{"id":"https://openalex.org/W3192265895","doi":"https://doi.org/10.1145/3469678.3469715","title":"A Meta-analysis: Evaluating the Effect of METTL3/METTL14 on m6A Level Based on Knockdown Samples","display_name":"A Meta-analysis: Evaluating the Effect of METTL3/METTL14 on m6A Level Based on Knockdown Samples","publication_year":2021,"publication_date":"2021-07-20","ids":{"openalex":"https://openalex.org/W3192265895","doi":"https://doi.org/10.1145/3469678.3469715","mag":"3192265895"},"language":"en","primary_location":{"id":"doi:10.1145/3469678.3469715","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3469678.3469715","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Fifth International Conference on Biological Information and Biomedical Engineering","raw_type":"proceedings-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100398043","display_name":"Yuxin Zhang","orcid":"https://orcid.org/0000-0003-1900-6712"},"institutions":[{"id":"https://openalex.org/I69356397","display_name":"Xi\u2019an Jiaotong-Liverpool University","ror":"https://ror.org/03zmrmn05","country_code":"CN","type":"education","lineage":["https://openalex.org/I69356397"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuxin Zhang","raw_affiliation_strings":["Xi'an Jiaotong and Liverpool University, China"],"affiliations":[{"raw_affiliation_string":"Xi'an Jiaotong and Liverpool University, China","institution_ids":["https://openalex.org/I69356397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020339836","display_name":"Yuxuan Wu","orcid":"https://orcid.org/0000-0003-1333-4627"},"institutions":[{"id":"https://openalex.org/I69356397","display_name":"Xi\u2019an Jiaotong-Liverpool University","ror":"https://ror.org/03zmrmn05","country_code":"CN","type":"education","lineage":["https://openalex.org/I69356397"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxuan Wu","raw_affiliation_strings":["Xi'an Jiaotong and Liverpool University, China"],"affiliations":[{"raw_affiliation_string":"Xi'an Jiaotong and Liverpool University, China","institution_ids":["https://openalex.org/I69356397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040574122","display_name":"Di Zhen","orcid":null},"institutions":[{"id":"https://openalex.org/I69356397","display_name":"Xi\u2019an Jiaotong-Liverpool University","ror":"https://ror.org/03zmrmn05","country_code":"CN","type":"education","lineage":["https://openalex.org/I69356397"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Di Zhen","raw_affiliation_strings":["Xi'an Jiaotong and Liverpool University, China"],"affiliations":[{"raw_affiliation_string":"Xi'an Jiaotong and Liverpool University, China","institution_ids":["https://openalex.org/I69356397"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090892714","display_name":"Kunqi Chen","orcid":"https://orcid.org/0000-0002-6025-8957"},"institutions":[{"id":"https://openalex.org/I69356397","display_name":"Xi\u2019an Jiaotong-Liverpool University","ror":"https://ror.org/03zmrmn05","country_code":"CN","type":"education","lineage":["https://openalex.org/I69356397"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kunqi Chen","raw_affiliation_strings":["Xi'an Jiaotong and Liverpool University, China"],"affiliations":[{"raw_affiliation_string":"Xi'an Jiaotong and Liverpool University, China","institution_ids":["https://openalex.org/I69356397"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062986831","display_name":"Jia Meng","orcid":"https://orcid.org/0000-0003-3455-205X"},"institutions":[{"id":"https://openalex.org/I69356397","display_name":"Xi\u2019an Jiaotong-Liverpool University","ror":"https://ror.org/03zmrmn05","country_code":"CN","type":"education","lineage":["https://openalex.org/I69356397"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Meng","raw_affiliation_strings":["Xi'an Jiaotong and Liverpool University, China"],"affiliations":[{"raw_affiliation_string":"Xi'an Jiaotong and Liverpool University, China","institution_ids":["https://openalex.org/I69356397"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5100398043"],"corresponding_institution_ids":["https://openalex.org/I69356397"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07520443,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11102","display_name":"HVDC