742110","https://openalex.org/W2387012743","https://openalex.org/W2047093218","https://openalex.org/W2034209754","https://openalex.org/W2374733173","https://openalex.org/W4385545720","https://openalex.org/W1980588181","https://openalex.org/W4251809457"],"abstract_inverted_index":{"Neurodegenerative":[0],"diseases":[1,24,59],"are":[2,17,74,150,167,184,201,216],"one":[3],"of":[4,52,56,70,80,91,107,118,121,131,134],"the":[5,12,20,44,65,78,97,105,112,119,194],"most":[6,21],"commonly":[7],"seen":[8],"diseases,":[9],"especially":[10],"among":[11,64],"elderly.":[13,66],"AD":[14,139,229],"and":[15,93,140,147,164,181,211,230],"PD":[16],"by":[18,41],"far":[19],"common":[22],"neurodegenerative":[23,58],"affecting":[25],"around":[26],"50":[27],"million":[28,40],"people":[29],"worldwide.":[30],"This":[31,124],"number":[32,51],"is":[33,104],"estimated":[34],"to":[35,38,48,76,89,127,156,170,186,191,218,227],"be":[36,77],"tripled":[37],"14":[39],"2060":[42],"as":[43,144,207],"world":[45],"population":[46],"continues":[47],"age.":[49],"The":[50,67,189],"individuals":[53],"at":[54],"risk":[55],"developing":[57],"will":[60],"also":[61],"increase,":[62],"particularly":[63],"neuropathological":[68,98],"hallmarks":[69],"Alzheimer's":[71],"Diseases":[72,102],"(AD)":[73],"thought":[75],"formation":[79],"beta":[81],"amyloid":[82],"plaques,":[83],"intracellular":[84],"neurofibrillary":[85],"tangles,":[86],"which":[87],"leads":[88],"loss":[90,106,117],"neurons":[92,110],"synapses.":[94],"In":[95,175],"contrast,":[96],"finding":[99],"for":[100,137],"Parkinson's":[101],"(PD)":[103],"dopamine":[108,165],"producing":[109],"in":[111,116],"substantia":[113],"nigra,":[114],"resulting":[115],"ability":[120],"voluntary":[122],"movements.":[123],"article":[125],"aims":[126],"provide":[128],"an":[129],"overview":[130],"different":[132],"types":[133],"treatments":[135,215],"used":[136,155],"treating":[138],"PD.":[141,174,231],"Drugs":[142],"such":[143,206],"acetylcholinesterase":[145],"inhibitors":[146],"NMDA":[148],"antagonists":[149],"currently":[151],"FDA":[152],"approved":[153],"medicines":[154,222],"treat":[157,228],"AD.":[158],"Monoamine":[159],"Oxidase":[160],"B":[161],"inhibitors,":[162],"Levodopa":[163],"agonist":[166],"drugs":[168,190,199],"prescribed":[169],"patients":[171,187],"diagnosed":[172],"with":[173,203,223],"addition,":[176],"music":[177],"therapy,":[178],"art":[179],"therapy":[180],"orientation":[182],"exercises":[183],"provided":[185],"alongside":[188],"slow":[192],"down":[193],"cognition":[195],"decline.":[196],"However,":[197],"those":[198],"usually":[200],"associated":[202],"side":[204,225],"effects":[205,226],"vomiting,":[208],"diarrhea,":[209],"headache":[210],"constipation.":[212],"Therefore,":[213],"better":[214],"required":[217],"have":[219],"more":[220],"effective":[221],"lower":[224]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