Systems and Fault Protection","score":0.9871000051498413,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-knockdown","display_name":"Gene knockdown","score":0.5675448179244995},{"id":"https://openalex.org/keywords/meta-analysis","display_name":"Meta-analysis","score":0.46555525064468384},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.37435394525527954},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.1613539159297943},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1407092809677124},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.06609576940536499}],"concepts":[{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5675448179244995},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.46555525064468384},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.37435394525527954},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1613539159297943},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1407092809677124},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.06609576940536499},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1145/3469678.3469715","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3469678.3469715","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Fifth International Conference on Biological Information and Biomedical Engineering","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W2002458471","https://openalex.org/W2009308529","https://openalex.org/W2044676948","https://openalex.org/W2085452046","https://openalex.org/W2327216023","https://openalex.org/W2342299314","https://openalex.org/W2532091902","https://openalex.org/W2600862208","https://openalex.org/W2743522323","https://openalex.org/W2754391888","https://openalex.org/W2754499625","https://openalex.org/W2806822607","https://openalex.org/W2912369228","https://openalex.org/W2923286987","https://openalex.org/W2951746943","https://openalex.org/W2979436219","https://openalex.org/W2989386604","https://openalex.org/W2989640395","https://openalex.org/W3008823185"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W4386799875","https://openalex.org/W4213065871","https://openalex.org/W4361818220","https://openalex.org/W4361818978","https://openalex.org/W4361818627","https://openalex.org/W3157667906","https://openalex.org/W2800322456","https://openalex.org/W2931234257"],"abstract_inverted_index":{"N6-methyladenosine":[0],"(m6A)":[1],"is":[2],"a":[3,46],"dynamic":[4],"modification":[5,160],"regulated":[6],"by":[7],"the":[8,30,36,51,61,65,72,85,90,96,103,107,152,155],"m6A":[9],"enzymes":[10],"prevalent":[11],"on":[12,64],"mRNA.":[13],"The":[14,58],"Mettl3":[15],"and":[16,32,53,95,115,132,146,159],"mettl14":[17],"are":[18],"two":[19,133],"subunits":[20],"of":[21,29,55,60,67,74,87,106,157,161],"methyltransferase.":[22],"Different":[23],"studies":[24],"have":[25,43],"shown":[26],"that":[27],"knockout":[28],"METL3":[31],"MTEL14":[33],"genes":[34],"has":[35],"potential":[37],"to":[38,49,83,102,117,144],"change":[39],"methylation":[40,69,162],"levels.":[41],"We":[42],"therefore":[44],"undertaken":[45],"meta-analysis":[47],"study":[48],"assess":[50],"quality":[52],"quantity":[54],"available":[56],"evidence.":[57],"focus":[59],"research":[62],"would":[63],"effects":[66],"mRNA":[68],"level":[70],"after":[71],"depletion":[73],"METTL3":[75,125],"or":[76],"METTL14.":[77],"R":[78],"package":[79],"\u201cMetafor\u201d":[80],"was":[81],"applied":[82],"output":[84],"model":[86],"random":[88],"effect,":[89],"regarding":[91],"risk":[92],"ratios":[93],"(RRs),":[94],"95%":[97],"confidence":[98],"intervals":[99],"(CIs).":[100],"Owing":[101],"high":[104],"heterogeneity":[105],"overall":[108],"data":[109],"(I2>99%),":[110],"some":[111],"samples":[112],"were":[113,142],"selected":[114],"excluded":[116],"an":[118],"acceptable":[119],"level.":[120,163],"Three":[121],"published":[122],"trials":[123],"for":[124,134],"(Q":[126,136],"=":[127,130,137,140],"12.85,":[128],"I2":[129,139],"37.8%)":[131],"METTL4":[135],"45.48,":[138],"82.9%)":[141],"qualified":[143],"review":[145],"analyze.":[147],"Consequently,":[148],"we":[149],"successfully":[150],"proved":[151],"correlation":[153],"between":[154],"knockdown":[156],"METTL3/METTL14":[158]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
